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Electroanalysis, ISSN 1040-0397, 08/2013, Volume 25, Issue 8, pp. 1813 - 1817
Journal Article
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2010, Volume 49, Issue 3, pp. 532 - 542
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 05/2019, Volume 39, Issue 5, pp. 839 - 840
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 05/2019, Volume 39, Issue 5, pp. 956 - 964
OBJECTIVE—ACT017 is a novel, first in class, therapeutic antibody to platelet GPVI (glycoprotein VI) with potent and selective antiplatelet effects. This... 
ACTIVATION | COLLAGEN | pharmacodynamics | HUMAN PLATELETS | FUTURE | immunoglobulin Fab fragment | FIBRIN | platelet membrane glycoprotein | platelet aggregation inhibitors | safety | pharmacokinetics | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | ISCHEMIC-STROKE
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 05/2011, Volume 123, Issue 17, pp. 1891 - 1899
Background-Blocking of glycoprotein VI-dependent pathways by interfering in vascular collagen sites is commonly seen as an attractive target for an... 
stroke | platelet aggregation inhibitors | platelet adhesion | glycoprotein VI | platelet aggregation | CARDIAC & CARDIOVASCULAR SYSTEMS | FAB FRAGMENT | THROMBUS FORMATION | ACUTE CORONARY SYNDROME | ADHESION | CLOPIDOGREL | IN-VIVO | PERIPHERAL VASCULAR DISEASE | SOLUBLE GPVI | MICE | HEMATOLOGY | ANTITHROMBOTIC PROTECTION | EXPRESSION | Injections, Intravenous | Cricetulus | Recombinant Fusion Proteins - adverse effects | Humans | Male | Immunoglobulin Fc Fragments - administration & dosage | Dose-Response Relationship, Drug | Young Adult | Platelet Aggregation Inhibitors - administration & dosage | Platelet Membrane Glycoproteins - administration & dosage | Adult | Platelet Membrane Glycoproteins - adverse effects | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - pharmacokinetics | Immunoglobulin Fc Fragments - adverse effects | Recombinant Fusion Proteins - administration & dosage | CHO Cells | Platelet Aggregation Inhibitors - adverse effects | Hemostasis - drug effects | Platelet Membrane Glycoproteins - pharmacokinetics | Cricetinae | Glycoproteins - administration & dosage | Collagen - administration & dosage | Animals | Platelet Count | Recombinant Fusion Proteins - pharmacokinetics | Aggregation | Safety and security measures | Blood platelets | Hemostasis | Patient outcomes | Atherosclerosis | Dosage and administration | Research | Drug therapy
Journal Article