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Phase 2 study of RO4929097, a gamma‐secretase inhibitor, in metastatic melanoma: SWOG 0933
Cancer, ISSN 0008-543X, 02/2015, Volume 121, Issue 3, pp. 432 - 440
metastatic melanoma | gamma‐secretase inhibitor | RO4929097 | Notch | Metastatic melanoma | Gamma-secretase inhibitor | Life Sciences & Biomedicine | Oncology | Science & Technology | Melanoma - metabolism | Receptors, Notch - metabolism | Humans | Middle Aged | Male | Receptors, Notch - genetics | Survival Rate | Melanoma - pathology | Enzyme Inhibitors - therapeutic use | Disease-Free Survival | Amyloid Precursor Protein Secretases - metabolism | Neoplasm Metastasis | Benzazepines - therapeutic use | Melanoma - immunology | Melanoma - drug therapy | Aged, 80 and over | Adult | Female | T-Lymphocytes - immunology | Aged | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Care and treatment | Usage | Protease inhibitors | Melanoma | Clinical trials | Research | Health aspects | Index Medicus | Abridged Index Medicus
Journal Article
The FEBS journal, ISSN 1742-464X, 01/2015, Volume 282, Issue 1, pp. 65 - 73
beta amyloid cleaving enzyme | gamma‐secretase complex | amyloid beta peptides | Alzheimer's disease | gamma-secretase complex | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Peptide Fragments - metabolism | Aspartic Acid Endopeptidases - antagonists & inhibitors | Pyrimidines - administration & dosage | Amyloid beta-Peptides - biosynthesis | Humans | Mice, Inbred C57BL | Alzheimer Disease - drug therapy | Pyrimidines - pharmacology | Brain - drug effects | Brain - metabolism | Drug Synergism | Protease Inhibitors - pharmacology | Amyloid Precursor Protein Secretases - metabolism | Animals | Aspartic Acid Endopeptidases - metabolism | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | HEK293 Cells | Protease Inhibitors - administration & dosage | Female | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Pyrans - administration & dosage | Pyrans - pharmacology | Index Medicus | Medicin och hälsovetenskap
Journal Article
Cancer treatment reviews, ISSN 0305-7372, 01/2018, Volume 62, pp. 50 - 60
Gamma secretase | Hedgehog | Wnt | Beta-catenin | Targeted therapy | Colorectal cancers | Life Sciences & Biomedicine | Oncology | Science & Technology | Neoplasms - metabolism | Lung Neoplasms - drug therapy | Humans | Lung Neoplasms - metabolism | Neoplastic Stem Cells | Hedgehog Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Breast Neoplasms - drug therapy | Breast Neoplasms - metabolism | Neoplasms - drug therapy | Cell Self Renewal | Receptors, Notch - antagonists & inhibitors | beta Catenin - antagonists & inhibitors | Colorectal Neoplasms - drug therapy | Hematologic Neoplasms - drug therapy | Wnt Proteins - antagonists & inhibitors | Colorectal Neoplasms - metabolism | Hematologic Neoplasms - metabolism | Wnt Signaling Pathway | Index Medicus | beta-catenin | colorectal cancers | gamma secretase
Journal Article
Journal of controlled release, ISSN 0168-3659, 10/2014, Volume 192, pp. 295 - 300
Gamma-secretase | Hyaluronan | Nanoparticle | Rheumatoid arthritis | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Dipeptides - therapeutic use | Nanoparticles - chemistry | Knee Joint - drug effects | Hyaluronic Acid - chemistry | Male | Drug Carriers - chemistry | Arthritis, Rheumatoid - pathology | Dipeptides - administration & dosage | Knee Joint - pathology | Animals | Knee Joint - immunology | Arthritis, Rheumatoid - drug therapy | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Arthritis, Rheumatoid - immunology | Cytokines - immunology | Index Medicus
Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 01/2020, Volume 71, Issue 1, pp. 196 - 213
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Ketones - pharmacology | Humans | Fluorenes - therapeutic use | Receptors, Notch - physiology | Treatment Outcome | Fluorenes - pharmacology | Benzazepines - pharmacology | Cholangiocarcinoma - etiology | Bile Duct Neoplasms - etiology | Dibenzazepines - pharmacology | Dibenzazepines - therapeutic use | Cholangiocarcinoma - drug therapy | Benzazepines - therapeutic use | Cell Line, Tumor | Ketones - therapeutic use | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Bile Duct Neoplasms - drug therapy | Receptors, Notch - drug effects | Precision medicine | Therapeutic applications | AKT protein | Notch protein | Transplantation | Secretase | Cholangiocarcinoma | Tumors | Metastases | Index Medicus | Theranostic response signature | Bile duct | Notch | Gamma-secretase (GS) inhibitor
Journal Article
Journal of neurochemistry, ISSN 0022-3042, 05/2011, Volume 117, Issue 3, pp. 359 - 374
amyloid | Alzheimer | gamma‐secretase | degeneration | gamma-secretase | Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurology | Organic mental disorders. Neuropsychology | Psychology. Psychoanalysis. Psychiatry | Adult and adolescent clinical studies | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Psychopathology. Psychiatry | Biological and medical sciences | Medical sciences | Alzheimer Disease - drug therapy | Animals | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Humans | Index Medicus
Journal Article
Clinical cancer research, ISSN 1078-0432, 12/2018, Volume 24, Issue 24, pp. 6136 - 6141
Life Sciences & Biomedicine | Oncology | Science & Technology | Lung Neoplasms - drug therapy | Receptors, Notch - metabolism | Humans | Lung Neoplasms - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Biomarkers, Tumor | Patient Selection | Protease Inhibitors - pharmacology | Amyloid Precursor Protein Secretases - metabolism | Receptors, Notch - antagonists & inhibitors | Signal Transduction - drug effects | Antineoplastic Agents - pharmacology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - drug therapy | Protease Inhibitors - therapeutic use | Index Medicus | non-small cell lung cancer | gamma secretase inhibitor | patient-derived xenograft | targets | Notch
Journal Article
Molecular and cellular endocrinology, ISSN 0303-7207, 01/2017, Volume 440, Issue C, pp. 125 - 137
TGF-β | Metastasis | Cadherin switch | Gamma secretase inhibitor | Epithelial-to-mesenchymal transition | Ovarian cancer | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cadherins - metabolism | Receptors, Notch - metabolism | Humans | Ovarian Neoplasms - pathology | Epithelial-Mesenchymal Transition - drug effects | Epithelial-Mesenchymal Transition - genetics | RNA, Messenger - metabolism | Cell Movement - genetics | Ovarian Neoplasms - genetics | Actin Cytoskeleton - drug effects | Transforming Growth Factor beta - adverse effects | Female | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Cadherins - genetics | Actin Cytoskeleton - metabolism | Neoplasm Invasiveness | Dipeptides - pharmacology | RNA, Messenger - genetics | Enzyme Inhibitors - pharmacology | beta Catenin - metabolism | Cell Shape - drug effects | Cell Movement - drug effects | Amyloid Precursor Protein Secretases - metabolism | Cell Line, Tumor | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Index Medicus
Journal Article