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ginsenosides (189) 189
pharmacology & pharmacy (185) 185
index medicus (173) 173
saponins (157) 157
rb-1 (146) 146
animals (136) 136
panax-ginseng (119) 119
chemistry, medicinal (112) 112
ginseng (106) 106
ginsenoside (106) 106
panax - chemistry (97) 97
chemistry, analytical (94) 94
rats (92) 92
ginsenoside rb-1 (90) 90
panax ginseng (85) 85
male (80) 80
plant sciences (73) 73
biotechnology & applied microbiology (71) 71
mice (71) 71
biotransformation (69) 69
biochemistry & molecular biology (68) 68
ginsenosides - pharmacology (64) 64
compound k (63) 63
ginsenosides - chemistry (63) 63
humans (62) 62
ginsenosides - metabolism (60) 60
cells (56) 56
metabolism (55) 55
biochemical research methods (54) 54
food science & technology (54) 54
transformation (50) 50
beta-glucosidase (49) 49
rb1 (47) 47
microbiology (46) 46
pharmacokinetics (45) 45
in-vitro (44) 44
performance liquid-chromatography (44) 44
integrative & complementary medicine (43) 43
metabolites (42) 42
rats, sprague-dawley (42) 42
analysis (41) 41
purification (41) 41
chemistry, multidisciplinary (39) 39
intestinal bacteria (39) 39
panax (39) 39
saponins - pharmacology (38) 38
chromatography, high pressure liquid - methods (37) 37
chromatography, high pressure liquid (36) 36
ginsenoside rb1 (36) 36
mass spectrometry (36) 36
panax notoginseng (36) 36
american ginseng (34) 34
rat plasma (34) 34
apoptosis (33) 33
identification (33) 33
reproducibility of results (33) 33
pharmacology (32) 32
absorption (31) 31
panax-notoginseng (31) 31
expression (30) 30
ginsenosides - analysis (30) 30
roots (30) 30
chemistry, applied (29) 29
ginsenosides - isolation & purification (29) 29
ginsenosides - pharmacokinetics (28) 28
liquid chromatography (28) 28
excretion (27) 27
plant extracts - pharmacology (27) 27
activation (26) 26
conversion (26) 26
neurosciences (26) 26
plant roots - chemistry (26) 26
biotechnology (25) 25
dose-response relationship, drug (25) 25
glucosidase (25) 25
mass-spectrometry (25) 25
notoginseng (24) 24
plasma (24) 24
root (24) 24
chemistry (23) 23
enzymes (23) 23
ginsenoside rg (23) 23
ginsenosides rb-1 (23) 23
human intestinal bacteria (23) 23
molecular structure (23) 23
araliaceae (22) 22
cells, cultured (22) 22
compound-k (22) 22
constituents (22) 22
female (22) 22
saponins - chemistry (22) 22
bacteria (21) 21
beta-glucosidase - metabolism (21) 21
bioavailability (21) 21
bioconversion (21) 21
chromatography (21) 21
inhibition (21) 21
rg1 (21) 21
temperature (21) 21
administration, oral (20) 20
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by Chen, GT and Yang, M and Song, Y and Lu, ZQ and Zhang, JQ and Huang, HL and Wu, LJ and Guo, DA
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, ISSN 0175-7598, 01/2008, Volume 77, Issue 6, pp. 1345 - 1350
Preparative-scale fermentation of ginsenoside Rb-1 (1) with Acremonium strictum AS 3.2058 gave three new compounds, 12 beta-hydroxydammar-3-one-20... 
biotransformation | PENICILLIUM-JANTHINELLUM | MODELS | RAT | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | Acremonium strictum | PANAX-NOTOGINSENG | ginsenoside Rb-1 | TRITERPENE SAPONINS | TANDEM MASS-SPECTROMETRY | IDENTIFICATION | MAMMALIAN METABOLISM
Journal Article
by Wang, JR and Yau, LF and Tong, TT and Feng, QT and Bai, LP and Ma, J and Hu, M and Liu, L and Jiang, ZH
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, ISSN 0021-8561, 03/2015, Volume 63, Issue 10, pp. 2689 - 2700
Oxygenated metabolites have been suggested as the major circulating metabolites of ginsenosides. In the current study, 10 oxygenated metabolites of ginsenoside... 
VIVO | ginseng | FOOD SCIENCE & TECHNOLOGY | ginsenoside Rb-1 | oxygenation | PROTOPANAXATRIOL | metabolites | BIOAVAILABILITY | POLYACETYLENES | IN-VITRO | PANAX | SAPONINS | AGRICULTURE, MULTIDISCIPLINARY | ROOTS | CHEMISTRY, APPLIED | NOTOGINSENG | EXTRACT
Journal Article
by Xu, QF and Fang, XL and Chen, DF
JOURNAL OF ETHNOPHARMACOLOGY, ISSN 0378-8741, 02/2003, Volume 84, Issue 2-3, pp. 187 - 192
Panax notoginseng is used as a therapeutic agent to stop haemorrhages and a tonic to promote health in Chinese medicine. Currently saponins of P. notoginseng... 
CHEMISTRY, MEDICINAL | ginsenoside Rb-1 | ginsenoside Rg | EXCRETION | INTESTINAL BACTERIA | PLANT SCIENCES | Panax notoginseng | METABOLISM | bioavailability | SAPONINS | INTEGRATIVE & COMPLEMENTARY MEDICINE | pharmacokinetics | PHARMACOLOGY & PHARMACY | ABSORPTION | HPLC
Journal Article
by Lu, J and Yao, L and Li, JX and Liu, SJ and Hu, YY and Wang, SH and Liang, WX and Huang, LQ and Dai, YJ and Wang, J and Gao, WY
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, ISSN 0021-8561, 09/2018, Volume 66, Issue 36, pp. 9446 - 9455
Ginsenosides attract great attention for their bioactivities. However, their contents are low, and many UDP-glycosyltransferases (UGTs) that play crucial roles... 
site-directed mutagenesis | RNA INTERFERENCE | PANAX-GINSENG | SYNTHASE GENE | FOOD SCIENCE & TECHNOLOGY | METABOLICALLY ENGINEERED YEASTS | PROTOPANAXATRIOL | QUINQUEFOLIUS | overexpression | SAPONINS | UGTs | ADVENTITIOUS ROOTS | biosynthesis | AGRICULTURE, MULTIDISCIPLINARY | ginsenoside | ACCUMULATION | CHEMISTRY, APPLIED | EXPRESSION
Journal Article
by Kang, A and Zhang, SJ and Zhu, D and Dong, Y and Shan, JJ and Xie, T and Wen, HM and Di, LQ
CHEMICO-BIOLOGICAL INTERACTIONS, ISSN 0009-2797, 10/2016, Volume 258, pp. 187 - 196
Ginsenoside Rb-1, an active ingredient in Panax ginseng, was widely used for its various biological activities. To clarify the role of the gut microbiota in... 
RB1 | Antimicrobials treatment | Ginsenoside Rb-1 | PANAX-GINSENG | BIOCHEMISTRY & MOLECULAR BIOLOGY | Deglycosylation metabolism | CHEMOPREVENTION | KAPPA-B | BIOAVAILABILITY | Microbiota | Restraint stress | IN-VITRO | INHIBITION | PHARMACOLOGY | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Pharmacokinetics | MASS SPECTROMETRY ANALYSIS | EXPOSURE
Journal Article
LIFE SCIENCES, ISSN 0024-3205, 01/2007, Volume 80, Issue 7, pp. 618 - 625
Evidence has accumulated that ginseng and its main active constituents, ginsenosides, possess anti-diabetic and insulin-sensitizing properties which may be... 
PEROXISOME-PROLIFERATOR | MEDICINE, RESEARCH & EXPERIMENTAL | GLUT1 | proliferation | PANAX-GINSENG | BLOOD-GLUCOSE | C/EBP alpha | BERRY EXTRACT | GLUCOSE TRANSPORTERS | PPAR gamma | ginsenosides Rb-1 | adipogenesis | INSULIN-RESISTANCE | KOREAN RED GINSENG | PPAR-GAMMA | ADIPOCYTE DIFFERENTIATION | PHARMACOLOGY & PHARMACY | 3T3-L1 adipocytes | GLUT4 | TYPE-2 DIABETES-MELLITUS
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 08/2012, Volume 84, Issue 4, pp. 532 - 539
Wrinkle formation is one of the primary characteristics of skin aging, the major cause of wrinkle is the loss of structural protein type I collagen in dermal... 
Type I collagen | Ginsenoside | miR-25 | PPARδ | Rb-1 | PPAR delta | PANAX-GINSENG | PPAR | AMPK | PHARMACOLOGY & PHARMACY | SKIN | MICRORNAS
Journal Article
JOURNAL OF MEDICINAL FOOD, ISSN 1096-620X, 11/2017, Volume 20, Issue 11, pp. 1127 - 1132
After cultivation of ginseng, ginsenosides, which are the major active ingredients of gingeng, were approved for use by the food industry, and began to be used... 
CHEMISTRY, MEDICINAL | PERFORMANCE | FATIGUE | FOOD SCIENCE & TECHNOLOGY | GINSENG | CANCER | BIOAVAILABILITY | interactions | SUPPLEMENTATION | NUTRITION & DIETETICS | MOOD | pharmacokinetics | ginsenosides | B-complex vitamins
Journal Article
by Li, X and Zhao, HX and Miao, R and Li, WY and Xiu, Y and Liu, SY
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, ISSN 0251-0790, 10/2017, Volume 38, Issue 10, pp. 1730 - 1736
Keggin-type dodeca tungstophosphoric acid(HPW) was used in the chemical transformation of ginsenoside Rb-1. The aim of this research is to analyze the... 
RB1 | Chemical transformation | ELECTROPHILICITY | Ginsenoside Rb-1 | PANAX-GINSENG | Heteroploy acid | MS | ELIMINATION | MICROBIAL TRANSFORMATION | CHEMISTRY, MULTIDISCIPLINARY | MASS-SPECTROMETRY | HPLC. HRMS/MSn/QqQ | METABOLISM | NOTOGINSENG | RG3
Journal Article
by Wu, LP and Jin, Y and Yin, CR and Bai, LL
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, ISSN 1367-5435, 04/2012, Volume 39, Issue 4, pp. 521 - 527
Rb-1 and Rg(1) are the major ginsenosides in protopanaxadiol and protopanaxatriol. Their content in ginsenosides was 23.8 and 17.6%, respectively. A total of... 
RB1 | Co-transformation | Ginsenoside Rg | CELLS | ACTIVATION | Ginsenoside Rb-1 | CONVERSION | GINSENG | MICROBIAL TRANSFORMATION | COMPOUND-K | Minor ginsenoside | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | Biotransformation | SOIL | FOOD MICROORGANISMS
Journal Article
by Son, JW and Kim, HJ and Oh, DK
BIOTECHNOLOGY LETTERS, ISSN 0141-5492, 04/2008, Volume 30, Issue 4, pp. 713 - 716
Under optimum conditions (pH 5, 75 degrees C, and 0.2 U purified enzyme ml(-1)), 4 mg ginsenoside Rd was produced from 5 mg reagent-grade ginsenoside Rb-1 in 5... 
TRANSFORMATION | CONVERSION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ginsenoside Rb-1 | ginsenoside production | Thermus caldophilus | ginsenoside Rd | beta-glucosidase
Journal Article
by Zhao, LF and Jiao, CX and Li, H and Jiao, LL and Ma, Y and Wu, W and Liu, SY
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, ISSN 0251-0790, 04/2018, Volume 39, Issue 4, pp. 667 - 673
The developed rapid resolution liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (RRLC-Q-TOF-MS) method was applied for analyzing... 
Protopanaxadiol type ginsenoside | Chemical transformation | Rapid resolution liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (RRLC-Q-TOF-MS) | PANAX-GINSENG | METABOLISM | LIQUID | HYDROLYSIS | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
PLANTA MEDICA, ISSN 0032-0943, 04/2014, Volume 80, Issue 6, pp. 509 - 516
Extraction of medicinally active components from natural health products has become an emerging source for drug discovery. Of particular interest for this work... 
CELLS | CHEMISTRY, MEDICINAL | PANAX-GINSENG | DMSO | MACROPHAGES | BIOLOGICAL-ACTIVITIES | HUMAN INTESTINAL BACTERIA | PLANT SCIENCES | 6 ''-O-acetylginsenoside Rb1 | IN-VITRO | SAPONINS | INTEGRATIVE & COMPLEMENTARY MEDICINE | ANTIOXIDANT | saponin | LIPOPOLYSACCHARIDE | immunosuppressive | PHARMACOLOGY & PHARMACY | GINSENOSIDES | Panax quinquefolius | Araliaceae
Journal Article
by Lin, FJ and Guo, XY and Lu, WY
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, ISSN 0003-6072, 11/2015, Volume 108, Issue 5, pp. 1117 - 1127
Ginsenosides are the major pharmacological components in ginseng. Microorganisms from a ginseng field were isolated to identify transformation of ginsenosides.... 
TRANSFORMATION | Ginsenoside Rd | Aspergillus versicolor | Ginsenoside Rb-1 | Biotransformation | Extracellular enzyme | IN-VIVO | PURIFICATION | MICROBIOLOGY | Strain screening
Journal Article
by Zhao, XS and Wang, J and Li, J and Fu, L and Gao, J and Du, XL and Bi, HT and Zhou, YF and Tai, GH
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, ISSN 1367-5435, 05/2009, Volume 36, Issue 5, pp. 721 - 726
Fourteen phytopathogenic fungi were tested for their ability to transform the major ginsenosides to the active minor ginsenoside Rd. The transformation... 
TRANSFORMATION | Ginsenoside Rd | Ginsenoside Rb-1 | PANAX-GINSENG | GLUCOSIDASE | CONVERSION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | Biotransformation | Cladosporium fulvum (syn. Fulvia fulva)
Journal Article
by Han, Y and Sun, B and Jiang, B and Hu, X and Spranger, MI and Zhang, Y and Zhao, Y
JOURNAL OF APPLIED MICROBIOLOGY, ISSN 1364-5072, 09/2010, Volume 109, Issue 3, pp. 792 - 798
Aims: This study examined the transformation pathways of ginsenosides G-Rb-1, G-Rb-3, and G-Rc by the fungus Fusarium sacchari. Methods and Results:... 
C-Mx and G-Mc | PANAX-GINSENG | MICROBIOLOGY | Fusarium sacchari | Rb-3 and Rc | INTESTINAL BACTERIA | transformation pathway | ginsenosides Rb-1 | SAPONINS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PHARMACOLOGY | DEGRADATION | metabolism | bioactive compounds C-K | FOOD MICROORGANISMS
Journal Article
by Choi, JR and Hong, SW and Kim, Y and Jang, SE and Kim, NJ and Han, MJ and Kim, DH
JOURNAL OF GINSENG RESEARCH, ISSN 1226-8453, 09/2011, Volume 35, Issue 3, pp. 301 - 307
To evaluate the difference in expressing pharmacological effects of ginseng by intestinal microflora between Koreans, metabolic activities of ginseng,... 
Ginsenoside Rg | CHEMISTRY, MEDICINAL | BIOACTIVE COMPOUNDS | Ginsenoside Rb-1 | APPEARANCE | TUMOR-CELLS | Metabolism | COMPOUND K | DIET | ANTIALLERGIC ACTIVITY | GENIPOSIDE | Intestinal microflora | FECAL BACTERIAL ENZYMES | GLYCYRRHIZIN | Pharmacological effect | RAT PLASMA
Journal Article
EUROPEAN JOURNAL OF PHARMACOLOGY, ISSN 0014-2999, 06/2012, Volume 685, Issue 1-3, pp. 126 - 132
This study aims to investigate the effects of ginsenoside Rb-1 on vascular intimal hyperplasia in rats and explore the mechanisms. The rat vascular neointimal... 
RB1 | Ginsenoside Rb-1 | Neointimal hyperplasia | PROLIFERATION | CARDIOMYOCYTES | HYPERTROPHY | ARTERIES | SIGNALING PATHWAY | Phosphorylation extracellular signal-regulated kinase 1/2 (pERK1/2) | Smooth muscle alpha-actin | ENDOTHELIAL-CELLS | NITRIC-OXIDE | Phenotype modulation | PHARMACOLOGY & PHARMACY | ACTIVATED PROTEIN-KINASES | EXPRESSION | Balloon-injury
Journal Article
by Kim, MK and Lee, JW and Lee, KY and Yang, DC
JOURNAL OF MICROBIOLOGY, ISSN 1225-8873, 10/2005, Volume 43, Issue 5, pp. 456 - 462
More than seventy strains of aerobic bacteria showing beta-glucosidase activity were isolated from a ginseng field, using a newly designed Esculin-R2A agar,... 
CELLS | Rb-1 | ginseng | LACTIC-ACID BACTERIA | PURIFICATION | ginsenoside | ALPHA | MICROBIOLOGY | MICE | BETA-GLUCOSIDASE | conversion
Journal Article
BIOTECHNOLOGY LETTERS, ISSN 0141-5492, 07/2006, Volume 28, Issue 14, pp. 1121 - 1127
Ginsenoside Rb-1 is the most predominant ginsenoside in Panax species (ginseng) and the hydrolysis of this ginsenoside produces pharmaceutically active... 
ginseng biotransformations | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ginsenoside F-2 | ginsenoside Rb-1 | Caulobacter leidyia
Journal Article
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