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gem-difluoroalkenes (88) 88
chemistry, organic (54) 54
chemistry, multidisciplinary (46) 46
fluorine (34) 34
f bond activation (24) 24
stereoselective-synthesis (20) 20
alkenes (19) 19
activation (18) 18
carbonyl-compounds (18) 18
grignard-reagents (17) 17
catalysis (16) 16
cross-coupling reactions (16) 16
medicinal chemistry (15) 15
nucleophilic 5-endo-trig cyclization (15) 15
fluorination (14) 14
diazo-compounds (13) 13
functionalized gem-difluoroalkenes (13) 13
index medicus (13) 13
concise synthesis (12) 12
cyclization (12) 12
derivatives (12) 12
gem-difluoroalkene (12) 12
halides (12) 12
organolithium reagents (12) 12
trifluoromethylation (12) 12
c-f bond (11) 11
functionalization (11) 11
synthesis (11) 11
crafts-type cyclization (10) 10
organic-synthesis (10) 10
palladium (10) 10
copper (9) 9
hydrodefluorination (9) 9
reagents (9) 9
chemistry, inorganic & nuclear (8) 8
fluorides (8) 8
access (7) 7
borylation (7) 7
chemical reactions (7) 7
electrophilic fluorination (7) 7
enantioselective synthesis (7) 7
esters (7) 7
fluor (7) 7
ketones (7) 7
olefins (7) 7
alkene (6) 6
alpha (6) 6
building-blocks (6) 6
chemistry, physical (6) 6
cross-coupling reaction (6) 6
difluoroolefination (6) 6
terminal alkynes (6) 6
trimethylchlorosilan (6) 6
trimethylchlorosilane (6) 6
3+2 cycloaddition (5) 5
alcohols (5) 5
alkylation (5) 5
aromatic compounds (5) 5
aryl bromides (5) 5
aryl fluorides (5) 5
c-f bond activation (5) 5
chemistry, applied (5) 5
coupling reactions (5) 5
defluorination (5) 5
difluoroalkenes (5) 5
difluoromethyl 2-pyridyl sulfone (5) 5
elimination (5) 5
one-carbon units (5) 5
one-pot synthesis (5) 5
organic chemistry (5) 5
stereoselectivity (5) 5
substitution (5) 5
synthetic methods (5) 5
1,1-difluoro-1-alkenes (4) 4
6-arylpurine (4) 4
acids (4) 4
addition-elimination reactions (4) 4
aldehydes (4) 4
alkenes - chemical synthesis (4) 4
alkenes - chemistry (4) 4
alkynes (4) 4
allyl fluoride (4) 4
alpha-fluoroalkenylation (4) 4
amines (4) 4
arylation (4) 4
asymmetric-synthesis (4) 4
bond formation (4) 4
c-f (4) 4
c-f bond cleavage (4) 4
carbon dioxide (4) 4
chemical synthesis (4) 4
cobalt catalysis (4) 4
conjugate addition (4) 4
efficient approach (4) 4
facile synthesis (4) 4
fluoride (4) 4
fluoroalkylation reactions (4) 4
generation (4) 4
intramolecular redox reaction (4) 4
light (4) 4
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Tetrahedron, ISSN 0040-4020, 10/2015, Volume 71, Issue 41, pp. 7892 - 7899
A direct and efficient approach for the trifluoromethylation and pentafluoroethylation of 1,1-diaryl-2,2-difluoroethenes with TMSCF 3 and TMSCF 2 CF 3 in the... 
Trifluoromethylation | (Pentafluoroethyl)trimethylsilane | gem-Difluoroalkenes | Pentafluoroethylation | (Trifluoromethyl)trimethylsilane
Journal Article
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, ISSN 1433-7851, 05/2017, Volume 56, Issue 21, pp. 5890 - 5893
Activation of the sp(3) C-F bond in 2-trifluoromethyl-1-alkenes was accomplished through treatment with a Lewis acid. In the presence of an equimolar amount of... 
carbocations | Lewis acids | C-F bond activation | 1,1-DIFLUOROALKENES | DIAZO-COMPOUNDS | ORGANOLITHIUM REAGENTS | CHEMISTRY, MULTIDISCIPLINARY | 3+2 CYCLOADDITION | HYDRODEFLUORINATION | 1,1-DIFLUORO-1-ALKENES | FUNCTIONALIZED GEM-DIFLUOROALKENES | allylation | CONCISE SYNTHESIS | CYCLIZATION | fluorine
Journal Article
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 07/2019, Volume 55, Issue 53, pp. 7599 - 7602
Literature methods to access gem-difluoroalkenes are largely limited to harsh, organometallic-based methods, and known photoredox-mediated processes are not... 
HALIDES | ELECTRON | GEM-DIFLUOROALKENES | FLUORINE | ELIMINATION | CHEMISTRY, MULTIDISCIPLINARY | F BOND ACTIVATION
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 02/2017, Volume 58, Issue 5, pp. 375 - 392
The -difluoroalkenes and related compounds have gained much attention from the organic synthetic community due to their widespread applications as versatile... 
gem-Difluoroalkenes | Synthesis | New reactions | C[sbnd]F functionalization
Journal Article
by Yang, LS and Li, CP and Wang, DC and Liu, H
JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 06/2019, Volume 84, Issue 11, pp. 7320 - 7330
Unprecedented Rh(III)-catalyzed C-H bond difluorovinylation of indoles has been successfully developed, and this method provided an example of direct... 
ACTIVATION | POTENT | BENZAMIDES | PHARMACEUTICALS | ANNULATION | CHEMISTRY, ORGANIC | GEM-DIFLUOROALKENES | CARBONYL-COMPOUNDS | FLUORINE | PROPARGYL ALCOHOLS | INHIBITORS
Journal Article
Organic Letters, ISSN 1523-7060, 02/2017, Volume 19, Issue 3, pp. 588 - 591
The construction of ring-fluorinated seven-membered carbocycles was readily achieved via the domino SN2′-type/SNV reaction between... 
HETEROCYCLES | NUCLEOPHILIC 5-ENDO-TRIG CYCLIZATION | 2-TRIFLUOROMETHYL-1-ALKENES | CHEMISTRY, ORGANIC | GEM-DIFLUOROALKENES | ALLOCOLCHICINOIDS | ONE-CARBON UNITS | CYTOTOXICITY | CARBOCYCLES | MOLECULES | HYDRODEFLUORINATION
Journal Article
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, ISSN 1433-7851, 11/2017, Volume 56, Issue 47, pp. 15073 - 15077
Described is a facile, scalable route to access functional-group-rich gem-difluoroalkenes. Using visible-light-activated catalysts in conjunction with an... 
radicals | LIGHT | ORGANOLITHIUM REAGENTS | alkenes | SINGLE-ELECTRON TRANSMETALATION | CHEMISTRY, MULTIDISCIPLINARY | P38 MAP KINASE | photochemistry | ORAL BIOAVAILABILITY | ARYL HALIDES | FUNCTIONALIZED GEM-DIFLUOROALKENES | alkylation | DUAL CATALYSIS | CONCISE SYNTHESIS | fluorine | DRUG-METABOLISM
Journal Article
by He, YW and Anand, D and Sun, ZC and Zhou, L
ORGANIC LETTERS, ISSN 1523-7060, 05/2019, Volume 21, Issue 10, pp. 3769 - 3773
A visible-light-promoted redox neutral gamma,gamma-difluoroallylation of cycloketone oxime ethers with trifluor-omethyl alkenes through C-C and C-F bond... 
FUNCTIONALIZATION | H CYANOALKYLATION | SUBSTITUTION | ACTIVATION | NUCLEOPHILIC 5-ENDO-TRIG CYCLIZATION | ACIDS | ESTERS | CHEMISTRY, ORGANIC | GEM-DIFLUOROALKENES | CARBONYL-COMPOUNDS | IMINYL RADICALS
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2018, Volume 16, Issue 47, pp. 9211 - 9217
The transformation of hydroximoyl fluorides to nitrile oxides for [3 + 2]-cycloaddition with alkynes has been achieved for the first time. The hydroximoyl... 
FUNCTIONALIZATION | SUBSTITUTION | OXIMES | REAGENTS | MECHANISM | CHEMISTRY, ORGANIC | GEM-DIFLUOROALKENES | GENERATION | SALTS | F BOND ACTIVATION | HYDRODEFLUORINATION
Journal Article
Organic Letters, ISSN 1523-7060, 02/2018, Volume 20, Issue 3, pp. 570 - 573
An example of Rh-catalyzed C–H activation with methyl trifluoroacrylate for the synthesis of fluoroolefins and heterocycles (benzoindolizines) is reported. The... 
FUNCTIONALIZATION | PALLADIUM | ACTIVATION | MERGING PHOTOREDOX | EFFICIENT APPROACH | CHEMISTRY, ORGANIC | GEM-DIFLUOROALKENES | BOND FORMATION | CATALYZED CYCLIZATION | N BOND | DIAZO-COMPOUNDS
Journal Article
ORGANIC LETTERS, ISSN 1523-7060, 02/2019, Volume 21, Issue 4, pp. 1130 - 1133
The first defluorinative ipso-functionalization reaction of (trifluoromethyl)alkenes is reported. This exclusively regioselective ipso-defluorooxylation of... 
SUBSTITUTION | ALKENES | ALKYL FLUORIDES | FLUORINE ELIMINATION | FUNCTIONALIZED GEM-DIFLUOROALKENES | CHEMISTRY, ORGANIC | H BONDS | CLEAVAGE | 3+2 CYCLOADDITION | ACCESS | HYDRODEFLUORINATION
Journal Article
by Yang, FY and Jin, YX and Wang, C
ORGANIC LETTERS, ISSN 1523-7060, 09/2019, Volume 21, Issue 17, pp. 6989 - 6994
An asymmetric Ni-catalyzed intramolecular reductive Heck reaction of unactivated alkenes tethered to aryl bromides has been accomplished, providing a variety... 
ENANTIOSELECTIVE SYNTHESIS | FORMAL SYNTHESIS | CONSTRUCTION | CHEMISTRY, ORGANIC | GEM-DIFLUOROALKENES | OLEFINS | ARYL | RING-SYSTEM | HYDROARYLATION | CYCLIZATION | CONJUGATE ADDITION
Journal Article
Organic Letters, ISSN 1523-7060, 03/2018, Volume 20, Issue 6, pp. 1638 - 1642
An efficient copper-catalyzed reductive defluorination of β-trifluoromethylated enones via an oxidative homocoupling of Grignard reagents is reported. The... 
ACTIVATION | FLUORINE ELIMINATION | ENANTIOSELECTIVE SYNTHESIS | CHEMISTRY, ORGANIC | GEM-DIFLUOROALKENES | 1,4-CONJUGATE ADDITION | DIAZO-COMPOUNDS | C-F BOND | STEREOSELECTIVE-SYNTHESIS | ELECTROREDUCTIVE DEFLUORINATION | CONJUGATE ADDITIONS
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2017, Volume 58, Issue 5, pp. 375 - 392
Journal Article
Chemical communications (Cambridge, England), ISSN 1359-7345, 06/2017, Volume 53, Issue 53, pp. 7168 - 7181
Fluorination of organic molecules significantly impacts the basic physicochemical properties of small and large biologically active molecules, agrichemicals,... 
Journal Article
Chemical science, ISSN 2041-6520, 01/2019, Volume 10, Issue 3, pp. 809 - 814
Herein, we report a nickel-catalyzed allylic defluorinative alkylation of trifluoromethyl alkenes through reductive decarboxylation of redox-active esters. The... 
Journal Article
Chemical Science, ISSN 2041-6520, 2019, Volume 10, Issue 3, pp. 809 - 814
Herein, we report a nickel-catalyzed allylic defluorinative alkylation of trifluoromethyl alkenes through reductive decarboxylation of redox-active esters. The... 
ARYL BROMIDES | HALIDES | N-HYDROXYPHTHALIMIDE ESTERS | DIFLUOROOLEFINATION | EFFICIENT APPROACH | COUPLING REACTIONS | GEM-DIFLUOROALKENES | FLUORINE | DIAZO-COMPOUNDS | CHEMISTRY, MULTIDISCIPLINARY | F BOND ACTIVATION
Journal Article
Chemical Communications, ISSN 1359-7345, 2018, Volume 54, Issue 46, pp. 5907 - 5910
A novel synthesis of alpha-CF3 and alpha-CF2H amines via the aminofluorination of gem-difluoroalkenes and mono-fluoroalkenes, respectively, is reported. The... 
ARYL BROMIDES | CROSS-COUPLING REACTIONS | COPPER-MEDIATED DIFLUOROMETHYLATION | GEM-DIFLUOROALKENES | STEREOSELECTIVE-SYNTHESIS | SILYL ETHERS | RITTER REACTION | CHEMISTRY, MULTIDISCIPLINARY | METAL-FREE | GRIGNARD-REAGENTS | DIFLUOROENOL SILYL
Journal Article
ACS Catalysis, ISSN 2155-5435, 10/2015, Volume 5, Issue 10, pp. 5947 - 5950
The nickel-catalyzed defluorinative coupling of 2-trifluoromethyl-1-alkenes and alkynes with the aid of Et3SiH provides 1,1-difluoro-1,4-dienes under mild... 
trifluoromethylalkenes | C-F bond activation | 1,4-dienes | β-fluorine elimination | alkynes | nickel catalysis | SUBSTITUTION | beta-fluorine elimination | BUILDING-BLOCKS | COMPLEXES | CHEMISTRY, PHYSICAL | C-F ACTIVATION | REGIOSELECTIVITY | CYCLIZATIONS | REDUCTIVE COUPLINGS | OXIDATIVE-ADDITION | GEM-DIFLUOROALKENES
Journal Article
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