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06/2014
One of the hallmarks of postprandial glucose homeostasis is the ability of insulin to promote glucose uptake into skeletal muscles. Insulin achieves this feat... 
Rac | 0487 | Actin | Muscle | GLUT4 | GTPase | Insulin
Dissertation
EMBO REPORTS, ISSN 1469-221X, 12/2005, Volume 6, Issue 12, pp. 1137 - 1142
Journal Article
Toxicological Sciences, ISSN 1096-6080, 08/2015, Volume 146, Issue 2, pp. 290 - 300
Journal Article
Molecular and cellular endocrinology, ISSN 0303-7207, 05/2019, pp. 110447 - 110447
The ability of adipose tissue to expand is dependent on adipocyte differentiation and adipose tissue glucose disposal. The CCAAT/enhancer-binding protein alpha... 
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 01/2018, Volume 280, pp. 33 - 44
In this study, we isolated two compounds from the leaves of (SA1, mangiferin and SA2, naringenin), and their structures were confirmed by infrared... 
Antidiabetic properties | Mangiferin and naringenin | NMR-Based metabolomics | PPARγ/GLUT4 signals | Molecular docking | GLUT4 signals | PPAR | Index Medicus
Journal Article
Journal of Applied Physiology, ISSN 8750-7587, 07/2005, Volume 99, Issue 1, pp. 338 - 343
Journal Article
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 06/2019, Volume 164, pp. 23 - 33
Statins inhibit cholesterol biosynthesis and lower serum LDL-cholesterol levels. They are generally well tolerated, but can cause insulin resistance in... 
Insulin receptor signaling | GLUT4 | Glucose transport | Insulin | Simvastatin | Akt/PKB
Journal Article
by Xiong, MR and Huang, Y and Liu, YJ and Huang, M and Song, GJ and Ming, Q and Ma, XH and Yang, J and Deng, SH and Wen, YZ and Shen, JH and Liu, QH and Zhao, P and Yang, XZ
MOLECULAR NUTRITION & FOOD RESEARCH, ISSN 1613-4125, 02/2018, Volume 62, Issue 3
Scope: The number of people with diabetes is increasing rapidly in the world. In the present study, the hypoglycemic activity and potential mechanism of... 
SYSTEM | diabetic mice | FOOD SCIENCE & TECHNOLOGY | INCREASES GLUCOSE-UPTAKE | SUFFICIENT | hypoglycemic agents | ergosterol | p-Akt | PHYTOSTEROLS | p-PKC | CHEMICAL-CONSTITUENTS | PATHWAY | GLUT4 TRANSLOCATION | DRUGS | GLUT4 | CELL | EXTRACT
Journal Article
Molecules, ISSN 1420-3049, 05/2019, Volume 24, Issue 10, p. 1992
Insulin resistance is a major risk factor for Alzheimer's disease (AD). Chenodeoxycholic acid (CDCA) and synthetic Farnesoid X receptor (FXR) ligands have... 
BACE1 | CREB/BDNF | GLP-1 | Alzheimer’s disease | Aβ42 | IRS-1/Akt/GLUT4 | insulin resistance | chenodeoxycholic acid | PPARγ
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 46, pp. 17853 - 17862
In skeletal muscle, the Rab GTPase-activating (GAP) protein TBC1D1 is phosphorylated by AKT and AMP-activated protein kinase (AMPK) in response to insulin and... 
Type 2 diabetes | glucose transport | MOUSE SKELETAL-MUSCLE | Rab10 | AS160 | ADIPOCYTES | insulin | STIMULATED GLUT4 TRANSLOCATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRAFFICKING | GLUCOSE-TRANSPORT | EXERCISE | glucose transporter type 4 (GLUT4) | CONTRACTION | SUBSTRATE | PHOSPHOTYROSINE-BINDING DOMAIN | RabGAPs | skeletal muscle | Index Medicus
Journal Article
JOURNAL OF CELLULAR PHYSIOLOGY, ISSN 0021-9541, 09/2018, Volume 233, Issue 9, pp. 6483 - 6494
Rab GTPases are key regulators of eukaryotic membrane traffic, and their functions and activities are limited to particular intracellular transport steps and... 
polarized transport | PHYSIOLOGY | Rab10 | CANINE KIDNEY-CELLS | NEURONAL POLARIZATION | CONTAINING VACUOLES | STIMULATED GLUT4 TRAFFICKING | ORGAN MORPHOGENESIS | PLASMA-MEMBRANE REPAIR | CELL BIOLOGY | CAENORHABDITIS-ELEGANS | PRIMARY CILIOGENESIS | NUCLEOTIDE EXCHANGE FACTOR | cilia | ENDOPLASMIC-RETICULUM | neurite outgrowth | GLUT4 | endoplasmic reticulum
Journal Article
Experimental Animals, ISSN 1341-1357, 2017
A high sucrose and high fat (HSHF) diet induces insulin resistance (IR) and increased susceptibility to type 2 diabetes mellitus (T2DM), but the underlying... 
mTOR | Akt | GLUT4 | insulin resistance
Journal Article
Experimental Cell Research, ISSN 0014-4827, 01/2017, Volume 350, Issue 2, pp. 336 - 348
Glomerular epithelial cells, podocytes, are insulin responsive and can develop insulin resistance. Here, we demonstrate that the small GTPase septin 7 forms a... 
Podocytes | Glucose uptake | GLUT4 storage vesicle | Septin 7 | Nonmuscle myosin IIA | SNARE | 3T3-L1 ADIPOCYTES | STIMULATED GLUCOSE-UPTAKE | SIGNALING PATHWAYS | PODOCYTE-SPECIFIC DELETION | DIABETIC-NEPHROPATHY | GLOMERULAR PODOCYTES | CELL BIOLOGY | LEUKOCYTE INCLUSIONS | ONCOLOGY | INSULIN-RESISTANCE | MYH9 | KIDNEY | Epithelial Cells - metabolism | Podocytes - metabolism | Septins - genetics | Glucose Transporter Type 4 - metabolism | Vesicular Transport Proteins - metabolism | Diabetic Nephropathies - metabolism | Humans | Diabetes Mellitus, Type 1 - metabolism | Rats | Nonmuscle Myosin Type IIA - metabolism | Insulin - metabolism | Animals | Transport Vesicles - metabolism | HEK293 Cells | Glucose - metabolism | Mice | Septins - metabolism | Kidney Tubules - metabolism | Glucose metabolism | Type 1 diabetes | Myosin | Insulin resistance | Glucose | Muscle proteins | Insulin | Dextrose | Index Medicus | INSULIN | PATIENTS | MYOSIN | PHOSPHORYLATION | GLUCOSE | CELL MEMBRANES | COMPLEXES | RATS | UPTAKE | GLOMERULI | RECEPTORS | 60 APPLIED LIFE SCIENCES | NMHC-IIA, nonmuscle myosin heavy chain IIA | GSV, GLUT4 storage vesicle | SNAP23, synaptosome-associated protein, 23 kDa | NM-IIA, nonmuscle myosin IIA | GLUT4, glucose transporter 4 | VAMP2, vesicle-associated membrane protein 2 | SNARE, N-ethylmaleimide–sensitive fusion protein attachment protein receptor | pp-RLC, phosphorylated myosin regulatory light chain | DN, diabetic nephropathy
Journal Article
CHEMICO-BIOLOGICAL INTERACTIONS, ISSN 0009-2797, 01/2018, Volume 280, pp. 33 - 44
In this study, we isolated two compounds from the leaves of Salacia oblonga (SA1, mangiferin and SA2, naringenin), and their structures were confirmed by... 
Mangiferin and naringenin | PPAR(gamma)/GLUT4 signals | BIOCHEMISTRY & MOLECULAR BIOLOGY | MODEL | H-1 | Molecular docking | HEART-DISEASE | PLASMA | PATHWAY | GLUCOSE | Antidiabetic properties | PHARMACOLOGY & PHARMACY | TOXICOLOGY | NMR-Based metabolomics | GLUT4 | EXTRACT
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1713, pp. 151 - 159
Total internal reflection fluorescence (TIRF) microscopy is a powerful method that allows examination of plasma membrane close events in real time. The last... 
Primary adipocytes | Microscopy | GLUT4 storage vesicles | Fluorescence | GSV | GLUT4 | TIRF | Index Medicus
Journal Article
FREE RADICAL BIOLOGY AND MEDICINE, ISSN 0891-5849, 09/2017, Volume 110, pp. 261 - 269
Previously published studies strongly suggested that insulin-and exercise-induced skeletal muscle glucose uptake require nitric oxide (NO) production. However,... 
Oxidative stress | SIGNALING PATHWAYS | Myotubes | ACTIVATED PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | Insulin | Skeletal muscle | FIBERS | TRANSPORT | Exercise | INHIBITION | CONTRACTION | Nitric oxide | GLUT4 TRANSLOCATION | ENDOCRINOLOGY & METABOLISM | Nitric oxide synthase | HYDROGEN-PEROXIDE | GLUT4 | STRESS
Journal Article
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