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Nature, ISSN 0028-0836, 01/2019, Volume 565, Issue 7740, pp. 511 - 515
.... In addition, the centre of the expanding growth plate becomes hypoxic, and local activation of the hypoxia-inducible transcription factor HIF-1a is necessary for chondrocyte survival by unidentified... 
METASTASIS | MULTIDISCIPLINARY SCIENCES | RESISTANCE | EXTRACELLULAR-MATRIX | MECHANISMS | MICE | GROWTH-FACTOR | PROLYL 4-HYDROXYLASES | BONE | HYPOXIA | CARTILAGE | Hydroxylation | Oxidation-Reduction | Proline - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases - genetics | Extracellular Matrix - metabolism | Glutamine - metabolism | Male | Bone Diseases - metabolism | Cartilage - metabolism | Growth Plate - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases - deficiency | Animals | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Glucose - metabolism | Collagen - biosynthesis | Lysine - metabolism | Mice | Bone Diseases - pathology | Ketoglutaric Acids - metabolism | Chondrocytes - metabolism | Osteogenesis | Cell proliferation | Transcription factors | Collagens | Proline | Biosynthesis | Kinases | Ossification | Proteins | Growth plate | Bone growth | Hypoxia-inducible factor 1a | Bioenergetics | Energy | Bone dysplasia | Extracellular matrix | Oxidation | Skeleton | Bone matrix | Vascular endothelial growth factor | Bone (endochondral) | Biodegradation | Cell survival | Metabolism | Gene expression | Vertebrates | Signaling | Bone mass | Lysine | Protein synthesis | Collagen | Fibrosis | Chondrocytes | Hypoxia | Endoplasmic reticulum | Glutamine | Cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2014, Volume 111, Issue 33, pp. 12097 - 12102
Journal Article
Journal Article
Journal Article
Developmental Cell, ISSN 1534-5807, 03/2012, Volume 22, Issue 3, pp. 597 - 609
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 12/2019, Volume 20, Issue 24, p. 6179
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, p. e0148372
...) has been identified as a key mediator for chondrocytes to response to fluctuations of oxygen availability during cartilage development or repair... 
ENDOCHONDRAL OSSIFICATION | IN-VITRO |