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2000, ISBN 0122981901, 327
One of the largest patient populations seen by neuropsychologists are older adults suffering from problems associated with aging. Further, the proportion of... 
Treatment | Neuropsychological tests | Geriatric neuropsychiatry | diagnosis | Geriatric neurology | Aged | Dementia | Psychology | Evaluation | Brain damage | Diagnosis | Older people | Diseases
eBook
Neurobiology of aging, ISSN 0197-4580, 03/2019
Frontotemporal dementia (FTD) is the second most common early-onset dementia. Up to half of the cases are familial, and several mutations have been identified... 
Journal Article
by Bruno, AE and Li, L and Kalabus, JL and Pan, YZ and Yu, AM and Hu, ZH
BMC GENOMICS, ISSN 1471-2164, 01/2012, Volume 13
Background: Single nucleotide polymorphisms (SNPs) can lead to the susceptibility and onset of diseases through their effects on gene expression at the... 
GRN | POLYMORPHISMS | RISK-FACTOR | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | BINDING-SITE | CANCER
Journal Article
Journal of Biomedical Informatics, ISSN 1532-0464, 07/2019, Volume 95, p. 103236
Event extraction and annotation has become a significant focus of recent efforts in biological text mining and information extraction (IE). However, event... 
Multi-domain | GRN | Biological event | Neural networks | Event extraction | GRNA
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 2017
Abstract Progranulin ( GRN ) gene mutations have been genetically associated with FTD and are present in about 23% of patients with familial FTD. However, the... 
Neurology | Internal Medicine
Journal Article
Indian Journal of Science and Technology, ISSN 0974-6846, 2015, Volume 8, Issue 26
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 2019
GRN null mutations are among the main genetic causes of frontotemporal dementia through progranulin haploinsufficiency. Most missense mutations are considered... 
GRN | Missense mutation | Progranulin | TDP-43 | Frontotemporal lobar degeneration | Frontotemporal dementia | C9orf72
Journal Article
Journal Article
AIP Conference Proceedings, ISSN 0094-243X, 2012, Volume 1429, pp. 194 - 199
Conference Proceeding
Breast Cancer Research, ISSN 1465-5411, 06/2018, Volume 20, Issue 1, pp. 59 - 15
Background: As crucial regulators of the immune response against pathogens, macrophages have been extensively shown also to be important players in several... 
ID4 | GRN | Breast cancer | HIF-1A | MiR-107 | TAMs | MIGRATION | ANGIOGENESIS | NEUROPILIN-2 | PROLIFERATION | BRCA1 | IDENTIFICATION | miR-107 | REGULATOR | ONCOLOGY | MUTANT P53 | DIFFERENTIATION | PROGRESSION | Care and treatment | Prognosis | Messenger RNA | Genetic aspects | Research | Gene expression | Macrophages
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 04/2019, Volume 76, pp. 214.e11 - 214.e15
Frontotemporal lobar degeneration caused by mutations is mainly associated with a TDP-43 type A proteinopathy. We present a family with autosomal dominant... 
Astrogliopathy | GRN mutations | ARTAG | Tauopathy | Neuropathology | PATHOLOGIES | PATTERNS | PROGRANULIN | NEUROSCIENCES | BRAIN | GERIATRICS & GERONTOLOGY | Proteins | Alzheimer's disease | Genetic aspects
Journal Article
Developmental Biology, ISSN 0012-1606, 09/2011, Volume 357, Issue 1, pp. 35 - 40
At present several entirely different explanatory approaches compete to illuminate the mechanisms by which animal body plans have evolved. Their respective... 
GRN evolution | GRN selection | MORPHOLOGICAL EVOLUTION | NETWORK | GENE | ADAPTATION | PATTERNS | DEVELOPMENTAL BIOLOGY | SPECIFICATION | DROSOPHILA | Animals | Gene Expression Regulation, Developmental | Transcription, Genetic | Gene Regulatory Networks | Genome | Systems Biology | Evolution, Molecular | Developmental biology
Journal Article
ALZHEIMER DISEASE & ASSOCIATED DISORDERS, ISSN 0893-0341, 10/2018, Volume 32, Issue 4, pp. 359 - 363
Journal Article
Journal Article
Frontiers in Genetics, ISSN 1664-8021, 2015, Volume 6, p. 160
Robust temporal and spatial patterns of cell types emerge in the course of normal development in multicellular organisms. The onset of degenerative diseases... 
Morphogenesis | Cell-fate | Stem-cells | GRN | Attractors | Epigenetic landscape | Cancer
Journal Article
Development (Cambridge, England), ISSN 0950-1991, 12/2018, Volume 145, Issue 24, p. dev167288
Evolution of the animal body plan is driven by changes in developmental gene regulatory networks (GRNs), but how networks change to control novel developmental... 
Embryogenesis | Subcircuits | Echinoderms | Regulatory states | GRN evolution | CELLS | INFORMATION | URCHIN EUCIDARIS-TRIBULOIDES | DEVELOPMENTAL BIOLOGY | SPECIFICATION | FATE | SEA-URCHIN | ENDOMESODERM | EVOLUTION | LINKAGES | SEGMENTATION
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