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Molecular Carcinogenesis, ISSN 0899-1987, 10/2017, Volume 56, Issue 10, pp. 2301 - 2316
Although GSK3β has been reported to have contrasting effects on the progression of different tumors, it's possible functions in esophageal squamous cell... 
GSK3β | PI3‐kinase | esophageal cancer | STAT3 | PI3-kinase | CANCER-CELLS | SURVIVAL | ACTIVATION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | BREAST-CANCER | ONCOLOGY | GSK3 | SIGNALING PATHWAY | GSK3-BETA | EXPRESSION | EPIDEMIOLOGY | Up-Regulation | Phosphorylation | Prognosis | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Gene Expression Regulation, Neoplastic | Male | Esophageal Neoplasms - pathology | Lithium Chloride - pharmacology | Esophageal Neoplasms - metabolism | Female | STAT3 Transcription Factor - metabolism | Esophageal Squamous Cell Carcinoma | Cell Survival - drug effects | Tyrphostins - pharmacology | Glycogen Synthase Kinase 3 beta - metabolism | Disease Progression | Cell Movement - drug effects | Animals | Signal Transduction - drug effects | Survival Analysis | Cell Line, Tumor | Mice | Pyridines - pharmacology | Development and progression | Squamous cell carcinoma | Synthesis | Glycogen | Analysis | Esophageal cancer | Leukocyte migration | Lithium chloride | Kinases | Tissues | Metastases | Cell adhesion & migration | Xenografts | Inhibition | Data analysis | Stat3 protein | Glycogen synthase kinase 3 | Data processing | Pharmacology | siRNA | Esophagus | Molecular modelling | Inhibitors | Cell lines | Differentiation | Viability | In vitro methods and tests | Cell migration | Tumors | Cancer | Esophageal Cancer | PI3-Kinase
Journal Article
Journal Article
Journal Article
by Ali, T and Kim, MO
JOURNAL OF PINEAL RESEARCH, ISSN 0742-3098, 08/2015, Volume 59, Issue 1, pp. 47 - 59
Alzheimer's disease (AD) is the most prevalent age-related neurodegenerative disease, pathologically characterized by the accumulation of amyloid beta (A)... 
OXIDATIVE STRESS | PHYSIOLOGY | Tau hyperphosphorylation | INDUCED SYNAPTIC DYSFUNCTION | ALZHEIMERS-DISEASE | TRANSGENIC MOUSE | neurodegeneration | Akt | NEUROSCIENCES | GSK3 signaling | synaptic disorder | SIGNALING PATHWAY | A(1-42) | IN-VIVO | ENDOCRINOLOGY & METABOLISM | PI3 | LONG-TERM POTENTIATION | RAT-BRAIN | INDUCED NEUROTOXICITY | PRECURSOR PROTEIN | melatonin | Brain | Melatonin | Analysis
Journal Article
Journal Article
Oncogene, ISSN 0950-9232, 10/2012, Volume 31, Issue 41, pp. 4472 - 4483
Elevated levels of the oncoprotein, osteopontin (OPN), are associated with poor outcome of several types of cancers including melanoma. We have previously... 
SPP1 | GSK3b | cancer | PP2A | DNAJB6 | OPN | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN PHOSPHATASE 2A | CELL BIOLOGY | BREAST-CANCER | METASTATIC MELANOMA | J-DOMAIN | ONCOLOGY | MRJ CO-CHAPERONE | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | GSK3 beta | WNT | EXPRESSION | T-CELLS | PROGRESSION | Osteopontin - genetics | Neoplasm Transplantation | Okadaic Acid - pharmacology | Phosphorylation | Molecular Chaperones - metabolism | Oligonucleotide Array Sequence Analysis | HSC70 Heat-Shock Proteins - metabolism | Humans | Lymphoid Enhancer-Binding Factor 1 - genetics | Gene Expression Regulation, Neoplastic | Transcriptome | Glycogen Synthase Kinase 3 beta | Osteopontin - metabolism | Epithelial-Mesenchymal Transition | Female | Transcription, Genetic | Protein Interaction Domains and Motifs | T Cell Transcription Factor 1 - metabolism | Melanoma - metabolism | Protein Structure, Tertiary | Skin Neoplasms - pathology | HSP40 Heat-Shock Proteins - metabolism | Nerve Tissue Proteins - physiology | HSP40 Heat-Shock Proteins - genetics | Protein Phosphatase 2 - antagonists & inhibitors | Down-Regulation | Molecular Chaperones - genetics | Glycogen Synthase Kinase 3 - metabolism | Lymphoid Enhancer-Binding Factor 1 - metabolism | Molecular Chaperones - physiology | Nerve Tissue Proteins - genetics | beta Catenin - metabolism | Melanoma - secondary | Skin Neoplasms - metabolism | T Cell Transcription Factor 1 - genetics | Nerve Tissue Proteins - metabolism | Animals | Mice, Nude | HSP40 Heat-Shock Proteins - physiology | Protein Phosphatase 2 - metabolism | Cell Line, Tumor | Protein Binding | Mice | Protein Processing, Post-Translational | Transcription | Wnt protein | Tumor cells | catenin | Melanoma | Glycogen synthase kinase 3 | Heat shock proteins | Osteopontin | Lymphocytes T | Malignancy | Tcf protein | Chaperones | Dephosphorylation | Hsp40 protein | protein phosphatase | LEF protein | Enhancers | Hsc70 protein | Cancer | Tumors | GSK3β
Journal Article
中国药理学报:英文版, ISSN 1671-4083, 2017, Volume 38, Issue 2, pp. 241 - 251
Journal Article
JOURNAL OF PINEAL RESEARCH, ISSN 0742-3098, 05/2018, Volume 64, Issue 4
Melatonin is involved in the physiological regulation of the beta-amyloid precursor protein (beta APP)-cleaving secretases which are responsible for generation... 
PHYSIOLOGY | ALZHEIMERS-DISEASE | secretase | MECHANISMS | AMYLOID PRECURSOR PROTEIN | TRANSGENIC MODEL | NEUROSCIENCES | TAU PHOSPHORYLATION | OVEREXPRESSION | NF-kappa B | ENDOCRINOLOGY & METABOLISM | PROLYL ISOMERASE PIN1 | NEURONS | Pin1 | GSK3 beta | melatonin | NF-KAPPA-B | EXPRESSION | Alzheimer's
Journal Article
DEVELOPMENT, ISSN 0950-1991, 07/2019, Volume 146, Issue 13
The central regulator of the Wnt/beta-catenin pathway is the Axin/APC/GSK3 beta destruction complex (DC), which, under unstimulated conditions, targets... 
ACTIVATION | Axin | Drosophila | DEVELOPMENTAL BIOLOGY | Destruction complex | LONG-RANGE ACTION | Wnt signaling | WINGLESS PROTEIN | APC | GSK3 | PATHWAY | COLOCALIZATION | beta-Catenin | TUMOR-SUPPRESSOR
Journal Article
Journal Article
Journal Article
世界胃肠病学杂志:英文版, ISSN 1007-9327, 2015, Volume 21, Issue 4, pp. 1148 - 1157
AIM: To develop a safe and effective agent for cholangiocarcinoma(CCA) chemotherapy. METHODS: A drug combination experiment was conducted to determine the... 
β-escin;Multi-drug | resistance;P-glycoprotein;GSK3β | P-glycoprotein | GSK3β | Multi-drug resistance | β escin | Cholangiocarcinoma | CELLS | APOPTOSIS | PHOSPHORYLATION | GLYCOGEN-SYNTHASE KINASE-3 | PROLIFERATION | KAPPA-B | beta-escin | CANCER | DISEASES | GENE-EXPRESSION | GSK3 beta | GASTROENTEROLOGY & HEPATOLOGY | Vincristine - pharmacology | Phosphorylation | Drug Resistance, Multiple - drug effects | Humans | Gene Expression Regulation, Neoplastic | Glycogen Synthase Kinase 3 beta | Bile Duct Neoplasms - enzymology | RNA, Messenger - metabolism | Bile Ducts, Intrahepatic - drug effects | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Transfection | Escin - pharmacology | Bile Duct Neoplasms - genetics | Genes, Reporter | Cholangiocarcinoma - enzymology | Bile Ducts, Intrahepatic - pathology | Glycogen Synthase Kinase 3 - metabolism | beta Catenin - metabolism | Bile Ducts, Intrahepatic - enzymology | beta Catenin - genetics | Mitomycin - pharmacology | Cholangiocarcinoma - pathology | Glycogen Synthase Kinase 3 - genetics | Signal Transduction - drug effects | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Cell Line, Tumor | Cholangiocarcinoma - genetics | Cell Proliferation - drug effects | Fluorouracil - pharmacology | Bile Duct Neoplasms - pathology | ATP Binding Cassette Transporter, Sub-Family B - genetics | Drug Resistance, Neoplasm - drug effects | Basic Study | β-escin
Journal Article
NEUROCHEMICAL RESEARCH, ISSN 0364-3190, 03/2017, Volume 42, Issue 3, pp. 918 - 924
Glioblastoma (GBM) is the most aggressive of primary brain tumors. Despite the progress in understanding the biology of the pathogenesis of glioma made during... 
GLIOMA-CELLS | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | Glioblastoma | GLYCOGEN-SYNTHASE KINASE-3 | C-MYC | GROWTH-RELATED VARIATIONS | AKT | ENZASTAURIN PLUS TEMOZOLOMIDE | NEUROSCIENCES | Therapeutic target | RADIATION-THERAPY | STEM-LIKE CELLS | MALIGNANT GLIOMAS | GSK3 beta | PHASE-I
Journal Article