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Journal Article
Neuroscience Letters, ISSN 0304-3940, 05/2017, Volume 650, pp. 8 - 11
A large meta-analysis recently identified six new loci associated with risk of PD, but subsequent studies have given discrepant results. Here we conducted a... 
Single-nucleotide polymorphism | MIR4697 | GCH1 | SIPA1L2 | VPS13C | Parkinson’s disease
Journal Article
Parkinsonism and Related Disorders, ISSN 1353-8020, 12/2017, Volume 45, pp. 81 - 84
GTP cyclohydrolase 1-deficient DOPA-responsive dystonia, caused by autosomal dominant mutation in the gene coding for GTP cyclohydrolase 1, is a rare disorder... 
Prevalence | Mutation | GCH1 | DOPA-responsive dystonia | CLINICAL NEUROLOGY
Journal Article
Metabolism, ISSN 0026-0495, 05/2019, Volume 94, pp. 96 - 104
GTP cyclohydrolase I (GTPCH) deficiency could impair the synthesis of tetrahydrobiopterin and causes metabolic diseases involving phenylalanine catabolism,... 
Dopa-responsive dystonia | GTP cyclohydrolase I deficiency | Mouse model | BH4 deficiency | GCH1
Journal Article
Brain, ISSN 0006-8950, 7/2009, Volume 132, Issue 7, pp. 1753 - 1763
Journal Article
Chinese Journal of Medical Genetics, ISSN 1003-9406, 04/2017, Volume 34, Issue 2, pp. 205 - 208
Journal Article
Parkinsonism and Related Disorders, ISSN 1353-8020, 2019, Volume 65, pp. 248 - 251
Introduction: Dopa-responsive dystonia (DRD) related to GCH1 mutation is a biochemical disorder. DRD is majorly characterized by dystonia and/or parkinsonism.... 
Parkinsonism | Guanosine triphosphate cyclohydrolase 1 | Dystonia | GCH1 | Dopa responsive dystonia | Residual sign | Genetic aspects | Parkinson's disease | Dopa | Analysis
Journal Article
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, ISSN 1128-3602, 11/2019, Volume 23, Issue 11, pp. 4564 - 4574
OBJECTIVE: To explore the effect of micro ribonucleic acid (miR)-124 on the spinal neuronal apoptosis and to explore its related mechanism. MATERIALS AND... 
REPAIR | GCH1 | MiR-124 | PHARMACOLOGY & PHARMACY | Spinal cord injury | CORD-INJURY | Apoptosis
Journal Article
Current Clinical Neurology, ISSN 1559-0585, 2019, pp. 241 - 244
Journal Article
JOURNAL OF THE NEUROLOGICAL SCIENCES, ISSN 0022-510X, 10/2016, Volume 369, pp. 1 - 4
Parkinson's disease (PD) is the second most common neurodegenerative disorder. Prevalence of PD increases steadily with age. A recent meta-analysis of... 
Parkinson's disease | GCH1 | GENE | VPS13C | Iranian population | MIR4697 | DOPA-RESPONSIVE DYSTONIA | ASSOCIATION | VARIANT | NEUROSCIENCES | CLINICAL NEUROLOGY | Polymorphism
Journal Article
Brain, ISSN 0006-8950, 2014, Volume 137, Issue 9, pp. 2480 - 2492
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 01/2019, Volume 73, pp. 231.e1 - 231.e6
encodes the enzyme guanosine triphospahte (GTP) cyclohydrolase 1, essential for dopamine synthesis in nigrostriatal cells, and rare mutations in may lead to... 
Parkinson disease | GTP cyclohydrolase 1 deficiency | Dopa-responsive dystonia (DRD) | GCH1 | POPULATION | METAANALYSIS | LOW-FREQUENCY | RISK | DYSTONIA | NEUROSCIENCES | COMPOUND HETEROZYGOTES | GERIATRICS & GERONTOLOGY | GENETICS | MUTATIONS | MIR4697 | GENOME-WIDE ASSOCIATION | Medicine, Experimental | Enzymes | Medical research | Neurosciences | Analysis | Medical societies
Journal Article
Journal of Translational Medicine, ISSN 1479-5876, 02/2018, Volume 16, Issue 1, pp. 43 - 6
Background: Candidate-gene studies on fibromyalgia susceptibility often include a small number of single nucleotide polymorphisms (SNPs), which is a... 
COMT gene | Alleles | Caucasian | GCH1 gene | Epidemiology | OPRM1 gene | Chronic pain | MEDICINE, RESEARCH & EXPERIMENTAL | POLYMORPHISMS
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 08/2018, Volume 68, pp. 159.e7 - 159.e14
A recent large-scale European-originated genome-wide association data meta-analysis followed by a replication study identified 6 new risk loci for Parkinson's... 
Parkinson's disease | Association | GCH1 | DDRGK1 | VPS13C | MIR4697 | SIPA1L2 | Polymorphism | RISK-FACTORS | METAANALYSIS | LOCI | NEUROSCIENCES | GERIATRICS & GERONTOLOGY | HAN CHINESE POPULATION | GENOME-WIDE ASSOCIATION | Medicine, Preventive | Analysis | Genomics | Asians | Preventive health services
Journal Article
Pigment Cell & Melanoma Research, ISSN 1755-1471, 09/2019, Volume 32, Issue 5, pp. 724 - 727
Although xanthophores are found widely among poikilothermic species, the developmental and biochemical pathways underlying differentiation of these pteridine‐... 
pteridine | tetrahydrobiopterin | GCH1 | neural crest | ONCOLOGY | CELL BIOLOGY | DERMATOLOGY | Sapropterin dihydrochloride | Analysis | Larvae | Base pairs | Zebrafish | Pteridine | Gene deletion | Embryos | Pigmentation | Gene sequencing | Microinjection | Clonal deletion | GTP cyclohydrolase | Deletion | Mutation | Localization | Deoxyribonucleic acid--DNA | DNA sequencing | Index Medicus
Journal Article