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NATURE IMMUNOLOGY, ISSN 1529-2908, 10/2012, Volume 13, Issue 10, pp. 991 - 999
Interleukin 17 (IL-17)-producing helper T cells (T(H)17 cells) are often present at the sites of tissue inflammation in autoimmune diseases, which has led to... 
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | TGF-BETA | MULTIPLE-SCLEROSIS | ARYL-HYDROCARBON RECEPTOR | IFN-GAMMA | TRANSFORMING GROWTH-FACTOR-BETA-1 | IL-17-PRODUCING T-CELLS | IMMUNOLOGY | INTERLEUKIN-7 RECEPTOR | CYTOKINE GM-CSF | TH17 CELLS
Journal Article
Nature Immunology, ISSN 1529-2908, 12/2007, Volume 8, Issue 12, pp. 1390 - 1397
Studies have shown that transforming growth factor-beta (TGF-beta) and interleukin 6 (IL-6) are required for the lineage commitment of pathogenic IL-17-... 
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | MULTIPLE-SCLEROSIS | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | TRANSFORMING GROWTH-FACTOR-BETA-1 | IMMUNE PATHOLOGY | HELPER-CELLS | CENTRAL-NERVOUS-SYSTEM | IMMUNOLOGY | CHRONIC INFLAMMATION | TRANSGENIC MICE | CUTTING EDGE
Journal Article
JOURNAL OF CELL BIOLOGY, ISSN 0021-9525, 12/2007, Volume 179, Issue 6, pp. 1311 - 1323
The conjunctive presence of mechanical stress and active transforming growth factor beta 1 (TGF-beta 1) is essential to convert fibroblasts into contractile... 
SMOOTH MUSCLE ACTIN | GROWTH-FACTOR-BETA | INCREASED EXPRESSION | INTEGRIN ALPHA-8-BETA-1 | IN-VIVO | TRANSFORMING GROWTH-FACTOR-BETA-1 | BINDING-PROTEIN | HUMAN LUNG FIBROBLASTS | PULMONARY-FIBROSIS | WOUND REPAIR | CELL BIOLOGY
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 09/2016, Volume 7, Issue 1, p. 12864
It is important to find better treatments for diabetic nephropathy (DN), a debilitating renal complication. Targeting early features of DN, including renal... 
KIDNEY-DISEASE | RENAL FIBROSIS | GROWTH-FACTOR-BETA | LONG NONCODING RNA | MESSENGER-RNA | ER-STRESS | MULTIDISCIPLINARY SCIENCES | TRANSFORMING GROWTH-FACTOR-BETA-1 | GENE-EXPRESSION | BINDING PROTEIN | TRANSCRIPTION FACTOR
Journal Article
NATURE REVIEWS CANCER, ISSN 1474-175X, 07/2006, Volume 6, Issue 7, pp. 506 - 520
Transforming growth factor-beta (TGF beta) signalling regulates cancer through mechanisms that function either within the tumour cell itself or through... 
SIGNAL-TRANSDUCTION | ANTIGEN-EXPRESSION | GROWTH-FACTOR-BETA | TO-MESENCHYMAL TRANSITION | ONCOLOGY | INGESTED APOPTOTIC CELLS | II RECEPTOR | IN-VIVO | STEM-CELL | TRANSFORMING GROWTH-FACTOR-BETA-1 TRANSGENE | MAMMARY EPITHELIAL-CELLS
Journal Article
by Tang, Y and Wu, XW and Lei, WQ and Pang, LJ and Wan, C and Shi, ZQ and Zhao, L and Nagy, TR and Peng, XY and Hu, JB and Feng, X and Van Hul, W and Wan, M and Cao, X
NATURE MEDICINE, ISSN 1078-8956, 07/2009, Volume 15, Issue 7, pp. 757 - U9
Bone remodeling depends on the precise coordination of bone resorption and subsequent bone formation. Disturbances of this process are associated with skeletal... 
MEDICINE, RESEARCH & EXPERIMENTAL | DOMAIN-SPECIFIC MUTATIONS | TGF-BETA | DIFFERENT POPULATIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | SIGNAL-TRANSDUCTION | GROWTH-FACTOR-BETA | CAMURATI-ENGELMANN-DISEASE | LATENCY-ASSOCIATED PEPTIDE | TRANSFORMING GROWTH-FACTOR-BETA-1 | OSTEOGENESIS IMPERFECTA | MICE
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2008, Volume 283, Issue 25, pp. 17003 - 17008
The cytokine, transforming growth factor-beta 1 (TGF-beta 1), converts naive T cells into regulatory T cells that prevent autoimmunity. However, in the... 
TGF-BETA | TOLERANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HELPER-CELLS | TRANSFORMING GROWTH-FACTOR-BETA-1 | T(H)17 | RECEPTOR | GENERATION | DIFFERENTIATION | INDUCTION | IL-21
Journal Article
The Journal of allergy and clinical immunology, ISSN 0091-6749, 9/2016, Volume 138, Issue 3, pp. 791 - 800.e4
Journal Article
by Meng, XM and Tang, PMK and Li, J and Lan, HY
FRONTIERS IN PHYSIOLOGY, ISSN 1664-042X, 03/2015, Volume 6, p. 82
TGF-beta (transforming growth factor-beta) is well identified as a central mediator in renal fibrosis. TGF-beta initiates canonical and non-canonical pathways... 
CRESCENTIC GLOMERULONEPHRITIS | therapeutics | PHYSIOLOGY | DIABETIC-NEPHROPATHY | renal fibrosis | MESENCHYMAL TRANSITION | TGF-beta | GROWTH-FACTOR-BETA | TRANSFORMING GROWTH-FACTOR-BETA-1 | MOUSE MODEL | THERAPEUTIC TARGET | LATENT TGF-BETA-1 | GENE-TRANSFER | Smads mediators | CHRONIC KIDNEY-DISEASE | mechanisms | TGF-β | Smads Mediators | Therapeutics
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 06/2019, Volume 25, Issue 12, pp. 3617 - 3629
Purpose: Because of disease heterogeneity, limited studies on effective chemotherapies and therapeutic agents for advanced gastric cancer are available.... 
EPITHELIAL-MESENCHYMAL TRANSITION | CADHERIN | INACTIVATION | INVASION | PROTEIN-4.1 | ONCOLOGY | PATTERNS | CELL-ADHESION | MECHANISMS | EXPRESSION | GROWTH-FACTOR BETA-1
Journal Article
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 04/2005, Volume 201, Issue 7, pp. 1061 - 1067
Transforming growth factor (TGF)-beta 1 is a major pluripotential cytokine with a pronounced immunosuppressive effect and its deficiency results in lethal... 
MEDICINE, RESEARCH & EXPERIMENTAL | MICE CAUSES | TGF-BETA | DISRUPTION | ENTEROPATHY | TOLERANCE | TRANSCRIPTION FACTOR FOXP3 | MOUSE | INDUCTION | IMMUNOLOGY | TRANSFORMING GROWTH FACTOR-BETA-1 | AUTOIMMUNE-DISEASE
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 04/2019, Volume 139, Issue 4, pp. 940 - 950
We assessed the roles of Smad7 in skin inflammation and wound healing using genetic and pharmacological approaches. In K5.TGFβ1/K5.Smad7 bigenic (double... 
OVEREXPRESSION | PLASMA | TRANSFORMING-GROWTH-FACTOR-BETA-1 | TRANSFORMING GROWTH-FACTOR-BETA-1 | KERATINOCYTES | INDUCTION | DERMATOLOGY
Journal Article
Cell Research, ISSN 1001-0602, 01/2009, Volume 19, Issue 1, pp. 89 - 102
The TGF beta signaling pathway is conserved from flies to humans and has been shown to regulate such diverse processes as cell proliferation, differentiation,... 
Tumor-suppression | Breast cancer | Metastasis | Cytostasis | EMT | Prognostics | SIGNALING PATHWAYS | HUMAN-BREAST-CANCER | TUMOR PROGRESSION | ENHANCES TUMORIGENESIS | cytostasis | MAMMARY-CARCINOMA | breast cancer | CELL-CYCLE ARREST | tumor-suppression | CELL BIOLOGY | SUPPRESSES METASTASIS | metastasis | prognostics | TRANSFORMING GROWTH-FACTOR-BETA-1 | BONE METASTASIS | GROWTH-FACTOR BETA-1
Journal Article