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MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, ISSN 1092-2172, 03/2016, Volume 80, Issue 1, pp. 1 - 43
Actinobacteria are Gram-positive bacteria with high G + C DNA content that constitute one of the largest bacterial phyla, and they are ubiquitously distributed... 
FACTOR REGULATORY CASCADE | A-FACTOR | AERIAL MYCELIUM FORMATION | COMPLETE GENOME SEQUENCE | BIOSYNTHETIC GENE-CLUSTER | SECONDARY METABOLISM | STREPTOMYCES-COELICOLOR A3 | MORPHOLOGICAL-DIFFERENTIATION | BACTERIAL-CELL-DIVISION | MICROBIOLOGY | ANTIBIOTIC PRODUCTION
Journal Article
Biochemistry, ISSN 0006-2960, 2019, Volume 58, Issue 25, pp. 2804 - 2808
Mitomycins make up a group of antitumor natural products that are biosynthesized from amino-hydroxybenzoic acid (AHBA) and N-acetylglucosamine (GlcNAc). While... 
GENE-CLUSTER | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI
Journal Article
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 05/2019, Volume 63, Issue 5
The nterococcal olysaccharide ntigen (Epa) locus of encodes enzymes and transporters involved in cell wall polysaccharide metabolism (1-3). 
Enterococcus faecalis | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | GENE-CLUSTER | Epa
Journal Article
Science, ISSN 0036-8075, 07/2015, Volume 349, Issue 6246, pp. 1254766 - 1254766
Journal Article
ACS CHEMICAL BIOLOGY, ISSN 1554-8929, 05/2019, Volume 14, Issue 5, pp. 845 - 849
The terminal step in the biosynthesis of nonribosomal peptides is the hydrolytic release and, frequently, macrocyclization of an aminoacyl-S-thioester by an... 
BIOSYNTHETIC GENE-CLUSTER | THIOESTERASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISCOVERY
Journal Article
Bioscience, Biotechnology, and Biochemistry, ISSN 0916-8451, 06/2018, Volume 82, Issue 6, pp. 1021 - 1030
In response to environmental stressors such as blast fungal infections, rice produces phytoalexins, an antimicrobial diterpenoid compound. Together with... 
diterpene phytoalexins | gene cluster | rice | Cytochrome P450 monooxygenase | Gene cluster | Diterpene phytoalexins | Rice | Index Medicus
Journal Article
by Wang, Mingxun and Carver, Jeremy J and Phelan, Vanessa V and Sanchez, Laura M and Garg, Neha and Peng, Yao and Nguyen, Don Duy and Watrous, Jeramie and Kapono, Clifford A and Luzzatto-Knaan, Tal and Porto, Carla and Bouslimani, Amina and Melnik, Alexey V and Meehan, Michael J and Liu, Wei-Ting and Crüsemann, Max and Boudreau, Paul D and Esquenazi, Eduardo and Sandoval-Calderón, Mario and Kersten, Roland D and Pace, Laura A and Quinn, Robert A and Duncan, Katherine R and Hsu, Cheng-Chih and Floros, Dimitrios J and Gavilan, Ronnie G and Kleigrewe, Karin and Northen, Trent and Dutton, Rachel J and Parrot, Delphine and Carlson, Erin E and Aigle, Bertrand and Michelsen, Charlotte F and Jelsbak, Lars and Sohlenkamp, Christian and Pevzner, Pavel and Edlund, Anna and McLean, Jeffrey and Piel, Jörn and Murphy, Brian T and Gerwick, Lena and Liaw, Chih-Chuang and Yang, Yu-Liang and Humpf, Hans-Ulrich and Maansson, Maria and Keyzers, Robert A and Sims, Amy C and Johnson, Andrew R and Sidebottom, Ashley M and Sedio, Brian E and Klitgaard, Andreas and Larson, Charles B and Boya, Cristopher A.P and Torres-Mendoza, Daniel and Gonzalez, David J and Silva, Denise B and Marques, Lucas M and Demarque, Daniel P and Pociute, Egle and O'Neill, Ellis C and Briand, Enora and Helfrich, Eric J. N and Granatosky, Eve A and Glukhov, Evgenia and Ryffel, Florian and Houson, Hailey and Mohimani, Hosein and Kharbush, Jenan J and Zeng, Yi and Vorholt, Julia A and Kurita, Kenji L and Charusanti, Pep and McPhail, Kerry L and Nielsen, Kristian Fog and Vuong, Lisa and Elfeki, Maryam and Traxler, Matthew F and Engene, Niclas and Koyama, Nobuhiro and Vining, Oliver B and Baric, Ralph and Silva, Ricardo R and Mascuch, Samantha J and Tomasi, Sophie and Jenkins, Stefan and Macherla, Venkat and Hoffman, Thomas and Agarwal, Vinayak and Williams, Philip G and Dai, Jingqui and Neupane, Ram and Gurr, Joshua and Rodríguez, Andrés M. C and Lamsa, Anne and Zhang, Chen and Dorrestein, Kathleen and Duggan, Brendan M and Almaliti, Jehad and Allard, Pierre-Marie and Phapale, Prasad and ...
Nature Biotechnology, ISSN 1087-0156, 09/2016, Volume 34, Issue 8, pp. 828 - 837
Journal Article
Journal of Biotechnology, ISSN 0168-1656, 01/2018, Volume 266, pp. 72 - 76
A novel type strain, Planococcus faecalis AJ003 , isolated from the feces of Antarctic penguins, synthesizes a rare C30 carotenoid,... 
Complete genome sequence | Gene cluster | Carotenoids | Planococcus faecalis
Journal Article
Marine Drugs, ISSN 1660-3397, 07/2019, Volume 17, Issue 7, p. 388
Rare actinobacterial species are considered as potential resources of new natural products. Marisediminicola antarctica ZS314T is the only type strain of the... 
actinobacteria | natural products | Antarctica | carotenoid | gene cluster | Marisediminicola
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 08/2000, Volume 192, Issue 3, pp. 421 - 431
Journal Article
ACS CHEMICAL BIOLOGY, ISSN 1554-8929, 02/2017, Volume 12, Issue 2, pp. 362 - 366
beta-Ketoacyl-acyl carrier protein (beta-Ketoacyl-ACP) synthase (KAS) III catalyzes the first step in fatty acid biosynthesis, involving a Claisen condensation... 
ACID | GENE-CLUSTER | ANALOGS | ENZYMES | BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal Article
Organic Letters, ISSN 1523-7060, 05/2018, Volume 20, Issue 10, pp. 2967 - 2971
Streptoseomycin (1), which is a rare macrodilactone with potent activities against microaerophilic bacteria, featuring a pentacyclic 5/14/10/6/6 ring system... 
COLORADOCIN | ANTIBIOTICS | DIALKYLMALEIC ANHYDRIDE | THERAPY | GENE-CLUSTER | HELICOBACTER-PYLORI INFECTION | RESISTANCE | CHEMISTRY, ORGANIC | Index Medicus
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 12/2016, Volume 138, Issue 48, pp. 15515 - 15518
Genomic and metagenomic investigations have recently led to the delineation of a novel class of natural products called ribosomally synthesized and... 
METHYLTRANSFERASE | GENE-CLUSTER | CLONING | ESCHERICHIA-COLI | BINDING DOMAIN | CHEMISTRY | METHIONINE SYNTHASE | THIOSTREPTON | CHEMISTRY, MULTIDISCIPLINARY | Life Sciences
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 02/2019, Volume 141, Issue 5, pp. 1961 - 1969
There is significant interest in diversifying the structures of polyketides to create new analogues of these bioactive molecules. This has traditionally been... 
GENE-CLUSTER | COA | RECOGNITION | MECHANISM | ACYLTRANSFERASE DOMAIN | BIOSYNTHESIS | PURIFICATION | SELECTIVITY | EFFICIENT | CHEMISTRY, MULTIDISCIPLINARY | REVEALS
Journal Article
International Journal of Food Microbiology, ISSN 0168-1605, 11/2019, Volume 309, pp. 108332 - 108332
is a major food-borne pathogen. infections are associated with various serotypes; to date, 71 K-serogroups of have been determined based on capsular... 
Vibrio parahaemolyticus | Epidemiological surveillance | Whole genome sequencing | Capsular polysaccharide gene cluster | Molecular K-serotyping | Index Medicus
Journal Article
ORGANIC LETTERS, ISSN 1523-7060, 07/2019, Volume 21, Issue 14, pp. 5407 - 5412
The structures of five linear lipopeptides, thaxteramides A1, A2, B1, B2, and C isolated from the myxobacterium Jahnella thaxteri, were elucidated. They have a... 
GENE-CLUSTER | SPECIFICITY | NATURAL-PRODUCTS | DRUG DISCOVERY | CONFIGURATION | CHEMISTRY, ORGANIC | IDENTIFICATION | MYXOBACTERIA | PEPTIDE SYNTHETASE | PREDICTION | INSIGHTS
Journal Article
Fungal Diversity, ISSN 1560-2745, 03/2010, Volume 41, Issue 1, pp. 1 - 16
Bioactive natural products from endophytic fungi, isolated from higher plants, are attracting considerable attention from natural product chemists and... 
Fungi | Endophytes | Host plants | Bioactive metabolites | TAXUS WALLACHIANA | SECONDARY METABOLISM | ASPERGILLUS-NIDULANS | MEDICINAL-PLANT | GRASS ENDOPHYTE | HIBISCUS-TILIACEUS | GENE-CLUSTER | MYCOLOGY | PINUS-TABULAEFORMIS | STRESS TOLERANCE | LOLINE ALKALOIDS
Journal Article
Organic Letters, ISSN 1523-7060, 06/2019, Volume 21, Issue 12, pp. 4490 - 4494
While high-colibactin-producing Escherichia coil is thought to be associated with colorectal oncogenesis, this study is complicated part due to an inability to... 
CHEMISTRY, ORGANIC | METABOLOMICS | GENE-CLUSTER | PRODRUG ACTIVATION MECHANISM | BIOSYNTHESIS | IN-VIVO
Journal Article
Organic Letters, ISSN 1523-7060, 06/2019, Volume 21, Issue 12, pp. 4676 - 4679
The biosynthesis of thioviridamide-like compounds has not been elucidated. Herein, we report that TvaF from the thioviridamide biosynthetic gene cluster is an... 
CHEMISTRY, ORGANIC | SUBSTRATE-SPECIFICITY | APOPTOSIS INDUCER | GENE-CLUSTER | HETEROLOGOUS EXPRESSION | NATURAL-PRODUCTS
Journal Article
Organic Letters, ISSN 1523-7060, 06/2019, Volume 21, Issue 12, pp. 4788 - 4792
Heterologous expression of a unique biosynthetic gene cluster (BGC) comprising a highly reducing polyketide synthase and stand-alone thioesterase genes in... 
SYNTHASE | ENCODES | SYSTEM | SPACE | BIOSYNTHETIC GENE-CLUSTER | RADICICOL | PATHWAY | CHEMISTRY, ORGANIC | HETEROLOGOUS EXPRESSION | INHIBITOR
Journal Article