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JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 06/2005, Volume 23, Issue 18, pp. 4152 - 4161
Purpose To study the toxicity and pharmacokinetic-pharmacodynamic profile of 17-allylamino, 17-demethoxygeldanamycin (17-AAG) and to recommend a dose for phase... 
SIGNAL-TRANSDUCTION | ANDROGEN RECEPTOR | HSP90 | APOPTOSIS | CANCER CELLS | ONCOLOGY | GELDANAMYCIN | MOLECULAR CHAPERONE | 17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN | INHIBITOR | ASSOCIATION
Journal Article
Leukemia, ISSN 0887-6924, 2002, Volume 16, Issue 4, pp. 455 - 462
Journal Article
ChemBioChem, ISSN 1439-4227, 03/2018, Volume 19, Issue 6, pp. 529 - 529
The cover feature picture shows new reblastatin derivatives obtained by a chemo‐biosemisynthetic approach with the corresponding aminobenzoic acid derivatives... 
inhibitors | heat shock proteins | Leishmania | geldanamycin | microarrays
Journal Article
JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 03/2019, Volume 84, Issue 5, pp. 2997 - 3003
We found that the activated carbon-molecular oxygen system promotes the conversion of hydroquinones to benzoquinones, naphthoquinones, and anthraquinones,... 
DIENES | BIFUNCTIONAL CATALYSTS | AMINES | GELDANAMYCIN | 1,4-NAPHTHOQUINONE DERIVATIVES | ESTERS | CHEMISTRY, ORGANIC | AEROBIC OXIDATION | ADDUCTS | AROMATIZATION
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2014, Volume 85, pp. 359 - 370
Journal Article
Organic Letters, ISSN 1523-7060, 02/2018, Volume 20, Issue 4, pp. 1058 - 1061
Overexpression of the pathway-specific positive regulator gene mas13 activated the cryptic gene cluster mas, resulting in the isolation of nine novel... 
STREPTOMYCES SP | NATURAL-PRODUCTS | BIOSYNTHESIS | GELDANAMYCIN | MACROLACTAMS | CHEMISTRY, ORGANIC | CHAINS | FAMILY
Journal Article
Acta Pharmaceutica Sinica B, ISSN 2211-3835, 09/2015, Volume 5, Issue 5, pp. 378 - 389
Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target. Many recent studies have provided convincing evidences of strong... 
Cancer drug discovery and development | HIF-1α inhibitors | HIF-1α | TRANSCRIPTIONAL ACTIVITY | DNA-BINDING | HIF-1 alpha | PROTEASOMAL DEGRADATION | FACTOR-I | ANTITUMOR-ACTIVITY | SIGNAL-TRANSDUCTION | SMALL-MOLECULE INHIBITORS | TUMOR-SUPPRESSOR PROTEIN | PHARMACOLOGY & PHARMACY | HIF-1 alpha inhibitors | HYPOXIA-INDUCIBLE FACTOR-1 | ENDOTHELIAL GROWTH-FACTOR | RCC, renal cell carcinoma | Ras, rat sarcoma | Raf, rapidly accelerated fibrosarcoma | EGF, epidermal growth factor | C-TAD, COOH-terminal TAD | HTS, high throughput screens | ARD-1, arrest-defective-1 | ELISA, enzyme-linked immunosorbent assay | pVHL, von Hippel-Lindau protein | LEP, leptin | ChIP, chromatin immunoprecipitation | IPAS, inhibitory PAS | IGF-BP3, IGF-factor-binding protein 3 | PAS, Per and Sim | mTOR, mammalian target of rapamycin | RT-PCR, reverse transcription polymerase chain reaction | CAC, circulating angiogenic cells | CoCl2, cobalt chloride | AKt, protein kinase B | TPT, topotecan | bHLH, basic-helix-loop-helix | LDHA, lactate dehydrogenase | GLUTs, glucose transporters | P, proline residue | ODDD, oxygen dependent degradation domain | TGF-α, transforming growth factor α | VEGF, vascular endothelial growth factor | CPTs, camptothecins | Mdm2, mouse double minute 2 homolog | PKM, pyruvate kinase M | AhR, aryl hydrocarbon receptor | K, lysine residue | IGF2, insulin-like growth factor 2 | GLUT3, glucose transporter 3 | CBP associated factor | eIF-4E, eukaryotic translation initiation factor 4E | MEK, MAPK | ADM, adrenomedullin | ARNT, aryl hydrocarbon nuclear translocator | HK2, hexokinase 2 | PHDs, prolyl-4-hydroxylases | PCAF, p300 | FIH-1, factor inhibiting HIF-1 | Review | SIRT 1, Sirtuin 1 | ERK kinase | C-MYC, myelocytomatosis virus oncogene cellular homolog | IGF-BP2, IGF-factor-binding protein 2 | N, asparagine residue | TAD, transactivation domains | HDAC, histone deacetylase | EMSA, electrophoretic mobility shift assay | LRP1, LDL-receptor-related protein 1 | Luc, luciferase | GAs, geldanamycins | HIF-1α, hypoxia-inducible factor-1α | HK1, hexokinase 1 | ID2, DNA-binding protein inhibitor | HPH, HIF-1 prolyl hydroxylases | NOS, nitric oxide synthase | N-TAD, NH2-terminal TAD | MNK, MAP kinase interacting kinase | MTs, microtubules | HRE, hypoxia response elements | ERK, extracellular signal-regulated kinase | EPO, erythropoietin | MAPK, mitogen-activated protein kinases | PI3K, phosphatidyl inositol-4,5-bisphosphate-3-kinase | DFO, deferoxamine | Top I, topoisomerase I | GLUT1, glucose transporter 1 | Hsp90, heat shock protein 90 | TGF-β3, transforming growth factor beta3 | 4E-BP1, eukaryotic translation initiation factor 4E (eIF-4E) binding protein p70 S6 kinase (S6K) | GA, geldanamycin
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 03/2007, Volume 13, Issue 6, pp. 1775 - 1782
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 05/2005, Volume 11, Issue 9, pp. 3385 - 3391
Purpose: 17-(Allylamino)-17-demethoxygeldanamycin (17AAG), a benzoquinone antibiotic, down-regulates oncoproteins by binding specifically to heat shock protein... 
HSP90 | CELLS | COMPLEX | PROTEIN | ONCOLOGY | 17-(ALLYLAMINO)-17-DEMETHOXYGELDANAMYCIN | GELDANAMYCIN | 17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN | RECEPTOR | 17-ALLYLAMINO,17-DEMETHOXYGELDANAMYCIN | DERIVATIVES
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2014, Volume 87, pp. 346 - 363
Heat shock protein 90 (Hsp90) is an attractive target for the development of antitumor agents. Geldanamycin (GA), the first Hsp90 inhibitor, has potent... 
Hsp90 | Synthesis | Molecular dynamic | Molecular dynamics | Geldanamycin | Hepatotoxicity | Antitumor activities
Journal Article
Journal of Microbiology and Biotechnology, ISSN 1017-7825, 2016, Volume 26, Issue 1, pp. 56 - 60
Two new glucosides (1 and 2) of geldanamycin (GA) analogs were obtained from in vitro glycosylation by UDP-glycosyltransferase (YjiC). Based on spectroscopic... 
Geldanamycin analogs | water solubility | glycosyltransferase | cytotoxicity
Journal Article
Medicinal research reviews, ISSN 0198-6325, 1/2016, Volume 36, Issue 1, pp. 92 - 118
The 90 kDa heat shock proteins (Hsp90) are responsible for the conformational maturation of nascent polypeptides and the rematuration of denatured proteins.... 
Hsp90 | chaperone | natural product-based drug design | radicicol | geldanamycin
Journal Article