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biochemistry & molecular biology (511) 511
phosphorylation (505) 505
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src homology 2 domain-containing, transforming protein 1 (114) 114
adaptor proteins, signal transducing - metabolism (113) 113
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proto-oncogene proteins - metabolism (113) 113
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kinases (101) 101
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intracellular signaling peptides and proteins (80) 80
phosphatidylinositol 3-kinases - metabolism (79) 79
protein structure, tertiary (78) 78
biological phenomena, cell phenomena, and immunity (77) 77
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Nature, ISSN 0028-0836, 2013, Volume 499, Issue 7457, pp. 166 - 171
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 5/2010, Volume 189, Issue 5, pp. 871 - 883
Endocytosis of the epidermal growth factor receptor (EGFR) is important for the regulation of EGFR signaling. However, EGFR endocytosis mechanisms are poorly... 
Endocytosis | Receptors | Phosphorylation | Internalization | Cell lines | Small interfering RNA | Antibodies | Growth factor receptors | Acetylation | Endosomes | RNA INTERFERENCE | DOMAIN | PROTEIN | COATED PIT ADAPTINS | TYROSINE PHOSPHORYLATION | LIGAND-INDUCED INTERNALIZATION | TRAFFICKING | COMPLEX AP-2 | EPSIN 1 | EGF RECEPTORS | CELL BIOLOGY | RNA, Small Interfering - genetics | Receptor, Epidermal Growth Factor - genetics | Protein Interaction Domains and Motifs - physiology | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Phosphorylation - genetics | Receptor, Epidermal Growth Factor - metabolism | Adaptor Protein Complex 2 - metabolism | Transfection | Swine | GRB2 Adaptor Protein - genetics | Lysine - metabolism | Ubiquitination - physiology | Proto-Oncogene Proteins c-akt - metabolism | Coated Pits, Cell-Membrane - metabolism | Endothelial Cells - metabolism | Cells, Cultured | Epidermal Growth Factor - metabolism | Clathrin - genetics | Adaptor Protein Complex 2 - genetics | Mutation - genetics | Clathrin - metabolism | Protein Processing, Post-Translational - physiology | Endocytosis - physiology | Animals | Models, Biological | Cell Line, Tumor | Amino Acid Substitution - genetics | GRB2 Adaptor Protein - metabolism | Post-translational modification | Analysis | Epidermal growth factor
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 3/2019, Volume 76, Issue 6, pp. 1185 - 1199
Receptor tyrosine kinases (RTKs) play key roles in various aspects of cell biology, including cell-to-cell communication, proliferation and differentiation,... 
Life Sciences | Biomedicine, general | Biochemistry, general | Life Sciences, general | Cell-based assay | Lapatinib | Receptor tyrosine kinases | TEV protease | Split TEV recruitment assay | Cell Biology | BIOCHEMISTRY & MOLECULAR BIOLOGY | I RECEPTOR | FAMILY | CELL BIOLOGY | BREAST-CANCER | INSULIN | EGFR LIGANDS | EPIDERMAL-GROWTH-FACTOR | PROTEIN-PROTEIN INTERACTIONS | MULTITARGETED INHIBITORS | BINDING | ERBB RECEPTORS | A549 Cells | Reproducibility of Results | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Humans | ErbB Receptors - genetics | Rats | Biological Assay - methods | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | PC12 Cells | Pyrimidines - metabolism | src Homology Domains | Lapatinib - pharmacology | Animals | Lapatinib - metabolism | Receptor Protein-Tyrosine Kinases - genetics | GRB2 Adaptor Protein - genetics | Protein Binding - drug effects | Cell Line, Tumor | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Acrylamides - metabolism | GRB2 Adaptor Protein - metabolism | Acrylamides - pharmacology | Tyrosine | Epidermal growth factor | Proteases | Detectors | Phenols | Psychotherapy | Cells | Phosphotyrosine | Homeostasis | High-throughput screening | Homology | Antagonists | Neurodevelopmental disorders | Cell interactions | Kinases | Assaying | Recruitment | Proteins | Genetic code | Coding | Growth factors | Adaptor proteins | Cell survival | Hepatocyte growth factor | ErbB protein | Adapters | Pharmacology | Insulin | Grb2 protein | Domains | Ligands | Receptor mechanisms | Biosensors | Adapter proteins | Cancer | Index Medicus | Original
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2017, Volume 292, Issue 14, pp. 5748 - 5759
Journal Article
Journal Article
Science Signaling, ISSN 1945-0877, 09/2017, Volume 10, Issue 498, p. eaal1482
Journal Article
Journal Article
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 06/2013, Volume 33, Issue 11, pp. 2188 - 2201
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2013, Volume 288, Issue 18, pp. 12722 - 12732
Clinically, circulating prolactin levels and density of the extracellular matrix (ECM) are individual risk factors for breast cancer. As tumors develop, the... 
MAMMOGRAPHIC DENSITY | INTEGRIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | EPITHELIAL-SPECIFIC DISRUPTION | GENE-EXPRESSION | RECEPTOR | STAT5 | RISK | EXTRACELLULAR-MATRIX | MAMMARY TUMORIGENESIS | FOCAL ADHESION KINASE | Focal Adhesion Kinase 1 - genetics | Humans | Extracellular Matrix - metabolism | Neoplasm Proteins - metabolism | Breast Neoplasms - metabolism | MAP Kinase Signaling System | Prolactin - metabolism | Extracellular Matrix - genetics | Prolactin - genetics | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Phosphorylation - genetics | Collagen Type I - genetics | GRB2 Adaptor Protein - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Female | Neoplasm Proteins - genetics | Focal Adhesion Kinase 1 - metabolism | Mammary Neoplasms, Animal - genetics | Collagen Type I - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Mammary Neoplasms, Animal - pathology | Animals | Breast Neoplasms - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Breast Neoplasms - pathology | Mammary Neoplasms, Animal - metabolism | Cell Line, Tumor | Mice | GRB2 Adaptor Protein - metabolism | Extracellular Matrix - pathology | Mitogen-Activated Protein Kinase 1 - metabolism | Desmoplasia | Extracellular Matrix | Prolactin | Collagen | Focal Adhesion Kinase | Breast Cancer | Density | Cell Biology
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2015, Volume 34, Issue 3, pp. 393 - 409
THEMIS is critical for conventional T‐cell development, but its precise molecular function remains elusive. Here, we show that THEMIS constitutively associates... 
THEMIS | apoptosis | TCR | SHP | negative feedback | SHP1 | ACTIVATION | TCR SIGNALING THRESHOLDS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-TYROSINE PHOSPHATASES | RECEPTOR | SHP-1 | THYMOCYTE POSITIVE SELECTION | CELL BIOLOGY | GENE | PROTEOMICS FACILITIES PIPELINE | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Cell Survival - genetics | Multiprotein Complexes - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Cell Differentiation - genetics | Multiprotein Complexes - metabolism | CD3 Complex - genetics | T-Lymphocytes - metabolism | GRB2 Adaptor Protein - genetics | Intracellular Signaling Peptides and Proteins - genetics | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Jurkat Cells | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | CD3 Complex - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Mice, Knockout | src Homology Domains | Proteins - genetics | Animals | Proteins - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | T-Lymphocytes - cytology | Mice | Receptors, Antigen, T-Cell - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics | Mutation | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | GRB2 Adaptor Protein - metabolism | Ligands | Phosphorylation | T cell receptors | Phosphatase | Immune system
Journal Article