Articles

UofT Libraries is getting a new library services platform in January 2021.
Learn more about the change.

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
science & technology (230) 230
life sciences & biomedicine (224) 224
humans (162) 162
animals (125) 125
gamma-secretase (102) 102
alzheimer's disease (95) 95
amyloid precursor protein secretases - antagonists & inhibitors (73) 73
notch (70) 70
mice (67) 67
amyloid precursor protein secretases - metabolism (64) 64
neurosciences & neurology (62) 62
neurosciences (59) 59
gamma-secretase inhibitor (55) 55
oncology (54) 54
biochemistry & molecular biology (52) 52
gamma secretase (50) 50
cell biology (48) 48
pharmacology & pharmacy (44) 44
receptors, notch - metabolism (44) 44
female (42) 42
alzheimer’s disease (40) 40
biological and medical sciences (36) 36
medical sciences (35) 35
signal transduction (35) 35
amyloid precursor protein (34) 34
gamma secretase inhibitor (34) 34
amyloid beta-peptides - metabolism (32) 32
cancer (32) 32
male (32) 32
neurology (31) 31
proteins (30) 30
secretase (29) 29
enzyme inhibitors - pharmacology (28) 28
alzheimer disease - metabolism (27) 27
amyloid (24) 24
alzheimer disease - drug therapy (23) 23
amyloid beta-protein precursor - metabolism (23) 23
cell line, tumor (23) 23
research (23) 23
presenilin (22) 22
gamma-secretase inhibitors (21) 21
mutation (21) 21
signal transduction - drug effects (21) 21
amyloid beta-protein (20) 20
mice, transgenic (19) 19
notch signaling (19) 19
analysis (18) 18
receptors, notch - antagonists & inhibitors (18) 18
alzheimers disease (17) 17
apoptosis (17) 17
app (17) 17
dose-response relationship, drug (17) 17
middle aged (17) 17
amyloid precursor protein secretases (16) 16
breast cancer (16) 16
membrane proteins - metabolism (16) 16
receptors, notch - genetics (16) 16
stem cells (16) 16
tumors (16) 16
aged (15) 15
clinical neurology (15) 15
enzymes (15) 15
mice, inbred c57bl (15) 15
protein binding (15) 15
antineoplastic agents - therapeutic use (14) 14
apoptosis - drug effects (14) 14
brain - metabolism (14) 14
chemistry, medicinal (14) 14
disease models, animal (14) 14
gamma‐secretase (14) 14
life sciences (14) 14
review (14) 14
amyloid beta (13) 13
biomedicine (13) 13
care and treatment (13) 13
cell proliferation - drug effects (13) 13
chemistry (13) 13
health aspects (13) 13
mental disorders (13) 13
pharmacology. drug treatments (13) 13
physical sciences (13) 13
alzheimer disease - genetics (12) 12
peptides (12) 12
physiological aspects (12) 12
protease inhibitors - pharmacology (12) 12
psychology. psychoanalysis. psychiatry (12) 12
receptor, notch1 - metabolism (12) 12
signal transduction - physiology (12) 12
adult (11) 11
alzheimer disease - enzymology (11) 11
amyloid precursor protein secretases - genetics (11) 11
biochemistry, general (11) 11
cell line (11) 11
cell proliferation (11) 11
clinical trials (11) 11
development and progression (11) 11
gamma secretase inhibitors (11) 11
genetic aspects (11) 11
kinases (11) 11
molecular biology (11) 11
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Phase 2 study of RO4929097, a gamma‐secretase inhibitor, in metastatic melanoma: SWOG 0933
by Lee, Sylvia M and Moon, James and Redman, Bruce G and Chidiac, Tarek and Flaherty, Lawrence E and Zha, Yuanyuan and Othus, Megan and Ribas, Antoni and Sondak, Vernon K and Gajewski, Thomas F and Margolin, Kim A
Cancer, ISSN 0008-543X, 02/2015, Volume 121, Issue 3, pp. 432 - 440
metastatic melanoma | gamma‐secretase inhibitor | RO4929097 | Notch | Metastatic melanoma | Gamma-secretase inhibitor | Life Sciences & Biomedicine | Oncology | Science & Technology | Melanoma - metabolism | Receptors, Notch - metabolism | Humans | Middle Aged | Male | Receptors, Notch - genetics | Survival Rate | Melanoma - pathology | Enzyme Inhibitors - therapeutic use | Disease-Free Survival | Amyloid Precursor Protein Secretases - metabolism | Neoplasm Metastasis | Benzazepines - therapeutic use | Melanoma - immunology | Melanoma - drug therapy | Aged, 80 and over | Adult | Female | T-Lymphocytes - immunology | Aged | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Care and treatment | Usage | Protease inhibitors | Melanoma | Clinical trials | Research | Health aspects | Index Medicus | Abridged Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Combining an amyloid‐beta (Aβ) cleaving enzyme inhibitor with a γ‐secretase modulator results in an additive reduction of Aβ production
by Strömberg, Kia and Eketjäll, Susanna and Georgievska, Biljana and Tunblad, Karin and Eliason, Kristina and Olsson, Fredrik and Radesäter, Ann‐Cathrin and Klintenberg, Rebecka and Arvidsson, Per I and Berg, Stefan and Fälting, Johanna and Cowburn, Richard F and Dabrowski, Michael
The FEBS journal, ISSN 1742-464X, 01/2015, Volume 282, Issue 1, pp. 65 - 73
beta amyloid cleaving enzyme | gamma‐secretase complex | amyloid beta peptides | Alzheimer's disease | gamma-secretase complex | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Peptide Fragments - metabolism | Aspartic Acid Endopeptidases - antagonists & inhibitors | Pyrimidines - administration & dosage | Amyloid beta-Peptides - biosynthesis | Humans | Mice, Inbred C57BL | Alzheimer Disease - drug therapy | Pyrimidines - pharmacology | Brain - drug effects | Brain - metabolism | Drug Synergism | Protease Inhibitors - pharmacology | Amyloid Precursor Protein Secretases - metabolism | Animals | Aspartic Acid Endopeptidases - metabolism | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | HEK293 Cells | Protease Inhibitors - administration & dosage | Female | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Pyrans - administration & dosage | Pyrans - pharmacology | Index Medicus | Medicin och hälsovetenskap
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors
by Krishnamurthy, Nithya and Kurzrock, Razelle
Cancer treatment reviews, ISSN 0305-7372, 01/2018, Volume 62, pp. 50 - 60
Gamma secretase | Hedgehog | Wnt | Beta-catenin | Targeted therapy | Colorectal cancers | Life Sciences & Biomedicine | Oncology | Science & Technology | Neoplasms - metabolism | Lung Neoplasms - drug therapy | Humans | Lung Neoplasms - metabolism | Neoplastic Stem Cells | Hedgehog Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Breast Neoplasms - drug therapy | Breast Neoplasms - metabolism | Neoplasms - drug therapy | Cell Self Renewal | Receptors, Notch - antagonists & inhibitors | beta Catenin - antagonists & inhibitors | Colorectal Neoplasms - drug therapy | Hematologic Neoplasms - drug therapy | Wnt Proteins - antagonists & inhibitors | Colorectal Neoplasms - metabolism | Hematologic Neoplasms - metabolism | Wnt Signaling Pathway | Index Medicus | beta-catenin | colorectal cancers | gamma secretase
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Hyaluronan nanoparticles bearing γ-secretase inhibitor: In vivo therapeutic effects on rheumatoid arthritis
by Heo, Roun and Park, Jong-Sung and Jang, Hye Jin and Kim, Seol-Hee and Shin, Jung Min and Suh, Yung Doug and Jeong, Ji Hoon and Jo, Dong-Gyu and Park, Jae Hyung
Journal of controlled release, ISSN 0168-3659, 10/2014, Volume 192, pp. 295 - 300
Gamma-secretase | Hyaluronan | Nanoparticle | Rheumatoid arthritis | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Dipeptides - therapeutic use | Nanoparticles - chemistry | Knee Joint - drug effects | Hyaluronic Acid - chemistry | Male | Drug Carriers - chemistry | Arthritis, Rheumatoid - pathology | Dipeptides - administration & dosage | Knee Joint - pathology | Animals | Knee Joint - immunology | Arthritis, Rheumatoid - drug therapy | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Arthritis, Rheumatoid - immunology | Cytokines - immunology | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Identification of a Pan‐Gamma‐Secretase Inhibitor Response Signature for Notch‐Driven Cholangiocarcinoma
by O’Rourke, Colm J and Matter, Matthias S and Nepal, Chirag and Caetano‐Oliveira, Rui and Ton, Phuongnga T and Factor, Valentina M and Andersen, Jesper B
Hepatology (Baltimore, Md.), ISSN 0270-9139, 01/2020, Volume 71, Issue 1, pp. 196 - 213
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Ketones - pharmacology | Humans | Fluorenes - therapeutic use | Receptors, Notch - physiology | Treatment Outcome | Fluorenes - pharmacology | Benzazepines - pharmacology | Cholangiocarcinoma - etiology | Bile Duct Neoplasms - etiology | Dibenzazepines - pharmacology | Dibenzazepines - therapeutic use | Cholangiocarcinoma - drug therapy | Benzazepines - therapeutic use | Cell Line, Tumor | Ketones - therapeutic use | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Bile Duct Neoplasms - drug therapy | Receptors, Notch - drug effects | Precision medicine | Therapeutic applications | AKT protein | Notch protein | Transplantation | Secretase | Cholangiocarcinoma | Tumors | Metastases | Index Medicus | Theranostic response signature | Bile duct | Notch | Gamma-secretase (GS) inhibitor
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Targets for AD treatment: conflicting messages from γ‐secretase inhibitors
by Sambamurti, Kumar and Greig, Nigel H and Utsuki, Tadanobu and Barnwell, Eliza L and Sharma, Ekta and Mazell, Cheryl and Bhat, Narayan R and Kindy, Mark S and Lahiri, Debomoy K and Pappolla, Miguel A
Journal of neurochemistry, ISSN 0022-3042, 05/2011, Volume 117, Issue 3, pp. 359 - 374
amyloid | Alzheimer | gamma‐secretase | degeneration | gamma-secretase | Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurology | Organic mental disorders. Neuropsychology | Psychology. Psychoanalysis. Psychiatry | Adult and adolescent clinical studies | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Psychopathology. Psychiatry | Biological and medical sciences | Medical sciences | Alzheimer Disease - drug therapy | Animals | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Humans | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Rethinking Gamma-secretase Inhibitors for Treatment of Non–small-Cell Lung Cancer: Is notch the target?
by Pine, Sharon R
Clinical cancer research, ISSN 1078-0432, 12/2018, Volume 24, Issue 24, pp. 6136 - 6141
Life Sciences & Biomedicine | Oncology | Science & Technology | Lung Neoplasms - drug therapy | Receptors, Notch - metabolism | Humans | Lung Neoplasms - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Biomarkers, Tumor | Patient Selection | Protease Inhibitors - pharmacology | Amyloid Precursor Protein Secretases - metabolism | Receptors, Notch - antagonists & inhibitors | Signal Transduction - drug effects | Antineoplastic Agents - pharmacology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - drug therapy | Protease Inhibitors - therapeutic use | Index Medicus | non-small cell lung cancer | gamma secretase inhibitor | patient-derived xenograft | targets | Notch
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Gamma secretase inhibitor impairs epithelial-to-mesenchymal transition induced by TGF-β in ovarian tumor cell lines
by Pazos, M.C and Abramovich, D and Bechis, A and Accialini, P and Parborell, F and Tesone, M and Irusta, G
Molecular and cellular endocrinology, ISSN 0303-7207, 01/2017, Volume 440, Issue C, pp. 125 - 137
TGF-β | Metastasis | Cadherin switch | Gamma secretase inhibitor | Epithelial-to-mesenchymal transition | Ovarian cancer | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cadherins - metabolism | Receptors, Notch - metabolism | Humans | Ovarian Neoplasms - pathology | Epithelial-Mesenchymal Transition - drug effects | Epithelial-Mesenchymal Transition - genetics | RNA, Messenger - metabolism | Cell Movement - genetics | Ovarian Neoplasms - genetics | Actin Cytoskeleton - drug effects | Transforming Growth Factor beta - adverse effects | Female | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Cadherins - genetics | Actin Cytoskeleton - metabolism | Neoplasm Invasiveness | Dipeptides - pharmacology | RNA, Messenger - genetics | Enzyme Inhibitors - pharmacology | beta Catenin - metabolism | Cell Shape - drug effects | Cell Movement - drug effects | Amyloid Precursor Protein Secretases - metabolism | Cell Line, Tumor | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights