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Biomedicine & Pharmacotherapy, ISSN 0753-3322, 06/2019, Volume 114, p. 108791
Lung cancer remains the leading cause of cancer incidence and mortality. Although cigarette smoke is regarded as a high risk factor for lung tumor initiation,... 
Stemness | GPRC5A | Smoke | Lung cancer
Journal Article
Cell Proliferation, ISSN 0960-7722, 09/2019, Volume 52, Issue 5, pp. e12661 - n/a
Objectives Circular RNAs (circRNAs) are non‐coding RNAs, some of which are thought to be involved in gastric cancer development. Here, we examined the... 
miR‐195 | GPRC5A | gastric cancer | CircRNA
Journal Article
Oncology Letters, ISSN 1792-1074, 01/2019, Volume 17, Issue 1, pp. 502 - 507
G protein-coupled receptor, family C, group 5 member A (GPRC5A) is a retinoid-inducible protein, which has been characterized as a tumor-suppressor gene in... 
Immunohistochemistry | Non-small cell lung carcinoma | GPRC5A | Prognosis | ONCOLOGY | TUMOR-SUPPRESSOR GPRC5A | GENE-EXPRESSION | PROTEIN-COUPLED RECEPTORS | MOLECULAR-CLONING | immunohistochemistry | non-small cell lung carcinoma | IDENTIFICATION | prognosis | RAI3
Journal Article
Cancer research, ISSN 0008-5472, 11/2010, Volume 70, Issue 21, pp. 8917 - 8926
Signal transduction and activator of transcription 3 (Stat3) is activated by cytokines and growth factors in lung cancers and regulates expression of genes... 
lung cancer | Stat3 | Lif | Gprc5a | apoptosis
Journal Article
Cancer Prevention Research, ISSN 1940-6207, 04/2010, Volume 3, Issue 4, pp. 424 - 437
Mouse models can be useful for increasing the understanding of lung tumorigenesis and assessing the potential of chemopreventive agents. We explored the role... 
Gprc5a | NF-κB | macrophages | mouse model | inflammation | Lung cancer | tumor suppressor
Journal Article
Cell Adhesion & Migration, ISSN 1933-6918, 09/2017, Volume 11, Issue 5-6, pp. 434 - 446
G-Protein Coupled Receptor (GPCR), Class C, Group 5, Member A (GPRC5A) has been implicated in several malignancies. The underlying mechanisms, however, remain... 
integrin β1 | matrix adhesion | GPRC5A | ECM | EphA2
Journal Article
International Journal of Cancer, ISSN 0020-7136, 02/2019, Volume 144, Issue 4, pp. 777 - 787
GPRC5A, a retinoic acid induced gene, is preferentially expressed in lung tissue. Gprc5a gene deletion leads to spontaneous lung tumor development. However,... 
lung cancer | MDM2 | GPRC5A | EGFR | WILD-TYPE P53 | PROTEIN | ONCOPROTEIN MDM2 | GENE | ONCOLOGY | PATHWAY | INFLAMMATION | DEGRADATION | PROMOTES | EXPRESSION | ASSOCIATION | MDM2 protein | Transcription | Epidermal growth factor receptors | Epithelial cells | p53 Protein | Lung cancer | Tumorigenicity | Gene deletion | Gene expression | Tissues | Ribonucleic acid--RNA | Proteins | Signal transduction | Signaling | Clonal deletion | Stem cells | Deletion | Retinoic acid | Cancer | Tumors
Journal Article
World Chinese Journal of Digestology, ISSN 1009-3079, 11/2014, Volume 22, Issue 31, pp. 4810 - 4815
Journal Article
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, ISSN 1936-2625, 2019, Volume 12, Issue 2, pp. 606 - 612
Purpose: Retinoic acid-induced gene 3 (RAI3) has been associated with tumorigeneses in several cancer types. To clarify the clinical significance of RAI3... 
gastric dysplasia | TUMOR PROGRESSION | CANCER CELLS | tissue microarray | PROTEIN-COUPLED RECEPTORS | SOCS-3 | PATHOLOGY | IDENTIFICATION | SUPPRESSOR GENE GPRC5A | gastric adenocarcinoma | EPITHELIUM | ONCOLOGY | POOR-PROGNOSIS | GROWTH | immunohistochemistry | EXPRESSION | RAI3
Journal Article
Experimental and Molecular Pathology, ISSN 0014-4800, 04/2019, Volume 107, pp. 51 - 56
Expression of the retinoic acid-induced protein 3 (RAI3) has been suggested to predict clinical outcome in a variety of malignancies. However, its role in... 
Immunohistochemistry | TMA | Esophageal squamous cell carcinoma | Esophageal cancer | Esophageal adenocarcinoma | RAI3 | CELLS | BARRETTS-ESOPHAGUS | PATHOLOGY | IDENTIFICATION | GPRC5A EXPRESSION | OVEREXPRESSION | GENE | POOR-PROGNOSIS | DISEASE | RECURRENCE | PROGRESSION | Cancer patients | Care and treatment | Squamous cell carcinoma | Patient outcomes | Analysis | Tretinoin
Journal Article
Molecular Therapy - Nucleic Acids, ISSN 2162-2531, 12/2018, Volume 13, pp. 633 - 641
Bladder cancer is a serious cancer in the world, especially in advanced countries. Bladder cancer stem cells (CSCs) drive bladder tumorigenesis and metastasis.... 
Gprc5a | peptide | cancer stem cells | bladder cancer | MEDICINE, RESEARCH & EXPERIMENTAL | DRIVEN | CIRCULAR RNA | TRANSLATION | CANCER STEM-CELLS
Journal Article
International Journal of Cancer, ISSN 0020-7136, 06/2017, Volume 140, Issue 12, pp. 2734 - 2747
Journal Article
Cancer Cell International, ISSN 1475-2867, 03/2017, Volume 17, Issue 1, p. 34
Background: G protein-coupled receptor family C group 5 member A (GPRC5A), a retinoic acid-inducible gene, is a lung tumor suppressor. Previously, we showed... 
GPRC5A | Leukoplakia | HNSCC | Prognostic marker | STAT3 | CYTOKINES | FOLLOW-UP | CANCER | ONCOLOGY | MALIGNANT-TRANSFORMATION | GROWTH-FACTORS | ORAL LEUKOPLAKIA | SIGNAL TRANSDUCERS | DIFFERENTIATION | EXPRESSION
Journal Article
International Journal of Cancer, ISSN 0020-7136, 10/2017, Volume 141, Issue 8, pp. 1589 - 1599
Despite the urgency for prevention and treatment of lung adenocarcinoma (LUAD), we still do not know drivers in pathogenesis of the disease. Earlier work... 
Gprc5a | Kras | carcinogenesis | whole‐exome sequencing | lung adenocarcinoma | whole-exome sequencing | STEM-CELLS | FIELD | CANCER GENOME | CLASSIFICATION | IDENTIFICATION | MORPHOGENESIS | ONCOGENE | INHIBITION | ONCOLOGY | COPY NUMBER | EXPRESSION | Lung Neoplasms - genetics | Lung Neoplasms - enzymology | Adenocarcinoma of Lung | Lung Neoplasms - chemically induced | Proto-Oncogene Proteins p21(ras) - genetics | Adenocarcinoma - chemically induced | Humans | Lung Neoplasms - metabolism | Adenocarcinoma - enzymology | Nitrosamines - toxicity | Receptors, G-Protein-Coupled - biosynthesis | Carcinogens - toxicity | Mice, Knockout | Cell Lineage | Adenocarcinoma - metabolism | Animals | Receptors, G-Protein-Coupled - deficiency | Adenocarcinoma - genetics | Mice | Receptors, G-Protein-Coupled - genetics | Mutation | Genes, Tumor Suppressor | Proto-Oncogene Proteins p21(ras) - metabolism | Adenocarcinoma | Lung cancer | Analysis | Genomics | Genetic research | Protein C | Genetic aspects | Cancer | Intervention | Animal models | G protein-coupled receptors | Copy number | Pathogenesis | Genomes | Tissues | Carcinogenesis | Human tissues | K-Ras protein | Prevention | Respiratory tract | c-Met protein | Proteins | Carcinogens | Alterations | Rodents | Lesions | Alveoli | Exposure | Surfactant protein C | Tobacco | In vivo methods and tests | Immunofluorescence | Tumors | Nicotine | Index Medicus | Lung adenocarcinoma
Journal Article