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1. Full Text Growth hormone secretagogues
: basic findings and clinical implications
by Ghigo, E. (Ezio)
1999, 1st ed., ISBN 0444829334, 341
Growth hormone secretagogues (GHS) administered alone or in combination with growth hormone releasing hexapeptides, are effective probes for the diagnosis of... 
physiology | Somatotropin | Somatotropin-Releasing Hormone | Growth hormone releasing factor | Biology, life sciences
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2. Full Text A Linear Fragment of Unacylated Ghrelin (UAG(6-13)) Protects Against Myocardial Ischemia/Reperfusion Injury in Mice in a Growth Hormone Secretagogue Receptor-Independent Manner
by Huynh, DN and Elimam, H and Bessi, VL and Menard, L and Burelle, Y and Granata, R and Carpentier, AC and Ong, H and Marleau, S
FRONTIERS IN ENDOCRINOLOGY, ISSN 1664-2392, 01/2019, Volume 9, p. 798
Unacylated ghrelin (UAG), the most abundant form of ghrelin in circulation, has been shown to exert cardioprotective effect in experimental cardiopathies. The... 
APOPTOSIS | CELLS | cardiac ischemia/reperfusion | isolated heart | CARDIOMYOCYTES | ISOPROTERENOL | hemodynamics | interleukin-6 | DES-ACYL GHRELIN | tumor necrosis factor-alpha | PEPTIDES | METABOLISM | unacylated ghrelin analogs | IN-VIVO | ENDOCRINOLOGY & METABOLISM | growth hormone secretagogue receptor | LIGAND | DESACYL-GHRELIN | Myocardial ischemia | Research | Ghrelin | Reperfusion injury | tumor necrosis factor-α
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3. Full Text Ghrelin: more than endogenous growth hormone secretagogue
by Kojima, Masayasu and Kangawa, Kenji
Annals of the New York Academy of Sciences, ISSN 0077-8923, 07/2010, Volume 1200, Issue 1, pp. 140 - 148
Since its discovery 10 years ago, intensive research has been performed on ghrelin. The significance of ghrelin as a growth hormone-releasing hormone, appetite... 
appetite regulation | ghrelin | growth hormone releasing | ACTIVATED PROTEIN-KINASE | ALPHA-CELLS | CIRCULATING GHRELIN | FOOD-INTAKE | O-ACYLTRANSFERASE | MULTIDISCIPLINARY SCIENCES | BETA-CELLS | NEUROPEPTIDE-Y | ENERGY-BALANCE | PRADER-WILLI-SYNDROME | TRANSGENIC MICE | Animals | Ghrelin - physiology | Growth Hormone-Releasing Hormone - physiology | Mice, Transgenic | Appetite - physiology | Mice | Energy Metabolism - physiology | Mice, Knockout | Somatotropin | Molecular genetics | Somatotropin releasing hormone | Proteases | Growth hormones | Rodents | Regulators | Protease | Precursors | Energy conservation | Transgenic | Hormones | Suppressors
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4. Full Text Heterogeneity of ghrelin/growth hormone secretagogue receptors: Toward the understanding of the molecular identity of novel ghrelin/GHS receptors
by Muccioli, Giampiero and Baragli, Alessandra and Granata, Riccarda and Papotti, Mauro and Ghigo, Ezio
Neuroendocrinology, ISSN 0028-3835, 11/2007, Volume 86, Issue 3, pp. 147 - 164
Ghrelin is a gastric polypeptide displaying strong GH-releasing activity by activation of the type 1a GH secretagogue receptor (GHS-R1a) located in the... 
Ghrelin | Receptor types | Growth hormone secretagogues | Signal Transduction - physiology | Receptors, Ghrelin - physiology | Animals | Hypothalamo-Hypophyseal System - physiology | Humans | Pituitary-Adrenal System - physiology
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5. Full Text Ghrelin Stimulation of Growth Hormone Release and Appetite Is Mediated through the Growth Hormone Secretagogue Receptor
by Yuxiang Sun and Pei Wang and Hui Zheng and Roy G. Smith and Richard D. Palmiter
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2004, Volume 101, Issue 13, pp. 4679 - 4684
Synthetic agonists of the growth hormone secretagogue receptor (GHSR) rejuvenate the pulsatile pattern of GH-release in the elderly, and increase lean but not... 
Appetite | Polymerase chain reaction | Biological Sciences | Receptors | DNA probes | Body fat | Food intake | Exons | Body weight | Mice | Bone density | GASTRIC BYPASS-SURGERY | OBESE SUBJECTS | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | ELDERLY SUBJECTS | PITUITARY | SECRETION | ARCUATE NUCLEUS | MK-677 | EXPRESSION | HYPOTHALAMUS | Body Composition | Peptide Hormones - pharmacology | Body Weight | Bone Density | Fasting | Appetite - drug effects | Receptors, Somatotropin - deficiency | DNA Primers | Reverse Transcriptase Polymerase Chain Reaction | Restriction Mapping | Receptors, Somatotropin - genetics | Mice, Knockout | Animals | Receptors, Somatotropin - physiology | Ghrelin | Base Sequence | Polymerase Chain Reaction | Growth Hormone - secretion | Insulin-Like Growth Factor I - metabolism | Somatotropin | Research | Obesity | Growth hormones | Anatomy & physiology | Older people | GHSR gene | growth hormone secretagogue receptors
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6. Full Text Ghrelin and Growth Hormone (GH) Secretagogues Potentiate GH-Releasing Hormone (GHRH)-Induced Cyclic Adenosine 3′,5′-Monophosphate Production in Cells Expressing Transfected GHRH and GH Secretagogue Receptors
by Cunha, Shane R and Mayo, Kelly E
Endocrinology, ISSN 0013-7227, 12/2002, Volume 143, Issue 12, pp. 4570 - 4582
GHRH stimulates GH secretion from somatotroph cells of the anterior pituitary via a pathway that involves GHRH receptor activation of adenylyl cyclase and... 
PRIMARY PITUITARY-CELLS | PROTEIN-KINASE-C | ACTIVATION | STIMULATION | HEXAPEPTIDE | ADENYLYL-CYCLASE | SOMATOSTATIN | ENDOCRINOLOGY & METABOLISM | GASTRIC-ACID SECRETION | IDENTIFICATION | PEPTIDE | Peptide Hormones - pharmacology | Tetrazoles - pharmacology | Humans | Receptors, Gastrointestinal Hormone - drug effects | Type C Phospholipases - metabolism | Growth Hormone-Releasing Hormone - pharmacology | Type C Phospholipases - antagonists & inhibitors | Recombinant Fusion Proteins | Immunosorbent Techniques | Transfection | Receptors, Cell Surface - drug effects | Vasoactive Intestinal Peptide - pharmacology | Ghrelin | Protein Kinase C - metabolism | Growth Hormone - secretion | Receptors, Cell Surface - physiology | Heterotrimeric GTP-Binding Proteins - physiology | Receptors, Pituitary Hormone-Regulating Hormone - genetics | Receptors, Vasoactive Intestinal Peptide - physiology | Receptors, Ghrelin | Gene Expression | Signal Transduction | Colforsin - pharmacology | Receptors, Gastrointestinal Hormone - physiology | Enzyme Inhibitors - pharmacology | Receptors, G-Protein-Coupled | Rats | Receptors, Neuropeptide - genetics | Protein Kinase C - antagonists & inhibitors | Benzazepines - pharmacology | Receptors, Vasoactive Intestinal Peptide - drug effects | Secretin - pharmacology | Drug Synergism | Hemagglutinins - genetics | Animals | Cyclic AMP - biosynthesis | Fluorescent Antibody Technique | HeLa Cells | Receptors, Cell Surface - genetics
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7. Full Text Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling
by Schellekens, Harriët and Van Oeffelen, Wesley E. P. A and Dinan, Timothy G and Cryan, John F
Journal of Biological Chemistry, ISSN 0021-9258, 01/2013, Volume 288, Issue 1, pp. 181 - 191
G protein-coupled receptors (GPCRs), such as the ghrelin receptor (GHS-R1a), the melanocortin 3 receptor (MC3), and the serotonin 2C receptor (5-HT2C), are... 
CROSS-TALK | SYSTEM | PROTEIN | MESSENGER-RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIGH-AFFINITY | SEROTONIN | GENE-TRANSFER | REWARD | BRAIN | FOOD | Eating | Green Fluorescent Proteins - metabolism | Signal Transduction | Calcium - metabolism | Humans | Receptor, Serotonin, 5-HT2C - metabolism | Gene Expression Regulation | Homeostasis | Feeding Behavior | Ghrelin - metabolism | Microscopy, Fluorescence - methods | Models, Biological | Protein Isoforms | HEK293 Cells | Receptors, Ghrelin - metabolism | Ligands | Dimerization | Obesity | Serotonin 2C Receptor | G Protein-coupled Receptors (GPCR) | Growth Hormone | Serotonin | Neurobiology | Heterodimerization | Dopamine Receptors | Ghrelin Receptor
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8. Full Text Effects of an Oral Growth Hormone Secretagogue in Older Adults
by White, Heidi K and Petrie, Charles D and Landschulz, William and MacLean, David and Taylor, Ann and Lyles, Kenneth and Wei, Jeanne Y and Hoffman, Andrew R and Salvatori, Roberto and Ettinger, Mark P and Morey, Miriam C and Blackman, Marc R and Merriam, George R and Capromorelin Study Grp and Capromorelin Study Group and for the Capromorelin Study Group
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 04/2009, Volume 94, Issue 4, pp. 1198 - 1206
Context: GH secretion declines with age, possibly contributing to reduced muscle mass, strength, and function. GH secretagogues (GHS) may increase muscle mass... 
GHRELIN | MEN | ENDOCRINOLOGY & METABOLISM | PHYSICAL PERFORMANCE | DISABILITY | LOWER-EXTREMITY FUNCTION | BODY-COMPOSITION | FACTOR-I | ELDERLY-PEOPLE | SECRETION | INSULIN SENSITIVITY | Pyrazoles - therapeutic use | Double-Blind Method | Administration, Oral | Humans | Male | Insulin-Like Growth Factor I - secretion | Body Composition - drug effects | Piperidines - therapeutic use | Aged, 80 and over | Placebos | Female | Human Growth Hormone - blood | Aged | Safety | Health Status | Human Growth Hormone - secretion
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9. Full Text Developing new PET tracers to image the growth hormone secretagogue receptor 1a (GHS-R1a)
by Kawamura, Kazunori and Fujinaga, Masayuki and Shimoda, Yoko and Yamasaki, Tomoteru and Zhang, Yiding and Hatori, Akiko and Xie, Lin and Wakizaka, Hidekatsu and Kumata, Katsushi and Ohkubo, Takayuki and Kurihara, Yusuke and Ogawa, Masanao and Nengaki, Nobuki and Zhang, Ming-Rong
Nuclear Medicine and Biology, ISSN 0969-8051, 2017, Volume 52, pp. 49 - 56
Abstract Introduction The growth hormone secretagogue receptor 1a (GHS-R1a) is the orphan G-protein-coupled receptor, and its endogenous ligand is ghrelin.... 
Radiology | GHS-R1a | Growth hormone secretagogue receptor | Ghrelin | PET | SYSTEM | GHRELIN RECEPTOR | OBESITY | PITUITARY | MICE | ANTAGONISTS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PEPTIDE | Tissue Distribution | Radioactive Tracers | Animals | Chemistry Techniques, Synthetic | Heterocyclic Compounds, 1-Ring - chemistry | Heterocyclic Compounds, 1-Ring - pharmacokinetics | Drug Design | Radiochemistry | Receptors, Ghrelin - metabolism | Mice | Positron-Emission Tomography - methods | Heterocyclic Compounds, 1-Ring - chemical synthesis | Methylation | Pets | Somatotropin | Neuroimaging | Neuroprotection | Brain | G protein-coupled receptors | Liver | Indole | Memory | Homeostasis | Small intestine | Learning | Synthesis | Biphenyl | Tomography | Pretreatment | Pancreas | Radioactivity | Food | Carbonyls | Medical imaging | Positron emission | Injection | Addiction | Growth hormones | Growth hormone | Positron emission tomography | Tracers
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10. Full Text Heterogeneity of Ghrelin/Growth Hormone Secretagogue Receptors
by Muccioli, Giampiero and Baragli, Alessandra and Granata, Riccarda and Papotti, Mauro and Ghigo, Ezio
Neuroendocrinology, ISSN 0028-3835, 11/2007, Volume 86, Issue 3, pp. 147 - 164
Ghrelin is a gastric polypeptide displaying strong GH-releasing activity by activation of the type 1a GH secretagogue receptor (GHS-R1a) located in the... 
Paper | GASTRIC-ACID-SECRETION | FOOD-INTAKE | PROTEIN-COUPLED RECEPTORS | growth hormone secretagogues | NEUROSCIENCES | DES-ACYL GHRELIN | receptor types | ghrelin | GROWTH-HORMONE | IN-VIVO | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | MOTILIN-RELATED PEPTIDE | CENTRAL-NERVOUS-SYSTEM | GH-RELEASING HORMONE
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11. Full Text Des-Acyl Ghrelin Induces Food Intake by a Mechanism Independent of the Growth Hormone Secretagogue Receptor
by Toshinai, Koji and Yamaguchi, Hideki and Sun, Yuxiang and Smith, Roy G and Yamanaka, Akihiro and Sakurai, Takeshi and Date, Yukari and Mondal, Muhtashan S and Shimbara, Takuya and Kawagoe, Takashi and Murakami, Noboru and Miyazato, Mikiya and Kangawa, Kenji and Nakazato, Masamitsu
Endocrinology, ISSN 0013-7227, 05/2006, Volume 147, Issue 5, pp. 2306 - 2314
Ghrelin, an acylated peptide produced predominantly in the stomach, stimulates feeding and GH secretion via interactions with the GH secretagogue type 1a... 
ENERGY-BALANCE | PROTEIN | HEALTHY-SUBJECTS | ENDOCRINOLOGY & METABOLISM | OREXIGENIC PEPTIDE | OREXIN | OCTANOYL GHRELIN | ARCUATE NUCLEUS | DESACYL GHRELIN | STOMACH | NEUROPEPTIDE-Y | Peptide Hormones - pharmacology | Receptors, G-Protein-Coupled - metabolism | Calcium - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Stomach - metabolism | Chromatography, High Pressure Liquid | Neuropeptide Y - metabolism | Peptide Hormones - metabolism | Time Factors | Ghrelin | Neurons - metabolism | Receptors, Ghrelin | Movement | Orexins | Peptides - chemistry | Growth Hormone - metabolism | Mice, Inbred C57BL | Proto-Oncogene Proteins c-fos - metabolism | Rats | Feeding Behavior | Neuropeptides - metabolism | Orexin Receptors | Receptors, Neuropeptide | Animals | Hypothalamus - metabolism | Cytosol - metabolism | Mice
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12. Full Text Development of Growth Hormone Secretagogues
by Smith, Roy G
Endocrine Reviews, ISSN 0163-769X, 05/2005, Volume 26, Issue 3, pp. 346 - 360
The GH secretagogues (GHS) were developed by reverse pharmacology. The objective was to develop small molecules with pharmacokinetics suitable for once-daily... 
BONE-MINERAL DENSITY | SYNTHETIC HEXAPEPTIDE | GH-RELEASING HEXAPEPTIDE | ENDOCRINOLOGY & METABOLISM | FOLLICLE-STIMULATING-HORMONE | BIOLOGICAL-ACTIVITIES | FACTOR-I | ARCUATE NUCLEUS | SOMATOSTATIN RECEPTOR | T-CELLS | LUTEINIZING-HORMONE | Tetrazoles - pharmacology | Humans | Molecular Sequence Data | Benzazepines - pharmacology | Peptide Hormones - metabolism | Animals | Hip Fractures - drug therapy | Piperidines - pharmacology | Ghrelin | Base Sequence | Secretory Rate - drug effects | Indoles - pharmacology | Oligopeptides - pharmacology | Human Growth Hormone - secretion | Spiro Compounds - pharmacology
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