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1. Full Text Sodium channel mutations and arrhythmias
by Liu, Nian and Priori, Silvia G and Ruan, Yanfei
Nature Reviews Cardiology, ISSN 1759-5002, 05/2009, Volume 6, Issue 5, pp. 337 - 348
since the identification of the first SCN5A mutation associated with long QT syndrome in 1995, several mutations in this gene for the a subunit of the cardiac... 
SCN5A MUTATION | BRUGADA-SYNDROME | CARDIAC & CARDIOVASCULAR SYSTEMS | INHERITED ARRHYTHMOGENIC DISEASES | BUNDLE-BRANCH BLOCK | NA+ CHANNEL | LONG-QT SYNDROME | ST-SEGMENT ELEVATION | CARDIAC CONDUCTION DISEASE | SICK SINUS SYNDROME | GENE-SPECIFIC THERAPY | Arrhythmias, Cardiac - metabolism | Protein Subunits | Genetic Predisposition to Disease | Arrhythmias, Cardiac - therapy | Risk Assessment | Humans | Risk Factors | Structure-Activity Relationship | Arrhythmias, Cardiac - physiopathology | Phenotype | Animals | Sodium Channels - chemistry | Sodium Channels - metabolism | Protein Conformation | Sodium Channels - genetics | Mutation | Arrhythmias, Cardiac - genetics | NAV1.5 Voltage-Gated Sodium Channel | Disease Models, Animal | Sodium channels | Gene mutations | Arrhythmia | Causes of | Genetic aspects | Research | Diagnosis | Heart conduction system | Health aspects | Heart diseases
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2. Full Text The Na(V)1.7 sodium channel: from molecule to man
by Dib-Hajj, SD and Yang, Y and Black, JA and Waxman, SG
NATURE REVIEWS NEUROSCIENCE, ISSN 1471-003X, 01/2013, Volume 14, Issue 1, pp. 49 - 62
The voltage-gated sodium channel Na(V)1.7 is preferentially expressed in peripheral somatic and visceral sensory neurons, olfactory sensory neurons and... 
SPINAL SENSORY NEURONS | ROOT GANGLION NEURONS | DRG NEURONS | EXTREME PAIN DISORDER | CLOSED-STATE INACTIVATION | SMALL FIBER NEUROPATHY | ELECTROPHYSIOLOGICAL PROPERTIES | VOLTAGE-GATED SODIUM | SMOOTH-MUSCLE-CELLS | OF-FUNCTION MUTATIONS | NEUROSCIENCES | Humans | Models, Molecular | Sodium Channel Blockers - pharmacology | Biophysics | Mutation - genetics | Peripheral Nerves - drug effects | Pain - pathology | Peripheral Nerves - physiopathology | Animals | Pain - genetics | Signal Transduction - drug effects | Pain - physiopathology | NAV1.7 Voltage-Gated Sodium Channel - metabolism | NAV1.7 Voltage-Gated Sodium Channel - genetics | Signal Transduction - physiology | Peripheral Nerves - metabolism | Tetrodotoxin - pharmacology
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3. Sodium channel trafficking
by Mercier, A and Bois, P and Chatelier, A
Handbook of Experimental Pharmacology, ISSN 0171-2004, 2018, Volume 246, pp. 125 - 145
Voltage-gated sodium channels (VGSC) are critical determinants of cellular electrical activity through the control of initiation and propagation of action... 
Trafficking modulators | Retrograde transport | Membrane targeting | Forward trafficking | Voltage-gated sodium channel
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4. Full Text The complete structure of an activated open sodium channel
by Sula, Altin and Booker, Jennifer and Ng, Leo C. T and Naylor, Claire E and Decaen, Paul G and Wallace, B.A
Nature Communications, ISSN 2041-1723, 02/2017, Volume 8, Issue 1, p. 14205
Voltage-gated sodium channels (Navs) play essential roles in excitable tissues, with their activation and opening resulting in the initial phase of the action... 
SUITE | C-TERMINAL DOMAIN | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | NACHBAC | SOFTWARE | Voltage-Gated Sodium Channels - genetics | Amino Acid Sequence | Sodium Channel Agonists - chemistry | Electrophysiology | Ion Channels - genetics | Models, Molecular | Voltage-Gated Sodium Channels - physiology | Ion Channels - physiology | Structure-Activity Relationship | Ion Channel Gating - physiology | Sequence Alignment | Ion Channel Gating - genetics | Prokaryotic Cells - metabolism | Prokaryotic Cells - chemistry | X-Ray Diffraction | Protein Domains | Protein Conformation | Voltage-Gated Sodium Channels - chemistry | Protein Interaction Domains and Motifs | Kinetics | Mutation | Sodium Channel Agonists - metabolism | Ion Channels - chemistry
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5. Full Text Resurgence of sodium channel research
by Goldin, A.L
Annual Review of Physiology, ISSN 0066-4278, 2001, Volume 63, Issue 1, pp. 871 - 894
A variety of isoforms of mammalian voltage-gated sodium channels have been described. Ten genes encoding sodium channel alpha subunits have been identified,... 
Resurgent current | Mutations | Expression | Cloning | PHYSIOLOGY | expression | ALPHA-SUBUNIT GENE | DORSAL-ROOT GANGLIA | NA+-CHANNEL | mutations | resurgent current | FUNCTIONAL EXPRESSION | LONG QT SYNDROME | CENTRAL-NERVOUS-SYSTEM | GATED ION CHANNELS | END-PLATE DISEASE | RAT-BRAIN | cloning | ADULT SKELETAL-MUSCLE | Animals | Humans | Sodium Channels - metabolism | Neurons - metabolism | Sodium Channels - genetics | Muscle Fibers, Skeletal - metabolism | Phylogeny | Evolution, Molecular | Sodium channels | Brain | Usage | Epilepsy | Electrophysiology | Research | Mammals | Gene expression | Cladistic analysis | Gene mutations | Human beings | Physiological aspects | Physiology | Genetic aspects | Paralysis
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6. Full Text Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution
by Shen, Huaizong and Zhou, Qiang and Pan, Xiaojing and Li, Zhangqiang and Wu, Jianping and Yan, Nieng
Science, ISSN 0036-8075, 03/2017, Volume 355, Issue 6328, pp. eaal4326 - eaal4326
Voltage-gated sodium (Nav) channels are responsible for the initiation and propagation of action potentials. They are associated with a variety of... 
SWISS-MODEL | GATING CHARGE | ORGANIC CATIONS | PROTEIN | C-TYPE INACTIVATION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | SLOW INACTIVATION | AMINO-ACID-RESIDUES | MOLECULAR DETERMINANTS | K+ CHANNEL | Cryoelectron Microscopy | Animals | Models, Chemical | Voltage-Gated Sodium Channels - ultrastructure | Conserved Sequence | Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - chemistry | Protein Domains | Voltage-Gated Sodium Channels - chemistry | Glycosylation | Periplaneta | Drugs | Residues | Calcium | Selectivity | Antagonists | Drug development | Inactivation | Proteins | Engineering | Chemical bonds | Sodium channels (voltage-gated) | Ion channels | Charge transfer | Localization | Gating | Sugar | Protein engineering | Calcium channels | Disulfide bonds | Channel gating | Calcium channels (voltage-gated) | Ions | Permeability | Electron microscopy | Neurological diseases | Sodium | Toxins | Mutation | Protein structure | Pharmaceuticals | Electric potential | Foundations | Voltage | Channels | Cockroaches
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7. Full Text The hitchhiker's guide to the voltage-gated sodium channel galaxy
by Ahern, Christopher A and Payandeh, Jian and Bosmans, Frank and Chanda, Baron
Journal of General Physiology, ISSN 0022-1295, 2016, Volume 147, Issue 1, pp. 1 - 24
Eukaryotic voltage-gated sodium (Na-v) channels contribute to the rising phase of action potentials and served as an early muse for biophysicists laying the... 
LOCAL-ANESTHETIC RECEPTOR | PHYSIOLOGY | SQUID GIANT-AXONS | SCORPION BETA-TOXIN | POLYPEPTIDE ANTHOPLEURIN-B | AMINO-ACID-RESIDUES | SEA-ANEMONE TOXIN | SURFACE-PLASMON RESONANCE | MU-CONOTOXIN-KIIIA | PLANAR LIPID-BILAYERS | QUATERNARY AMMONIUM ION | Voltage-Gated Sodium Channels - chemistry | Animals | Permeability | Ions - metabolism | Humans | Protein Structure, Tertiary - physiology
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8. Full Text Painful peripheral neuropathy and sodium channel mutations
by Hoeijmakers, Janneke G.J and Faber, Catharina G and Merkies, Ingemar S.J and Waxman, Stephen G
Neuroscience Letters, ISSN 0304-3940, 06/2015, Volume 596, pp. 51 - 59
Peripheral neuropathy can lead to neuropathic pain in a subset of patients. Painful peripheral neuropathy is a debilitating disorder, reflected by a reduced... 
Painful peripheral neuropathy | Small-fiber neuropathy | Voltage-gated sodium channels | NERVE | WHITE-MATTER | ROOT GANGLION NEURONS | NA(V)1.7 MUTATION | OF-FUNCTION MUTATIONS | NEUROSCIENCES | SLOW-INACTIVATION | SENSORY NEURONS | SCN9A | FAMILIAL HEMIPLEGIC MIGRAINE | Voltage-Gated Sodium Channels - genetics | Neurons - pathology | Neuralgia - genetics | Humans | Peripheral Nervous System Diseases - physiopathology | Axons - pathology | Ganglia, Spinal - pathology | Neurons - metabolism | Peripheral Nervous System Diseases - pathology | Mutation | Neuralgia - physiopathology | Peripheral Nervous System Diseases - genetics | Voltage-Gated Sodium Channels - metabolism | Ganglia, Spinal - metabolism | Neurosciences | Genetic aspects
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9. Full Text Recent progress in sodium channel modulators for pain
by Bagal, Sharan K and Chapman, Mark L and Marron, Brian E and Prime, Rebecca and Storer, R. Ian and Swain, Nigel A
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2014, Volume 24, Issue 16, pp. 3690 - 3699
Voltage-gated sodium channels (Na s) are an important family of transmembrane ion channel proteins and Na drug discovery is an exciting field. Pharmaceutical... 
Electrophysiology screening | Sodium channel drugs | Sodium channel structure | Sodium channel toxins | Voltage-gated sodium channels | CHEMISTRY, MEDICINAL | CRYSTAL-STRUCTURE | DRUG DISCOVERY | PROTX-II | CHEMISTRY, ORGANIC | MECHANISMS | OF-FUNCTION MUTATIONS | POTENT | INHIBITOR | TETRODOTOXIN | HUWENTOXIN-IV | NA+ CURRENT | Animals | Pain - drug therapy | Humans | Sodium Channel Blockers - therapeutic use | Sodium Channel Blockers - pharmacology | Voltage-Gated Sodium Channels - chemistry | Sodium Channel Blockers - chemistry | Drug Discovery | Voltage-Gated Sodium Channels - metabolism
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10. Full Text Sodium channel SCN1A and epilepsy: Mutations and mechanisms
by Escayg, Andrew and Goldin, Alan L
Epilepsia, ISSN 0013-9580, 09/2010, Volume 51, Issue 9, pp. 1650 - 1658
Summary Mutations in a number of genes encoding voltage‐gated sodium channels cause a variety of epilepsy syndromes in humans, including genetic (generalized)... 
Genetics | Knockout mice | GEFS | Dravet syndrome | Knock‐in mice | Knock-in mice | ISOFORM NACH6 | NA(V)1.1 | CLINICAL NEUROLOGY | FEBRILE SEIZURES PLUS | MOUSE MODEL | MISSENSE MUTATION | SEVERE MYOCLONIC EPILEPSY | AUXILIARY SUBUNITS | GENERALIZED EPILEPSY | SUBUNIT GENE | UP-REGULATION | Epilepsy, Generalized - genetics | Humans | Rats | Mutation - genetics | Nerve Tissue Proteins - genetics | NAV1.1 Voltage-Gated Sodium Channel | Channelopathies - genetics | Animals | Seizures, Febrile - genetics | Mosaicism | Mice | Sodium Channels - genetics | Disease Models, Animal | Epilepsies, Myoclonic - genetics | GABA | Genetic aspects | Seizures (Medicine) | Molecular genetics | Analysis | Epilepsy | Animal models | g-Aminobutyric acid | Channel gating | Neurons | Sodium channels (voltage-gated) | Mutation | Seizures
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11. Full Text Gain-of-function mutations in sodium channel Na(V)1.9 in painful neuropathy
by Huang, Jianying and Han, Chongyang and Estacion, Mark and Vasylyev, Dymtro and Hoeijmakers, Janneke G. J and Gerrits, Monique M and Tyrrell, Lynda and Lauria, Giuseppe and Faber, Catharina G and Dib-Hajj, Sulayman D and Merkies, Ingemar S. J and Waxman, Stephen G and PROPANE Study Grp and PROPANE Study Group
Brain, ISSN 0006-8950, 06/2014, Volume 137, Issue Pt 6, pp. 1627 - 1642
The aetiology of painful peripheral neuropathy is often unknown. Huang et al. sequence the gene encoding sodium channel Na(v)1.9 in 393 patients with small... 
AFFERENT NEURONS | RAT | ROOT GANGLION NEURONS | DYNAMIC CLAMP | channelopathy | DRG NEURONS | MOUSE | sensory neurons | current-clamp | NEUROSCIENCES | CLINICAL NEUROLOGY | voltage-clamp | DRG | PRIMARY SENSORY NEURONS | SMALL-FIBER NEUROPATHY | EXPRESSION | RESISTANT NA+ CURRENT | Membrane Potentials - genetics | Humans | Middle Aged | Male | Peripheral Nervous System Diseases - physiopathology | Membrane Potentials - physiology | Pain - metabolism | Mutation, Missense - genetics | Peripheral Nervous System Diseases - metabolism | Pain - genetics | Neurons - physiology | NAV1.9 Voltage-Gated Sodium Channel - genetics | Female | NAV1.7 Voltage-Gated Sodium Channel - genetics | Aged | Peripheral Nervous System Diseases - genetics
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12. Full Text Crystallographic insights into sodium-channel modulation by the β4 subunit
by John Gilchrist and Samir Das and Filip Van Petegem and Frank Bosmans
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2013, Volume 110, Issue 51, pp. 20363 - 20363
Voltage-gated sodium (Nav) channels are embedded in a multicomponent membrane signaling complex that plays a crucial role in cellular excitability. Although... 
PNAS Plus Significance Statements | ProTx-II | X-ray structure | Beta4 subunit | Disease mutations | Voltage-gated sodium channel | Protein Structure, Tertiary | Voltage-Gated Sodium Channel beta-4 Subunit - chemistry | Protein Structure, Secondary | Humans | NAV1.2 Voltage-Gated Sodium Channel - genetics | Xenopus laevis | Voltage-Gated Sodium Channel beta-1 Subunit - chemistry | Crystallography, X-Ray | Epilepsy - metabolism | Structure-Activity Relationship | Voltage-Gated Sodium Channel beta-4 Subunit - metabolism | Cysteine - chemistry | Mutation, Missense | NAV1.2 Voltage-Gated Sodium Channel - metabolism | Cysteine - genetics | NAV1.2 Voltage-Gated Sodium Channel - chemistry | Animals | Voltage-Gated Sodium Channel beta-4 Subunit - genetics | Voltage-Gated Sodium Channel beta-1 Subunit - genetics | Epilepsy - genetics | Cysteine - metabolism | Voltage-Gated Sodium Channel beta-1 Subunit - metabolism | Amino Acid Substitution | Biological Sciences | disease mutations | PNAS Plus | beta4 subunit | voltage-gated sodium channel
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13. Full Text Sodium Channel Inactivation: Molecular Determinants and Modulation
by Werner Ulbricht
Physiological Reviews, ISSN 0031-9333, 10/2005, Volume 85, Issue 4, pp. 1271 - 1301
Voltage-gated sodium channels open (activate) when the membrane is depolarized and close on repolarization (deactivate) but also on continuing depolarization... 
PROTEIN-KINASE-C | PHYSIOLOGY | PIG VENTRICULAR MYOCYTES | SQUID GIANT-AXONS | STEADY-STATE PROPERTIES | VOLTAGE-GATED SODIUM | SKELETAL-MUSCLE SODIUM | SEA-ANEMONE TOXIN | CARDIAC NA+ CHANNELS | MYELINATED NERVE-FIBERS | SCORPION ALPHA-TOXIN | Humans | Electrophysiology | Sodium Channels - physiology | Muscle, Skeletal - physiology | Anesthetics, Local - pharmacology | Point Mutation | Animals | Membrane Potentials | Sodium Channels - chemistry | Protein Isoforms | Sodium Channels - genetics | Kinetics | Sodium Channel Blockers | Physiological aspects | Sodium channels | Research
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