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Journal Article
2013, ISBN 9780444626158, Volume 39, 43
Chalcones are a group of plant-derived polyphenolic compounds that possess a wide variety of biological activities. Several lead compounds with various... 
Natural products | Insulin | Chalcones | Diabetes | Glucose homeostasis | Antidiabetic | Insulin secretagogue
Reference
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 08/2019
BACKGROUND & AIMSThe intestine regulates glucose homeostasis, but it is not clear whether chronic intestinal inflammation affects risk for type 2 diabetes. We... 
Index Medicus
Journal Article
Metabolism, ISSN 0026-0495, 11/2019, Volume 100
Glutamate dehydrogenase 1 (GDH1) contributes to glucose-stimulated insulin secretion in murine β-cells, but not to basic insulin release. The implications of... 
GLUD2 transgenic mice | hGDH2 | Expression | Glucose homeostasis | Body weight | Metabolism
Journal Article
Diabetes, ISSN 0012-1797, 12/2010, Volume 59, Issue 12, pp. 3090 - 3098
OBJECTIVE-Conditional gene targeting has been extensively used for in vivo analysis of gene function in beta-cell biology. The objective of this study was to... 
INSULIN | ELEMENTS | GLUCOSE-HOMEOSTASIS | EFFICIENT RECOMBINATION | ISLETS | ENDOCRINOLOGY & METABOLISM | PDX1 | RECEPTOR | DIFFERENTIATION | PROMOTER | STRAIN | Islet Studies
Journal Article
by Liu, C and Li, SM and Liu, TH and Borjigin, J and Lin, JD
NATURE, ISSN 0028-0836, 05/2007, Volume 447, Issue 7143, pp. 477 - U4
The mammalian clock regulates major aspects of energy metabolism, including glucose and lipid homeostasis and mitochondrial oxidative metabolism(1,2). The... 
CELLS | GLUCOSE-HOMEOSTASIS | RHYTHMS | OSCILLATORS | PGC-1-ALPHA | MULTIDISCIPLINARY SCIENCES | LIVER | COMPONENT | MICE | CONTROLLING MITOCHONDRIAL BIOGENESIS | CIRCADIAN GENE-EXPRESSION
Journal Article
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 03/2008, Volume 9, Issue 3, pp. 193 - 205
Nearly unlimited supplies of energy-dense foods and technologies that encourage sedentary behaviour have introduced a new threat to the survival of our... 
SKELETAL-MUSCLE | GLUCOSE-HOMEOSTASIS | SIGNALING PATHWAYS | TYROSINE-PHOSPHATASE 1B | RAT PANCREATIC-ISLETS | UNCOUPLING PROTEIN-2 | SATURATED FATTY-ACIDS | KNOCKOUT MICE | HEPATIC STEATOSIS | NMR ISOTOPOMER ANALYSIS | CELL BIOLOGY
Journal Article
Diabetes, ISSN 0012-1797, 06/2012, Volume 61, Issue 6, pp. 1479 - 1489
Type 2 diabetes mellitus is associated with alterations in bile acid (BA) signaling. The aim of our study was to test whether pancreatic beta-cells contribute... 
DIABETES-MELLITUS | FXR | GLUCOSE-HOMEOSTASIS | METABOLISM | ISLETS | LIVER | ENDOCRINOLOGY & METABOLISM | SENSITIVITY | LIGAND | EXPRESSION | PROTECTS
Journal Article
12/2012
Purpose: To investigate the anti-diabetic, hepatoprotective and lipid homeostatic activity of Cinnamomum Zeylanicum aqueous bark extract on streptozotocin... 
Glucose homeostasis | Lipid homeostasis | Hypoglycemia | Streptozotocin | Cinnamomum zeylanicum | Type 1 diabetes mellitus
Web Resource
Archives of Physiology and Biochemistry, ISSN 1381-3455, 06/2018, pp. 1 - 9
We tested the hypothesis that glucocorticoid (GC) exposure in female rats would lead to glucose dysregulation and elevated cardiac inflammatory biomarkers,... 
DPP-4 | glucose homeostasis | VCAM-1 | GSK-3 | Dexamethasone
Journal Article
Cell, ISSN 0092-8674, 2008, Volume 135, Issue 1, pp. 61 - 73
Overnutrition is associated with chronic inflammation in metabolic tissues. Whether metabolic inflammation compromises the neural regulatory systems and... 
SYSNEURO | HUMDISEASE | BODY-WEIGHT | GLUCOSE-HOMEOSTASIS | ENHANCED LEPTIN SENSITIVITY | FOOD-INTAKE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | MICE | DIET-INDUCED OBESITY | BRAIN | REPRODUCTION | INDUCED INSULIN-RESISTANCE | CELL BIOLOGY
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 02/2019, Volume 104, Issue 2, pp. 223 - 233
Purpose: Human brown adipose tissue (BAT) has gained considerable attention as a potential therapeutic target for obesity and type 2 diabetes; however, whether... 
THERMOGENESIS | INDIVIDUALS | GLUCOSE-HOMEOSTASIS | OBESITY | TEMPERATURE | ENDOCRINOLOGY & METABOLISM | FAT | EXPENDITURE | EXERCISE | MUSCLES | AGE
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2019, Volume 62, Issue 12, pp. 5844 - 5862
The NAD(+)-dependent deacetylase SIRT2 represents an attractive target for drug development. Here, we designed and synthesized drug-like SIRT2-selective... 
GLUCOSE-HOMEOSTASIS | ACTIVATION | CHEMISTRY, MEDICINAL | PROTEIN | HISTONE DEACETYLASE SIRT6 | ACETYLATION | PGC-1-ALPHA | CHROMAN-4-ONE | TUMOR-SUPPRESSOR | CANCER | PROMOTES
Journal Article
Oncotarget, ISSN 1949-2553, 07/2018, Volume 9, Issue 58, pp. 31173 - 31186
Inconclusive results have been published regarding the impact of nut consumption on glucose/insulin homeostasis and inflammatory factors. Furthermore, it... 
Inflammation | Insulin homeostasis | Nut | Glucose homeostasis | Mediation analysis
Journal Article
CELL METABOLISM, ISSN 1550-4131, 07/2009, Volume 10, Issue 1, pp. 13 - 26
Accumulation of unfolded protein within the endoplasmic reticulum (ER) attenuates mRNA translation through PERK-mediated phosphorylation of eukaryotic... 
DIABETES-MELLITUS | INSULIN | GLUCOSE-HOMEOSTASIS | UNFOLDED PROTEIN RESPONSE | MESSENGER-RNA | PROINSULIN BIOSYNTHESIS | INITIATION | ER STRESS | ENDOCRINOLOGY & METABOLISM | MICE | ENDOPLASMIC-RETICULUM STRESS | CELL BIOLOGY
Journal Article
Journal of Clinical Medicine, ISSN 2077-0383, 07/2019, Volume 8, Issue 8, p. 1091
Glycemic responses to bariatric surgery are highly heterogeneous among patients and defining response types remains challenging. Recently developed data-driven... 
glucose homeostasis | bariatric surgery | latent trajectory | diabetes
Journal Article
Toxicology, ISSN 0300-483X, 09/2019, Volume 425, pp. 152242 - 152242
Some previous studies showed that organotin compounds induced diabetes in animal models. The underlying mechanisms should be further revealed. In this study,... 
Organotin compounds | β-Cell function | Glucose homeostasis | Gluconeogenesis | α-Cell function | Index Medicus
Journal Article
Toxicology, ISSN 0300-483X, 08/2019, Volume 424, pp. 152236 - 152236
Epidemiological and experimental data have implicated the role of di(2-ethylhexyl) phthalate (DEHP) and its metabolite mono(2-ethylhexyl) phthalate (MEHP) in... 
Insulin resistance | MEHP | CRISPR/Cas9 | Retinol binding protein 4 | Glucose homeostasis | DEHP | Index Medicus
Journal Article