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animals (21) 21
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Journal Article
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, p. e95399
Insulin degrading enzyme (IDE) is a potential drug target in the treatment of type 2 diabetes (T2D... 
CAFETERIA DIET | CLEARANCE | INHIBITION | MULTIDISCIPLINARY SCIENCES | RESISTANCE | PPAR-GAMMA | HYPERINSULINEMIA | FATTY-ACIDS | MULTIPLE SERINE KINASES | TNF-ALPHA | NF-KAPPA-B | Liver - pathology | Palmitic Acid - pharmacology | Gene Expression - drug effects | Obesity - drug therapy | Diet, High-Fat - adverse effects | Hepatocytes - metabolism | RNA, Messenger - metabolism | Obesity - genetics | Hepatocytes - cytology | Insulysin - antagonists & inhibitors | Liver - drug effects | Obesity - etiology | Thiazolidinediones - pharmacology | Hepatocytes - drug effects | Insulin - pharmacology | Insulysin - metabolism | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Glucagon - pharmacology | Hypoglycemic Agents - pharmacology | Obesity - pathology | Tumor Necrosis Factor-alpha - pharmacology | Insulin - metabolism | Animals | Cell Line, Tumor | Insulysin - genetics | Mice | Blood Glucose - metabolism | Care and treatment | RNA | Analysis | Metabolic diseases | Diagnosis | Insulin | Health aspects | Risk factors | Regulations | Biomedical research | Enzyme activity | Glucagon | Laboratories | Pathogenesis | Liver | mRNA | Adipocytes | Hepatoma | Kinases | Palmitic acid | Experiments | Degradation | Proteins | Antioxidants | Control | Reduction | Enzymatic activity | Rodents | Animal tissues | Tumor necrosis factor-TNF | Obesity | Enzymes | Fasting | Pioglitazone | Diabetes mellitus | Tumor necrosis factor-α | Fatty acids | Diet | Hepatocytes | Insulin resistance | Diabetes
Journal Article
Biomedica Biochimica Acta, ISSN 0232-766X, 01/1984, Volume 43, Issue 1, pp. 29 - 38
Insulin degrading enzymes of rat liver cytosol, the so-called insulin and glucagon degrading proteinase (IGP... 
cathepsin D | insulin | protein-disulphide reductase (glutathione) | liver | glucagon | protein disulphide-isomerase | rats
Journal Article
Biomedica Biochimica Acta, ISSN 0232-766X, 1984, Volume 43, Issue 1, pp. 39 - 46
Insulin and glucagon degrading proteinase (EC 3.4.23.5) purified from rat liver cytosol was characterized using radioiodinated insulin and glucagon as substrates... 
Liver - metabolism | Rats | Chelating Agents - pharmacology | Insulin - metabolism | Animals | Phenanthrolines - pharmacology | Cathepsins - metabolism | Cytosol - metabolism | Glucagon - metabolism | Cathepsin D | Kinetics | Cathepsins - antagonists & inhibitors | Hydrogen-Ion Concentration | Metals - pharmacology
Journal Article
Biomedica Biochimica Acta, ISSN 0232-766X, 01/1984, Volume 43, Issue 1, pp. 39 - 46
Insulin and glucagon degrading proteinase purified from rat liver cytosol was characterized using radioiodinated insulin and glucagon as substrates... 
cathepsin D | insulin | liver | metals | glucagon | rats
Journal Article
Journal of Psychiatric Research, ISSN 0022-3956, 2009, Volume 43, Issue 13, pp. 1095 - 1105
Journal Article
General and Comparative Endocrinology, ISSN 0016-6480, 1983, Volume 49, Issue 3, pp. 414 - 427
...), and thiol proteinase inhibitors, but no inhibition by EDTA; and 2) a neutral (pH 7.3) activity showing marked sensitivity to thiol proteinase inhibitors, sensitivity to antipain and leupeptin, but no sensitivity to PMSF, EDTA, or pepstatin... 
Insulin - pharmacology | Islets of Langerhans - drug effects | Mitochondria - enzymology | Fishes - metabolism | Liver - enzymology | Lysosomes - enzymology | Rats | Glucagon - pharmacology | Cytosol - enzymology | Protease Inhibitors - pharmacology | Insulin - metabolism | Albumins - pharmacology | Animals | Glucagon - metabolism | Islets of Langerhans - ultrastructure | Proinsulin - pharmacology | Hydrogen-Ion Concentration
Journal Article
Biochimica et biophysica acta, ISSN 0006-3002, 02/1976, Volume 422, Issue 2, p. 254
... : protein-disulfide oxidoreductase, EC 1.8.4.2) and the A and B chain-degrading enzyme(s). The effects of EDTA argue against the implication of cathepsins in insulin... 
Amylases - metabolism | Protein Disulfide Reductase (Glutathione) - metabolism | Insulin - metabolism | Animals | Oxidoreductases - metabolism | Islets of Langerhans - enzymology | Rats | Glucagon - metabolism | Kinetics | In Vitro Techniques | Microbial Collagenase | Peptide Hydrolases - metabolism
Journal Article
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