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European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2014, Volume 85, pp. 418 - 437
The 2′-deoxynucleoside 5′-phosphate -hydrolase 1 (DNPH1) has been proposed as a new molecular target for cancer treatment. Here, we describe the synthesis of a... 
Inhibitor | Cross-coupling reaction | DNPH1 | Nucleoside analogues | Crystal structure | Cancer | 5'-MONOPHOSPHATE N-GLYCOSIDASE | CHEMISTRY, MEDICINAL | CYTOSTATIC 6-ARYLPURINE NUCLEOSIDES | C-MYC | HL-60 CELLS | LEAVING GROUPS | 2'-DEOXYRIBONUCLEOSIDE 5'-MONOPHOSPHATE | ANTICANCER ACTIVITY | CROSS-COUPLING REACTIONS | PROTEIN-LIGAND COMPLEXES | HYDROLASE RCL | Purine Nucleotides - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Proto-Oncogene Proteins - chemistry | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Molecular Targeted Therapy | Purine Nucleotides - chemistry | N-Glycosyl Hydrolases - chemistry | Purine Nucleotides - metabolism | Antineoplastic Agents - metabolism | Enzyme Inhibitors - chemistry | Drug Design | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Chemistry Techniques, Synthetic | Enzyme Inhibitors - metabolism | N-Glycosyl Hydrolases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Nuclear Proteins - metabolism | Purine Nucleotides - chemical synthesis | Antineoplastic Agents - chemistry | Nuclear Proteins - chemistry | N-Glycosyl Hydrolases - metabolism | Animals | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Protein Conformation | Molecular Docking Simulation | Drug Screening Assays, Antitumor | Enzymes | Colon cancer | Leukemia | Crystals | Hydrolases | Nucleotides | Structure | Nuclear Proteins/chemistry | Purine Nucleotides/metabolism | Proto-Oncogene Proteins/antagonists & inhibitors | Enzyme Inhibitors/metabolism | Enzyme Inhibitors/pharmacology | Life Sciences | Antineoplastic Agents/pharmacology | N-Glycosyl Hydrolases/antagonists & inhibitors | Nuclear Proteins/antagonists & inhibitors | N-Glycosyl Hydrolases/metabolism | Nuclear Proteins/metabolism | Purine Nucleotides/chemistry | Enzyme Inhibitors/chemistry | Purine Nucleotides/chemical synthesis | Enzyme Inhibitors/chemical synthesis | Antineoplastic Agents/metabolism | N-Glycosyl Hydrolases/chemistry | Proto-Oncogene Proteins/chemistry | Biochemistry, Molecular Biology | Proto-Oncogene Proteins/metabolism | Purine Nucleotides/pharmacology | Antineoplastic Agents/chemistry | Antineoplastic Agents/chemical synthesis
Journal Article
Chemistry (Weinheim an der Bergstrasse, Germany), ISSN 0947-6539, 2018, Volume 24, Issue 71, pp. 19081 - 19088
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2004, Volume 47, Issue 10, pp. 2587 - 2598
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 02/2019, Volume 2019, Issue 5, pp. 1114 - 1124
A synthetic approach to 4a‐carba‐d‐lyxofuranose derivatives starting from d‐lyxose is described. The protected 4a‐carba‐β‐d‐lyxofuranose was employed as the... 
Carbocycles | Enzymes | Inhibitors | Molecular modelling | Cyclitols | MANNOSTATIN-A | CYCLOPENTITOLS | ANALOGS | CHEMISTRY, ORGANIC | GLYCOSIDASE INHIBITORS | KETONES | CARBOCYCLIC NUCLEOSIDES | NEPLANOCIN | REDUCTIVE AMINATION | S-ADENOSYLHOMOCYSTEINE HYDROLASE | ARISTEROMYCIN
Journal Article
Tetrahedron: Asymmetry, ISSN 0957-4166, 2007, Volume 18, Issue 2, pp. 282 - 289
The synthesis of -DIM [1,4-dideoxy-1,4-imino- -mannitol] and of 1,4-imino- - - - -heptitol from - - - -heptono-1,4-lactone depends on the use of pentan-3-one... 
HALICHONDRIN-B | 1S | ASYMMETRIC-SYNTHESIS | ANALOGS | (-)-SWAINSONINE | SWAINSONINE | CHEMISTRY, ORGANIC | CHEMISTRY, PHYSICAL | NATURAL OCCURRENCE | STEREOSELECTIVE-SYNTHESIS | GLYCOSIDASE INHIBITORS | CHEMISTRY, INORGANIC & NUCLEAR
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 12/2018, Volume 81, pp. 119 - 126
A series of classical and newly synthesized thymol bearing oxypropanolamine compounds were synthesized and characterized. Their antibacterial activity on and... 
α-glycosidase | Oxypropanolamine | Antibacterial effects | Carbonic anhydrase | Acetylcholinesterase | BUTYRYLCHOLINESTERASE | CARBONIC-ANHYDRASE | alpha-glycosidase | NATURAL-PRODUCTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESSENTIAL OIL | CHEMISTRY, ORGANIC | II INHIBITION | ALPHA-GLUCOSIDASE INHIBITORS | IN-VIVO | ANTIMICROBIAL ACTIVITY | MANNICH-BASES | Cholinergic Antagonists - chemical synthesis | Escherichia coli - drug effects | Humans | Carbonic Anhydrase II - metabolism | Structure-Activity Relationship | Carbonic Anhydrase I - metabolism | Enzyme Inhibitors - chemical synthesis | Carbonic Anhydrase II - antagonists & inhibitors | Cholinergic Antagonists - pharmacology | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Molecular Structure | Diabetes Mellitus - drug therapy | Enzyme Inhibitors - pharmacology | Diabetes Mellitus - metabolism | Hypoglycemic Agents - chemistry | Pseudomonas aeruginosa - drug effects | Hypoglycemic Agents - pharmacology | Anti-Bacterial Agents - chemical synthesis | Carbonic Anhydrase I - antagonists & inhibitors | Cholinergic Antagonists - chemistry | Hypoglycemic Agents - chemical synthesis | Anti-Bacterial Agents - pharmacology | Acetylcholine - antagonists & inhibitors | Acinetobacter baumannii - drug effects | Staphylococcus aureus - drug effects | Acetylcholinesterase - metabolism | alpha-Glucosidases - metabolism | Phenols | Enzyme inhibitors | Isoenzymes | Antibacterial agents | Escherichia coli
Journal Article