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PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e35513
Background: Recent data indicate the Signal Transducer and Activator of Transcription 3 (STAT3) pathway is required for VEGF production and angiogenesis in... 
BREAST-CANCER CELLS | ACTIVATOR | ENDOTHELIAL-CELLS | BIOLOGY | TRANSCRIPTION-3 | OSTEOSARCOMA | EXPRESSION | TUMORS | GROWTH-SUPPRESSIVE ACTIVITY | PRECLINICAL TESTING PROGRAM | SIGNAL TRANSDUCER | Osteosarcoma - drug therapy | Neovascularization, Physiologic - drug effects | Humans | Actins - metabolism | Anthraquinones - administration & dosage | Angiogenesis Inhibitors - administration & dosage | Microtubules - metabolism | Female | Phosphorylation - drug effects | Myocytes, Smooth Muscle - drug effects | Vascular Endothelial Growth Factor A - pharmacology | Osteosarcoma - metabolism | Cell Survival - drug effects | Angiogenesis Inhibitors - pharmacology | Mice, SCID | Sulfonamides - pharmacology | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Animals | Neovascularization, Pathologic - drug therapy | Cell Line, Tumor | Anthraquinones - pharmacology | Cell Proliferation - drug effects | Mice | Neovascularization, Pathologic - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Sulfonamides - administration & dosage | Endothelial Cells - drug effects | Antimitotic agents | Antineoplastic agents | Vascular endothelial growth factor | Analysis | Pediatrics | Fibroblast growth factor | Phosphorylation | Transcription | Tissue factor | Staining | Smooth muscle | Metastasis | Kinases | Cell adhesion & migration | Anticancer properties | Angiogenesis | Liver cancer | Biomedical materials | Cell growth | Tubulin | Osteosarcoma | Actin | Xenografts | Biocompatibility | Physiology | Inhibition | Growth factors | Plugs | CD34 antigen | Medical research | Wound healing | Fibroblast growth factor 1 | Stat3 protein | Pharmacology | Breast cancer | Endothelial cells | Gelatinase B | Children & youth | Robust control | Bone cancer | Inhibitors | Antiangiogenics | Antitumor activity | Umbilical cord | Molecular biology | Tumors | Apoptosis
Journal Article
Expert Opinion on Drug Discovery, ISSN 1746-0441, 08/2019, Volume 14, Issue 8, pp. 821 - 842
Journal Article
Journal Article
by Wei, CC and Ball, S and Lin, L and Liu, AG and Fuchs, JR and Li, PK and Li, CL and Lin, JY
INTERNATIONAL JOURNAL OF ONCOLOGY, ISSN 1019-6439, 01/2011, Volume 38, Issue 1, pp. 279 - 285
Signal transducers and activators of transcription 3 (STAT3) signaling is persistently activated in many types of cancer cells, and represents a valid target... 
SURVIVAL | APOPTOSIS | ACTIVATION | signal transducers and activators of transcription 3 | CURCUMIN | IL-6 | BREAST-CANCER CELLS | IN-VITRO | THERAPY | ONCOLOGY | SIGNALING PATHWAY | rhabdomyosarcoma | PROTEINS | GROWTH-SUPPRESSIVE ACTIVITY
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 2013, Volume 19, Issue 11, pp. 2047 - 2069
Journal Article
Journal Article
Current Drug Targets, ISSN 1389-4501, 2012, Volume 13, Issue 14, pp. 1799 - 1819
Breast cancer remains the leading cause of cancer death among females worldwide. It signifies a shift from the previous decade during which the most common... 
Molecular targets | Chemotherapy | Breast cancer | Curcumin | Chemoprevention | Curcuminoids | DRUG-DELIVERY | curcuminoids | FACTOR-KAPPA-B | molecular targets | chemotherapy | LUNG METASTASIS | ANTICANCER ACTIVITY | IN-VITRO | chemoprevention | GENE-EXPRESSION | AGENT CURCUMIN | PHARMACOLOGY & PHARMACY | GROWTH-SUPPRESSIVE ACTIVITY | PLGA NANOPARTICLES | curcumin | MAMMARY-GLAND
Journal Article
Scientific Reports, ISSN 2045-2322, 04/2017, Volume 7, Issue 1, p. 46352
Signal transducer and activator of transcription 3 (STAT3) is a well-known antitumor target. Exogenous ROS insult can lead to selective cytotoxicity against... 
LUNG-CANCER | APOPTOSIS | IN-VITRO | VIVO | TRANSCRIPTION 3 STAT3 | PHOSPHORYLATION | SMALL-MOLECULE INHIBITORS | MULTIDISCIPLINARY SCIENCES | TUMOR-CELLS | GROWTH-SUPPRESSIVE ACTIVITY | SIGNAL TRANSDUCER | Reactive Oxygen Species | Antineoplastic Agents - chemical synthesis | Curcumin - chemistry | Humans | Molecular Conformation | Protein Transport - drug effects | Structure-Activity Relationship | Curcumin - chemical synthesis | Benzyl Compounds - chemistry | MCF-7 Cells | Drug Design | Cell Cycle Checkpoints - genetics | Female | Antineoplastic Agents - pharmacology | Molecular Structure | Phosphorylation - drug effects | STAT3 Transcription Factor - metabolism | Disease Models, Animal | Chemistry Techniques, Synthetic | Curcumin - pharmacology | Antineoplastic Agents - chemistry | Molecular Dynamics Simulation | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Benzyl Compounds - pharmacology | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Protein Binding | Cell Proliferation - drug effects | Mice | Molecular Docking Simulation | Benzyl Compounds - chemical synthesis | STAT3 Transcription Factor - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Phosphorylation | Hybrids | Cell survival | Transcription | Epithelial cells | Stat3 protein | Cytotoxicity | Breast cancer | Drug resistance | Nuclear transport | Interleukin 6 | Cell cycle | Antitumor activity | Oxidation | Interferon | Curcumin | Stat1 protein | Deoxyribonucleic acid--DNA | Apoptosis
Journal Article