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Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2012, Volume 122, Issue 4, pp. 1541 - 1552
Patients with triple-negative breast cancer (TNBC) - defined by lack of estrogen receptor and progesterone receptor expression as well as lack of human... 
SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | P53 MUTATION | PATHWAY | PROTEIN-KINASE | 7-HYDROXYSTAUROSPORINE UCN-01 | DNA-DAMAGE | PREDICTIVE-VALUE | CDC25A PHOSPHATASE | CELL-CYCLE CHECKPOINTS | S-PHASE CHECKPOINT | Thiophenes - therapeutic use | Apoptosis - drug effects | Humans | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Receptors, Progesterone - genetics | Receptors, Progesterone - analysis | Breast Neoplasms - chemistry | Camptothecin - administration & dosage | Antineoplastic Agents, Phytogenic - therapeutic use | Camptothecin - analogs & derivatives | Thiophenes - pharmacology | Tumor Suppressor Protein p53 - deficiency | Breast Neoplasms - drug therapy | DNA, Neoplasm - drug effects | Protein Kinase Inhibitors - administration & dosage | Urea - therapeutic use | Mice, Inbred NOD | Mice | DNA Damage | Cell Cycle - drug effects | Genes, cdc | Staurosporine - pharmacology | Urea - pharmacology | Staurosporine - administration & dosage | Neoplasm Proteins - physiology | Staurosporine - analogs & derivatives | Cell Line, Tumor - transplantation | Receptors, Estrogen - analysis | Thiophenes - administration & dosage | Molecular Targeted Therapy | Genes, p53 | Urea - analogs & derivatives | Female | Antineoplastic Agents - pharmacology | Cell Line, Tumor - metabolism | Urea - administration & dosage | Protein Kinases - drug effects | Receptors, Estrogen - genetics | Camptothecin - therapeutic use | Mice, SCID | Xenograft Model Antitumor Assays | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Genes, erbB-2 | Protein Kinase Inhibitors - therapeutic use | Staurosporine - therapeutic use | Protein Kinases - physiology | Checkpoint Kinase 1 | Neoplasm Proteins - analysis | Protein Kinase Inhibitors - pharmacology | Breast cancer | Genetic aspects | Research | Gene mutations | Health aspects | DNA damage | Index Medicus | Abridged Index Medicus | Estrogen | Càncer de mama | Ratolins (Animals de laboratori) | Apoptosi | Receptors d'hormones | Hormone receptors | Chemotherapy | Mice (Laboratory animals) | Progesterone | Quimioteràpia | Progesterona | Estrògens | Apoptosis
Journal Article
Nature Cell Biology, ISSN 1465-7392, 2014, Volume 16, Issue 9, pp. 864 - 875
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2010, Volume 107, Issue 37, pp. 16090 - 16095
Journal Article
by Xu, J and Li, Y and Wang, F and Wang, X and Cheng, B and Ye, F and Xie, X and Zhou, C and Lu, W
Oncogene, ISSN 0950-9232, 02/2013, Volume 32, Issue 8, pp. 976 - 987
MicroRNAs (miRNAs) act as important gene regulators in human genomes and their aberrant expression links to many malignancies. We previously identified a... 
p-Chk1 | progression | miR-424 | Chk1 | cervical cancer | PROFILES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | CELL BIOLOGY | MICRORNA MIR-21 | BREAST-CANCER | TONGUE | LYMPH-NODE METASTASIS | ONCOLOGY | POOR-PROGNOSIS | GENETICS & HEREDITY | CHECKPOINT | DIFFERENTIATION | SQUAMOUS-CELL CARCINOMAS | Protein Kinases - metabolism | Up-Regulation | Phosphorylation | Protein Kinases - genetics | Humans | Apoptosis - genetics | Uterine Cervical Neoplasms - pathology | Cell Movement - genetics | Matrix Metalloproteinase 9 - metabolism | Transfection | Uterine Cervical Neoplasms - metabolism | Female | G1 Phase - genetics | 3' Untranslated Regions | Cell Growth Processes - genetics | Protein Kinases - biosynthesis | Genes, Tumor Suppressor | Down-Regulation | MicroRNAs - biosynthesis | Uterine Cervical Neoplasms - genetics | S Phase - genetics | Disease Progression | Cell Line, Tumor | Checkpoint Kinase 1 | MicroRNAs - genetics | Development and progression | Genetic aspects | MicroRNA | Research | Analysis | Cervical cancer | Proteins | Gene expression | Medical prognosis | Index Medicus | Cell culture | CHK1 protein | Genomes | Malignancy | Matrix metalloproteinase | Tumor cell lines | Cervix | Lymph nodes | Metastases | Polymerase chain reaction | 3' Untranslated regions | Tumor suppressor genes | miRNA | Differentiation | Cell migration | Apoptosis | Tumors
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2013, Volume 85, Issue 4, pp. 1110 - 1118
Purpose To explore the activity of a potent Chk1 inhibitor (SAR-020106) in combination with radiation. Methods and Materials Colony and mechanistic in vitro... 
Radiology | Hematology, Oncology and Palliative Medicine | CELLS | REPAIR | ONCOLOGY | PATHWAY | ABROGATION | KINASE | CHECKPOINT | TUMORIGENESIS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | P53 | Microscopy - methods | Cell Cycle - genetics | G2 Phase - genetics | Tumor Stem Cell Assay - methods | Humans | DNA Repair - radiation effects | DNA Repair - genetics | Cyclin-Dependent Kinase Inhibitor p21 - deficiency | G2 Phase - drug effects | Radiation Tolerance - radiation effects | Isoquinolines - pharmacology | DNA Damage - genetics | Time-Lapse Imaging - methods | DNA Damage - drug effects | DNA Repair - drug effects | Protein Kinases - drug effects | Mitosis - radiation effects | Cell Cycle - radiation effects | Radiation-Sensitizing Agents - pharmacology | Radiation Tolerance - genetics | Tumor Suppressor Protein p53 - deficiency | Immunohistochemistry - methods | Radiation Tolerance - drug effects | Animals | Mitosis - drug effects | Histones - analysis | Mice, Nude | Papillomaviridae - classification | Cell Line, Tumor | Checkpoint Kinase 1 | Mice | HeLa Cells | Cell Cycle - drug effects | Pyrazines - pharmacology | Apoptosis | Papillomavirus infections | Index Medicus | APOPTOSIS | HEAD | IRRADIATION | IN VITRO | CARCINOMAS | RADIOLOGY AND NUCLEAR MEDICINE | TUMOR CELLS | GENE RECOMBINATION | IN VIVO | NECK | RADIOSENSITIVITY | DNA DAMAGES
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 9/2001, Volume 154, Issue 5, pp. 913 - 923
Journal Article
Oncogene, ISSN 0950-9232, 06/2009, Volume 28, Issue 24, pp. 2314 - 2323
Journal Article
British Journal of Cancer, ISSN 0007-0920, 05/2009, Volume 100, Issue 9, pp. 1425 - 1433
Curcumin has been shown to inhibit the growth of various types of cancer cells; however, at concentrations much above the clinically achievable levels in... 
Curcumin | Chk1 | G2/M arrest | DNA damage | Pancreatic cancer | CARCINOMA-CELLS | DNA-DAMAGE | DOWN-REGULATION | REGULATED GENE-PRODUCTS | FACTOR-KAPPA-B | BENZYL ISOTHIOCYANATE | I CLINICAL-TRIAL | pancreatic cancer | ONCOLOGY | PROSTATE-CANCER | CHEMOPREVENTIVE AGENT | curcumin | Cell Cycle Proteins - drug effects | Protein Kinases - metabolism | Gene Expression Regulation, Enzymologic - drug effects | Protein Kinases - genetics | Gene Silencing - drug effects | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Collagen Type XI - metabolism | DNA-Binding Proteins - metabolism | Pancreatic Neoplasms - drug therapy | Transfection | Tumor Suppressor Proteins - genetics | Caspase 3 - drug effects | Cell Cycle Proteins - genetics | Gene Expression Regulation, Neoplastic - drug effects | Protein-Serine-Threonine Kinases - metabolism | DNA Damage - drug effects | Protein Kinases - drug effects | Tumor Suppressor Proteins - metabolism | Collagen Type XI - drug effects | Pancreatic Neoplasms - pathology | Cell Cycle Proteins - metabolism | Curcumin - pharmacology | DNA-Binding Proteins - drug effects | Pancreatic Neoplasms - enzymology | Protein-Serine-Threonine Kinases - genetics | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Cell Division - drug effects | Protein-Serine-Threonine Kinases - drug effects | Cell Line, Tumor | Checkpoint Kinase 1 | Tumor Suppressor Proteins - drug effects | Cell Cycle - drug effects | Index Medicus | Translational Therapeutics | M arrest
Journal Article