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JOURNAL OF NATURAL PRODUCTS, ISSN 0163-3864, 07/2019, Volume 82, Issue 7, pp. 1979 - 1988
Alzheimer's disease (AD) is a neurodegenerative disease and a common cause of dementia, manifesting as progressive memory loss and cognitive decline.... 
CELLS | CHEMISTRY, MEDICINAL | GSK-3-BETA | NEURONS | PHARMACOLOGY & PHARMACY | ACCUMULATION | PLANT SCIENCES
Journal Article
CELL DEATH & DISEASE, ISSN 2041-4889, 05/2018, Volume 9, Issue 6, p. 655
Alzheimer's disease (AD) is a dreadful neurodegenerative disease that leads to severe impairment of cognitive function, leading to a drastic decline in the... 
MIGRATION | ACTIVATION | GSK-3-BETA | HYPERPHOSPHORYLATION | MECHANISMS | AMYLOID PRECURSOR PROTEIN | KINASE-I | EXPRESSION | HDAC6 | TAUOPATHIES | CELL BIOLOGY
Journal Article
Science, ISSN 0036-8075, 5/2008, Volume 320, Issue 5876, pp. 667 - 670
Glycogen synthase kinase 3β (GSK3β) is involved in metabolism, neurodegeneration, and cancer. Inhibition of GSK3β activity is the primary mechanism that... 
Proteins | Phosphorylation | Thymocytes | Spleen cells | Transgenic animals | Glycogen | Stem cells | Actins | Reports | Cellular immunity | Grants | CELLS | KINASE PATHWAY | ACTIVATION | PROTEIN | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GSK-3-BETA | C-MYC | CHECKPOINT | BETA-CATENIN | PROGRESSION
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2018, Volume 144, pp. 843 - 858
Glycogen Synthase Kinase-3 (GSK-3) is a serine/threonine kinase which is ubiquitously expressed and is regarded as a regulator for various cellular events and... 
GSK-3 inhibitors | Diabetes | Neurodegeneration | Alzheimer's | Cancer | DESIGN | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | NATURAL-PRODUCTS | GSK3 INHIBITORS | SELECTIVE GSK-3-BETA INHIBITORS | 3-BETA | IN-VITRO | BIOLOGICAL EVALUATION | DRUG TARGET | DERIVATIVES
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 2006, Volume 24, Issue 4, pp. 627 - 633
Glycogen synthase kinase 3 (GSK3), a key component of the insulin and wnt signaling pathways, is unusual, as it is constitutively active and is inhibited in... 
PROTEINS | SIGNALING | TRANSFORMATION | TYROSINE PHOSPHORYLATION | MECHANISM | GSK3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLYCOGEN-SYNTHASE KINASE-3 | GSK-3-BETA | INHIBITORS | IDENTIFICATION | CELL-FATE SPECIFICATION | PHOSPHORYLATION SITES | CELL BIOLOGY
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 06/2010, Volume 30, Issue 26, pp. 8852 - 8864
Neuronal migration is an essential process for the development of the cerebral cortex. We have previously shown that LKB1, an evolutionally conserved polarity... 
IN-VITRO | PROTEIN | EPITHELIAL-CELLS | APC | POLARITY | MICROTUBULES | DYNEIN | CELL-MIGRATION | GSK-3-BETA | POLARIZATION | NEUROSCIENCES
Journal Article
JOURNAL OF NEUROCHEMISTRY, ISSN 0022-3042, 11/2015, Volume 135, Issue 3, pp. 630 - 637
We recently found that sAPP decreases amyloid-beta generation by directly associating with -site amyloid precursor protein (APP)-converting enzyme 1 (BACE1),... 
SECRETASE | BRAIN-INJURY | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GSK-3-BETA | tau | NEURONAL LOSS | CLEAVAGE | NEUROSCIENCES | BACE1 | GLYCOGEN-SYNTHASE KINASE-3-BETA | GSK3 | HYPOTHESIS | GENERATION | sAPP | Alzheimer's disease | TRANSGENIC MICE | Enzymes | Synthesis | Glycogen | Amyloid beta-protein | Proteins | Phosphorylation | Kinases | Alzheimers disease
Journal Article
by Zhao, JH and Li, XH and Chen, XJ and Cai, YJ and Wang, Y and Sun, WJ and Mai, H and Yang, JQ and Fan, WH and Tang, P and Ou, MQ and Zhang, Y and Huang, XM and Zhao, B and Cui, LL
JOURNAL OF CELLULAR PHYSIOLOGY, ISSN 0021-9541, 07/2019, Volume 234, Issue 7, pp. 10411 - 10420
G protein-coupled receptor kinase 5 (GRK5) is a serine/threonine kinase whose dysfunction results in cognitive impairment and Alzheimer-like pathology,... 
DEFICIENCY LEADS | PHYSIOLOGY | PROTEIN | COUPLED RECEPTOR KINASES | GSK-3-BETA | INVOLVEMENT | BETA AGGREGATION | tau | ALPHA-SYNUCLEIN | NEUROTOXICITY | CELL BIOLOGY | GRK5 | GSK3 | HYPERPHOSPHORYLATION | Alzheimer's disease | TRANSGENIC MICE | Genetic engineering | Synthesis | Glycogen
Journal Article
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 09/2018, Volume 54, Issue 71
A reagent generated from TMSN3/KMnO4/BnEt3NCl was found to promote an S(H)2' radical azidation of a bromo silyl enol ether to furnish an azido silyl enol ether... 
ORGANIC-SYNTHESIS | INHIBITION | ABSOLUTE-CONFIGURATION | FORMAL SYNTHESIS | ENOL ETHERS | GSK-3-BETA | ALKYNYLIODONIUM SALTS | FACILE ISOMERIZATION | CHEMISTRY, MULTIDISCIPLINARY | CORAL SEA | SPONGE AGELAS-DENDROMORPHA
Journal Article
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 08/2018, Volume 66, Issue 30, pp. 7899 - 7906
Feedstuffs are severely contaminated by zearalenone (ZEA) worldwide. A specific dietary level of ZEA could cause malformations of the reproductive organs of... 
Wnt-1/β-catenin | zearalenone | post-weaning piglets | ovaries | estrogen receptors | PIGS | APOPTOSIS | CELLS | REPRODUCTIVE-SYSTEM | FOOD SCIENCE & TECHNOLOGY | GSK-3-BETA | TOXICITY | GLYCOGEN-SYNTHASE KINASE-3-BETA | Wnt-1/beta-catenin | METABOLISM | AGRICULTURE, MULTIDISCIPLINARY | MICE | CHEMISTRY, APPLIED | WNT/BETA-CATENIN PATHWAY
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 2013, Volume 33, Issue 1, pp. S141 - S144
Journal Article
by Xiong, T and Tang, J and Zhao, J and Chen, H and Zhao, F and Li, J and Qu, Y and Ferriero, D and Mu, D
NEUROSCIENCE, ISSN 0306-4522, 08/2012, Volume 216, pp. 123 - 132
Akt has been demonstrated as a survival kinase in brain after hypoxia-ischemia (HI). Previous studies have shown that glycogen synthase kinase-3 beta (GSK-3... 
APOPTOSIS | hypoxia-ischemia | ACTIVATION | PHOSPHORYLATION | GLYCOGEN-SYNTHASE KINASE-3 | GSK-3-BETA | neonatal | AKT | brain | NEUROSCIENCES | DEGENERATION | INHIBITION | NEURONAL POLARITY | axon | injury
Journal Article
JOURNAL OF CELLULAR PHYSIOLOGY, ISSN 0021-9541, 07/2019, Volume 234, Issue 7, pp. 10698 - 10708
Long noncoding RNAs (lncRNAs) are considered as regulators of gene expression in cancers. However, cancer profiling has little focused on noncoding genes.... 
GLYCOGEN-SYNTHASE-KINASE-3-BETA | CELLS | LOCALIZATION | PHYSIOLOGY | proliferation | LONG NONCODING RNAS | GSK-3-BETA | breast cancer | glycogen | OPPORTUNITIES | CHALLENGES | CELL BIOLOGY | INACTIVATION | long noncoding RNA | migration | synthase kinase 3 | EXPRESSION | Synthesis | Glycogen | Genes | Development and progression | Antisense RNA | Breast cancer | Metastasis | Gene expression
Journal Article
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, ISSN 0021-8561, 09/2019, Volume 67, Issue 37, pp. 10285 - 10295
Fluoride (F) is capable of promoting abnormal proliferation and differentiation in primary cultured mouse osteoblasts (OB cells), although the underlying... 
proliferation | FOOD SCIENCE & TECHNOLOGY | GSK-3-BETA | fluoride | MECHANISMS | BETA-CATENIN | CANCER | CULTURE | Wnt/beta-catenin signaling pathway | INHIBITION | Ca2 | AGRICULTURE, MULTIDISCIPLINARY | osteoblasts | BONE | DIFFERENTIATION | CHEMISTRY, APPLIED | EXPRESSION | PROMOTES
Journal Article
by Zeng, C and Jiang, W and Yang, XY and He, CH and Wang, W and Xing, JG
SCIENTIFIC REPORTS, ISSN 2045-2322, 11/2018, Volume 8
We previously demonstrated the cardio-protection mediated by the total flavonoid extracted from Dracocephalum moldavica L. (TFDM) following myocardial ischemia... 
PERMEABILITY TRANSITION PORE | PI3K/AKT PATHWAY | IN-VITRO | ACTIVATION | INHIBITION | H9C2 CARDIOMYOCYTES | MULTIDISCIPLINARY SCIENCES | INDUCED CARDIOPROTECTION | GSK-3-BETA | MYOCARDIAL ISCHEMIA/REPERFUSION INJURY | PROTECTS
Journal Article
Autophagy, ISSN 1554-8627, 07/2017, Volume 13, Issue 7, pp. 1221 - 1234
Parkinson disease (PD) is a life-threatening neurodegenerative movement disorder with unmet therapeutic intervention. We have identified a small molecule... 
autophagy | TH | neurodegeneration, SNCA | high-throughput screening | MPTP | autolysosomes | 6-Bio | NEURODEGENERATIVE DISEASE | PROTEIN | GLYCOGEN-SYNTHASE KINASE-3 | GSK-3-BETA | DOPAMINERGIC-NEURONS | SUBSTANTIA-NIGRA | CELL BIOLOGY | MOUSE MODEL | MICE | INHIBITORS | PARKINSONS-DISEASE
Journal Article
by Zhu, LY and Yang, NH and Du, GQ and Li, CC and Liu, GQ and Liu, SJ and Xu, YJ and Di, YA and Pan, W and Li, X
JOURNAL OF CELLULAR BIOCHEMISTRY, ISSN 0730-2312, 02/2019, Volume 120, Issue 2, pp. 1156 - 1164
Colorectal neoplasia differentially expressed (CRNDE) is a significantly upregulated long noncoding RNA in hepatocellular carcinoma (HCC). CRNDE could promote... 
MIGRATION | METASTASIS | CANCER CELLS | colorectal neoplasia differentially expressed (CRNDE) | BIOCHEMISTRY & MOLECULAR BIOLOGY | GSK-3-BETA | hepatocellular carcinoma (HCC) | PROLIFERATION | EMT | SUFFICIENT | CELL BIOLOGY | epithelial-mesenchymal transition (EMT) | catenin signaling pathway | INVASION | Wnt | EXPRESSION | NONCODING RNA CRNDE | Stem cells | Hepatoma
Journal Article
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