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1. Full Text DNA damage foci: Meaning and significance
by Rothkamm, Kai and Barnard, Stephen and Moquet, Jayne and Ellender, Michele and Rana, Zohaib and Burdak‐Rothkamm, Susanne
Environmental and Molecular Mutagenesis, ISSN 0893-6692, 07/2015, Volume 56, Issue 6, pp. 491 - 504
The discovery of DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the... 
genotoxicity | γH2AX | 53BP1 | DNA double‐strand break | ionizing radiation | Ionizing radiation | DNA double-strand break | Genotoxicity | H2AX | DOUBLE-STRAND BREAKS | REPAIR PATHWAY CHOICE | ENVIRONMENTAL SCIENCES | GAMMA-H2AX FOCI | MEDIATED GENOMIC INSTABILITY | CANCER-PATIENTS | HISTONE H2AX PHOSPHORYLATION | DOSE IONIZING-RADIATION | IN-VIVO FORMATION | GENETICS & HEREDITY | TOXICOLOGY | PERIPHERAL-BLOOD LYMPHOCYTES | HOMOLOGOUS RECOMBINATION | Biomarkers - metabolism | Animals | DNA Damage - physiology | DNA Repair | Humans | Radiation Monitoring - methods | Histones - metabolism | Mutagenicity Tests - methods | DNA Breaks, Double-Stranded | DNA Damage - radiation effects | Radiation, Ionizing | Genetic research | DNA damage | DNA
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2. Full Text γH2AX foci analysis for monitoring DNA double-strand break repair: Strengths, limitations and optimization
by Löbrich, Markus and Shibata, Atsushi and Beucher, Andrea and Fisher, Anna and Ensminger, Michael and Goodarzi, Aaron A and Barton, Olivia and Jeggo, Penny A
Cell Cycle, ISSN 1538-4101, 02/2010, Volume 9, Issue 4, pp. 662 - 669
DNA double-strand breaks (DSBs) represent an important radiation-induced lesion and impaired DSB repair provides the best available correlation with... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Ionizing radiation | Pulsed-field gel electrophoresis | γH2AX foci | Hydrogen peroxide | Single-stranded DNA | Ataxia telangiectasia | Double-strand break repair | RECOGNITION | double-strand break repair | hydrogen peroxide | CANCER | CELL BIOLOGY | DAMAGE RESPONSE | single-stranded DNA | gamma H2AX foci | ataxia telangiectasia | S-PHASE | pulsed-field gel electrophoresis | CELL-CYCLE | ATM | CHECKPOINT | RADIOSENSITIVITY | IONIZING-RADIATION | CONTRIBUTES | ionizing radiation
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3. Full Text γH2AX foci formation in the absence of DNA damage: Mitotic H2AX phosphorylation is mediated by the DNA-PKcs/CHK2 pathway
by Tu, Wen-Zhi and Li, Bing and Huang, Bo and Wang, Yu and Liu, Xiao-Dan and Guan, Hua and Zhang, Shi-Meng and Tang, Yan and Rang, Wei-Qing and Zhou, Ping-Kun
FEBS Letters, ISSN 0014-5793, 11/2013, Volume 587, Issue 21, pp. 3437 - 3443
Phosphorylated H2AX is considered to be a biomarker for DNA double-strand breaks (DSB), but recent evidence suggests that γH2AX does not always indicate the... 
DNA-PKcs | CHK2 | Mitosis | γH2AX | DNA damage | CELLS | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | DOUBLE-STRAND BREAKS | HISTONE H2AX | CELL BIOLOGY | GENOMIC INSTABILITY | REPAIR | BIOPHYSICS | gamma H2AX | ATM | CHECKPOINT | Phosphorylation | Mitosis - radiation effects | Ataxia Telangiectasia Mutated Proteins - metabolism | Signal Transduction | Humans | DNA - metabolism | Oligopeptides - metabolism | DNA - radiation effects | DNA Breaks, Double-Stranded | Checkpoint Kinase 2 - metabolism | Histones - genetics | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | DNA Damage | HeLa Cells | Histones - metabolism | Radiation, Ionizing | Index Medicus
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4. Full Text Nanostructure of DNA repair foci revealed by superresolution microscopy
by Sisario, Dmitri and Memmel, Simon and Doose, Sören and Neubauer, Julia and Zimmermann, Heiko and Flentje, Michael and Djuzenova, Cholpon S and Sauer, Markus and Sukhorukov, Vladimir L
FASEB Journal, ISSN 0892-6638, 12/2018, Volume 32, Issue 12, pp. 6469 - 6477
Induction of DNA double-strand breaks (DSBs) by ionizing radiation leads to formation of micrometer-sized DNA-repair foci, whose organization on the... 
Double-strand breaks | Ionizing radiation | DNA-PK | gH2AX | DSTORM | H2AX | CHROMATIN FIBER | CATALYTIC SUBUNIT | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT PROTEIN-KINASE | HISTONE H2AX | double-strand breaks | CELL BIOLOGY | NUCLEOSOME CORE | DAMAGE RESPONSE | GAMMA-H2AX FOCI | PHOSPHORYLATED H2AX | BIOLOGY | dSTORM | IONIZING-RADIATION | ionizing radiation
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5. Full Text γ-H2AX foci are increased in lymphocytes in vivo in young children 1 h after very low-dose X-irradiation: a pilot study
by Halm, Brunhild M and Franke, Adrian A and Lai, Jennifer F and Turner, Helen C and Brenner, David J and Zohrabian, Vatche M and DiMauro, Robert
Pediatric Radiology, ISSN 0301-0449, 10/2014, Volume 44, Issue 10, pp. 1310 - 1317
Computed tomography (CT) is an imaging modality involving ionizing radiation. The presence of γ-H2AX foci after low to moderate ionizing radiation exposure has... 
Pediatrics | Radiation dose | Medicine & Public Health | Computed tomography | Lymphocytic γ-H2AX foci formation | Oncology | Nuclear Medicine | Children | Imaging / Radiology | Ultrasound | Neuroradiology | Lymphocytic gamma-H2AX foci formation | UNITED-STATES | DNA-DAMAGE | DOUBLE-STRAND BREAKS | HISTONE H2AX | COMPUTED-TOMOGRAPHY | LOW-LEVEL | CANCER-RISKS | HELICAL CT | PEDIATRICS | IONIZING-RADIATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | EXPOSURE | Lymphocytes - physiology | Pilot Projects | Histones - genetics | Histones - radiation effects | Humans | Infant | Male | Tomography, X-Ray Computed | Lymphocytes - radiation effects | DNA Damage | Radiation Dosage | Dose-Response Relationship, Radiation
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6. Full Text Manual versus automated γ-H2AX foci analysis across five European laboratories: Can this assay be used for rapid biodosimetry in a large scale radiation accident?
by Rothkamm, Kai and Barnard, Stephen and Ainsbury, Elizabeth A and Al-hafidh, Jenna and Barquinero, Joan-Francesc and Lindholm, Carita and Moquet, Jayne and Perälä, Marjo and Roch-Lefèvre, Sandrine and Scherthan, Harry and Thierens, Hubert and Vral, Anne and Vandersickel, Veerle
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, ISSN 1383-5718, 08/2013, Volume 756, Issue 1-2, pp. 170 - 173
The identification of severely exposed individuals and reassurance of the ‘worried well’ are of prime importance for initial triage following a large scale... 
Gamma-H2AX | Ionizing radiation | Biomarker | Biological dosimetry | DNA double-strand break | Radiation-induced foci | HUMAN-LYMPHOCYTES | CELLS | DNA-DAMAGE | DOUBLE-STRAND BREAKS | REPAIR | X-RAYS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | TOXICOLOGY | EXPOSURE
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7. Full Text Does γH2AX foci formation depend on the presence of DNA double strand breaks?
by Takahashi, Akihisa and Ohnishi, Takeo
Cancer Letters, ISSN 0304-3835, 2005, Volume 229, Issue 2, pp. 171 - 179
H2AX is a histone variant that is systematically found and ubiquitously distributed throughout the genome. Since it has been reported that DNA double-strand... 
Double strand break | Environmental factors | Replication arrest | γH2AX | double strand break | environmental factors | SERINE 139 | HEAT-SHOCK | INDUCTION | MAMMALIAN-CELLS | CHO CELLS | DAMAGE | HISTONE H2AX PHOSPHORYLATION | ONCOLOGY | gamma H2AX | S-PHASE | ATM | HOMOLOGOUS RECOMBINATION | replication arrest
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8. Full Text Establishment of a γ-H2AX foci-based assay to determine biological dose of radon to red bone marrow in rats
by Wang, Jing and He, Linfeng and Fan, Dunhuang and Ding, Defang and Wang, Xufei and Gao, Yun and Zhang, Xuxia and Li, Qiang and Chen, Honghong
Scientific Reports, ISSN 2045-2322, 07/2016, Volume 6, Issue 1, p. 30018
The biodosimetric information is critical for assessment of cancer risk in populations exposed to high radon. However, no tools are available for biological... 
HUMAN-LYMPHOCYTES | GAMMA-H2AX FOCI | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | DOUBLE-STRAND BREAKS | HUMAN FIBROBLASTS | CHILDHOOD LEUKEMIA | IONIZING-RADIATION | HIGH-LET | H2AX PHOSPHORYLATION
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9. Full Text Retention of γH2AX foci as an indication of lethal DNA damage
by Olive, Peggy L
Radiotherapy and Oncology, ISSN 0167-8140, 2011, Volume 101, Issue 1, pp. 18 - 23
Abstract The application of biological responses of tumours to predict clinical responses to treatment represents a challenging goal with the potential to... 
Hematology, Oncology and Palliative Medicine | Tumour response | γH2AX | DNA damage | Prediction | DOUBLE-STRAND BREAKS | TUMOR-CELLS | RADIATION SENSITIVITY | MAMMALIAN-CELLS | LUNG-CANCER | PHOSPHORYLATED HISTONE H2AX | ONCOLOGY | gamma H2AX | RESIDUAL GAMMA-H2AX | REPAIR FOCI | RADIOSENSITIVITY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | CANCER CELL-LINES | Gene Targeting - methods | Predictive Value of Tests | Cell Death - radiation effects | Apoptosis - radiation effects | Biomarkers, Tumor - analysis | Humans | DNA Repair - physiology | Apoptosis - genetics | Drug Resistance, Neoplasm | Treatment Outcome | DNA Repair - genetics | Radiation Dosage | Chemoradiotherapy | DNA Breaks, Double-Stranded | Neoplasms - chemistry | Neoplasms - therapy | Flow Cytometry | Cell Death - genetics | Histones - analysis | Histones - radiation effects | Neoplasms - genetics | Cell Line, Tumor | DNA Damage - genetics | Radiation, Ionizing
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10. Full Text Induction and Repair of DNA DSB as Revealed by H2AX Phosphorylation Foci in Human Fibroblasts Exposed to Low- and High-LET Radiation: Relationship with Early and Delayed Reproductive Cell Death
by F. Antonelli and A. Campa and G. Esposito and P. Giardullo and M. Belli and V. Dini and S. Meschini and G. Simone and E. Sorrentino and S. Gerardi and G. A. P. Cirrone and M. A. Tabocchini
Radiation Research, ISSN 0033-7587, 2015, Volume 183, Issue 4, pp. 417 - 431
The spatial distribution of radiation-induced DNA breaks within the cell nucleus depends on radiation quality in terms of energy deposition pattern. It is... 
DAMAGE-RESPONSE | DOUBLE-STRAND BREAKS | HISTONE H2AX | HEAT-LABILE SITES | MAMMALIAN-CELLS | DEFICIENT CELLS | TRACK STRUCTURE | IRRADIATION | GAMMA-H2AX FOCI | BIOPHYSICS | BIOLOGY | IONIZING-RADIATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Cell Line | Cell Death - radiation effects | Mutation - radiation effects | Humans | DNA Repair - radiation effects | DNA Breaks, Double-Stranded - radiation effects | Phosphorylation - radiation effects | Fibroblasts - radiation effects | Fibroblasts - cytology | Linear Energy Transfer | Histones - metabolism | Kinetics | Dose-Response Relationship, Radiation | Fibroblasts - metabolism
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11. Full Text Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization
by Costes, S.V and Chiolo, I and Pluth, J.M and Barcellos-Hoff, M.H and Jakob, B
Mutation Research-Reviews in Mutation Research, ISSN 1383-5742, 2010, Volume 704, Issue 1, pp. 78 - 87
DNA damage sensing proteins have been shown to localize to the sites of DNA double strand breaks (DSB) within seconds to minutes following ionizing radiation... 
DSB | Chromatin | Complex damage | γH2AX | 53BP1 | ATMp | Review | Repair kinetics | DEACETYLASE INHIBITOR | LOW-LET RADIATION | DOUBLE-STRAND BREAKS | HETEROCHROMATIN PROTEIN-1 | MAMMALIAN-CELLS | POSITIONAL STABILITY | PHOSPHORYLATED HISTONE H2AX | GAMMA-H2AX FOCI | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | gamma H2AX | GENETICS & HEREDITY | HUMAN FIBROBLASTS | NUCLEAR FOCI | TOXICOLOGY | Chromatin - ultrastructure | Models, Theoretical | Chromatin - metabolism | Tumor Suppressor Proteins - metabolism | Humans | Cell Cycle Proteins - metabolism | Chromatin Assembly and Disassembly | Intracellular Signaling Peptides and Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA Breaks, Double-Stranded | DNA-Binding Proteins - metabolism | DNA Repair | DNA Damage | Histones - metabolism | Tumor Suppressor p53-Binding Protein 1 | Dose-Response Relationship, Radiation | Protein-Serine-Threonine Kinases - metabolism
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12. Full Text Mean frequency and relative fluorescence intensity measurement of γ‐H2AX foci dose response in PBL exposed to γ‐irradiation: An inter‐ and intra‐laboratory comparison and its relevance for radiation triage
by Venkateswarlu, Raavi and Tamizh, Selvan G and Bhavani, Manivannan and Kumar, Arun and Alok, Amit and Karthik, Kanagaraj and Kalra, Namita and Vijayalakshmi, J and Paul, Solomon F. D and Chaudhury, N. K and Venkatachalam, Perumal
Cytometry Part A, ISSN 1552-4922, 12/2015, Volume 87, Issue 12, pp. 1138 - 1146
Measurement of γ‐H2AX protein changes in the peripheral blood lymphocytes (PBL) of individuals exposed to ionizing radiation is a simple, sensitive, and rapid... 
γ‐H2AX foci | dose response curve | inter and intra‐laboratory comparison | γ‐irradiation | biodosimetry | Inter and intra-laboratory comparison | Biodosimetry | γ-H2AX foci | Dose response curve | γ-irradiation | ASSAY | QUANTIFICATION | inter and intra-laboratory comparison | BIOCHEMICAL RESEARCH METHODS | DOUBLE-STRAND BREAKS | OPTIMIZED METHOD | DAMAGE | CELL BIOLOGY | PHOSPHORYLATED HISTONE H2AX | REPAIR | gamma-H2AX foci | PERIPHERAL-BLOOD LYMPHOCYTES | gamma-irradiation | IONIZING-RADIATION | Lymphocytes - metabolism | Gamma Rays | Automation | Cell Separation | Humans | Fluorescence | Male | Flow Cytometry | Adult | Female | Lymphocytes - radiation effects | Histones - metabolism | Kinetics | Cobalt Radioisotopes
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13. Full Text ATR-dependent radiation-induced γH2AX foci in bystander primary human astrocytes and glioma cells
by Burdak-Rothkamm, S and Short, S.C and Folkard, M and Rothkamm, K and Prise, K.M
Oncogene, ISSN 0950-9232, 02/2007, Volume 26, Issue 7, pp. 993 - 1002
Radiotherapy is an important treatment for patients suffering from high-grade malignant gliomas. Non-targeted ( bystander) effects may influence these cells'... 
Targeted irradiation | Bystander signalling | Charged particle irradiation | γH2AX | DNA damage | ATR | bystander signalling | ALPHA-PARTICLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOUBLE-STRAND BREAKS | HISTONE H2AX | CHARGED-PARTICLE MICROBEAM | targeted irradiation | CELL BIOLOGY | GENOMIC INSTABILITY | REACTIVE OXYGEN | ONCOLOGY | gamma H2AX | IRRADIATED-CELLS | GENETICS & HEREDITY | MEDIATED INTERCELLULAR COMMUNICATION | HUMAN FIBROBLASTS | charged particle irradiation | IONIZING-RADIATION | Phosphorylation | Coculture Techniques | Humans | Histones - biosynthesis | Glioma - radiotherapy | Glioma - metabolism | Astrocytes - radiation effects | Histones - radiation effects | Protein-Serine-Threonine Kinases - radiation effects | Glioma - pathology | Cell Cycle Proteins - genetics | Signal Transduction - radiation effects | Bystander Effect - radiation effects | Cell Line | Protein-Serine-Threonine Kinases - physiology | Cell Cycle Proteins - radiation effects | Protein-Serine-Threonine Kinases - genetics | Signal Transduction - genetics | Ataxia Telangiectasia Mutated Proteins | S Phase - genetics | S Phase - radiation effects | Cell Line, Tumor | S Phase - physiology | Signal Transduction - physiology | Cell Cycle Proteins - physiology | Astrocytes - metabolism
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