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Cell, ISSN 0092-8674, 02/2016, Volume 164, Issue 5, pp. 999 - 1014
Journal Article
Science, ISSN 0036-8075, 09/2015, Volume 349, Issue 6255, pp. aaa5612 - aaa5612
Journal Article
Nature, ISSN 0028-0836, 07/2011, Volume 475, Issue 7356, pp. 386 - 391
The generation of functional hepatocytes independent of donor liver organs is of great therapeutic interest with regard to regenerative medicine and possible... 
MURINE MODEL | HEPATIC-DYSFUNCTION | PANCREAS PROGENITORS | TYROSINEMIA TYPE-I | LIVER-FUNCTION | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | FACTOR NETWORK | DIRECT CONVERSION | GENE-EXPRESSION | ENRICHED TRANSCRIPTION FACTORS | Hydrolases - genetics | Liver - enzymology | Hepatocyte Nuclear Factor 1-alpha - genetics | Tail - cytology | Liver Diseases - pathology | Gene Expression Profiling | Hepatocyte Nuclear Factor 3-gamma - genetics | Hepatocytes - metabolism | Hepatocyte Nuclear Factor 1-alpha - metabolism | Liver - physiopathology | Regenerative Medicine - methods | DNA-Binding Proteins - deficiency | Cell Differentiation - genetics | Hepatocytes - cytology | Hepatocyte Nuclear Factor 3-gamma - metabolism | Liver Diseases - enzymology | Hepatocytes - transplantation | Hepatocytes - physiology | Fibroblasts - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - deficiency | GATA4 Transcription Factor - metabolism | Tissue Engineering - methods | Transduction, Genetic | Cells, Cultured | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Liver Diseases - therapy | GATA4 Transcription Factor - genetics | Survival Rate | Hydrolases - deficiency | Mice, SCID | Cell Lineage | Animals | Liver - physiology | Mice, Inbred NOD | Fibroblasts - cytology | Liver - cytology | Mice | Liver Diseases - physiopathology | Physiological aspects | Fibroblasts | Transcription factors | Research | Embryonic stem cells | Liver cells | Proteins | Gene expression | Tissue engineering | Cell adhesion & migration
Journal Article
Circulation, ISSN 0009-7322, 03/2017, Volume 135, Issue 10, pp. 978 - 995
BACKGROUND:Reprogramming of cardiac fibroblasts into induced cardiomyocyte-like cells in situ represents a promising strategy for cardiac regeneration. A... 
Heart | Regeneration | Transcription factors | Cell differentiation | MOUSE FIBROBLASTS | cell differentiation | DEXAMETHASONE | CARDIAC & CARDIOVASCULAR SYSTEMS | EXPRESSION ANALYSIS | regeneration | transcription factors | HEART-FAILURE | CATENIN | heart | PLURIPOTENT STEM-CELLS | GROWTH-FACTOR-BETA | INHIBITION | AMPLIFICATION | FUNCTIONAL CARDIOMYOCYTES | PERIPHERAL VASCULAR DISEASE | Dioxoles - therapeutic use | MEF2 Transcription Factors - genetics | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | Wnt Proteins - metabolism | Benzamides - therapeutic use | Dioxoles - pharmacology | Transforming Growth Factor beta - antagonists & inhibitors | Benzamides - pharmacology | Fibroblasts - metabolism | GATA4 Transcription Factor - metabolism | Myocytes, Cardiac - cytology | Cells, Cultured | GATA4 Transcription Factor - genetics | Myocardium - pathology | Transcription Factors - genetics | T-Box Domain Proteins - genetics | T-Box Domain Proteins - metabolism | Heart - diagnostic imaging | Cellular Reprogramming - drug effects | Transcription Factors - metabolism | Magnetic Resonance Imaging | Animals | Myocardial Infarction - drug therapy | Fibroblasts - drug effects | Heterocyclic Compounds, 3-Ring - therapeutic use | MEF2 Transcription Factors - metabolism | Myocytes, Cardiac - metabolism | Fibroblasts - cytology | Mice | Wnt Proteins - antagonists & inhibitors | Transforming Growth Factor beta - metabolism | Care and treatment | Heart cells | Dosage and administration | Research | Transforming growth factors | Heart diseases | reprogramming | cardiac differentiation | calcium | heart regeneration
Journal Article
Journal Article
Nature, ISSN 0028-0836, 2012, Volume 485, Issue 7400, pp. 593 - 598
The reprogramming of adult cells into pluripotent cells or directly into alternative adult cell types holds great promise for regenerative medicine. We... 
HEART | DEFINED FACTORS | STEM-CELLS | REPAIR | MULTIDISCIPLINARY SCIENCES | DIRECT CONVERSION | INJURY | GENE-TRANSFER | DIFFERENTIATION | EXPRESSION | ADULT | Heart - physiology | Male | Regenerative Medicine - methods | Cellular Reprogramming | Myocardial Infarction - therapy | Myocardial Infarction - pathology | Cell Transdifferentiation | Female | Myocardial Infarction - physiopathology | Cicatrix - therapy | MEF2 Transcription Factors | Fibroblasts - metabolism | Heart - physiopathology | GATA4 Transcription Factor - metabolism | Myocytes, Cardiac - cytology | Myogenic Regulatory Factors - genetics | Thymosin - pharmacology | Biomarkers - analysis | Gene Expression Regulation | Myogenic Regulatory Factors - metabolism | GATA4 Transcription Factor - genetics | Myocardium - pathology | Fibroblasts - pathology | T-Box Domain Proteins - genetics | Genetic Vectors - genetics | T-Box Domain Proteins - metabolism | Myocardium - cytology | Cell Lineage | Animals | Myocardial Infarction - drug therapy | Myocytes, Cardiac - drug effects | Myocytes, Cardiac - physiology | Fibroblasts - drug effects | Myocytes, Cardiac - metabolism | Cicatrix - pathology | Fibroblasts - cytology | Mice | Thymosin - therapeutic use | Medical research | Regenerative medicine | Heart cells | Physiological aspects | Fibroblasts | Medicine, Experimental | Research | Proteins | Musculoskeletal system | Cardiomyocytes | Heart attacks | Rodents | Stem cells | Cellular reprogramming | Cardiac fibroblast | Thymosin β4 | Cardiomyocyte
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2010, Volume 285, Issue 1, pp. 793 - 804
Journal Article
PLoS Genetics, ISSN 1553-7390, 02/2011, Volume 7, Issue 2, p. e1001313
Journal Article
Developmental Biology, ISSN 0012-1606, 2011, Volume 358, Issue 2, pp. 368 - 378
Members of the GATA family of transcription factors are critical regulators of heart development and mutations in 2 of them, and are associated with outflow... 
Endocardial cushion | Transcription factors | Congenital heart disease | Septal defects | Heart development | Double outlet right ventricle | VENTRAL MORPHOGENESIS | MOUSE HEART | CARDIAC NEURAL CREST | DEVELOPMENTAL BIOLOGY | TUBE FORMATION | CONGENITAL HEART-DISEASE | GENE-EXPRESSION | MUTATIONS | HOLT-ORAM-SYNDROME | TRANSCRIPTION FACTOR | COOPERATIVE INTERACTION | Aortic Valve Stenosis - genetics | Heart Defects, Congenital - embryology | Humans | GATA5 Transcription Factor - metabolism | Aortic Valve Stenosis - embryology | RNA, Messenger - metabolism | Endocardial Cushion Defects - genetics | Heart Defects, Congenital - genetics | GATA5 Transcription Factor - genetics | Gene Expression Regulation, Developmental | Endocardial Cushion Defects - embryology | Female | GATA5 Transcription Factor - deficiency | Fetal Heart - metabolism | Heart Septal Defects, Ventricular - embryology | GATA4 Transcription Factor - metabolism | Heart Septal Defects, Ventricular - genetics | GATA6 Transcription Factor - deficiency | Fetal Heart - embryology | Mice, Inbred C57BL | RNA, Messenger - genetics | GATA4 Transcription Factor - genetics | Endocardial Cushion Defects - metabolism | GATA6 Transcription Factor - metabolism | Mice, Knockout | Heart Septal Defects, Ventricular - metabolism | Pregnancy | Phenotype | Animals | GATA4 Transcription Factor - deficiency | Aortic Valve Stenosis - metabolism | Heterozygote | Heart Defects, Congenital - metabolism | Mice | GATA6 Transcription Factor - genetics | Developmental biology | Aortic valve stenosis
Journal Article