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Environmental Health Perspectives, ISSN 0091-6765, 12/2008, Volume 116, Issue 12, pp. 1648 - 1655
Journal Article
2008, Cancer drug discovery and development, ISBN 9781597453561, xi, 393
The epidermal growth factor (EGF) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor... 
drug therapy | Signal Transduction | drug effects | metabolism | Neoplasms | antagonists & inhibitors | Receptor, Epidermal Growth Factor | Clinical & internal medicine | Cancer | Chemotherapy | Treatment | Medicine & Public Health | Cancer Research | Oncology
Book
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2014, Volume 111, Issue 45, pp. E4869 - E4877
The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation.... 
Structure-based drug design | Drug discovery | Cancer drug resistance | Kinase inhibitor | structure-based drug design | WILD-TYPE | MULTIDISCIPLINARY SCIENCES | BCR-ABL | GROWTH-FACTOR RECEPTORS | DRUG-RESISTANCE | kinase inhibitor | LUNG-CANCER | GENE FUSIONS | cancer drug resistance | SELECTIVE INHIBITOR | drug discovery | THERAPEUTIC TARGET | FACTOR RECEPTOR 4 | REGULATES PROLIFERATION | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Receptor, Epidermal Growth Factor - genetics | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Mutation, Missense | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Protein Kinase Inhibitors - chemistry | Receptor, Epidermal Growth Factor - metabolism | Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Binding Sites | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Receptor, Epidermal Growth Factor - chemistry | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Amino acids | T cell receptors | Mutation | Kinases | Binding sites | Adenosine triphosphatase | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Journal Article
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2012, Volume 448, Issue 2, pp. 213 - 220
To investigate the range of autoinhibitory mechanisms used by TKDs (tyrosine kinase domains) from the insulin receptor family of RTKs (receptor tyrosine... 
X-ray crystallography | Insulin receptor kinase | Autoinhibition | Receptor tyrosine kinase (RTK) | Receptor tyrosine kinase-like orphan receptor 2 (Ror2) | Tropomyosin receptor kinase A (TrkA) | ALK | CRYSTAL-STRUCTURE | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CATALYTIC DOMAIN | autoinhibition | receptor tyrosine kinase-like orphan receptor 2 (Ror2) | ANAPLASTIC LYMPHOMA KINASE | GROWTH-FACTOR RECEPTOR | LUNG-CANCER | insulin receptor kinase | INHIBITION | receptor tyrosine kinase (RTK) | MUTATIONS | tropomyosin receptor kinase A (TrkA) | EGF RECEPTOR | Neoplasms - metabolism | Humans | Receptor, trkA - antagonists & inhibitors | Crystallography, X-Ray | Antigens, CD - genetics | Antigens, CD - metabolism | Neoplasms - genetics | Receptor, Insulin - genetics | Protein Structure, Quaternary | Antigens, CD - chemistry | Recombinant Proteins - metabolism | Amino Acid Sequence | Catalytic Domain | Recombinant Proteins - antagonists & inhibitors | Receptor Tyrosine Kinase-like Orphan Receptors - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Receptor, Insulin - antagonists & inhibitors | Amino Acid Motifs | Receptor Tyrosine Kinase-like Orphan Receptors - antagonists & inhibitors | Receptor Tyrosine Kinase-like Orphan Receptors - chemistry | Receptor, trkA - metabolism | Receptor, Insulin - chemistry | Receptor, trkA - chemistry | Receptor, trkA - genetics | Receptor Tyrosine Kinase-like Orphan Receptors - genetics | Receptor, Insulin - metabolism | Mutation | Enzyme Activation - genetics | In Vitro Techniques | Index Medicus | ALK, anaplastic lymphoma kinase | FGFR, fibroblast growth factor receptor | Trk, tropomyosin receptor kinase | C-lobe, C-terminal lobe | EGFR, epidermal growth factor receptor | TKD, tyrosine kinase domain | DTT, dithiothreitol | NSCLC, non-small-cell lung cancer | TCEP, tris-(2-carboxyethyl)phosphine | COSMIC, Catalogue Of Somatic Mutations In Cancer | Ni-NTA, Ni2+-nitrilotriacetate | N-lobe, N-terminal lobe | RTK, receptor tyrosine kinase | CDK, cyclin-dependent kinase | IGF1R, insulin-like growth factor 1 receptor | MuSK, muscle-specific kinase | IRK, insulin receptor kinase | Ror, receptor tyrosine kinase-like orphan receptor
Journal Article
The Journal of Pathology, ISSN 0022-3417, 12/2017, Volume 243, Issue 4, pp. 481 - 495
Oesophageal squamous cell carcinomas and oesophageal adenocarcinomas show distinct patterns of ErbB expression and dimers. The functional effects of specific... 
non‐apoptotic blebbing | cell migration | ErbB homodimers | cell invasion | ErbB heterodimers | oesophageal cancer | non-apoptotic blebbing | MIGRATION | PROTEIN OVEREXPRESSION | PATHOLOGY | P63 | CANCER | EGFR | IN-VITRO | ONCOLOGY | HER-2/NEU GENE AMPLIFICATION | EXPRESSION | ASSOCIATION | CARCINOMA | Phosphorylation | Receptor, ErbB-3 - metabolism | Epithelial Cells - metabolism | Receptor, ErbB-2 - genetics | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | ErbB Receptors - genetics | Receptor, ErbB-2 - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Esophageal Neoplasms - pathology | Transfection | Esophageal Neoplasms - metabolism | Cell Differentiation | Protein Interaction Domains and Motifs | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Esophageal Squamous Cell Carcinoma | ErbB Receptors - metabolism | Signal Transduction | Neoplasm Invasiveness | Epithelial Cells - pathology | Receptor, ErbB-3 - genetics | Metabolomics - methods | Esophageal Neoplasms - genetics | Cell Line, Tumor | Protein Binding | Cell Movement | Analysis | Epidermal growth factor | Cytokeratin | Leukocyte migration | Epithelial cells | AKT protein | Activation | Kinases | Carcinogenesis | Cell adhesion & migration | Signal transduction | Carcinogens | Cell activation | Dimerization | Inducers | Squamous cell carcinoma | Epidermal growth factor receptors | ErbB protein | Invasiveness | Cultures | Cell differentiation | Epithelium | Rounding | ErbB-2 protein | Esophagus | Phospholipase C | Phospholipase | Signaling | Dimers | Cell migration | Cancer | Apoptosis | Index Medicus
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 08/2007, Volume 6, Issue 8, pp. 2158 - 2167
Insulin-like growth factor-I receptor (IGF-IR) and its ligands, IGF-I and IGF-II, are up-regulated in a variety of human cancers. In tumors, such as... 
Protein tyrosine kinases | Small Molecules and Other Therapeutics Agents | Autocrine-paracrine signaling | COLORECTAL-CANCER RISK | BREAST-CANCER | SARCOMA-CELLS | ONCOLOGY | PLASMA-LEVELS | IGF-BINDING PROTEIN-3 | FACTOR SYSTEM | ANTIBODY | ANTITUMOR-ACTIVITY | EXPRESSION | TUMORIGENESIS | Receptor, IGF Type 1 - metabolism | Receptor, IGF Type 1 - antagonists & inhibitors | Humans | Pyrazines - administration & dosage | Imidazoles - chemistry | Imidazoles - administration & dosage | Autocrine Communication - drug effects | Antineoplastic Agents - administration & dosage | Imidazoles - pharmacokinetics | Protein Kinase Inhibitors - chemistry | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Protein Kinase Inhibitors - pharmacokinetics | Tumor Stem Cell Assay | Imidazoles - pharmacology | Antineoplastic Agents - chemistry | Enzyme Activation - drug effects | Insulin-Like Growth Factor II - metabolism | Blood Glucose - drug effects | Xenograft Model Antitumor Assays | Protein Kinase Inhibitors - administration & dosage | Pyrazines - chemistry | Animals | Signal Transduction - drug effects | Mice, Nude | Pyrazines - pharmacokinetics | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Colorectal Neoplasms - pathology | Pyrazines - pharmacology | Index Medicus
Journal Article