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index medicus (707) 707
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zinc finger protein gli3 (510) 510
mice (416) 416
gli3 (404) 404
humans (356) 356
nerve tissue proteins - genetics (284) 284
developmental biology (273) 273
kruppel-like transcription factors - genetics (249) 249
nerve tissue proteins - metabolism (226) 226
signal transduction (214) 214
kruppel-like transcription factors - metabolism (213) 213
sonic hedgehog (206) 206
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mutation (187) 187
gene expression regulation, developmental (185) 185
transcription factors - genetics (182) 182
mouse (181) 181
expression (178) 178
male (173) 173
hedgehog proteins - metabolism (172) 172
genetics & heredity (168) 168
cell biology (167) 167
kruppel-like transcription factors (159) 159
hedgehog proteins (147) 147
animal structures (137) 137
dna-binding proteins - genetics (133) 133
sonic-hedgehog (131) 131
zinc finger protein gli2 (131) 131
shh (129) 129
embryonic structures (124) 124
hedgehog proteins - genetics (124) 124
nerve tissue proteins (124) 124
transcription factors - metabolism (113) 113
zinc finger protein gli1 (111) 111
gene (110) 110
hedgehog (105) 105
gene expression (103) 103
xenopus proteins (103) 103
biochemistry & molecular biology (98) 98
phenotype (98) 98
repressor proteins (95) 95
polydactyly - genetics (94) 94
research (88) 88
genes (87) 87
genetic aspects (87) 87
proteins (87) 87
mice, knockout (83) 83
vertebrate limb (83) 83
mutations (82) 82
article (80) 80
limb development (79) 79
mice, transgenic (78) 78
morphogenesis (76) 76
molecular biology (75) 75
transcription factors (75) 75
dna-binding proteins - metabolism (73) 73
trans-activators - metabolism (72) 72
greig cephalopolysyndactyly syndrome (70) 70
in situ hybridization (68) 68
analysis (67) 67
gli2 (67) 67
mice, inbred c57bl (67) 67
mice, mutant strains (67) 67
signal transduction - physiology (67) 67
trans-activators - genetics (66) 66
patched receptors (63) 63
polydactyly (63) 63
molecular sequence data (61) 61
gene-expression (60) 60
base sequence (59) 59
body patterning (59) 59
extremities - embryology (58) 58
homeodomain proteins - genetics (57) 57
neural-tube (57) 57
signal transduction - genetics (57) 57
floor plate (56) 56
cancer (55) 55
polarizing activity (55) 55
activation (54) 54
cubitus-interruptus (54) 54
genetics (54) 54
hedgehog protein (54) 54
multidisciplinary sciences (53) 53
neurosciences (53) 53
syndrome (53) 53
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differentiation (52) 52
nerve tissue proteins - physiology (52) 52
abnormalities, multiple - genetics (50) 50
body patterning - genetics (50) 50
research article (50) 50
cell differentiation (49) 49
proliferation (49) 49
gli1 (47) 47
homeodomain proteins - metabolism (47) 47
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Journal Article
03/2012
The Sonic hedgehog (Shh) signaling pathway plays a critical role in murine gastric development. When Shh is knocked out in the mouse embryonic stomach,... 
0369 | mouse | hedgehog pathway | 0758 | 0307 | gastric development | Gli3
Dissertation
Journal Article
Journal Article
Development, ISSN 0950-1991, 2009, Volume 136, Issue 24, pp. 4177 - 4185
Journal Article
Journal Article
Genes and Development, ISSN 0890-9369, 02/2002, Volume 16, Issue 4, pp. 421 - 426
The bHLH transcription factor dHAND is required for establishment of SHH signaling by the limb bud organizer in posterior mesenchyme, a step crucial to... 
Polarizing region | Alx4 | SHH signalling | DHAND | Gli3 | Limb development | BHLH TRANSCRIPTION FACTOR | HOXB-8 | ZONE | MOUSE | DEVELOPMENTAL BIOLOGY | ESTABLISHMENT | FEEDBACK LOOP | CELL BIOLOGY | INACTIVATION | GENETICS & HEREDITY | POLARIZING ACTIVITY | ZPA FORMATION | EXPRESSION | Repressor Proteins | Transcription Factors - deficiency | Vertebrates - embryology | Zinc Finger Protein Gli3 | Helix-Loop-Helix Motifs | DNA-Binding Proteins - deficiency | Extremities - embryology | Trans-Activators - physiology | Hedgehog Proteins | Feedback | Trans-Activators - genetics | Mesoderm - ultrastructure | Basic Helix-Loop-Helix Transcription Factors | Gene Expression Regulation, Developmental - physiology | Proteins - physiology | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Zinc Fingers | Morphogenesis - genetics | Intercellular Signaling Peptides and Proteins | Zebrafish Proteins | Nerve Tissue Proteins | Transcription Factors - genetics | Xenopus Proteins | DNA-Binding Proteins - genetics | Mice, Knockout | Kruppel-Like Transcription Factors | Proteins - genetics | Animals | Trans-Activators - deficiency | Mice | Morphogenesis - physiology | Hedgehogs | Analysis | Genetic research | Physiological aspects | Genetic aspects | Genetic transcription | Gene expression | Alx4 gene | Gli3 gene | dHAND gene | Sonic hedgehog protein | GLI3 protein | Index Medicus | limb development | dHAND | Research Communication | SHH signaling | polarizing region
Journal Article
CELL, ISSN 0092-8674, 02/2000, Volume 100, Issue 4, pp. 423 - 434
Ci/Gli zinc finger proteins mediate the transcriptional effects of Hedgehog protein signals. In Drosophila, Ci action as transcriptional repressor or activator... 
PROTEIN-KINASE-A | VENTRAL NEURAL-TUBE | CUBITUS-INTERRUPTUS | FLOOR PLATE | SIGNALING PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | TERMINAL CLEAVAGE PRODUCT | PATTERNING ACTIVITY | TRANSCRIPTION FACTOR | GREIG CEPHALOPOLYSYNDACTYLY SYNDROME | SONIC-HEDGEHOG | CELL BIOLOGY | Phosphorylation | Humans | Repressor Proteins | Zinc Finger Protein Gli2 | Zinc Finger Protein Gli3 | Molecular Sequence Data | DNA-Binding Proteins - metabolism | Hedgehog Proteins | Gene Expression Regulation, Developmental | Base Sequence | Body Patterning | Antibodies - immunology | Transcription, Genetic | Transcription Factors - immunology | Cyclic AMP-Dependent Protein Kinases - metabolism | DNA-Binding Proteins - immunology | Trans-Activators | Nerve Tissue Proteins | Transcription Factors - genetics | Xenopus Proteins | DNA-Binding Proteins - genetics | Chick Embryo | Limb Buds - embryology | Nuclear Proteins | Kruppel-Like Transcription Factors | Transcription Factors - metabolism | Animals | Proteins - metabolism | Mice | Protein Processing, Post-Translational | COS Cells | DNA, Complementary | Vertebrates | Carrier proteins | Physiological aspects | Genetic aspects | Research | Genetic transcription | Cytochemistry | Cell migration | Extremities (Anatomy) | Gli3 gene | Hedgehog protein | Cubitus interruptus protein | Sonic hedgehog protein | Gli3 protein | Index Medicus
Journal Article
International journal of oncology, ISSN 1019-6439, 12/2018, Volume 53, Issue 6, pp. 2458 - 2472
Oral squamous cell carcinoma (OSCC) is an extremely aggressive disease associated with a poor prognosis. Previous studies have established that cancer stem... 
Oral squamous cell carcinoma | Cancer stem cell-like cells | CD44 | GLI3 | Stem cell signaling pathways | cancer stem cell-like cells | oral squamous cell carcinoma | MESENCHYMAL TRANSITION | BREAST-CANCER | EPITHELIAL-CELLS | ONCOLOGY | GASTRIC-CANCER | THERAPEUTIC RESISTANCE | CLINICAL-IMPLICATIONS | GENE-EXPRESSION | TUMOR-GROWTH | HUMAN HOMOLOG | stem cell signaling pathways | HEDGEHOG SIGNALING PATHWAY | Cell Proliferation | Prognosis | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Mouth Neoplasms - metabolism | Gene Knockdown Techniques | Neoplastic Stem Cells - metabolism | Epithelial-Mesenchymal Transition | Hyaluronan Receptors - metabolism | Neoplastic Stem Cells - pathology | Adult | Mouth Neoplasms - genetics | Zinc Finger Protein Gli3 - metabolism | Signal Transduction | Neoplasm Invasiveness | Tumor Burden | Nerve Tissue Proteins - genetics | Zinc Finger Protein Gli3 - genetics | Nerve Tissue Proteins - metabolism | Survival Analysis | Cell Line, Tumor | Mouth Neoplasms - pathology | Aged | Cell Movement | Transcription factors | Motility | Oral cancer | Metastasis | Gene expression | Kinases | Cell adhesion & migration | Proteins | Signal transduction | Cell growth | Epidermal growth factor | Medical prognosis | Morphology | Stem cells | Cell cycle | Ligands | Mutation | Tumors
Journal Article
Human mutation, ISSN 1059-7794, 2010, Volume 31, Issue 10, pp. 1142 - 1154
Journal Article
Development, ISSN 0950-1991, 05/2011, Volume 138, Issue 10, pp. 2079 - 2088
Primary cilia have essential functions in vertebrate development and signaling. However, little is known about cilia function in brain morphogenesis, a process... 
Primary cilium | Telencephalon | Olfactory bulb | Ftm (Rpgrip1l) | Mouse | Gli3 | FATE SPECIFICATION | NEURONAL DIFFERENTIATION | DEVELOPMENTAL BIOLOGY | REGULATES DEVELOPMENT | BASAL BODY PROTEIN | JOUBERT-SYNDROME | OLFACTORY-BULB | PROGENITOR POOL | GENE-EXPRESSION | INTRAFLAGELLAR TRANSPORT | REPRESSOR FUNCTIONS | Cilia - physiology | Humans | Zinc Finger Protein Gli3 | DNA Primers - genetics | Olfactory Bulb - metabolism | Olfactory Bulb - embryology | Morphogenesis | Kruppel-Like Transcription Factors - metabolism | Mice, Mutant Strains | Base Sequence | Body Patterning | Female | Cell Differentiation | Olfactory Bulb - cytology | Microscopy, Electron, Scanning | Telencephalon - metabolism | Telencephalon - cytology | Mice, Inbred C57BL | Mutant Proteins - genetics | Mutant Proteins - metabolism | Telencephalon - embryology | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Pregnancy | Animals | Sensory Receptor Cells - cytology | Adaptor Proteins, Signal Transducing - deficiency | Adaptor Proteins, Signal Transducing - genetics | Mice | Protein Processing, Post-Translational | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Kruppel-Like Transcription Factors - genetics | Index Medicus | Brain | Pattern formation | Fetuses | Gestation | Pallium | Gli3 protein | Repressors | Proteolysis | Development | Cilia | Life Sciences | Animal genetics | Genetics | Development Biology | Cellular Biology | Embryology and Organogenesis | Cell Behavior
Journal Article
Cytogenetic and Genome Research, ISSN 1424-8581, 01/2018, Volume 153, Issue 2, pp. 56 - 65
GLI family zinc finger proteins are transcriptional effectors of the sonic hedgehog signaling pathway. GLI regulates gene expression and repression at various... 
Original Article | Greig cephalopolysyndactyly syndrome | GLI family zinc finger protein | Contiguous gene deletion syndrome | Culler-Jones syndrome | SNP array | Pallister-Hall syndrome | Sonic hedgehog pathway | MOUSE | HEDGEHOG | CELL BIOLOGY | SHH | HYPOPITUITARISM | PATHWAY | GENES | DISEASE | GENETICS & HEREDITY | MUTATIONS | SPECTRUM | PROTEINS | Chromosomes, Human, Pair 2 - ultrastructure | Chromosomes, Human, Pair 7 - ultrastructure | Sequence Deletion | Oligonucleotide Array Sequence Analysis | Humans | Nerve Tissue Proteins - deficiency | Child, Preschool | Acrocephalosyndactylia - genetics | Cleft Palate - genetics | Hedgehog Proteins - physiology | Hemangioma, Cavernous, Central Nervous System - genetics | Intellectual Disability - genetics | Chromosomes, Human, Pair 2 - genetics | Zinc Finger Protein Gli3 - deficiency | Zinc Finger Protein Gli2 - deficiency | Karyotyping | Nuclear Proteins - deficiency | Female | Nuclear Proteins - genetics | Abnormalities, Multiple - genetics | Zinc Finger Protein Gli2 - genetics | Glucose Intolerance - genetics | Nerve Tissue Proteins - physiology | Morphogenesis - genetics | Signal Transduction - genetics | Nerve Tissue Proteins - genetics | Zinc Finger Protein Gli3 - genetics | Syndrome | Zinc Finger Protein Gli3 - physiology | Dwarfism - genetics | Zinc Finger Protein Gli2 - physiology | Phenotype | Models, Biological | Adolescent | Nuclear Proteins - physiology | Chromosomes, Human, Pair 7 - genetics | Index Medicus
Journal Article
by Cao, T and Wang, CB and Yang, M and Wu, CQ and Wang, BL
DEVELOPMENTAL BIOLOGY, ISSN 0012-1606, 07/2013, Volume 379, Issue 2, pp. 221 - 228
Anterioposterior vertebrate limb patterning is controlled by opposing action between Sonic Hedgehog (Shh) and the G1i3 transcriptional repressor. Unexpectedly,... 
BETA-TRCP | PHENOTYPE | DEVELOPMENTAL BIOLOGY | INDUCTION | Gli3 | GLI3 PROTEIN | Hedgehog | SHH | ACTIVATOR | FLOOR PLATE | Limb patterning | MICE | VERTEBRATE LIMB | GENE-FUNCTION
Journal Article
Neurology, ISSN 0028-3878, 07/2019, Volume 93, Issue 3, pp. e237 - e251
OBJECTIVEIntensive genetic analysis was performed to reveal comprehensive molecular insights into hypothalamic hamartoma (HH). METHODSThirty-eight individuals... 
OFD1 | LOCALIZATION | DEFECTS | NOONAN | PATHWAY | TRAFFICKING | ASPHYXIATING THORACIC DYSTROPHY | SOMATIC MUTATIONS | GLI3 | CLINICAL NEUROLOGY | PRIMARY CILIA
Journal Article