X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (3056) 3056
Publication (486) 486
Book Chapter (50) 50
Book Review (36) 36
Conference Proceeding (5) 5
Dissertation (2) 2
Government Document (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (1839) 1839
index medicus (1768) 1768
animals (1599) 1599
gamma-secretase (1452) 1452
alzheimer's disease (1231) 1231
amyloid precursor protein (898) 898
neurosciences (852) 852
alzheimers-disease (850) 850
mice (822) 822
biochemistry & molecular biology (760) 760
cell biology (550) 550
amyloid precursor protein secretases - metabolism (545) 545
gamma-secretase inhibitor (536) 536
alzheimer disease - metabolism (458) 458
amyloid beta-peptides - metabolism (451) 451
γ-secretase (432) 432
notch (429) 429
gamma-secretase inhibitors (414) 414
amyloid beta-protein precursor - metabolism (408) 408
in-vivo (406) 406
signal transduction (395) 395
amyloid precursor protein secretases - antagonists & inhibitors (392) 392
a-beta (379) 379
presenilin (378) 378
pharmacology & pharmacy (346) 346
gamma-secretase activity (342) 342
proteins (341) 341
alzheimer disease - drug therapy (320) 320
article (320) 320
female (306) 306
male (302) 302
oncology (300) 300
membrane proteins - metabolism (292) 292
amyloid beta-protein (291) 291
expression (280) 280
intracellular domain (270) 270
alzheimer’s disease (265) 265
presenilin-1 (257) 257
brain (255) 255
mutation (252) 252
transgenic mice (249) 249
cell line, tumor (247) 247
chemistry, medicinal (247) 247
cells, cultured (246) 246
research (243) 243
precursor protein (240) 240
receptors, notch - metabolism (239) 239
amyloid precursor protein secretases (237) 237
alzheimer disease - genetics (232) 232
mice, transgenic (231) 231
alzheimers disease (230) 230
secretase (230) 230
proteolysis (228) 228
alzheimer disease - pathology (224) 224
cancer (220) 220
cell line (220) 220
disease models, animal (216) 216
cleavage (215) 215
apoptosis (214) 214
enzyme inhibitors - pharmacology (214) 214
activation (212) 212
neurology (203) 203
amyloid beta-protein precursor - genetics (201) 201
app (200) 200
mouse model (199) 199
rats (199) 199
brain - metabolism (196) 196
analysis (191) 191
peptides (191) 191
clinical neurology (184) 184
membrane proteins - genetics (183) 183
multidisciplinary sciences (180) 180
beta-secretase (176) 176
amyloid-beta (174) 174
endopeptidases - metabolism (172) 172
amyloid (171) 171
neurons (171) 171
familial alzheimers-disease (170) 170
neurons - metabolism (170) 170
neurodegenerative diseases (165) 165
gene expression (161) 161
inhibitors (159) 159
signal transduction - drug effects (158) 158
mice, inbred c57bl (156) 156
peptide fragments - metabolism (154) 154
mental disorders (153) 153
alzheimer disease - physiopathology (150) 150
signal transduction - physiology (150) 150
cells (149) 149
chemistry, organic (149) 149
biophysics (148) 148
amyloid precursor protein secretases - genetics (147) 147
amino acid sequence (144) 144
aspartic acid endopeptidases (144) 144
genetic aspects (144) 144
pathology (144) 144
alzheimer disease (141) 141
nonsteroidal antiinflammatory drugs (140) 140
physiological aspects (140) 140
in-vitro (138) 138
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (3076) 3076
French (5) 5
Japanese (5) 5
Chinese (4) 4
German (2) 2
Polish (2) 2
Czech (1) 1
Spanish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


by Wang, MY and Ma, XD and Wang, J and Wang, L and Wang, Y
INTERNATIONAL JOURNAL OF ONCOLOGY, ISSN 1019-6439, 04/2014, Volume 44, Issue 4, pp. 1401 - 1409
Notch signaling is implicated in ovarian cancer tumorigenesis and inhibition of Notch signaling with -secretase inhibitor DAPT resulted in reduction of tumor... 
APOPTOSIS | ovarian cancer | secretase inhibitor | CERVICAL-CANCER | FATE | LINES | ENDOMETRIAL CANCER | BREAST-CANCER | cisplatin-resistant cancer | ONCOLOGY | Notch signaling | Notch1 | PATHWAY | Hes1 | GAMMA-SECRETASE | EXPRESSION | CARCINOMA | DAPT
Journal Article
Clinical Therapeutics, ISSN 0149-2918, 2012, Volume 34, Issue 3, pp. 654 - 667
Journal Article
ACS CHEMICAL NEUROSCIENCE, ISSN 1948-7193, 08/2019, Volume 10, Issue 8, pp. 3398 - 3403
Knowledge of how transition state inhibitors bind to gamma-secretase is of major importance for the design of new Alzheimer's disease therapies. On the basis... 
enzyme dynamics | PRESENILIN | gamma-Secretase drug binding | A-BETA-40 | CHEMISTRY, MEDICINAL | gamma-secretase transition state inhibition | MECHANISM | ACTIVE-SITE | MODULATORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMYLOID-BETA-PROTEIN | CLEAVAGE | NEUROSCIENCES | PEPTIDES | enzyme inhibition | ligand-receptor docking | DYNAMICS | MUTATIONS
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 09/2010, Volume 70, Issue 17, pp. 6870 - 6879
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 01/2001, Volume 76, Issue 1, pp. 173 - 181
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 03/2016, Volume 7, Issue 3, pp. 294 - 299
Cyclophilin D (CypD), a peptidylprolyl isomerase F (PPIase), plays a central role in opening the mitochondrial membrane permeability transition pore leading to... 
CypD | mitochondrial dysfunction | amyloid β | mPTP | small molecules | ACTIVATION | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | MEMBRANE | SECRETASE INHIBITORS | amyloid beta | PERMEABILITY TRANSITION | CYCLOSPORINE-A | AMYLOID-BETA | GAMMA-SECRETASE | CONTRIBUTES | STRUCTURE-BASED DESIGN
Journal Article
Journal Article
EXPERT OPINION ON INVESTIGATIONAL DRUGS, ISSN 1354-3784, 03/2011, Volume 20, Issue 3, pp. 325 - 341
Areas covered: This article briefly reviews the profile of gamma gamma-secretase inhibitors that have reached the clinic and discusses the clinical issues... 
PRESENILIN | NOTCH | COGNITIVE IMPAIRMENT | BETA-PEPTIDE | AMYLOID PRECURSOR PROTEIN | SYNAPTIC PLASTICITY | gamma-secretase inhibitors | beta-amyloid | Notch processing | MEDICINAL CHEMISTRY | IN-VIVO | A-BETA | PHARMACOLOGY & PHARMACY | Alzheimer's disease | INTRACELLULAR DOMAIN
Journal Article