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Nature, ISSN 0028-0836, 2014, Volume 505, Issue 7485, pp. 691 - 695
Journal Article
Nature, ISSN 0028-0836, 11/2018, Volume 563, Issue 7729, pp. 131 - 136
Accurate repair of DNA double-stranded breaks by homologous recombination preserves genome integrity and inhibits tumorigenesis. Cyclic GMP-AMP synthase (cGAS)... 
CELLS | CYCLIC GMP-AMP | MULTIDISCIPLINARY SCIENCES | DOUBLE-STRAND BREAKS | CYTOSOLIC DNA | HISTONE H2AX | HOMOLOGOUS RECOMBINATION | PARP-1 | CANCER | Neoplasms - metabolism | Phosphorylation | Humans | Male | Intracellular Signaling Peptides and Proteins - metabolism | Neoplasm Proteins - metabolism | DNA Breaks, Double-Stranded | Cell Nucleus - enzymology | Cell Cycle Proteins - antagonists & inhibitors | Nucleotidyltransferases - deficiency | Cell Nucleus - metabolism | Neoplasms - genetics | Protein Binding - drug effects | HEK293 Cells | src-Family Kinases - metabolism | Adult | Female | Membrane Proteins - metabolism | Active Transport, Cell Nucleus | Nucleotidyltransferases - metabolism | Recombinational DNA Repair - genetics | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Poly (ADP-Ribose) Polymerase-1 - metabolism | Piperazines - pharmacology | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Phthalazines - pharmacology | Animals | Cell Line, Tumor | Mice | DNA Damage | Cell Transformation, Neoplastic - pathology | Neoplasms - pathology | Cellular signal transduction | Research | Carcinogenesis | DNA repair | Transferases | Tyrosine | DNA damage | Analysis | Genomics | DNA | Genomes | Health aspects | Sugars | Tumors | Monosaccharides | Animal models | Homologous recombination | Lung cancer | Poly(ADP-ribose) | Homology | Innate immunity | Kinases | ADP | Immunity | Cancer therapies | Genomic instability | Proteins | Ribose | Cyclic GMP | Cell cycle | Fibroblasts | Tumorigenesis | Localization | Repair | Protein-tyrosine kinase | Deoxyribonucleic acid--DNA | Translocation | Stability | AMP | Nuclear transport | Poly(ADP-ribose) Polymerase 1 | Interferon regulatory factor 3 | Micronuclei | Instability | Interferon | Cancer | Apoptosis | Index Medicus
Journal Article
Journal Article
Journal Article
Future Medicinal Chemistry, ISSN 1756-8919, 06/2018, Volume 10, Issue 11, pp. 1301 - 1317
Aim: Persistent activation of STING pathway is the basis for several autoimmune diseases. STING is activated by cGAMP, which is produced by cGAS in the... 
cGAS | STING | 2′,3′-cGAMP | autoinflammatory disease | suramin | DNA SENSOR | CYCLIC GMP-AMP | ACTIVATION | CHEMISTRY, MEDICINAL | CRYSTAL-STRUCTURE | 2 ',3 ' cGAMP | INTERFERON-BETA | MAMMALIAN-CELLS | AICARDI-GOUTIERES-SYNDROME | STRUCTURAL BASIS | STING PATHWAY | AUTOIMMUNE-DISEASE
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 9/2014, Volume 193, Issue 5, pp. 2394 - 2404
IFNβ has been implicated as an effector of oviduct pathology resulting from genital chlamydial infection in the mouse model. In this study, we investigated the... 
STING | IFN-β | Chlamydia | cyclic GMP-AMP synthase
Journal Article
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, ISSN 1000-1182, 04/2017, Volume 35, Issue 2, pp. 203 - 207
Journal Article
CHEMIE IN UNSERER ZEIT, ISSN 0009-2851, 02/2014, Volume 48, Issue 1, pp. 9 - 9
Zyklische Dinucleotide, bei denen zwei Riboseeinheiten durch Phosphodiesterbindungen ringformig verbunden sind, galten lange Zeit als Besonderheit der... 
2ND-MESSENGER | DI-GMP | CYCLIC GMP-AMP | CYTOSOLIC DNA | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Nature, ISSN 0028-0836, 03/2019, Volume 567, Issue 7747, pp. 262 - 266
Cyclic GMP-AMP (cGAMP) synthase (cGAS) detects infections or tissue damage by binding to microbial or self DNA in the cytoplasm(1). Upon binding DNA, cGAS... 
SYNTHASE | CYCLIC GMP-AMP | MAVS | PROTEIN | ROLES | MULTIDISCIPLINARY SCIENCES | ADAPTER | SENSOR | Biological research | Autophagy (Cytology) | Enzymes | Physiological aspects | Interferon | Research | Cytoplasm | Biology, Experimental
Journal Article
by Wu, JJ and Chen, YJ and Dobbs, N and Sakai, T and Liou, J and Miner, JJ and Yan, N
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 04/2019, Volume 216, Issue 4, pp. 867 - 883
STING gain-of-function mutations cause lung disease and T cell cytopenia through unknown mechanisms. Here, we found that these mutants induce chronic... 
SYNTHASE | MEDICINE, RESEARCH & EXPERIMENTAL | CYCLIC GMP-AMP | TREX1 | KINASE | CGAS | INNATE IMMUNE SENSOR | IMMUNOLOGY
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 07/2019, Volume 9, Issue 1, pp. 9825 - 19
Journal Article
18.