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Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1 - 11
Acid-sensing ion channels (ASICs) evolved to sense changes in extracellular acidity with the divalent cation calcium (Ca2+) as an allosteric modulator and... 
BIOMOLECULAR SIMULATIONS | PAIN | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | FORCE-FIELD | PARTICLE MESH EWALD | PARAMETERS | MOLECULAR-DYNAMICS SIMULATIONS | ASIC3 | WATER | Sodium channels | Channel opening | Calcium | Channel gating | Blocking | Acidity | Glycine | Molecular chains | Allosteric properties | Acids | Calcium-binding protein | Ion channels | Glutamates | Gating | Binding sites | Calcium ions
Journal Article
FRONTIERS IN CELLULAR NEUROSCIENCE, ISSN 1662-5102, 12/2013, Volume 7
P2X receptors are ATP-gated non-selective cation channels involved in many different physiological processes, such as synaptic transmission, inflammation, and... 
CROSS-LINK | ACTIVATION | AGONIST BINDING | mutagenesis | NEUROSCIENCES | P2X receptors | FUNCTIONAL-PROPERTIES | EXTRACELLULAR LOOP | CONSERVED PROLINE RESIDUES | engineered site-directed labeling | GLYCINE RESIDUES | AMINO-ACIDS | gating | crystal structure | ION-CHANNEL | ATP | CYSTEINE RESIDUES | binding site
Journal Article
Journal Article
ELIFE, ISSN 2050-084X, 10/2019, Volume 8
The treatment of chronic pain is poorly managed by current analgesics, and there is a need for new classes of drugs. We recently developed a series of... 
NEUROTRANSMITTER | MECHANISM | BIOLOGY | ALTERNATING ACCESS | VALIDATION | DYNAMICS | VERSION | X-RAY STRUCTURES | INHIBITORS | RELEASE | DOPAMINE TRANSPORTER | Animal models | Pain perception | Lipids | Amino acids | Drug development | Analgesia | Allosteric properties | Pain | Analgesics | Glycine transporter | Standard deviation | Transmembrane domains | Mutation | Binding sites
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2016, Volume 11, Issue 7, p. e0159896
[This corrects the article DOI: 10.1371/journal.pone.0157583.]. 
Glycine | Glycine transporter | Transporter | Binding sites
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2017, Volume 112, Issue 3, pp. 556a - 556a
Journal Article
Neuropharmacology, ISSN 0028-3908, 07/2019, Volume 153, pp. 121 - 133
The zinc ion (Zn ) and proton (H ) are critical regulators for the glycine receptor chloride channel in physiological and pathological conditions. Both ions... 
Proton | Pentameric ligand-gated ion channel | Channel blocker | Allostery | Glycine receptor | Zinc | ACTIVATION | ANTAGONIST | MOLECULAR DETERMINANTS | MECHANISMS | IDENTIFICATION | NEUROSCIENCES | SIGNAL-TRANSDUCTION | POTENTIATION | GABA | PHARMACOLOGY & PHARMACY | CHLORIDE CONDUCTANCE | MODULATION | Protons | Physiological aspects | Zinc compounds | Glycine
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 07/2017, Volume 18, Issue 7, p. 1416
Journal Article
Process Biochemistry, ISSN 1359-5113, 10/2015, Volume 50, Issue 10, pp. 1600 - 1606
The inositol 1,4,5-triphosphate receptor (IP R), an IP -gated Ca release channel on the endoplasmic reticulum (ER) membrane, plays a critical role in... 
ATP binding site | Purification | IP3 receptor 1 (IP3R1) | Molecular modeling | Chaperone co-expression | Circular dichroism | receptor 1 (IP | R1
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 12/2011, Volume 18, Issue 36, pp. 5483 - 5506
Excitatory neurotransmission mediated by NMDA (N-methyl-D-aspartic acid) receptors plays a key role in both healthy and diseased processes in the brain.... 
Brain | Glutamic acid | Glutamic acid receptors (ionotropic) | Data processing | N-Methyl-D-aspartic acid receptors | Glutamic acid receptors | Ion channels | Glycine | Structure-activity relationships | Neurotransmission
Journal Article