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Human Molecular Genetics, ISSN 0964-6906, 03/2019, Volume 28, Issue 6, pp. 928 - 941
Abstract Very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is the most common defect of mitochondrial long-chain fatty acid β-oxidation. Patients... 
SUPEROXIDE | FATTY-ACID OXIDATION | JP4-039 | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRIHEPTANOIN TREATMENT | MTP DEFICIENCIES | STRESS-RESPONSE | GENETICS & HEREDITY | GS-NITROXIDE | ENDOPLASMIC-RETICULUM | HYDROGEN-PEROXIDE | General
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2018, Volume 819, pp. 207 - 216
Journal Article
IN VIVO, ISSN 0258-851X, 11/2019, Volume 33, Issue 6, pp. 1757 - 1766
Background/Aim: We tested JP4-039, a GS-nitroxide radiation damage mitigator in proton therapy of Fanconi anemia (FA) mice. Materials and Methods: Fanca(-/-)... 
toxicity | MARROW SUPPRESSION | MEDICINE, RESEARCH & EXPERIMENTAL | HEAD | Fanconi anemia | GS-NITROXIDE JP4-039 | RADIOPROTECTION | DAMAGE | PROTECTS | DELIVERY | mucositis | radiation protector | ORAL-CAVITY MUCOSITIS | proton | Index Medicus
Journal Article
Future Oncology, ISSN 1479-6694, 12/2014, Volume 10, Issue 15, pp. 2345 - 2357
Only two radioprotective compounds, amifostine and palifermin, currently have the US FDA approval for use in radiation therapy. However, several agents have... 
radioprotection | free radical scavengers | growth factors | radiation mitigators | antioxidants | radiation therapy | PROTECTS MICE | GS-NITROXIDE JP4-039 | CONVERTING ENZYME-INHIBITORS | NECK-CANCER | CELL LUNG-CANCER | CATALYTIC METALLOPORPHYRIN ANTIOXIDANT | INDUCED ORAL MUCOSITIS | ONCOLOGY | RANDOMIZED PHASE-II | SUPEROXIDE-DISMUTASE | NORMAL TISSUE-INJURY
Journal Article
IN VIVO, ISSN 0258-851X, 05/2019, Volume 33, Issue 3, pp. 675 - 688
Background/Aim: The cause of fatal neuromuscular amyotrophic lateral sclerosis (ALS) is not known. Materials and Methods: Ninety-day-old... 
MEDICINE, RESEARCH & EXPERIMENTAL | Total body irradiation | ALS | CELL TRANSPLANTATION | MUTANT SUPEROXIDE-DISMUTASE | NLRP3 INFLAMMASOME | marrow origin | spinal cord M2 cells | MOTOR-NEURON DEGENERATION | MOUSE MODEL | DISEASE | NITRIC-OXIDE | GS-NITROXIDE | MUTATIONS
Journal Article
Journal Article
Organic Process Research & Development, ISSN 1083-6160, 01/2012, Volume 16, Issue 1, pp. 26 - 34
Journal Article
IN VIVO, ISSN 0258-851X, 03/2017, Volume 31, Issue 2, pp. 159 - 168
Background/Aim: Total-body irradiation and/or administration of chemotherapy drugs in bone marrow transplantation induce cytokines that can suppress... 
MEDICINE, RESEARCH & EXPERIMENTAL | chemotherapy drugs | mouse bone marrow | STROMAL CELL-LINES | GS-NITROXIDE JP4-039 | SMAD3(-/-) MICE | Fanconi Anemia | CANCER | TRANSPLANTATION | TGF-beta | MMS350 | HEMATOPOIESIS | JP4-039 | RADIORESISTANCE | MALIGNANCIES | total body irradiation | mitigators | molecular radiation | CULTURES | PULMONARY-FIBROSIS
Journal Article
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 02/2018, Volume 150, pp. 169 - 175
Journal Article
Frontiers in Oncology, ISSN 2234-943X, 2014, Volume 4, p. 24
Radiation oncologists have observed variation in normal tissue responses between patients in many instances with no apparent explanation. The association of... 
GS-nitroxide | Mitochondria | Fanconi anemia | Radioprotectors | Clinical radiosensitivity | Fanconi Anemia | Clinical Radiosensitivity | GS-Nitroxide
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2016, Volume 95, Issue 3, pp. 1032 - 1041
Journal Article
Strahlentherapie und Onkologie, ISSN 0179-7158, 8/2014, Volume 190, Issue 8, pp. 745 - 752
Journal Article
Radiation Research, ISSN 0033-7587, 2013, Volume 180, Issue 5, pp. 474 - 490
A water-soluble ionizing radiation mitigator would have considerable advantages for the management of acute and chronic effects of ionizing radiation. We... 
GS-NITROXIDE JP4-039 | ACUTE LUNG INJURY | IRRADIATION | ENGRAFTMENT | TOTAL-BODY | BIOPHYSICS | INFLAMMATION | BIOLOGY | NRF2 PROTECTS | MNSOD-PL | GENE-THERAPY | MICE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Safrole - administration & dosage |