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Genes & Diseases, ISSN 2352-3042, 09/2016, Volume 3, Issue 3, pp. 198 - 210
Temozolomide (TMZ) is an oral alkylating agent used to treat glioblastoma multiforme (GBM) and astrocytomas. However, at least 50% of TMZ treated patients do... 
Resistance | Temodar | Temozolomide | Adaptive | Intrinsic | Glioblastoma
Journal Article
International Journal of Molecular Sciences, ISSN 1422-0067, 10/2019, Volume 20, Issue 21, p. 5347
Glioblastoma (GBM) is the most popular primary central nervous system cancer and has an extremely expansive course. Aggressive tumor growth correlates with... 
pd1 ligand | glioblastoma multiforme | gbm | pd1
Journal Article
Molecular Cancer, ISSN 1476-4598, 06/2017, Volume 16, Issue 1, pp. 100 - 16
Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary tumor in the central nervous system. One of the most widely used... 
GBM | PI3K | MTOR | Glioblastoma | ADVANCED SOLID TUMORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHASE-II | KINASE INHIBITOR | VIVO ANTITUMOR-ACTIVITY | PI3K/MTOR INHIBITOR | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR | I DOSE-ESCALATION | CELL LUNG-CANCER | ONCOLOGY | METASTATIC BREAST-CANCER | mTOR | CHRONIC LYMPHOCYTIC-LEUKEMIA | TOR Serine-Threonine Kinases - metabolism | Humans | Brain Neoplasms - pathology | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - metabolism | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Brain Neoplasms - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Antineoplastic Agents - adverse effects | Glioblastoma - metabolism | Brain Neoplasms - mortality | Catalysis | Drug Evaluation, Preclinical | Proto-Oncogene Proteins c-akt - metabolism | Isoenzymes | Treatment Outcome | Antineoplastic Agents - chemistry | Brain Neoplasms - drug therapy | Drug Discovery | Clinical Studies as Topic | Protein Kinase Inhibitors - administration & dosage | Animals | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Glioblastoma - pathology | Glioblastoma - drug therapy | Glioblastoma - mortality | Care and treatment | Genetic aspects | Cellular signal transduction | Research | Glioblastoma multiforme | TOR protein | Drugs | Plasma | Phosphorylation | Prognosis | Motility | Brain cancer | Central nervous system | Clinical trials | AKT protein | Kinases | Phosphatase | Synergism | Alkylation | Proteins | Angiogenesis | Signal transduction | Cell growth | Epidermal growth factor | DNA methylation | Deoxyribonucleic acid--DNA | Medical research | Cell survival | Rapamycin | Metabolism | Patients | 1-Phosphatidylinositol 3-kinase | Inhibitors | Protein synthesis | Medical prognosis | Ligands | Solid tumors | Temozolomide | Mutation | Methylation | Tumors | Apoptosis
Journal Article
Genes and Cancer, ISSN 1947-6019, 01/2012, Volume 3, Issue 1, pp. 3 - 15
Glioblastoma multiforme (GBM) is an aggressive grade IV astrocytoma with a 1-year median survival rate despite current treatment modalities. A thorough... 
glioma | microarray | GBM | review | miR | Review
Journal Article
Anticancer Research, ISSN 0250-7005, 01/2017, Volume 37, Issue 1, pp. 21 - 33
Glioblastoma multiforme (GBM) represents the most malignant primary brain tumor in adults with generally dismal prognosis, early clinical deterioration and... 
GBM | Targeted therapy | Immunotherapy | Clinical trials | PD1 inhibition | Immune checkpoint inhibitors | Review | Personalized medicine | Glioblastoma multiforme | CTLA4 inhibition | targeted therapy | NEWLY-DIAGNOSED GLIOBLASTOMA | INTEGRATED GENOMIC ANALYSIS | RECURRENT GLIOBLASTOMA | BEVACIZUMAB PLUS IRINOTECAN | OPEN-LABEL | immune checkpoint inhibitors | personalized medicine | RADIATION-THERAPY | CELL LUNG-CANCER | PHASE-II TRIAL | ONCOLOGY | review | immunotherapy | clinical trials | CENTRAL-NERVOUS-SYSTEM | HIGH-GRADE GLIOMAS | Humans | Antibodies, Monoclonal - adverse effects | Tumor Microenvironment | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Brain Neoplasms - metabolism | Brain Neoplasms - immunology | Molecular Targeted Therapy - trends | Glioblastoma - genetics | Antineoplastic Agents - adverse effects | Immunotherapy - trends | Angiogenesis Inhibitors - therapeutic use | Biomarkers, Tumor - metabolism | Glioblastoma - metabolism | Biomarkers, Tumor - antagonists & inhibitors | Molecular Targeted Therapy - adverse effects | Brain Neoplasms - genetics | Treatment Outcome | Immunotherapy - adverse effects | Glioblastoma - therapy | Animals | Glioblastoma - immunology | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | Brain Neoplasms - therapy | Biomarkers, Tumor - genetics | Biomarkers, Tumor - immunology
Journal Article
Journal of Neurosciences in Rural Practice, ISSN 0976-3147, 05/2012, Volume 3, Issue 2, pp. 174 - 177
ABSTRACT Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor. GBM in children is less common than in adults and has a better... 
Case Report | recraniotomy | pediatric GBM | multicentric GBM | Multifocal GBM | Case studies | Care and treatment | Patient outcomes | Tumors in children | Diagnosis | Radiotherapy | Glioblastoma multiforme | Pediatrics | Postoperative period | Medical imaging | Radiation therapy | Tumors | Children & youth | Quality of life | pediatric gbm | multifocal gbm | multicentric gbm
Journal Article