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Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 70, pp. 114980 - 114994
The signaling pathway involving the R-spondins and its cognate receptor, GPR48/LGR4, is crucial in development and carcinogenesis. However, the functional... 
RSPO2 | mutation | GPR48/LGR4 | BRAF | β-catenin pathway | Papillary thyroid carcinoma | STEM-CELLS | TYROSINE KINASE | DOWN-REGULATION | PROTEIN-COUPLED RECEPTORS | BRAFV600E mutation | BETA-CATENIN | IDENTIFICATION | CANCER | CELL BIOLOGY | GENE | WNT/BETA-CATENIN | beta-catenin pathway | papillary thyroid carcinoma | LGR5
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 497, Issue 7450, pp. 517 - 520
Journal Article
Nature Medicine, ISSN 1078-8956, 05/2016, Volume 22, Issue 5, pp. 539 - 546
Journal Article
Journal Article
Development, ISSN 0950-1991, 08/2009, Volume 136, Issue 16, pp. 2747 - 2756
G-protein-coupled receptor (GPCR) 48 (Gpr48; Lgr4), a newly discovered member of the glycoprotein hormone receptor subfamily of GPCRs, is an orphan GPCR of... 
Bone formation | Bone remodeling | Mouse | Atf4 | Gpr48 (Lgr4) | DOWN-REGULATION | DEVELOPMENTAL BIOLOGY | ACTIVATING TRANSCRIPTION FACTOR-4 | OSTEOCALCIN GENE | PARATHYROID-HORMONE | NULL MICE | DIFFERENTIATION | EXPRESSION | SKELETAL DEVELOPMENT | LGR4 | Chondrocytes - cytology | Osteogenesis - physiology | Receptors, G-Protein-Coupled - metabolism | Integrin-Binding Sialoprotein | Sialoglycoproteins - metabolism | Bone Remodeling - physiology | Osteoclasts - cytology | Protein Isoforms - metabolism | Embryo, Mammalian - anatomy & histology | Gene Expression Regulation, Developmental | Collagen - genetics | Osteoblasts - cytology | Cell Differentiation - physiology | Cyclic AMP - metabolism | Osteoporosis - physiopathology | Chondrocytes - metabolism | Bone and Bones - cytology | Cyclic AMP-Dependent Protein Kinases - metabolism | Bone Density | Bone and Bones - physiology | Osteocalcin - metabolism | Osteoblasts - physiology | Cells, Cultured | Activating Transcription Factor 4 - genetics | Osteoclasts - metabolism | Mice, Knockout | Collagen - metabolism | Embryo, Mammalian - physiology | Animals | Activating Transcription Factor 4 - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Signal Transduction - physiology | Mice | Receptors, G-Protein-Coupled - genetics | Protein Isoforms - genetics
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 37, pp. 15525 - 15537
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, p. e0168320
Journal Article
Asian Pacific Journal of Cancer Prevention, ISSN 1513-7368, 2013, Volume 14, Issue 8, pp. 4775 - 4778
The key signaling networks regulating cancer cell proliferation remain to be defined. The leucine-rich repeat containing G-protein coupled receptor 48 (GPR48)... 
Cell proliferation | Cancer cell | GPR48 | Wnt/β-catenin | cell proliferation | DOWN-REGULATION | cancer cell | ONCOLOGY | PATHWAY | Wnt/beta-catenin | LEADS | COUPLED RECEPTOR 48 | MICE | KNOCKOUT | EXPRESSION | LGR4 | MALE REPRODUCTIVE-TRACT
Journal Article
Cancer Letters, ISSN 0304-3835, 2016, Volume 383, Issue 2, pp. 161 - 170
Abstract Lgr4 is a member of the leucine-rich, G protein–coupled receptor family of proteins, and has recently been shown to augment Wnt/β-catenin signaling... 
Hematology, Oncology and Palliative Medicine | Lgr4 | β-Catenin | Squamous cell carcinoma | ERK1/2 | TPA | ACTIVATION | GPR48 | PROLIFERATION | GENE | ONCOLOGY | beta-Catenin | RECEPTORS | UP-REGULATION | EXPRESSION | MOUSE SKIN | Cyclin D1 - metabolism | Tetradecanoylphorbol Acetate | Cell Proliferation | Receptors, G-Protein-Coupled - metabolism | Papilloma - enzymology | Humans | Neoplasms, Experimental - enzymology | Cell Transformation, Neoplastic - chemically induced | Neoplasms, Experimental - chemically induced | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Transcription Factor AP-1 - metabolism | Neoplasms, Experimental - pathology | Skin Neoplasms - enzymology | Transfection | RNA Interference | Time Factors | Cell Transformation, Neoplastic - genetics | Neoplasms, Experimental - genetics | Papilloma - pathology | Keratinocytes - enzymology | Papilloma - chemically induced | Wnt Signaling Pathway | Skin Neoplasms - pathology | Papilloma - genetics | Genetic Predisposition to Disease | MAP Kinase Kinase 1 - metabolism | Skin Neoplasms - chemically induced | Cell Transformation, Neoplastic - metabolism | Mice, Knockout | Keratinocytes - pathology | Phenotype | Animals | Receptors, G-Protein-Coupled - deficiency | Cyclin D1 - genetics | Skin Neoplasms - genetics | Cell Line, Tumor | Receptors, G-Protein-Coupled - genetics | Cell Transformation, Neoplastic - pathology | Transcription factors | Phosphorylation | Wnt protein | Colorectal cancer | Activation | Metastasis | Leucine | Cyclin D1 | Kinases | Cancer therapies | Carcinogenesis | Experiments | Skin cancer | Proteins | β-catenin | Signal transduction | Carcinogens | Pathways | Rodents | Conflicts of interest | Tumorigenesis | Cloning | Melanoma | Extracellular signal-regulated kinase | Gene expression | Signaling | Papilloma | Skin | Mice | Acetic acid | Tumors | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, p. e78144
Journal Article