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Biomaterials, ISSN 0142-9612, 01/2020, Volume 227, p. 119570
Excessive release of interleukin-1β (IL-1β) is well-known to provoke cascades of inflammatory responses thus contributing to the pathogenesis of... 
Gasdermin D | Alcohol-induced steatohepatitis | Galactose | Interleukin-1β | Interleukin-1 receptor antagonist | Apolipoprotein A-I
Journal Article
by Lu, YY and Meng, R and Wang, XY and Xu, YJ and Tang, YT and Wu, JF and Xue, QQ and Yu, SL and Duan, MW and Shan, DY and Wang, QD and Wang, HC and Billiar, TR and Xiao, XZ and Chen, FP and Lu, B
NATURE COMMUNICATIONS, ISSN 2041-1723, 09/2019, Volume 10, Issue 1, pp. 4044 - 12
Journal Article
Journal Article
Immunobiology, ISSN 0171-2985, 12/2019
Journal Article
by López-Isac, Elena and Acosta-Herrera, Marialbert and Kerick, Martin and Assassi, Shervin and Satpathy, Ansuman T and Granja, Jeffrey and Mumbach, Maxwell R and Beretta, Lorenzo and Simeón, Carmen P and Carreira, Patricia and Ortego-Centeno, Norberto and Castellvi, Ivan and Bossini-Castillo, Lara and Carmona, F. David and Orozco, Gisela and Hunzelmann, Nicolas and Distler, J. rg H. W and Franke, Ane and Lunardi, Claudio and Moroncini, Gianluca and Gabrielli, Armando and de Vries-Bouwstra, Jeska and Wijmenga, Cisca and Koeleman, Bobby P. C and Nordin, Annika and Padyukov, Leonid and Hoffmann-Vold, Anna-Maria and Lie, Benedicte and Ríos, R and Callejas, J. L and Vargas-Hitos, J. A and García-Portales, R and Camps, M. T and Fernández-Nebro, A and González-Escribano, M. F and García-Hernández, F. J and Castillo, M. J and Aguirre, M. A and Gómez-Gracia, I and Fernández-Gutiérrez, B and Roíguez-Roíguez, L and García de la Peña, P and Vicente, E and Aneu, J. L and Fernández de Castro, M and López-Longo, F. J and Martínez, L and Fonollosa and Voskuyl, A. E and European Scleroderma Grp and ASIG and European Scleroderma Group and Australian Scleroderma Interest Group (ASIG) and Department of Rheumatology and Lund University and Lund Systemic Sclerosis Research Group and Forskargruppen för systemisk skleros, Lund and Reumatologi och molekylär skelettbiologi and Hjärt-lungsjukdom - information, stöd och bemötande and Lunds universitet and Cardiopulmonary disease - information, support and reception
Nature Communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 1 - 14
Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide... 
VISUALIZATION | METAANALYSIS | VARIANTS | AUTOIMMUNITY | HUMAN-CELLS | ANNOTATION | MULTIDISCIPLINARY SCIENCES | GENES | CLASSIFICATION | GENOME-WIDE ASSOCIATION | REVEALS | Vascular diseases | Target recognition | Pathways | Systemic sclerosis | Fibrosis | Rheumatic diseases | Genomes | Functional analysis | Autoimmune diseases | Loci | transcription factor | mitochondrial ribosomal protein s7 | c terminal src kinase | Medical and Health Sciences | single nucleotide polymorphism | major clinical study | interleukin 12 receptor subunit beta 2 | epigenetics | interleukin 12 receptor subunit beta 1 | Bayesian network | complexin 3 | cell component | Basic Medicine | nucleoporin 85 | cell expansion | post GPI attachment to proteins 3 | proteasome 26S subunit, non-ATPase 3 | Clinical Medicine | genetic analysis | diacylglycerol kinase theta | protein acetylation | centromere antibody | fibrosis | ribonuclease P and MRP subunit p25 | T lymphocyte | ORMDL sphingolipid biosynthesis regulator 3 | TNFAIP3 interacting protein 1 | gasdermin A | unclassified drug | cohort analysis | Medicin och hälsovetenskap | Reumatologi och inflammation | Article | zona pellucida binding protein 2 | gene identification | CD4+ T lymphocyte | cell | Klinisk medicin | Rheumatology and Autoimmunity | Medicinsk genetik | Medical Genetics | phosphopantothenoylcysteine decarboxylase | Rho GTPase activating protein 31 | STAT4 protein | systemic sclerosis | immune response | rheumatic disease | human | molecular genetics | meta-analysis | histone 3 lysine 27 | cluster of differentiation 247 | risk factor | interferon consensus sequence binding protein | gene locus | genome | lectin, mannose binding 1 like | disease incidence | controlled study | vascular disease | genome-wide association study | Medicinska och farmaceutiska grundvetenskaper | mortality
Journal Article
Frontiers in Cellular and Infection Microbiology, ISSN 2235-2988, 11/2019, Volume 9
Cell death is central to development, organismal homeostasis, and immune responses. The cell death field has experienced tremendous progress by delineating the... 
infection | gasdermin D | MLKL | innate immunity | caspase-1 | inflammasome
Journal Article
SCIENCE, ISSN 0036-8075, 11/2019, Volume 366, Issue 6466, pp. 688 - 689
Journal Article
Clinical Immunology, ISSN 1521-6616, 11/2019, Volume 208, p. 108232
variants result in reduced enzymatic activity of procaspase-1 and impaired IL-1β release. Despite this, affected individuals can develop systemic... 
Pyroptosome | Pyroptosis | Speck | NLRP3 | Inflammasome | Gasdermin D | Interleukin-1 converting enzyme | Apoptosis-associated speck-like protein containing a CARD (ASC) | IL-1β | Caspase-1
Journal Article
Cellular Microbiology, ISSN 1462-5814, 11/2019, Volume 21, Issue 11, p. n/a
Journal Article
European Journal of Immunology, ISSN 0014-2980, 11/2019, Volume 49, Issue 11, pp. 1998 - 2011
AIM2 is a cytosolic innate immune receptor which recognizes double‐stranded DNA (dsDNA) released during cellular perturbation and pathogenic assault. AIM2... 
pyroptosis | gasdermin | AIM2 | cell death | inflammasome | Cell proliferation | Disease | Epithelial cells | Interleukin | Colorectal carcinoma | Chronic infection | Homeostasis | Viruses | Infections | Parasites | Cytosol | Inflammatory diseases | Fungi | Microbiota | Intestine | Skin diseases | Assembly | Deoxyribonucleic acid--DNA | Cytokines | Secretion | Diabetes mellitus | Perturbation | Secretions | Cell death | Kidney diseases | Cardiovascular diseases | Cancer
Journal Article
Kidney International, ISSN 0085-2538, 11/2019, Volume 96, Issue 5, pp. 1105 - 1120
Inflammation and tubular cell death are the hallmarks of acute kidney injury. However, the precise mechanism underlying these effects has not been fully... 
caspase-11 | acute kidney injury | gasdermin D | interleukin-18 | GSDMD | APOPTOSIS | ACTIVATION | MINCLE | RECEPTOR | INHIBITION | UROLOGY & NEPHROLOGY | INFLAMMATORY CASPASES | MICE | STEATOHEPATITIS
Journal Article
Trends in Immunology, ISSN 1471-4906, 11/2019, Volume 40, Issue 11, pp. 1035 - 1052
Journal Article