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gem-difluoroalkenes (91) 91
chemistry, organic (56) 56
chemistry, multidisciplinary (49) 49
fluorine (35) 35
f bond activation (26) 26
stereoselective-synthesis (20) 20
alkenes (19) 19
cross-coupling reactions (19) 19
activation (18) 18
carbonyl-compounds (18) 18
grignard-reagents (17) 17
catalysis (16) 16
index medicus (16) 16
nucleophilic 5-endo-trig cyclization (16) 16
diazo-compounds (15) 15
fluorination (15) 15
functionalized gem-difluoroalkenes (15) 15
medicinal chemistry (14) 14
concise synthesis (13) 13
cyclization (13) 13
derivatives (12) 12
halides (12) 12
organolithium reagents (12) 12
trifluoromethylation (12) 12
c-f bond (11) 11
functionalization (11) 11
gem-difluoroalkene (11) 11
synthesis (11) 11
copper (10) 10
crafts-type cyclization (10) 10
organic-synthesis (10) 10
palladium (10) 10
reagents (10) 10
hydrodefluorination (9) 9
chemical reactions (8) 8
chemistry, inorganic & nuclear (8) 8
fluorides (8) 8
access (7) 7
borylation (7) 7
difluoroolefination (7) 7
electrophilic fluorination (7) 7
enantioselective synthesis (7) 7
esters (7) 7
fluor (7) 7
ketones (7) 7
olefins (7) 7
terminal alkynes (7) 7
alkene (6) 6
alpha (6) 6
aromatic compounds (6) 6
c-f (6) 6
chemistry, physical (6) 6
cross-coupling reaction (6) 6
difluoromethyl 2-pyridyl sulfone (6) 6
organic chemistry (6) 6
trimethylchlorosilan (6) 6
trimethylchlorosilane (6) 6
1,1-difluoro-1-alkenes (5) 5
3+2 cycloaddition (5) 5
alcohols (5) 5
alkylation (5) 5
aryl bromides (5) 5
aryl fluorides (5) 5
bond formation (5) 5
building-blocks (5) 5
c-f bond activation (5) 5
chemistry, applied (5) 5
coupling reactions (5) 5
defluorination (5) 5
difluoroalkenes (5) 5
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fluoroalkylation reactions (5) 5
one-carbon units (5) 5
one-pot synthesis (5) 5
stereoselectivity (5) 5
substitution (5) 5
substrates (5) 5
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acids (4) 4
addition-elimination reactions (4) 4
aldehydes (4) 4
alkenes - chemical synthesis (4) 4
alkenes - chemistry (4) 4
alkynes (4) 4
alpha-fluoroalkenylation (4) 4
amines (4) 4
aryl (4) 4
arylation (4) 4
arylboronic acids (4) 4
asymmetric-synthesis (4) 4
biological-activity (4) 4
c-f bond cleavage (4) 4
carbon dioxide (4) 4
chemical bonds (4) 4
chemical synthesis (4) 4
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Asian Journal of Organic Chemistry, ISSN 2193-5807, 05/2019, Volume 8, Issue 5, pp. 661 - 664
A radical defluorinative alkylation method of 1‐trifluoromethyl alkenes and 1,3‐butadienes with 4‐alkyl‐1,4‐dihydropyridines under visible light irradiation is... 
alkylation | photoredox | radicals | difluoroalkenes | C−F bond cleavage | ADDITION-REACTION | NUCLEOPHILIC 5-ENDO-TRIG CYCLIZATION | C-F bond cleavage | CHEMISTRY, ORGANIC | ALPHA | 4-ALKYL-1,4-DIHYDROPYRIDINES | ELIMINATION | RADICAL-ADDITION | FUNCTIONALIZATION | ESTERS | GEM-DIFLUOROALKENES | FLUORINE
Journal Article
ORGANOMETALLICS, ISSN 0276-7333, 03/2019, Volume 38, Issue 5, pp. 1021 - 1030
This contribution brings to light the first example of an a F elimination process in manganese organometallic chemistry. As shown in a recent contribution... 
NUCLEOPHILIC TRIFLUOROMETHYLATION | EFFICIENT PRECURSOR | MAGNETIC RESONANCE SPECTRA | CARBON BONDS | CHEMISTRY | CHEMISTRY, ORGANIC | GEM-DIFLUOROALKENES | RADICAL POLYMERIZATION | POLYSILANE DERIVATIVES | TRANSITION-METALS | C-F | CHEMISTRY, INORGANIC & NUCLEAR | Polymers | Chemical Sciences
Journal Article
Organic Letters, ISSN 1523-7060, 2019, Volume 21, Issue 4, pp. 1130 - 1133
The first defluorinative ipso-functionalization reaction of (trifluoromethyl)alkenes is reported. This exclusively regioselective ipso-defluorooxylation of... 
SUBSTITUTION | ALKENES | ALKYL FLUORIDES | FLUORINE ELIMINATION | FUNCTIONALIZED GEM-DIFLUOROALKENES | CHEMISTRY, ORGANIC | H BONDS | CLEAVAGE | 3+2 CYCLOADDITION | ACCESS | HYDRODEFLUORINATION
Journal Article
Asian Journal of Organic Chemistry, ISSN 2193-5807, 02/2019, Volume 8, Issue 2, pp. 279 - 282
A mild and efficient method for the synthesis of unsymmetrical 2,5‐disubstituted 1,3,4‐oxadiazoles by condensation of gem‐difluoroalkenes with acyl hydrazides... 
acyl hydrazides | gem-difluoroalkenes | cyclization | synthetic methods | 1,3,4-oxadiazoles | C-H ALKYLATION | ACCESS 1,3,4-OXADIAZOLES | ONE-POT SYNTHESIS | NUCLEOPHILIC 5-ENDO-TRIG CYCLIZATION | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | F BOND ACTIVATION | FUNCTIONALIZATION | CRAFTS-TYPE CYCLIZATION | RING | OXIDATIVE CYCLIZATION
Journal Article
by Zhang, J and Wang, BY and Liu, YS and Cao, S
CHINESE JOURNAL OF ORGANIC CHEMISTRY, ISSN 0253-2786, 01/2019, Volume 39, Issue 1, pp. 249 - 256
An efficient method for the synthesis of various Z-fluorostyrene derivatives via nickel-catalyzed cross-coupling of gem-difluorostyrenes with organozinc... 
gem-difluorostyrenes | nickel-catalyzed | ACIDS | SECONDARY | CHEMISTRY, ORGANIC | TERTIARY | HYDRODEFLUORINATION | 2-FLUOROALLYLIC ACETATES | PRIMARY ALKYL | organozinc reagents | ALPHA-FLUOROALKENYLATION | DIFLUOROALKENES | monofluoroalkenes | SELECTIVE SYNTHESIS
Journal Article
Chemical Science, ISSN 2041-6520, 2019, Volume 10, Issue 3, pp. 809 - 814
Herein, we report a nickel-catalyzed allylic defluorinative alkylation of trifluoromethyl alkenes through reductive decarboxylation of redox-active esters. The... 
ARYL BROMIDES | HALIDES | N-HYDROXYPHTHALIMIDE ESTERS | DIFLUOROOLEFINATION | EFFICIENT APPROACH | COUPLING REACTIONS | GEM-DIFLUOROALKENES | FLUORINE | DIAZO-COMPOUNDS | CHEMISTRY, MULTIDISCIPLINARY | F BOND ACTIVATION
Journal Article
Chemical science, ISSN 2041-6520, 01/2019, Volume 10, Issue 3, pp. 809 - 814
Herein, we report a nickel-catalyzed allylic defluorinative alkylation of trifluoromethyl alkenes through reductive decarboxylation of redox-active esters. The... 
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 01/2019, Volume 58, Issue 2, pp. 390 - 402
Journal Article
ACS Catalysis, ISSN 2155-5435, 01/2019, Volume 9, Issue 1, pp. 775 - 780
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2018, Volume 16, Issue 47, pp. 9211 - 9217
The transformation of hydroximoyl fluorides to nitrile oxides for [3 + 2]-cycloaddition with alkynes has been achieved for the first time. The hydroximoyl... 
FUNCTIONALIZATION | SUBSTITUTION | OXIMES | REAGENTS | MECHANISM | CHEMISTRY, ORGANIC | GEM-DIFLUOROALKENES | GENERATION | SALTS | F BOND ACTIVATION | HYDRODEFLUORINATION
Journal Article
by He, SJ and Pi, JL and Li, Y and Lu, X and Fu, Y
ACTA CHIMICA SINICA, ISSN 0567-7351, 12/2018, Volume 76, Issue 12, pp. 956 - 961
The incorporation of fluorine atoms or fluorine-containing fragments to specifical sites of organic compounds would result in unique diversifications in... 
DIVERSE SYNTHESIS | nickel | fluorinated alkenyl boronate | UNACTIVATED SECONDARY | ACTIVATION | CHEMISTRY, MULTIDISCIPLINARY | H FUNCTIONALIZATION | FACILE SYNTHESIS | alkyl halides | Suzuki-type cross-coupling | BONDS | GEM-DIFLUOROALKENES | STEREOSELECTIVE-SYNTHESIS | fluorinated olefin | Z-FLUOROALKENES | TRIFLUOROMETHYLATION
Journal Article
by Hu, JY and Yang, YD and Lou, ZZ and Ni, CF and Hu, JB
CHINESE JOURNAL OF CHEMISTRY, ISSN 1001-604X, 12/2018, Volume 36, Issue 12, pp. 1202 - 1208
Journal Article
Chinese Journal of Chemistry, ISSN 1001-604X, 12/2018, Volume 36, Issue 12, pp. 1202 - 1208
In this paper, a fluoro‐hydroxylation of gem‐difluoroalkenes is demonstrated. This protocol uses sequential electrophilic fluorination with Selectfluor and... 
trifluoromethyl carbinol | difunctionalization | gem‐difluoroalkene | electrophilic fluorination | 18O‐labeling | gem-difluoroalkene | O-labeling
Journal Article
Organic Chemistry Frontiers, ISSN 2052-4110, 11/2018, Volume 5, Issue 22, pp. 3240 - 3244
A photocatalytic decarboxylative/defluorinative [4 + 3] annulation of o-hydroxyphenylacetic acids and trifluoromethyl alkenes was developed. The reaction... 
VISIBLE-LIGHT | 2-TRIFLUOROMETHYL-1-ALKENES | BUILDING-BLOCKS | CONSTRUCTION | LIGHT PHOTOREDOX CATALYSIS | CHEMISTRY, ORGANIC | GEM-DIFLUOROALKENES | FUNCTIONAL-GROUPS | ALKYNES | F BOND ACTIVATION | 3+2 CYCLOADDITION
Journal Article
Advanced Synthesis & Catalysis, ISSN 1615-4150, 10/2018, Volume 360, Issue 20, pp. 3894 - 3899
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2018, Volume 16, Issue 38, pp. 6909 - 6917
A novel and efficient method for the synthesis of difluoromethylated enynes by the reaction of alpha-(trifluoromethyl)styrenes with terminal alkynes with the... 
PALLADIUM | ALKENES | CROSS-COUPLING REACTIONS | CATALYZED AMINODIFLUOROALKYLATION | ENANTIOSELECTIVE SYNTHESIS | FLUORINATED ENYNES | CHEMISTRY, ORGANIC | GEM-DIFLUOROALKENES | STEREOSELECTIVE-SYNTHESIS | Z ISOMERIZATION | HIGHLY EFFICIENT
Journal Article