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Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/2019, Volume 519, Issue 3, pp. 497 - 504
Emerging evidence has uncovered the extremely important roles of long noncoding RNAs (lncRNAs) in the progression of malignant tumors which includes numerous... 
NR2F1 | ESCC | NR2F1-AS1 | GLI2
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 7, pp. 732 - 740
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2014, Volume 111, Issue 23, pp. 8541 - 8546
Journal Article
Archives of Medical Research, ISSN 0188-4409, 05/2019, Volume 50, Issue 4, pp. 225 - 233
High vascularization is a major characteristic of renal cell carcinoma (RCC). Thus, exploration of molecules promoting the tumor vascularization in RCC is... 
Angiogenesis | YAP | RCC | VEGFA | Gli2
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2006, Volume 103, Issue 12, pp. 4505 - 4510
Hedgehogs (Hhs) are key signaling regulators of stem cell maintenance and tissue patterning in embryos, and activating mutations in the pathway that increase... 
Hedgehogs | Phosphorylation | 3T3 cells | NIH 3T3 cells | Neurons | Small interfering RNA | Gene expression regulation | Repression | Physiological regulation | Genetic mutation | Protein kinase A | Gli2 phosphorylation | Glycogen synthase kinase 3β | BETA-ARRESTIN-2 | PROTEIN-KINASE | REQUIRES PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | GLYCOGEN-SYNTHASE KINASE-3 | TRANSDUCTION | Gli2 | INSULIN | CUBITUS-INTERRUPTUS | PATHWAY | glycogen synthase kinase 3 beta | CYCLOPAMINE | protein kinase A | phosphorylation | MEDULLOBLASTOMA | Neoplasms - metabolism | NIH 3T3 Cells | Insulin-Like Growth Factor I - pharmacology | Zinc Finger Protein Gli2 | Glycogen Synthase Kinase 3 | Glycogen Synthase Kinase 3 beta | Neurons - cytology | Phosphatidylinositol 3-Kinases - metabolism | Hedgehog Proteins | Kruppel-Like Transcription Factors - metabolism | Cell Differentiation | Neurons - metabolism | Phosphorylation - drug effects | Chondrogenesis | Proto-Oncogene Proteins c-akt - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Embryonic Development | Animals | Signal Transduction - drug effects | Chickens | Trans-Activators - metabolism | Mice | Zinc Finger Protein GLI1 | Mutation | Transcription, Genetic - genetics | Kruppel-Like Transcription Factors - genetics | Physiological aspects | Genetic aspects | Genetic transcription | Analysis | Biological Sciences | glycogen synthase kinase 3β
Journal Article
Journal Article
Development, ISSN 0950-1991, 2009, Volume 136, Issue 24, pp. 4177 - 4185
Journal Article
Cell death & disease, ISSN 2041-4889, 07/2017, Volume 8, Issue 7, pp. e2926 - e2926
mTORC2 is aberrantly activated in cancer and therefore is considered to be an important therapeutic target. The hedgehog pathway, which is also often... 
TRANSCRIPTIONAL ACTIVITY | GLIOBLASTOMA | COMPLEX | ACTIVATION | MECHANISM | GLIOMA | GROWTH | MAHANINE | CANCER | MOTILITY | CELL BIOLOGY | Neoplastic Stem Cells - cytology | Zinc Finger Protein GLI1 - metabolism | Neoplastic Stem Cells - drug effects | Humans | Hedgehog Proteins - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Cyclin E - genetics | Rapamycin-Insensitive Companion of mTOR Protein - metabolism | Cell Nucleus - metabolism | Rapamycin-Insensitive Companion of mTOR Protein - genetics | Snail Family Transcription Factors - genetics | Neoplastic Stem Cells - metabolism | Zinc Finger Protein Gli2 - antagonists & inhibitors | Glioblastoma - metabolism | Rapamycin-Insensitive Companion of mTOR Protein - antagonists & inhibitors | Mechanistic Target of Rapamycin Complex 2 - antagonists & inhibitors | Nuclear Proteins - genetics | Zinc Finger Protein Gli2 - genetics | Cell Survival - drug effects | Snail Family Transcription Factors - metabolism | Zinc Finger Protein GLI1 - genetics | Glycogen Synthase Kinase 3 beta - antagonists & inhibitors | Nuclear Proteins - metabolism | Glycogen Synthase Kinase 3 beta - metabolism | Zinc Finger Protein Gli2 - metabolism | Cell Movement - drug effects | Mechanistic Target of Rapamycin Complex 2 - metabolism | Signal Transduction - drug effects | Glioblastoma - pathology | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Cyclin E - metabolism | Carbazoles - pharmacology | Transcription | Brain tumors | Gli2 protein | Glioblastoma | Metastasis | Cyclin D1 | Kinases | Gene expression | Glioblastoma multiforme | Nuclear transport | Metastases | Cyclin D2 | Angiogenesis | Regeneration | Ubiquitination | Stem cells | Cyclin E | Protein transport | Vascular endothelial growth factor | Cancer | Original
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 02/2012, Volume 18, Issue 3, pp. 869 - 881
Purpose: Within heterogeneous tumors, subpopulations often labeled cancer stem cells (CSC) have been identified that have enhanced tumorigenicity and... 
ONCOLOGY | ALDEHYDE DEHYDROGENASE | THERAPEUTIC TARGET | ANTIBODY | DEFINES | DRUG-RESISTANCE | GROWTH-FACTOR | EXPRESSION | CARCINOMA | HEDGEHOG | ENDOGLIN CD105 | Immunohistochemistry | Adenocarcinoma - pathology | Aldehyde Dehydrogenase - analysis | Antigens, CD - biosynthesis | Humans | Zinc Finger Protein Gli2 | Aldehyde Dehydrogenase - biosynthesis | Ovarian Neoplasms - pathology | Laser Capture Microdissection | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Antigens, CD - genetics | Antigens, CD - analysis | Ovarian Neoplasms - genetics | Endoglin | Adenocarcinoma - metabolism | Neoplastic Stem Cells - metabolism | Nuclear Proteins - biosynthesis | Neoplastic Stem Cells - pathology | Female | Adenocarcinoma - genetics | Ovarian Neoplasms - metabolism | Receptors, Cell Surface - biosynthesis | Nuclear Proteins - genetics | Kruppel-Like Transcription Factors - biosynthesis | Neoplasm Recurrence, Local - metabolism | Hyaluronan Receptors - biosynthesis | Reverse Transcriptase Polymerase Chain Reaction | AC133 Antigen | Blotting, Western | Glycoproteins - biosynthesis | Hyaluronan Receptors - analysis | Signal Transduction - physiology | Glycoproteins - analysis | Drug Resistance, Neoplasm - physiology | Kruppel-Like Transcription Factors - genetics | Peptides - analysis | Receptors, Cell Surface - genetics | aldehyde dehydrogenase | cancer stem cell | ovarian cancer | ALDH1A1 | CD105 | endoglin | gli1 | CD44 | gli2 | CD133
Journal Article
Tumor Biology, ISSN 1010-4283, 10/2016, Volume 37, Issue 10, pp. 13403 - 13412
Despite great advances have been made in the understanding of biology of osteosarcoma, the molecular mechanisms involved in osteosarcoma tumorigenesis and... 
Biomedicine | Osteosarcoma | Cancer Research | GLI2 pathway | Proliferation | Metastasis | Long noncoding RNA | BREAST-CANCER | INVASION | SCREEN | ONCOLOGY | TAMOXIFEN RESISTANCE | CELL-PROLIFERATION | GLI2 | Up-Regulation | Cell Proliferation | Humans | Lung Neoplasms - metabolism | Transcriptional Activation | Zinc Finger Protein Gli2 | Gene Expression Regulation, Neoplastic | Bone Neoplasms - pathology | Immunoenzyme Techniques | Bone Neoplasms - metabolism | Lung Neoplasms - secondary | Kruppel-Like Transcription Factors - metabolism | Female | Bone Neoplasms - genetics | Tumor Cells, Cultured | Nuclear Proteins - genetics | Real-Time Polymerase Chain Reaction | Osteosarcoma - metabolism | Lung Neoplasms - genetics | RNA, Messenger - genetics | Nuclear Proteins - metabolism | RNA, Long Noncoding - genetics | Reverse Transcriptase Polymerase Chain Reaction | Disease Progression | Xenograft Model Antitumor Assays | Animals | Cell Cycle | Mice, Nude | Mice | Mice, Inbred BALB C | Osteosarcoma - genetics | Kruppel-Like Transcription Factors - genetics | Osteosarcoma - pathology | Apoptosis | Cell Movement | Medical colleges | Chromatin | Genes | Genetic research | Development and progression | Antisense RNA | Genetic aspects | Genetic transcription | Bone cancer | Cell growth | Gene expression | Ribonucleic acid--RNA
Journal Article
Cancer Research, ISSN 0008-5472, 06/2006, Volume 66, Issue 12, pp. 6063 - 6071
Journal Article