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Stem Cells, ISSN 1066-5099, 01/2010, Volume 28, Issue 1, pp. 17 - 28
Radiotherapy represents the most effective nonsurgical treatments for gliomas. However, gliomas are highly radioresistant and recurrence is nearly universal.... 
Radioresistance | Glioma | Cancer stem cells | Radioresponse | Notch | APOPTOSIS | GAMMA-SECRETASE INHIBITOR | DNA-DAMAGE | MOUSE MODELS | TUMOR-INITIATING CELLS | BRAIN-TUMORS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | BREAST-CANCER | GROWTH-FACTOR RECEPTOR | ONCOLOGY | HUMAN GLIOBLASTOMA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IONIZING-RADIATION | HEMATOLOGY | Cell Proliferation | Neoplastic Stem Cells - drug effects | Humans | Glycoproteins - metabolism | Receptor, Notch2 - genetics | Phosphatidylinositol 3-Kinases - metabolism | Glioblastoma - radiotherapy | Antigens, CD - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Peptides - metabolism | Transfection | Neoplastic Stem Cells - metabolism | RNA Interference | Time Factors | Cell Death | Neoplastic Stem Cells - pathology | Glioblastoma - metabolism | Signal Transduction - radiation effects | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Spheroids, Cellular | Neoplastic Stem Cells - radiation effects | Cell Survival | Radiation-Sensitizing Agents - pharmacology | Enzyme Inhibitors - pharmacology | Receptor, Notch2 - metabolism | Receptor, Notch1 - metabolism | Tumor Burden | AC133 Antigen | Radiation Tolerance - drug effects | Xenograft Model Antitumor Assays | Amyloid Precursor Protein Secretases - metabolism | Animals | Mice, Nude | Glioblastoma - pathology | Myeloid Cell Leukemia Sequence 1 Protein | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Glioblastoma - drug therapy | Receptor, Notch1 - genetics | Dose-Response Relationship, Radiation | Index Medicus
Journal Article
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 08/2012, Volume 72, Issue 15, pp. 3828 - 3838
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2017, Volume 23, Issue 11, pp. 1352 - 1361
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2011, Volume 108, Issue 38, pp. 16062 - 16067
Gliomas contain a small number of treatment-resistant glioma stem cells (GSCs), and it is thought that tumor regrowth originates from GSCs, thus rendering GSCs... 
Lactates | Cellular metabolism | Glioma | Stem cells | Cell lines | Glycolysis | Progenitor cells | Cellular differentiation | Tumors | Cancer | INITIATING CELLS | PYRUVATE-KINASE | PATHWAY | MULTIDISCIPLINARY SCIENCES | IN-VIVO | ISOFORM | IDENTIFICATION | TUMOR-GROWTH | CANCER | RADIATION | GLIOBLASTOMA PATIENTS | Immunohistochemistry | Reactive Oxygen Species - metabolism | Uncoupling Agents - pharmacology | Neoplastic Stem Cells - drug effects | Tissue Array Analysis | Humans | Stem Cells - metabolism | Glycolysis - drug effects | Glioma - metabolism | Oligomycins - pharmacology | Neoplastic Stem Cells - metabolism | Adenosine Triphosphate - metabolism | Deoxyglucose - pharmacology | Glioma - pathology | Oxygen Consumption | Positron-Emission Tomography - methods | Clone Cells - metabolism | Blotting, Western | Lactates - metabolism | Energy Metabolism | Glucose - pharmacokinetics | Cell Line, Tumor | Glucose - metabolism | Stem Cells - drug effects | Proteasome Endopeptidase Complex - metabolism | Physiological aspects | Cell metabolism | Research | Diagnosis | Gliomas | Glucose | Metabolism | Pyruvate kinase | Brain tumors | Acidification | Oxygen consumption | imaging | Emissions | Glucose metabolism | Progeny | Mitochondria | Oxidative phosphorylation | Glioma cells | Cell cycle | Metabolic pathways | Lactic acid | ATP | Positron emission tomography | Index Medicus | Biological Sciences
Journal Article
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2010, Volume 12, Issue 11, pp. 1113 - 1125
Macrophages (MΦs)/microglia that constitute the dominant tumor-infiltrating immune cells in glioblastoma are recruited by tumor-secreted factors and are... 
Immune suppression | Innate immunity | Cancer stem cells | Macrophages | Signal transducer and activator of transcription 3 | Microglia | ACTIVATION | TOLL-LIKE RECEPTOR | TGF-BETA SUPERFAMILY | signal transducer and activator of transcription 3 | FACTOR-KAPPA-B | CLINICAL NEUROLOGY | macrophages | GLIOBLASTOMA | innate immunity | ONCOLOGY | TUMOR-ASSOCIATED MACROPHAGES | cancer stem cells | ANTITUMOR IMMUNITY | SUPPRESSOR-CELLS | immune suppression | microglia | T-CELLS | Microglia - metabolism | Phosphorylation | Humans | Brain Neoplasms - pathology | Neoplastic Stem Cells - immunology | Brain Neoplasms - metabolism | Glioma - metabolism | Cell Movement - immunology | Signal Transduction - immunology | Brain Neoplasms - immunology | Flow Cytometry | Microglia - immunology | Transfection | Chemotactic Factors - metabolism | Neoplastic Stem Cells - metabolism | Glioma - pathology | Neoplastic Stem Cells - pathology | Macrophages - immunology | STAT3 Transcription Factor - metabolism | Cytokines - immunology | Chemotactic Factors - immunology | Enzyme-Linked Immunosorbent Assay | Cell Separation | Cells, Cultured | Glioma - immunology | Blotting, Western | Immunity, Innate - immunology | Macrophages - metabolism | STAT3 Transcription Factor - immunology | Chemotaxis, Leukocyte - immunology | Cytokines - biosynthesis | Index Medicus | Basic and Translational Investigations
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2013, Volume 110, Issue 21, pp. 8644 - 8649
Journal Article