X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (1426) 1426
Publication (177) 177
Book Chapter (43) 43
Dissertation (20) 20
Book Review (15) 15
Conference Proceeding (4) 4
Government Document (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (723) 723
animals (605) 605
gsk-3β (541) 541
humans (502) 502
gsk-3 (466) 466
gsk-3 beta (431) 431
glycogen synthase kinase 3 - metabolism (427) 427
phosphorylation (382) 382
glycogen synthase kinase 3 beta (329) 329
biochemistry & molecular biology (327) 327
glycogen synthase kinase 3 - antagonists & inhibitors (326) 326
glycogen-synthase kinase-3 (316) 316
mice (271) 271
neurosciences (271) 271
apoptosis (258) 258
cell biology (244) 244
rats (228) 228
male (215) 215
beta-catenin (208) 208
pharmacology & pharmacy (196) 196
alzheimers-disease (194) 194
glycogen (191) 191
activation (174) 174
alzheimer's disease (170) 170
expression (169) 169
chemistry, medicinal (168) 168
signal transduction (162) 162
signal transduction - drug effects (160) 160
lithium (153) 153
enzyme inhibitors - pharmacology (149) 149
cell line, tumor (144) 144
synthesis (142) 142
kinases (141) 141
akt (139) 139
glycogen-synthase kinase-3-beta (139) 139
oncology (137) 137
glycogen synthase kinase 3 (132) 132
protein kinase inhibitors - pharmacology (126) 126
inhibition (125) 125
cells, cultured (123) 123
cancer (116) 116
proto-oncogene proteins c-akt - metabolism (112) 112
β-catenin (108) 108
protein-kinase (107) 107
proteins (104) 104
apoptosis - drug effects (103) 103
article (100) 100
phosphorylation - drug effects (97) 97
glycogen synthase kinase 3 - genetics (96) 96
beta catenin - metabolism (94) 94
dose-response relationship, drug (94) 94
oxidative stress (93) 93
rats, sprague-dawley (92) 92
gsk-3 inhibitors (91) 91
glycogen synthase kinase 3 beta - metabolism (90) 90
female (87) 87
cell line (86) 86
inhibitors (86) 86
pathway (84) 84
disease models, animal (82) 82
brain (80) 80
analysis (76) 76
growth (76) 76
neurons - drug effects (74) 74
blotting, western (73) 73
kinase (72) 72
neurons (72) 72
phosphatidylinositol 3-kinases - metabolism (72) 72
structure-activity relationship (72) 72
macromolecular substances (71) 71
neurology (71) 71
nf-kappa-b (71) 71
chemistry, organic (70) 70
signal transduction - physiology (70) 70
biophysics (69) 69
cell proliferation - drug effects (69) 69
cells (69) 69
tau (69) 69
glycogen synthase kinase-3 (68) 68
indoles - pharmacology (68) 68
wnt (68) 68
tau proteins - metabolism (65) 65
mice, inbred c57bl (64) 64
in-vitro (63) 63
proliferation (63) 63
research (63) 63
protein kinase inhibitors - chemistry (62) 62
alzheimer’s disease (57) 57
cell proliferation (57) 57
neuroprotective agents - pharmacology (57) 57
cell survival - drug effects (56) 56
inflammation (56) 56
chemistry, multidisciplinary (55) 55
neurodegeneration (55) 55
neuroprotection (55) 55
signaling pathway (55) 55
in-vivo (54) 54
insulin (54) 54
protein (54) 54
glycogen synthase kinase 3 beta - antagonists & inhibitors (52) 52
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (1474) 1474
Chinese (6) 6
Japanese (3) 3
Russian (3) 3
German (2) 2
French (1) 1
Spanish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Medicinal Research Reviews, ISSN 0198-6325, 01/2013, Volume 33, Issue 1, pp. 139 - 189
With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes an overwhelming health, social, economic, and political problem to... 
antioxidant drugs | CDK5 inhibitors | anti‐inflammatory drugs | AChE peripheral anionic site | CK‐1 inhibitors | ERK2‐inhibitors | overload | BACE‐1 inhibitors | amyloid–β antiaggregating agents | dyshomeostasis | NSAIDs | neuroprotection | multitarget drugs | GSK‐3β inhibitors | dual AChE inhibitors | metal chelators | Alzheimer's disease | oxidative stress | multiactive compounds | 1,4‐dihydropyridines | voltage‐dependent calcium channels | Neuroprotection | Oxidative stress | Dual AChE inhibitors | Anti-inflammatory drugs | GSK-3β inhibitors | Antioxidant drugs | Metal chelators | Multitarget drugs | Voltage-dependent calcium channels | CK-1 inhibitors | BACE-1 inhibitors | 1,4-dihydropyridines | ERK2-inhibitors | Multiactive compounds | Amyloid-β antiaggregating agents | GSK-3 ss inhibitors | anti-inflammatory drugs | Ca2+ dyshomeostasis | voltage-dependent calcium channels | TYROSINE KINASE INHIBITOR | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | POTENT ACETYLCHOLINESTERASE INHIBITORS | amyloid-ss antiaggregating agents | M1 MUSCARINIC AGONISTS | CHEMISTRY, MEDICINAL | AMYLOID PRECURSOR PROTEIN | MOLECULAR MODELING INVESTIGATIONS | HERPES-SIMPLEX-VIRUS | TACRINE-DIHYDROPYRIDINE HYBRIDS | PERIPHERAL ANIONIC SITE | NMDA RECEPTOR ANTAGONIST | Ca2+ overload | Calcium Channels - metabolism | Humans | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | tau Proteins - metabolism | Receptors, N-Methyl-D-Aspartate | Alzheimer Disease - enzymology | Enzyme Inhibitors - therapeutic use | Disease Progression | Alzheimer Disease - pathology | Amyloid Precursor Protein Secretases - metabolism | Butyrylcholinesterase - metabolism | Amyloid beta-Peptides - metabolism | Ligands | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Binding Sites | Acetylcholinesterase - metabolism | Care and treatment | Calcium channels | Glycogen | Development and progression | Glutamate | Target marketing | Antioxidants | Methyl aspartate | Enzyme inhibitors | Synthesis | Surface active agents | Drug therapy | Cancer
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2009, Volume 17, Issue 5, pp. 2017 - 2029
Design, synthesis and structure–activity relationships of novel oxadiazole derivatives as GSK-3β inhibitors are reported. Glycogen synthase kinase-3β (GSK-3β)... 
GSK-3β | Oxadiazole | Drug design | Alzheimer’s disease | Alzheimer's disease | ALZHEIMER-DISEASE | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | GSK-3-BETA | CHEMISTRY, ORGANIC | POTENT INHIBITORS | TAU-HYPERPHOSPHORYLATION | FILAMENTS | SELECTIVE INHIBITORS | THERAPIES | GSK-3 beta | BRAIN | TRANSGENIC MICE
Journal Article
FRONTIERS IN MOLECULAR NEUROSCIENCE, ISSN 1662-5099, 2011, Volume 4, p. 32
Inhibiting glycogen synthase kinase-3 (GSK-3) activity via pharmacological intervention has become an important strategy for treating neurodegenerative and... 
WNT SIGNALING PATHWAY | PROTEIN-KINASE | ALZHEIMERS-DISEASE | GLYCOGEN-SYNTHASE KINASE-3 | protein kinases | CNS | NEURONAL CELL-DEATH | GSK-3 | NEUROSCIENCES | BETA-CATENIN STABILIZATION | CYCLIN-DEPENDENT KINASES | SMALL-MOLECULE INHIBITORS | EMBRYONIC STEM-CELLS | GSK-3 inhibitors | INSULIN-MIMETIC ACTION | protein kinase
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 04/2019, Volume 167, pp. 211 - 225
To target the multi-facets of Alzheimer's disease (AD), a series of novel GSK-3β inhibitors containing the 2,3-diaminopyridine moiety were designed and... 
Multifunctional agents | Antioxidant | Alzheimer's disease | GSK-3β inhibitors | Metal chelator | TARGET | OXIDATIVE STRESS | DESIGN | CHEMISTRY, MEDICINAL | GLYCOGEN-SYNTHASE KINASE-3 | DIRECTED LIGANDS | GSK-3 beta inhibitors | DISCOVERY | PREDICTION | A beta | HYPOTHESIS | THERAPEUTIC STRATEGIES | DERIVATIVES
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2019, Volume 164, pp. 448 - 470
Glycogen Synthase Kinase-3 (GSK-3) is a constitutively dynamic, omnipresent serine/threonine protein kinase regularly called as a “multitasking kinase” due to... 
GSK-3β | Synthetic analogs | SAR | Molecular docking | CHEMISTRY, MEDICINAL | GSK3 INHIBITOR | THERAPEUTIC STRATEGY | ALZHEIMERS-DISEASE | KINASE 3-BETA INHIBITORS | SELECTIVE GSK-3-BETA INHIBITORS | TAU PHOSPHORYLATION | IN-VITRO | SMALL-MOLECULE INHIBITORS | BIOLOGICAL EVALUATION | GSK-3 beta | STRUCTURE-BASED DESIGN
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2016, Volume 107, pp. 63 - 81
Journal Article