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Journal of Biological Chemistry, ISSN 0021-9258, 2014, Volume 289, Issue 36, pp. 25262 - 25275
Journal Article
International Immunopharmacology, ISSN 1567-5769, 11/2013, Volume 17, Issue 3, pp. 638 - 650
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue... 
Signaling | Receptors | Inflammation | Kinases | Neutrophils | ACTIVATED PROTEIN-KINASE | COLONY-STIMULATING FACTOR | LEUKOCYTE ADHESION DEFICIENCY | IMMUNOLOGY | SRC-FAMILY KINASES | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | HIGH-AFFINITY RECEPTOR | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | NF-KAPPA-B | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 10/2009, Volume 1179, Issue 1, pp. 120 - 143
Markers of hyperactive central corticotropin releasing factor (CRF) systems and CRF-related single nucleotide polymorphisms (SNPs) have been identified in... 
extracellular signal-regulated kinase, ERK | mitogen-activated protein kinase, MAPK | urocortin 2, UCN2 | G protein-coupled receptor, GPCR | brain-derived neurotrophic factor, BDNF | CRF receptor type 2, CRF2 receptor | urocortin 3, UCN3 | corticotropin releasing factor, CRF | CRF receptor type 1, CRF1 receptor | GPCR kinase, GRK | cyclic 3′,5′-adenosine monophosphate, cyclic AMP | extracellular signal‐regulated kinase, ERK | brain‐derived neurotrophic factor, BDNF | G protein‐coupled receptor, GPCR | mitogen‐activated protein kinase, MAPK | cyclic 3′,5′‐adenosine monophosphate, cyclic AMP | Urocortin 2, UCN2 | Corticotropin releasing factor, CRF | Urocortin 3, UCN3 | HOMOLOGOUS DESENSITIZATION | FACTOR TYPE-1 | cyclic 3 ', 5 '-adenosine monophosphate | BASOLATERAL AMYGDALA | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-COUPLED RECEPTORS | ELEMENT-BINDING PROTEIN | BETA-ARRESTIN | MAPK | MECHANISM REGULATING STRESS | mitogen-activated protein kinase | TEENAGE SUICIDE VICTIMS | CORTICOTROPIN-RELEASING-FACTOR | NEUROTROPHIC FACTOR EXPRESSION | cyclic AMP | Receptors, Corticotropin-Releasing Hormone - metabolism | Pituitary-Adrenal System - metabolism | Stress, Psychological - drug therapy | Humans | Anxiety - physiopathology | Receptors, Corticotropin-Releasing Hormone - agonists | Hypothalamo-Hypophyseal System - metabolism | Depression - drug therapy | Depression - metabolism | Signal Transduction - drug effects | Models, Biological | Stress, Psychological - metabolism | Signal Transduction - physiology | Anxiety Disorders - metabolism | Anxiety Disorders - drug therapy | Coenzymes | Depression, Mental | ACTH | Cyclic adenylic acid | Peptide hormones | Psychiatric services | Membrane proteins | Tranquilizing drugs | Antidepressants | Anxiety | G proteins | Adenylic acid | Protein kinases | cyclic 3′,5′-adenosine monophosphate cyclic AMP
Journal Article
BRITISH JOURNAL OF PHARMACOLOGY, ISSN 0007-1188, 01/2015, Volume 172, Issue 2, pp. 469 - 481
Background and PurposeThe majority of studies examining desensitization of the -opioid receptor (MOR) have examined those located at cell bodies. However, MORs... 
LOCUS-CERULEUS NEURONS | AGONIST EFFICACY | POTASSIUM CURRENTS | opioid | PKC | PROTEIN-COUPLED RECEPTORS | ARRIVE GUIDELINES | desensitization | morphine | opiate | nerve terminal | DOPAMINE NEURONS | CONCISE GUIDE | PHARMACOLOGY & PHARMACY | GPCR kinase (GRK) | tolerance | GABAERGIC NEURONS | K+ CHANNELS | ventral tegmental area (VTA) | BRAIN NEURONS
Journal Article
PLoS Genetics, ISSN 1553-7390, 10/2017, Volume 13, Issue 10, p. e1007032
The NALCN/NCA ion channel is a cation channel related to voltage-gated sodium and calcium channels. NALCN has been reported to be a sodium leak channel with a... 
CAENORHABDITIS-ELEGANS | HETEROTRIMERIC G-PROTEINS | GAIN-OF-FUNCTION | SEVERE INTELLECTUAL DISABILITY | SIGNALING PATHWAY | COUPLED RECEPTOR KINASES | SODIUM LEAK CHANNEL | GENETICS & HEREDITY | PLECKSTRIN HOMOLOGY DOMAIN | BETA-GAMMA-SUBUNITS | PUTATIVE CATION CHANNEL | GTP-Binding Protein alpha Subunits, Gi-Go - genetics | Promoter Regions, Genetic | Genome-Wide Association Study | G-Protein-Coupled Receptor Kinases - genetics | G-Protein-Coupled Receptor Kinases - metabolism | Signal Transduction | Caenorhabditis elegans - genetics | Dopamine - pharmacology | Gene Expression Regulation | Interneurons - drug effects | Caenorhabditis elegans Proteins - metabolism | Ion Channels - genetics | Mixed Function Oxygenases - metabolism | Acetylcholine - metabolism | Receptors, Dopamine D2 - metabolism | Receptors, Dopamine D2 - genetics | Animals | Caenorhabditis elegans - drug effects | Interneurons - metabolism | Ion Channels - metabolism | Epistasis, Genetic | Mixed Function Oxygenases - genetics | Caenorhabditis elegans Proteins - genetics | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Caenorhabditis elegans | Calcium channels | Dopamine | Neurons | Analysis | Phenols | Cellular signal transduction | G proteins | Genetic screening | Dopamine receptors | Neurophysiology | Phosphorylation | Interneurons | G protein-coupled receptors | Calcium channels (voltage-gated) | Epistasis | Kinases | Locomotion | Signal transduction | Signaling | Sodium | Nematodes | Sodium channels (voltage-gated) | Ion channels | Transduction | Membrane potential | Mutation | Dopamine D2 receptors | Worms | Guanosinetriphosphatase | Function analysis | Structure-function relationships
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2007, Volume 404, Issue 1, pp. 71 - 80
beta(2)-ARs (beta(2)-adrenoceptors) become desensitized rapidly upon recruitment of cytosolic beta-arrestin. PDE4D5 (family 4 cAMP-specific phosphodiesterase,... 
adrenoceptor | Desensitization | Peptide array | β-arrestin | cAMP | Phosphodiesterase 4 (PDE4) | MEMBRANE SUPPORTS | ACTIVATION | KINASE-A | phosphodiesterase 4 (PDE4) | beta-arrestin | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIAC MYOCYTES | peptide array | PROTEIN-COUPLED RECEPTORS | ISOFORM | beta-adrenoceptor | desensitization | COMPARTMENTALIZED PHOSPHODIESTERASES | ENZYMES | INHIBITORS | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | Cell Line | Arrestins - chemistry | Cyclic Nucleotide Phosphodiesterases, Type 4 | Humans | Cyclic Nucleotide Phosphodiesterases, Type 3 | Models, Molecular | Recombinant Proteins - chemistry | Arrestins - genetics | Phosphoric Diester Hydrolases - genetics | Arrestins - metabolism | Kidney | Phosphoric Diester Hydrolases - chemistry | Transfection | beta-Arrestin 2 | beta-Arrestin 1 | beta-Arrestins | Protein Array Analysis | Protein Conformation | Binding Sites | GFP, green fluorescent protein | GRK, GPCR kinase | GST, glutathione S-transferase | β2-adrenoceptor | β2-AR, β2-adrenoceptor | PKA, cAMP-dependent protein kinase | HEK-293, human embryonic kidney | siRNA, small interfering RNA | PDE, phosphodiesterase | ERK, extracellular-signal-regulated kinase | GPCR, G-protein-coupled receptor | MEF, mouse embryonic fibroblast | VSV, vesicular-stomatitis virus | AKAP79, A-kinase-anchoring protein 79
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2005, Volume 385, Issue 3, pp. 625 - 637
GPCRs (G-protein-coupled receptors) play an extremely important role in transducing extracellular signals across the cell membrane with high specificity and... 
Arrestin | Bioluminescence resonance energy transfer (BRET) | Oligomerization | G-protein-coupled receptor (GPCR) | Fluorescence resonance energy transfer (FRET) | BRET | BIOLUMINESCENCE-RESONANCE | TRANSFER BRET | LIGAND-INDEPENDENT DIMERIZATION | FUNCTIONAL GABA(B) RECEPTOR | fluorescence resonance energy transfer (FRET) | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESONANCE ENERGY-TRANSFER | BETA-ARRESTIN | AGONIST-DEPENDENT DISSOCIATION | arrestin | HUMAN OXYTOCIN RECEPTOR | bioluminescence resonance energy transfer | oligomerization | HORMONE-RECEPTOR | HUMAN THYROTROPIN RECEPTOR | Animals | Receptors, G-Protein-Coupled - metabolism | Cell Survival | Humans | Protein Structure, Quaternary | Cells - metabolism | Fluorescence Resonance Energy Transfer | Protein Binding | Receptors, G-Protein-Coupled - agonists | Receptors, G-Protein-Coupled - chemistry | Cells - cytology | DAMGO, [D-Ala2-MePhe4-Gly(ol)5]enkephalin | BRET, bioluminescence resonance energy transfer | GRK, GPCR kinase | TRHR, thyrotropin-releasing hormone receptor | YFP, yellow fluorescent protein | BRET1, original BRET methodology using coelenterazine h as the substrate for Renilla luciferase | SSTR, somatostatin receptor | GABAB1R, γ-aminobutyric acid B1 receptor | Review | GABAB2R, γ-aminobutyric acid B2 receptor | GnRHR, gonadotropin-releasing hormone receptor | GPCR, G-protein-coupled receptor | TM, transmembrane helix | pbFRET, photobleaching FRET | D2R, dopamine D2 receptor | CFP, cyan fluorescent protein | AR, adrenergic receptor | GFP, green fluorescent protein | MTR, melatonin receptor | FRET, fluorescence resonance energy transfer | bioluminescence resonance energy transfer (BRET) | HA, haemagglutinin | Kir channel, inwardly rectifying K+ channel | CHO, Chinese-hamster ovary | LH, luteinizing hormone | PTHR, parathyroid hormone receptor | Rluc, Renilla luciferase | ER, endoplasmic reticulum | ET, endothelin | RET, resonance energy transfer | BRET2, modified BRET methodology using DeepBlueC™ coelenterazine as the substrate for Renilla luciferase
Journal Article