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Behavioural Brain Research, ISSN 0166-4328, 08/2013, Volume 251, pp. 18 - 24
•The NMDA receptor complex plays a functional role in autism.•Rats bred for low rates of hedonic ultrasonic calls show an autistic-like phenotype.•GLYX-13, a... 
Autism | Ultrasonic vocalization | GLYX-13 | Rat | Selective breeding | NMDA Receptor
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 05/2017, Volume 42, Issue 6, pp. 1231 - 1242
GLYX-13 is a putative NMDA receptor modulator with glycine-site partial agonist properties that produces rapid antidepressant effects, but without the... 
NMDA RECEPTOR BLOCKADE | PSYCHIATRY | HIPPOCAMPAL BDNF | RAPASTINEL GLYX-13 | NEUROSCIENCES | REACTION-TIME-TASK | MTOR | HEAD-TWITCH RESPONSE | PARTIAL AGONIST | MEDIAL PREFRONTAL CORTEX | PHARMACOLOGY & PHARMACY | STRESS | METAPLASTICITY PROCESS | Original
Journal Article
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 04/2013, Volume 38, Issue 5, pp. 729 - 742
Journal Article
NeuroReport, ISSN 0959-4965, 09/2019, Volume 30, Issue 13, pp. 863 - 866
In humans, chronic pain is often expressed as a spontaneous emotional response which can lead to fragmented sleep. Rat 50-kHz and 20-kHz ultrasonic... 
pain | NYX-2925 | chronic constriction injury | MODEL | circadian rhythms | NMDA receptors | SYNAPTIC PLASTICITY | REWARD | NEUROSCIENCES | KETAMINE | NEUROPATHIC PAIN | GLYX-13 | MEDIAL PREFRONTAL CORTEX | ultrasonic vocalizations | rapastinel | Psychological aspects | Physiological aspects | Models | Animal vocalization | Research | Neurological research | Chronic pain
Journal Article
Pharmacology, Biochemistry and Behavior, ISSN 0091-3057, 01/2020, Volume 188, p. 172827
Conventional antidepressant medications, which act on monoaminergic systems, have significant limitations, including a time lag of weeks to months and low... 
DEPRESSION | FUNCTIONAL PARTIAL AGONIST | NMDA RECEPTOR BLOCKADE | STAR-ASTERISK-D | MONOCLONAL-ANTIBODY | ACTING ANTIDEPRESSANTS | SYNAPTIC PLASTICITY | NEUROSCIENCES | SITE PARTIAL AGONIST | GLYX-13 | BEHAVIORAL SCIENCES | PHARMACOLOGY & PHARMACY | SMALL GTPASES
Journal Article
Journal Article
Psychopharmacology, ISSN 0033-3158, 10/2016, Volume 233, Issue 19-20, pp. 3647 - 3657
The N-methyl-d-aspartate (NMDA) receptor antagonists, including R-ketamine and rapastinel (formerly GLYX-13), show rapid antidepressant effects in animal... 
Antidepressant | R-ketamine | Rapastinel | Brain-derived neurotrophic factor | Synaptogenesis | PATH | FUNCTIONAL PARTIAL AGONIST | BDNF | PSYCHIATRY | D-ASPARTATE ANTAGONIST | NEUROSCIENCES | TRIAL | GLYX-13 | PHARMACOLOGY & PHARMACY | SUSTAINED ANTIDEPRESSANT | RAPID-ONSET | Nucleus Accumbens - metabolism | Disks Large Homolog 4 Protein - metabolism | Disks Large Homolog 4 Protein - drug effects | Male | Hippocampus - drug effects | Brain - metabolism | Brain-Derived Neurotrophic Factor - drug effects | Depression - drug therapy | CA3 Region, Hippocampal - drug effects | Prefrontal Cortex - drug effects | Dentate Gyrus - drug effects | Stress, Psychological - metabolism | CA3 Region, Hippocampal - metabolism | Antidepressive Agents - pharmacology | Brain-Derived Neurotrophic Factor - metabolism | Swimming | Receptor, trkB - drug effects | Receptors, AMPA - metabolism | Disease Models, Animal | Dentate Gyrus - metabolism | Excitatory Amino Acid Antagonists - pharmacology | Hindlimb Suspension | Brain - drug effects | Hippocampus - metabolism | Animals | Prefrontal Cortex - metabolism | Mice | Ketamine - pharmacology | Nucleus Accumbens - drug effects | Oligopeptides - pharmacology | Receptor, trkB - metabolism | Receptors, AMPA - drug effects | Ketamine | Antidepressants | Depression, Mental | Comparative analysis | Drug therapy | Stress (Psychology) | Health aspects | Psychopharmacology | Stress | Original Investigation
Journal Article
Clinical Psychological Science, ISSN 2167-7026, 7/2014, Volume 2, Issue 4, pp. 472 - 494
Mammalian brains contain seven primary-process affective substrates for primal emotional feelings and behaviors. Scientific labels for these interactive... 
Medial forebrain bundle | GLYX-13 | PANIC system | Deep brain stimulation | Anterior cingulate area | SEEKING system | Depression | PLAY system | Preclinical models
Journal Article