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Cell, ISSN 0092-8674, 09/2013, Volume 154, Issue 6, pp. 1380 - 1389
Targeted genome editing technologies have enabled a broad range of research and medical applications. The Cas9 nuclease from the microbial CRISPR-Cas system is... 
SYSTEM | CELLS | BACTERIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENERATION | KNOCKOUT | NUCLEASE | CELL BIOLOGY | Streptococcus pyogenes - genetics | Gene Targeting - methods | Animals | RNA, Guide - genetics | Base Sequence | Streptococcus pyogenes - enzymology | Zygote - metabolism | Molecular Sequence Data | Mice | Genome | DNA Breaks, Double-Stranded | RNA | Genomics
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 05/2015, Volume 11, Issue 5, pp. 316 - 318
Directly modulating the activity of genome-editing proteins has the potential to increase their specificity by reducing activity following target locus... 
NUCLEASE SPECIFICITY | RNA | NICKASES | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLEAVAGE | DIRECTED EVOLUTION | MAMMALIAN-CELLS | DELIVERY | INTEIN
Journal Article
NATURE BIOTECHNOLOGY, ISSN 1087-0156, 08/2019, Volume 37, Issue 8, pp. 945 - 945
Engineered nucleases have gained broad appeal for their ability to mediate highly efficient genome editing. However the specificity of these reagents remains a... 
ENDONUCLEASE | THERAPY | RECOGNITION | VARIANTS | CRISPR-CAS9 NUCLEASES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ZINC-FINGER PROTEINS | OFF-TARGET CLEAVAGE | CAS9 | BINDING | GENOME | T cells | Nucleases | Genetic aspects | Therapeutic applications | Genomes | Lymphocytes T | Zinc | Lymphocytes | Zinc finger | Reagents | Reaction kinetics | Affinity | Cleavage | Kinetics | Zinc finger proteins | Catalysis | Genetic modification | Deoxyribonucleic acid--DNA
Journal Article
Nature chemical biology, 05/2015, Volume 11, Issue 5, p. 316
Journal Article
Genes & Diseases, ISSN 2352-3042, 09/2014, Volume 1, Issue 1, pp. 6 - 7
Journal Article
Nature Reviews Genetics, ISSN 1471-0056, 05/2016, Volume 17, Issue 5, pp. 300 - 312
Journal Article
Hematology/Oncology Clinics of North America, ISSN 0889-8588, 10/2017, Volume 31, Issue 5, pp. 787 - 795
Therapeutic gene editing is significant for medical advancement. Safety is intricately linked to the specificity of the editing tools used to cut at precise... 
Off-target | Safety | Specific | Gene therapy | Gene editing | MUTAGENESIS | NUCLEASE ARCHITECTURE | ONCOLOGY | CLEAVAGE | HEMATOLOGY | GENOME | SEQ | Gene Targeting | Gene Transfer Techniques | Animals | Transduction, Genetic | DNA Repair | Humans | Homologous Recombination | Gene Editing - methods | Genetic Vectors - genetics | Genetic Therapy - adverse effects | Genetic Therapy - methods
Journal Article