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gem-difluoroalkenes (88) 88
chemistry, organic (55) 55
chemistry, multidisciplinary (47) 47
fluorine (34) 34
f bond activation (26) 26
stereoselective-synthesis (20) 20
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activation (18) 18
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diazo-compounds (15) 15
functionalized gem-difluoroalkenes (15) 15
index medicus (15) 15
medicinal chemistry (15) 15
fluorination (14) 14
concise synthesis (13) 13
cyclization (12) 12
derivatives (12) 12
gem-difluoroalkene (12) 12
halides (12) 12
organolithium reagents (12) 12
trifluoromethylation (12) 12
c-f bond (11) 11
functionalization (11) 11
synthesis (11) 11
crafts-type cyclization (10) 10
organic-synthesis (10) 10
palladium (10) 10
copper (9) 9
hydrodefluorination (9) 9
reagents (9) 9
chemical reactions (8) 8
chemistry, inorganic & nuclear (8) 8
fluorides (8) 8
access (7) 7
borylation (7) 7
electrophilic fluorination (7) 7
enantioselective synthesis (7) 7
esters (7) 7
fluor (7) 7
ketones (7) 7
olefins (7) 7
alkene (6) 6
alpha (6) 6
building-blocks (6) 6
c-f (6) 6
chemistry, physical (6) 6
cross-coupling reaction (6) 6
difluoromethyl 2-pyridyl sulfone (6) 6
difluoroolefination (6) 6
organic chemistry (6) 6
terminal alkynes (6) 6
trimethylchlorosilan (6) 6
trimethylchlorosilane (6) 6
3+2 cycloaddition (5) 5
alcohols (5) 5
alkylation (5) 5
aromatic compounds (5) 5
aryl bromides (5) 5
aryl fluorides (5) 5
c-f bond activation (5) 5
chemistry, applied (5) 5
coupling reactions (5) 5
defluorination (5) 5
difluoroalkenes (5) 5
elimination (5) 5
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stereoselectivity (5) 5
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1,1-difluoro-1-alkenes (4) 4
6-arylpurine (4) 4
acids (4) 4
addition-elimination reactions (4) 4
aldehydes (4) 4
alkenes - chemical synthesis (4) 4
alkenes - chemistry (4) 4
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allyl fluoride (4) 4
alpha-fluoroalkenylation (4) 4
amines (4) 4
arylation (4) 4
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biological-activity (4) 4
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c-f bond cleavage (4) 4
carbon dioxide (4) 4
chemical bonds (4) 4
chemical synthesis (4) 4
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CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 11/2019, Volume 55, Issue 9, pp. 13486 - 1355
Journal Article
by Fan, P and Zhang, C and Lan, Y and Lin, ZY and Zhang, LC and Wang, C
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 10/2019, Volume 55, Issue 84, pp. 12691 - 12694
Hydrofunctionalization of trifluoromethyl alkenes is highly challenging, because the nucleophilic addition is oftentimes followed by beta-F elimination in this... 
ELECTROPHILIC ALKENES | ADDITION-REACTION | NUCLEOPHILIC 5-ENDO-TRIG CYCLIZATION | ALKYLATION | FUNCTIONALIZED GEM-DIFLUOROALKENES | MAGNETIC-RESONANCE | REGIOSELECTIVE 1,4-TRIFLUOROMETHYLATION | FLUORINE | DECATUNGSTATE ANION | CHEMISTRY, MULTIDISCIPLINARY | RADICAL REACTIONS
Journal Article
by Lin, ZY and Lan, Y and Wang, C
ORGANIC LETTERS, ISSN 1523-7060, 10/2019, Volume 21, Issue 20, pp. 8316 - 8322
Unactivated alkyl chlorides are abundant building blocks in organic synthesis, but they have been rarely engaged in cross-electrophile coupling. Herein, we... 
4-EXO CYCLIZATIONS | NICKEL | NUCLEOPHILIC 5-ENDO-TRIG CYCLIZATION | BIOLOGICAL-ACTIVITY | FUNCTIONALIZED GEM-DIFLUOROALKENES | DIFLUOROMETHYL 2-PYRIDYL SULFONE | CHEMISTRY, ORGANIC | DIAZO-COMPOUNDS | C-F | F BOND ACTIVATION | ALKYL-HALIDES
Journal Article
by Ma, T and Chen, YT and Li, YX and Ping, YY and Kong, WQ
ACS CATALYSIS, ISSN 2155-5435, 10/2019, Volume 9, Issue 10, pp. 9127 - 9133
Enantioselective Ni-catalyzed reductive aryl monofluoroalkenylation of alkenes between aryl bromides and gem-difluoroalkenes has been developed. The reaction... 
enantioselectivity | DIVERSE SYNTHESIS | reductive cross-coupling gem-difluoroalkenes | CHEMISTRY, PHYSICAL | Ni-catalyst | oxindole | F BOND ACTIVATION | FLUOROOLEFINS | FUNCTIONALIZATION | CROSS-COUPLING REACTIONS | monofluoroalkenylation | GEM-DIFLUOROALKENES | FLUORINE | DICARBOFUNCTIONALIZATION | TRIFLUOROMETHYLATION
Journal Article
Chinese Journal of Chemistry, ISSN 1001-604X, 10/2019, Volume 37, Issue 10, pp. 1009 - 1014
Summary of main observation and conclusion Silylated fluoroalkenes are important synthetic intermediates with complementary reactivity, which play a key role... 
CATALYSIS | GEM-DIFLUOROALKENES | FLUORINATION | DEFLUOROBORYLATION | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | F BOND ACTIVATION | BORYLATION | SILYLATION | TRIFLUOROMETHYLATION | HYDRODEFLUORINATION | Density functionals | Specific gravity
Journal Article
by Yang, FY and Jin, YX and Wang, C
ORGANIC LETTERS, ISSN 1523-7060, 09/2019, Volume 21, Issue 17, pp. 6989 - 6994
An asymmetric Ni-catalyzed intramolecular reductive Heck reaction of unactivated alkenes tethered to aryl bromides has been accomplished, providing a variety... 
ENANTIOSELECTIVE SYNTHESIS | FORMAL SYNTHESIS | CONSTRUCTION | CHEMISTRY, ORGANIC | GEM-DIFLUOROALKENES | OLEFINS | ARYL | RING-SYSTEM | HYDROARYLATION | CYCLIZATION | CONJUGATE ADDITION
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 08/2019, Volume 58, Issue 35, pp. 11998 - 12003
Journal Article
by Yan, SS and Wu, DS and Ye, JH and Gong, L and Zeng, X and Ran, CK and Gui, YY and Li, J and Yu, DG
ACS CATALYSIS, ISSN 2155-5435, 08/2019, Volume 9, Issue 8, pp. 6987 - 6992
An effective Cu-catalyzed selective formal carboxylation of C-F bonds with an atmospheric pressure of CO2 is reported. A variety of gem-difluoroalkenes,... 
selectivity | HALIDES | carbon dioxide | PALLADIUM | ACTIVATION | C-F bond cleavage | CHEMISTRY, PHYSICAL | FUNCTIONALIZATION | copper catalysis | ALKENES | ESTERS | carboxylation | CHLORIDES | GEM-DIFLUOROALKENES | CARBON-DIOXIDE | BORYLATION
Journal Article
ACS CATALYSIS, ISSN 2155-5435, 08/2019, Volume 9, Issue 8, pp. 6890 - 6895
The highly enantioselective copper-catalyzed three-component boroacylation of 1,1-disubstituted allenes is reported by using a class of chiral ligands... 
enantioselectivity | ASYMMETRIC-SYNTHESIS | BETA-TRIFLUOROMETHYL | SCOPE | COMPLEXES | quaternary stereocenter | CHEMISTRY, PHYSICAL | allenes | CYCLOADDITION | BORYLCUPRATION | LIGANDS | CONSTRUCTION | copper | GEM-DIFLUOROALKENES | boroacylation | BORYLATION
Journal Article
Chemistry – An Asian Journal, ISSN 1861-4728, 08/2019, Volume 14, Issue 15, pp. 2584 - 2587
Defluorinative C(sp3)−P bond formation of α‐trifluoromethyl alkenes with phosphine oxides or phosphonates have been achieved under catalyst‐ and oxidant‐free... 
α-trifluoromethyl alkenes | gem-difluoroalkenes | SN2′ process | C(sp3)−P bond | phosphorylation | STYRENES | OXIDATIVE C-C | ALKYLATION | CASCADE | DIPHENYLPHOSPHINE | CHEMISTRY, MULTIDISCIPLINARY | DEHYDROGENATIVE-COUPLING REACTIONS | S(N)2 ' process | PHOSPHONOPEPTIDES | TRIFLUOROMETHYL ALKENES | PHOSPHINE OXIDES | alpha-trifluoromethyl alkenes | EFFICIENT | C(sp)-P bond | Oxides | Nitriles | Olefins | Phosphonates
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 07/2019, Volume 58, Issue 31, pp. 10688 - 10692
The reaction of [Rh(H)(PEt3)3] (1) with the refrigerant HFO‐1234yf (2,3,3,3‐tetrafluoropropene) affords an efficient route to obtain [Rh(F)(PEt3)3] (3) by C−F... 
silanes | C−H activation | olefins | fluorine | rhodium | PALLADIUM | ACIDS | COMPLEXES | USEFUL TOOL | CHEMISTRY, MULTIDISCIPLINARY | FUNCTIONALIZATION | C-H activation | HEXAFLUOROPROPENE | CATALYTIC HYDRODEFLUORINATION | TETRAFLUOROETHYLENE | GEM-DIFLUOROALKENES | STEREOSELECTIVE-SYNTHESIS | Propylene | Fluorides | Rhodium | Bonds | Silane | Refrigerants | Hydrogen bonds | Fluorine | Activation | Catalysis | Fluorination
Journal Article
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 07/2019, Volume 55, Issue 53, pp. 7599 - 7602
Literature methods to access gem-difluoroalkenes are largely limited to harsh, organometallic-based methods, and known photoredox-mediated processes are not... 
HALIDES | ELECTRON | GEM-DIFLUOROALKENES | FLUORINE | ELIMINATION | CHEMISTRY, MULTIDISCIPLINARY | F BOND ACTIVATION
Journal Article
by Yang, LS and Li, CP and Wang, DC and Liu, H
JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 06/2019, Volume 84, Issue 11, pp. 7320 - 7330
Unprecedented Rh(III)-catalyzed C-H bond difluorovinylation of indoles has been successfully developed, and this method provided an example of direct... 
ACTIVATION | POTENT | BENZAMIDES | PHARMACEUTICALS | ANNULATION | CHEMISTRY, ORGANIC | GEM-DIFLUOROALKENES | CARBONYL-COMPOUNDS | FLUORINE | PROPARGYL ALCOHOLS | INHIBITORS
Journal Article
by Yang, Y and Zhou, QH and Cai, JJ and Xue, T and Liu, YL and Jiang, Y and Su, YM and Chung, LW and Vicic, DA
CHEMICAL SCIENCE, ISSN 2041-6520, 05/2019, Volume 10, Issue 20, pp. 5275 - 5282
We report herein the exploitment of the partially fluorinated trifluoroethyl as precatalyst ligands in nickelcatalyzed Suzuki-type alkylation and... 
TRANSITION-METAL CATALYSIS | CROSS-COUPLING REACTIONS | DIRECT DIFLUOROMETHYLATION | ARYL BORONIC ACIDS | C-C | BOND FORMATION | GEM-DIFLUOROALKENES | FLUOROALKYLATION REACTIONS | REDUCTIVE ELIMINATION | CHEMISTRY, MULTIDISCIPLINARY | ARYLBORONIC ACIDS
Journal Article
by He, YW and Anand, D and Sun, ZC and Zhou, L
ORGANIC LETTERS, ISSN 1523-7060, 05/2019, Volume 21, Issue 10, pp. 3769 - 3773
A visible-light-promoted redox neutral gamma,gamma-difluoroallylation of cycloketone oxime ethers with trifluor-omethyl alkenes through C-C and C-F bond... 
FUNCTIONALIZATION | H CYANOALKYLATION | SUBSTITUTION | ACTIVATION | NUCLEOPHILIC 5-ENDO-TRIG CYCLIZATION | ACIDS | ESTERS | CHEMISTRY, ORGANIC | GEM-DIFLUOROALKENES | CARBONYL-COMPOUNDS | IMINYL RADICALS
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 05/2019, Volume 58, Issue 20, pp. 6772 - 6775
A facile synthetic procedure for the preparation of α‐trifluoromethyl carboxylic acids and esters was achieved through multicomponent coupling reactions... 
fluorination | carbon dioxide | gem-difluoroalkenes | cesium fluoride | carboxylic acids | Cesium fluorides | Fluoride | Carbon dioxide | Esters | Cesium | Chemical reactions | Inflammation | Carboxylic acids | Nonsteroidal anti-inflammatory drugs
Journal Article
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, ISSN 1433-7851, 05/2019, Volume 58, Issue 20, pp. 6772 - 6775
A facile synthetic procedure for the preparation of -trifluoromethyl carboxylic acids and esters was achieved through multicomponent coupling reactions between... 
TRANSFORMATION | carbon dioxide | PRACTICAL SYNTHESIS | CATALYZED SYNTHESIS | fluorination | gem-difluoroalkenes | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | cesium fluoride | carboxylic acids | FLUORINE | 5-LIPOXYGENASE | ENANTIOSELECTIVE ALPHA-TRIFLUOROMETHYLATION | CARBON-DIOXIDE | CYCLIZATION | FLUOROARYLATION | Esters | Organic acids
Journal Article
Asian Journal of Organic Chemistry, ISSN 2193-5807, 05/2019, Volume 8, Issue 5, pp. 661 - 664
A radical defluorinative alkylation method of 1‐trifluoromethyl alkenes and 1,3‐butadienes with 4‐alkyl‐1,4‐dihydropyridines under visible light irradiation is... 
alkylation | photoredox | radicals | difluoroalkenes | C−F bond cleavage | ADDITION-REACTION | NUCLEOPHILIC 5-ENDO-TRIG CYCLIZATION | C-F bond cleavage | CHEMISTRY, ORGANIC | ALPHA | 4-ALKYL-1,4-DIHYDROPYRIDINES | ELIMINATION | RADICAL-ADDITION | FUNCTIONALIZATION | ESTERS | GEM-DIFLUOROALKENES | FLUORINE
Journal Article