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1. Full Text Metabotropic glutamate receptor subtype 5 (mGlu5) is necessary for estradiol mitigation of light-induced anxiety behavior in female rats
by Miller, Christiana K and Krentzel, Amanda A and Patisaul, Heather B and Meitzen, John
Physiology & behavior, ISSN 0031-9384, 02/2020, Volume 214, pp. 112770 - 112770
Female | Anxiety | Estradiol | Metabotropic glutamate receptor 5 | Estrogen | Psychology, Biological | Social Sciences | Life Sciences & Biomedicine | Behavioral Sciences | Psychology | Science & Technology | Index Medicus
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2. Full Text Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu 5)
by Varnes, Jeffrey G and Marcus, Andrew P and Mauger, Russell C and Throner, Scott R and Hoesch, Valerie and King, Megan M and Wang, Xia and Sygowski, Linda A and Spear, Nathan and Gadient, Reto and Brown, Dean G and Campbell, James B
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 2011, Volume 21, Issue 5, pp. 1402 - 1406
mGlu5 | Schizophrenia | NMDAr | Positive allosteric modulator | N-Methyl- d-aspartate receptor | Glutamate | Metabotropic glutamate receptor 5 | N-Methyl-d-aspartate receptor | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Psycholeptics: tranquillizer, neuroleptic | Glutamatergic system (aspartate and other excitatory aminoacids) | Psychology. Psychoanalysis. Psychiatry | Neurotransmitters. Neurotransmission. Receptors | Psychopharmacology | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Neuropharmacology | Inhibitory Concentration 50 | Receptor, Metabotropic Glutamate 5 | Receptors, Metabotropic Glutamate - metabolism | Allosteric Regulation | Drug Design | Index Medicus | Allosteric properties | Solubility | carbonyls | Nitrogen | ketones | phenylacetylene | Glutamic acid receptors (metabotropic)
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3. Full Text The metabotropic glutamate receptor 5 radioligand [11C]AZD9272 identifies unique binding sites in primate brain
by Varnäs, Katarina and Juréus, Anders and Finnema, Sjoerd J and Johnström, Peter and Raboisson, Patrick and Amini, Nahid and Takano, Akihiro and Stepanov, Vladimir and Halldin, Christer and Farde, Lars
Neuropharmacology, ISSN 0028-3908, 06/2018, Volume 135, pp. 455 - 463
Autoradiography | Fenobam | PET imaging | Negative allosteric modulator | Metabotropic glutamate receptor 5 | AZD9272 | Pharmacology & Pharmacy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Primates | Amino acids | Glutamate | Mental illness | Index Medicus | Medicin och hälsovetenskap
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4. Full Text Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease
by Haas, Laura T and Salazar, Santiago V and Kostylev, Mikhail A and Um, Ji Won and Kaufman, Adam C and Strittmatter, Stephen M
Brain (London, England : 1878), ISSN 0006-8950, 02/2016, Volume 139, Issue 2, pp. 526 - 546
amyloid-beta oligomers | cellular prion protein | metabotropic glutamate receptor 5 | Alzheimer's disease | homer | Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Prion Proteins | Prions - metabolism | Prions - genetics | Frontal Lobe - metabolism | Humans | Mice, Inbred C57BL | Receptor, Metabotropic Glutamate 5 - metabolism | Alzheimer Disease - pathology | Mice, Knockout | Receptor, Metabotropic Glutamate 5 - genetics | Animals | Alzheimer Disease - metabolism | HEK293 Cells | Signal Transduction - physiology | Mice | Alzheimer Disease - genetics | Frontal Lobe - pathology | Intracellular Fluid - metabolism | Organ Culture Techniques | Protein Binding - physiology | Index Medicus | Abridged Index Medicus | Alzheimer’s disease | 1010 | Original
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5. Full Text Test–retest variability of [11C]ABP688 estimates of metabotropic glutamate receptor subtype 5 availability in humans
by Smart, Kelly and Cox, Sylvia M. L and Nagano‐Saito, Atsuko and Rosa‐Neto, Pedro and Leyton, Marco and Benkelfat, Chawki
Synapse (New York, N.Y.), ISSN 0887-4476, 09/2018, Volume 72, Issue 9, pp. e22041 - n/a
[11C]ABP688 | test–retest | positron emission tomography | metabotropic glutamate receptor type 5 | C]ABP688 | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Glutamate | Analysis | Menstruation | Mood | Amygdala | Menstrual cycle | Cortex | Neostriatum | Anxiety | Hydrocortisone | Glutamic acid receptors (metabotropic) | Positron emission tomography | Index Medicus
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6. Full Text Test–retest reproducibility of the metabotropic glutamate receptor 5 ligand [18F]FPEB with bolus plus constant infusion in humans
by Park, Eunkyung and Sullivan, Jenna M and Planeta, Beata and Gallezot, Jean-Dominique and Lim, Keunpoong and Lin, Shu-Fei and Ropchan, Jim and McCarthy, Timothy J and Ding, Yu-Shin and Morris, Evan D and Williams, Wendol A and Huang, Yiyun and Carson, Richard E
European journal of nuclear medicine and molecular imaging, ISSN 1619-7070, 9/2015, Volume 42, Issue 10, pp. 1530 - 1541
Human | Medicine & Public Health | Reproducibility | Orthopedics | Oncology | Nuclear Medicine | Imaging / Radiology | Cardiology | [ 18 F]FPEB | Metabotropic glutamate receptor 5 | Positron emission tomography | [ | F]FPEB | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology | Brain - diagnostic imaging | Reproducibility of Results | Pyridines - administration & dosage | Radiopharmaceuticals - pharmacokinetics | Humans | Pyridines - pharmacokinetics | Male | Molecular Imaging - methods | Positron-Emission Tomography - methods | Receptor, Metabotropic Glutamate 5 - metabolism | Nitriles - pharmacokinetics | Brain - metabolism | Nitriles - administration & dosage | Radiopharmaceuticals - administration & dosage | Tissue Distribution | Young Adult | Sensitivity and Specificity | Adult | Infusions, Intravenous | Tomography | Brain | Neurotransmitters | Medical imaging | Index Medicus
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7. Full Text In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [11C]ABP688 and [18F]FPEB
by DeLorenzo, Christine and Gallezot, Jean-Dominique and Gardus, John and Yang, Jie and Planeta, Beata and Nabulsi, Nabeel and Ogden, R Todd and Labaree, David C and Huang, Yiyun H and Mann, J John and Gasparini, Fabrizio and Lin, Xin and Javitch, Jonathan A and Parsey, Ramin V and Carson, Richard E and Esterlis, Irina
Journal of cerebral blood flow and metabolism, ISSN 0271-678X, 8/2017, Volume 37, Issue 8, pp. 2716 - 2727
test–retest | F]FPEB | C]ABP688 | metabotropic glutamate receptor subtype 5 | Positron emission tomography | Endocrinology & Metabolism | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Hematology | Science & Technology | Brain - diagnostic imaging | Reproducibility of Results | Nitriles - pharmacology | Humans | Male | Molecular Imaging | Positron-Emission Tomography - methods | Healthy Volunteers | Receptor, Metabotropic Glutamate 5 - metabolism | Brain - metabolism | Image Processing, Computer-Assisted | Sensitivity and Specificity | Oximes - pharmacology | Protein Binding | Adult | Female | Pyridines - pharmacology | Radiopharmaceuticals | Index Medicus | [11C]ABP688 | [18F]FPEB | Original
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8. Full Text Metabotropic glutamate receptor 5 (mGlu5)‐positive allosteric modulators differentially induce or potentiate desensitization of mGlu5 signaling in recombinant cells and neurons
by Hellyer, Shane D and Albold, Sabine and Sengmany, Kathy and Singh, Junaid and Leach, Katie and Gregory, Karen J
Journal of neurochemistry, ISSN 0022-3042, 11/2019, Volume 151, Issue 3, pp. 301 - 315
biased modulation | context dependence | metabotropic glutamate receptor 5 | desensitization | positive allosteric modulator | Amino acids | Nitriles | Nervous system diseases | Drug discovery | Glutamate | Neurons | Kidneys | Calcium (intracellular) | Desensitization | Calcium | Activation | Pharmacology | Benzamide | Neuromodulation | Modulators | Neurological diseases | Allosteric properties | Neostriatum | Receptor mechanisms | Glutamic acid receptors (metabotropic) | Index Medicus
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9. Full Text Imaging Glutamate Homeostasis in Cocaine Addiction with the Metabotropic Glutamate Receptor 5 Positron Emission Tomography Radiotracer [11 C]ABP688 and Magnetic Resonance Spectroscopy
by Martinez, Diana and Slifstein, Mark and Nabulsi, Nabeel and Grassetti, Alexander and Urban, Nina B.L and Perez, Audrey and Liu, Fei and Lin, Shu-Fei and Ropchan, Jim and Mao, Xiangling and Kegeles, Lawrence S and Shungu, Dikoma C and Carson, Richard E and Huang, Yiyun
Biological psychiatry (1969), ISSN 0006-3223, 2014, Volume 75, Issue 2, pp. 165 - 171
Psychiatry | cocaine self-administration | magnetic resonance spectroscopy | Addiction | positron emission tomography | cocaine | metabotropic glutamate receptor 5 | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Drug addiction | Psychology. Psychoanalysis. Psychiatry | Adult and adolescent clinical studies | Psychopathology. Psychiatry | Addictive behaviors | Biological and medical sciences | Medical sciences | Oximes | Pyridines | Brain - diagnostic imaging | Choice Behavior - drug effects | Magnetic Resonance Spectroscopy | Humans | Glutamine - metabolism | Homeostasis | Male | Positron-Emission Tomography | Receptor, Metabotropic Glutamate 5 - metabolism | Corpus Striatum - metabolism | Case-Control Studies | Brain - metabolism | Young Adult | Cocaine - administration & dosage | Self Administration | Cocaine-Related Disorders - metabolism | Functional Neuroimaging | Cocaine-Related Disorders - diagnostic imaging | Adult | Glutamic Acid - metabolism | Corpus Striatum - diagnostic imaging | Carbon Radioisotopes | Drug abuse | Medical colleges | PET imaging | Nuclear magnetic resonance spectroscopy | Amino acids | Cocaine | Glutamate | Index Medicus
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