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Life Sciences, ISSN 0024-3205, 2007, Volume 80, Issue 5, pp. 468 - 475
We investigated the effect of magnolol (5,5′-diallyl-2,2′-dihydroxybiphenyl), a marker compound isolated from the cortex of , in non-obese type 2 diabetic... 
Magnolol | Diabetic nephropathy | Goto–Kakizaki rat | Goto-Kakizaki rat | KIDNEY-DISEASE | MEDICINE, RESEARCH & EXPERIMENTAL | PROTEINURIA | MODEL | MELLITUS | GROWTH-FACTOR-BETA | HYPERGLYCEMIA | magnolol | HONOKIOL | GLUCOSE | MICROALBUMINURIA | MESANGIAL CELLS | PHARMACOLOGY & PHARMACY | diabetic nephropathy | Immunohistochemistry | Islets of Langerhans - drug effects | Kidney Cortex - drug effects | Diabetes Mellitus, Experimental - drug therapy | Kidney Cortex - metabolism | Transforming Growth Factor beta1 - metabolism | Diabetic Nephropathies - drug therapy | Male | Diabetes Mellitus, Type 2 - metabolism | Rats, Inbred Strains | Biphenyl Compounds - therapeutic use | Plant Bark - chemistry | Lignans - therapeutic use | Proteinuria - prevention & control | Sorbitol - metabolism | Magnolia - chemistry | Islets of Langerhans - metabolism | Diabetes Mellitus, Experimental - metabolism | Collagen Type IV - metabolism | Hypoglycemic Agents - therapeutic use | Biphenyl Compounds - isolation & purification | Diabetic Nephropathies - metabolism | Rats | Lignans - isolation & purification | Lignans - administration & dosage | Hypoglycemic Agents - isolation & purification | Insulin - metabolism | Animals | Glycation End Products, Advanced - metabolism | Plant Roots - chemistry | Biphenyl Compounds - administration & dosage | Creatinine - analysis | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Diabetic nephropathies | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2004, Volume 381, Issue 1, pp. 13 - 18
We imaged and analysed the motion of single insulin secretory granules near the plasma membrane in live pancreatic beta-cells, from normal and diabetic... 
Membrane fusion | Insulin release | Pancreatic β-cell | Exocytosis | Total internal reflection fluorescence microscopy (TIRFM) | Diabetes mellitus | EVANESCENT-WAVE MICROSCOPY | total internal reflection fluorescence microscopy (TIRFM) | ISLETS | BIOCHEMISTRY & MOLECULAR BIOLOGY | diabetes mellitus | MELLITUS | FACTOR ATTACHMENT PROTEIN | membrane fusion | insulin release | GREEN FLUORESCENT PROTEIN | pancreatic beta-cell | GK RATS | GLUCOSE-METABOLISM | exocytosis | EXPRESSION | SECRETORY GRANULES | Immunohistochemistry | Recombinant Proteins - metabolism | Green Fluorescent Proteins | Membrane Fusion | Rats, Wistar | Secretory Vesicles - chemistry | Insulin - immunology | Secretory Vesicles - metabolism | Islets of Langerhans - chemistry | Rats | Male | Image Processing, Computer-Assisted - methods | Exocytosis - physiology | Insulin - metabolism | Animals | Microscopy, Fluorescence - methods | Islets of Langerhans - metabolism | Rats, Mutant Strains | Islets of Langerhans - cytology | Diabetes Mellitus, Experimental - metabolism | Insulin Secretion | Luminescent Proteins - metabolism | Index Medicus | GFP, green fluorescent protein | FBS, fetal bovine serum | pancreatic β-cell | Accelerated Publication | KRB, Krebs–Ringer buffer | GK, Goto–Kakizaki | RRP, readily-releasable pool | eGFP, enhanced GFP | TIRF, total internal reflection fluorescence | TIRFM, TIRF microscopy
Journal Article
Journal Article
Clinical Science, ISSN 0143-5221, 05/2012, Volume 122, Issue 10, pp. 473 - 483
Diabetes is a strong risk factor for premature and severe stroke. The GLP-IR (glucagon-like peptide-1 receptor) agonist Ex-4 (exendin-4) is a drug for the... 
Neuroprotection | Exendin-4 (Ex-4) | Goto-Kakizaki (GK) rat | Neurogenesis | Middle cerebral artery occlusion (MCAO) | MEDICINE, RESEARCH & EXPERIMENTAL | middle cerebral artery occlusion (MCAO) | RISK-FACTORS | ADULT BRAIN | TOTAL NUMBER | DOPAMINERGIC-NEURONS | SUBVENTRICULAR ZONE | EXENDIN-4 | exendin-4 (Ex-4) | neuroprotection | neurogenesis | ANIMAL-MODEL | CEREBRAL-ISCHEMIA | HIPPOCAMPAL NEUROGENESIS | PARKINSONS-DISEASE | Neuroprotective Agents - therapeutic use | Receptors, Glucagon - agonists | Microglia - drug effects | Rats | Stroke Volume - drug effects | Male | Stroke - drug therapy | Hyperglycemia - drug therapy | Animals | Glucagon-Like Peptide-1 Receptor | Brain Ischemia - drug therapy | Brain Ischemia - pathology | Venoms - therapeutic use | Cell Proliferation - drug effects | Neurogenesis - drug effects | Diabetes Mellitus, Type 2 - drug therapy | Drug Evaluation, Preclinical | Diabetes Mellitus, Type 2 - complications | Peptides - therapeutic use | Index Medicus | T2D, Type 2 diabetes | BrdU, bromodeoxyuridine | MCAO, MCA occlusion | DAPI, 4′,6-diamidino-2-phenylindole | DCX, doublecortin | GK, Goto–Kakizaki | Goto–Kakizaki (GK) rat | CNS, central nervous system | MCA, middle cerebral artery | IHC, immunohistochemistry | Ex-4, exendin-4 | bw, body weight | GLP-1R, glucagon-like peptide-1 receptor | SVZ, subventricular zone | Medical Biotechnology | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinsk bioteknologi | Biomedicinsk laboratorievetenskap/teknologi | Biomedical Laboratory Science/Technology
Journal Article
Endocrinology, ISSN 0013-7227, 04/2005, Volume 146, Issue 4, pp. 2069 - 2076
The effects of the incretin mimetic exenatide (exendin-4) on metabolic parameters, insulin sensitivity, and β-cell mass were examined in nondiabetic,... 
DEPENDENT DIABETES-MELLITUS | GOTO-KAKIZAKI RAT | GLUCAGON-LIKE PEPTIDE-1 | CLAMP TECHNIQUE | FOOD-INTAKE | IN-VIVO | ENDOCRINOLOGY & METABOLISM | PLASMA-GLUCOSE | SULFONYLUREA-TREATED PATIENTS | SYNTHETIC EXENDIN-4 | GLUCOSE DISPOSAL
Journal Article
Histology and Histopathology, ISSN 0213-3911, 12/2017, Volume 32, Issue 12, pp. 1341 - 1350
Background. The aim of this study was to investigate the relation between the different bariatric surgeries and pancreatic beta-cell turnover. Material and... 
Beta-cell mass | Diabetes | Pancreas | Bariatric-surgery | Insulin-secreting cells | VERTICAL SLEEVE GASTRECTOMY | GASTRIC BYPASS | GOTO-KAKIZAKI RATS | REGENERATION | WEIGHT-LOSS | MECHANISMS | PATHOLOGY | INSULIN SENSITIVITY | CELL BIOLOGY | DIABETES-MELLITUS | GLUCOSE-HOMEOSTASIS | GLUCAGON-LIKE PEPTIDE-1 | Insulin-Secreting Cells | Bariatric Surgery | Rats | Male | Animals | Rats, Wistar
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 03/2008, Volume 153, Issue 5, pp. 894 - 906
Journal Article
Obesity Surgery, ISSN 0960-8923, 11/2013, Volume 23, Issue 11, pp. 1734 - 1742
Journal Article
Nutrition Research, ISSN 0271-5317, 2014, Volume 34, Issue 2, pp. 160 - 167
Journal Article
Journal Article