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Blood, ISSN 0006-4971, 04/2013, Volume 121, Issue 17, pp. 3345 - 3363
Journal Article
British Journal of Haematology, ISSN 0007-1048, 12/2014, Volume 167, Issue 5, pp. 587 - 599
Summary Children with constitutional trisomy 21 (cT21, Down Syndrome, DS) are at a higher risk for both myeloid and B‐lymphoid leukaemias. The myeloid... 
acute megakaryoblastic leukaemia | transient abnormal myelopoiesis | GATA1 | trisomy 21 | Down syndrome acute lymphoblastic leukaemia | Acute megakaryoblastic leukaemia | Trisomy 21 | Transient abnormal myelopoiesis | INHERITED MUTATION | HEMATOLOGICAL ABNORMALITIES | CLINICAL CHARACTERISTICS | ACUTE MYELOID-LEUKEMIA | NATURAL-HISTORY | TRANSIENT MYELOPROLIFERATIVE DISORDER | ACUTE LYMPHOBLASTIC-LEUKEMIA | MOUSE MODEL | ACUTE MEGAKARYOBLASTIC LEUKEMIA | HEMATOLOGY | GATA1 MUTATIONS | Leukemia, B-Cell - metabolism | Chromosomes, Human, Pair 21 - metabolism | Down Syndrome - metabolism | Humans | Leukemia, Myeloid - genetics | Preleukemia - pathology | Child, Preschool | Hematopoietic Stem Cells - pathology | Neoplasm Proteins - metabolism | Gene Expression Regulation, Leukemic - genetics | Leukemia, Myeloid - pathology | Preleukemia - genetics | Myelopoiesis | Neoplasm Proteins - genetics | Child | Stem Cell Niche - genetics | Down Syndrome - pathology | Leukemia, B-Cell - pathology | Hematopoietic Stem Cells - metabolism | Chromosomes, Human, Pair 21 - genetics | GATA1 Transcription Factor - metabolism | Preleukemia - metabolism | Animals | Leukemia, B-Cell - genetics | Leukemia, Myeloid - metabolism | Adolescent | Down Syndrome - genetics | GATA1 Transcription Factor - genetics | Mice | Analysis | Leukemia | Down syndrome
Journal Article
Journal Article
Cell, ISSN 0092-8674, 03/2018, Volume 173, Issue 1, pp. 90 - 103.e19
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2017, Volume 127, Issue 4, pp. 1316 - 1320
Journal Article
Trends in Genetics, ISSN 0168-9525, 2013, Volume 30, Issue 1, pp. 1 - 9
Highlights • Ldb1 complexes are primary instruments of Gata1- and Tal1-mediated erythroid gene activation. • Ldb1 oligomerization facilitates long-range... 
Medical Education | Tal1 | transcriptional regulation | Ldb1 complexes | erythropoiesis | ChIP-Seq | Gata1 | Klf1 | Erythropoiesis | Transcriptional regulation | BETA-GLOBIN LOCUS | CHROMATIN OCCUPANCY | MICE LACKING | HEMATOPOIETIC STEM-CELLS | FACTOR GATA-1 | GENETICS & HEREDITY | GENOME-WIDE ANALYSIS | PROTEIN LMO2 | KRUPPEL-LIKE FACTOR | FACTOR EKLF GENE | LEUKEMIA GENE | Proto-Oncogene Proteins - metabolism | Promoter Regions, Genetic | Basic Helix-Loop-Helix Transcription Factors - genetics | Epigenetic Repression | Gene Expression Regulation | Proto-Oncogene Proteins - genetics | Binding Sites - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | LIM Domain Proteins - metabolism | GATA1 Transcription Factor - metabolism | Sequence Analysis, DNA | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Animals | Basic Helix-Loop-Helix Transcription Factors - metabolism | Kruppel-Like Transcription Factors - metabolism | GATA1 Transcription Factor - genetics | LIM Domain Proteins - genetics | Models, Animal | Mice | Kruppel-Like Transcription Factors - genetics | T-Cell Acute Lymphocytic Leukemia Protein 1 | Erythropoiesis - genetics | Oligomers | Genetic aspects | Genetic transcription | Genes | Analysis | Leukemia | DNA binding proteins | T cells | Protein binding | Ldb1-complexes
Journal Article