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Nature, ISSN 0028-0836, 02/2003, Volume 421, Issue 6924, pp. 753 - 756
Cell polarity is a fundamental property of all cells. In higher eukaryotes, the small GTPase Cdc42, acting through a Par6-atypical protein kinase C (aPKC)... 
COMPLEX | ACTIVATION | PHOSPHORYLATION | MICROTUBULES | DYNEIN | MULTIDISCIPLINARY SCIENCES | XENOPUS EMBRYOS | GSK3-BETA | C-ELEGANS | BINDING | PROTEIN EB1
Journal Article
SCIENCE, ISSN 0036-8075, 03/2000, Volume 287, Issue 5458, pp. 1606 - 1609
The Wnt cell-cell signaling pathway plays a critical and evolutionarily conserved role in directing cell fates during embryogenesis. In addition, inappropriate... 
PATHWAYS | AXIN | PROTEIN | APC | POLARITY | MULTIDISCIPLINARY SCIENCES | GSK3-BETA | BETA-CATENIN | NEGATIVE REGULATOR
Journal Article
BLOOD, ISSN 0006-4971, 07/2019, Volume 134, Issue 4, pp. 363 - 373
Targeting the B-cell receptor and phosphatidylinositol 3-kinase/mTOR signaling pathways has shown meaningful, but incomplete, antitumor activity in lymphoma.... 
INHIBITION | PANCREATIC-CANCER | GSK3-BETA | GSK-3 | LEUKEMIA | DIFFERENTIATION | ACCUMULATION | CELL-SURVIVAL | HEMATOLOGY | KINASE-3-BETA | EXPRESSION
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2018, Volume 24, Issue 17, pp. 4332 - 4345
Purpose: Prostate cancer translational research has been hampered by the lack of comprehensive and tractable models that represent the genomic landscape of... 
ORGANOID CULTURES | INACTIVATION | CELLS | TUMOR XENOGRAFTS | EVOLUTION | ONCOLOGY | PHOSPHORYLATION | GSK3-BETA | KINASE INHIBITORS | MAP | MOUSE MODELS | patient-derived-xenografts | prostate cancer | LuCaP | organoids
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 11/2018, Volume 29, Issue 11, pp. 2658 - 2670
Background The bile acid-activated receptors, including the membrane G protein-coupled receptor TGR5 and nuclear farnesoid X receptor (FXR), have roles in... 
KIDNEY-DISEASE | PHYSIOLOGY | MECHANISM | PROLIFERATION | AQP2 | cAMP | TGR5 | lithium | LIVER | VASOPRESSIN | UROLOGY & NEPHROLOGY | GSK3-BETA | MICE | NEPHROGENIC DIABETES-INSIPIDUS | Basic Research
Journal Article
Journal of Cell Science, ISSN 0021-9533, 08/2009, Volume 122, Issue 16, pp. 2969 - 2979
Polarised cell migration is required for various cell behaviours and functions. Actin and microtubules are coupled structurally and distributed asymmetrically... 
GSK-3 | IQGAP1 | Microtubule | EB1 | CLASP2 | PROTEIN | ACTIN-FILAMENTS | CELL BIOLOGY | GSK3-BETA PHOSPHORYLATION | CDC42 | APC | CELL-MIGRATION | RAC1 | RHO-GTPASES | POLARIZATION | BINDING
Journal Article
New Journal of Chemistry, ISSN 1144-0546, 2016, Volume 40, Issue 7, pp. 6109 - 6119
A series of aryl anilinomaleimide based derivatives has been synthesized and evaluated for in vitro glycogen synthase kinase-3 beta (GSK-3 beta) inhibitory... 
GLYCOGEN-SYNTHASE-KINASE-3 | GSK3-BETA | GSK-3 INHIBITORS | METABOLISM | MOOD DISORDERS | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Journal of Cell Science, ISSN 0021-9533, 10/2009, Volume 122, Issue 20, pp. 3595 - 3604
Journal Article
by Hwang, IH and Park, J and Kim, JM and Kim, SI and Choi, JS and Lee, KB and Yun, SH and Lee, MG and Park, SJ and Jang, IS
FASEB JOURNAL, ISSN 0892-6638, 09/2016, Volume 30, Issue 9, pp. 3107 - 3116
Diabetes mellitus is a complex and heterogeneous disease, which has -cell dysfunction at its core. Glucotoxicity affects pancreatic islets, causing -cell... 
SURVIVAL | MECHANISM | glucose toxicity | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | THIOREDOXIN-INTERACTING PROTEIN | CELL BIOLOGY | BIOLOGY | Bax | GSK3-BETA | TSPAN2 | WNT
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2004, Volume 24, Issue 44, pp. 9993 - 10002
Glycogen synthase kinase-3beta(GSK-3beta)is a critical activator of neuronal apoptosis induced by a diverse array of neurotoxic insults. However, the... 
Bax | Mitochondria | Phosphorylation | Cerebellar granule neuron | Glycogen synthase kinase | Apoptosis | CEREBELLAR GRANULE NEURONS | SURVIVAL | TRANSLOCATION | mitochondria | KINASE | apoptosis | NEUROSCIENCES | PROGRAMMED CELL-DEATH | PATHWAY | DISEASE | glycogen synthase kinase | GSK3-BETA | cerebellar granule neuron | phosphorylation | BCL-2 FAMILY | GROWTH-FACTOR-I | Cellular | Molecular
Journal Article
by Hu, H and Zhao, CL and Zhang, PG and Liu, YL and Jiang, YL and Wu, EQ and Xue, H and Liu, CY and Li, ZH
EXPERIMENTAL AND MOLECULAR PATHOLOGY, ISSN 0014-4800, 04/2019, Volume 107, pp. 158 - 164
Backgrounds: Osteoactivin (OA) is a key regulator promoting bone marrow stromal cells osteogenesis progress, while Dexamethasone (Dex) could inhibit OA induced... 
INDUCED OSTEOPOROSIS | OSTEOACTIVIN | DEXAMETHASONE | OSTEOBLAST DIFFERENTIATION | BMSC | miR-26b | PATHOLOGY | MESENCHYMAL STEM-CELLS | RESCUES | BONE-FORMATION | GSK3-beta | DEX | MIRNAS | EXPRESSION | Osteogenesis
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 7286 - 15
The neurobehavioral effects of paternal smoking and nicotine use have not been widely reported. In the present study, nicotine exposure induced depression in... 
DEPRESSION | CELLS | CIGARETTE-SMOKING | DEFICIT HYPERACTIVITY DISORDER | MULTIDISCIPLINARY SCIENCES | RESISTANCE | GSK3-BETA | LITHIUM | BRAIN | PRENATAL SMOKING EXPOSURE | PREGNANCY | Phosphorylation | Wnt protein | Hyperactivity | DNA methylation | Thalamus | Heredity | Mental depression | Nicotine | Smoking | CpG islands
Journal Article
Toxicology, ISSN 0300-483X, 08/2019, Volume 424, pp. 152233 - 152233
Saikosaponins-d (SSd) is a major bioactive compound isolated from Radix Bupleuri, an herb widely used in traditional Chinese medicine. Emerging studies... 
GSK3β | β-catenin | Saikosaponins-d | Neurogenesis | Neural progenitor cell | beta-catenin | ACTIVATION | MORRIS WATER MAZE | GLYCOGEN-SYNTHASE KINASE-3-BETA | RADIX-BUPLEURI | OVEREXPRESSION | MEMORY | PATHWAY | STEM-CELL | GSK3-BETA | PHARMACOLOGY & PHARMACY | TOXICOLOGY | GSK3 beta | HIPPOCAMPAL NEUROGENESIS | Index Medicus
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 07/2018, Volume 38, Issue 14
Myotonic dystrophy type 2 (DM2) Is a neuromuscular disease caused by an expansion of intronic CCTG repeats in the CNBP gene, which encodes a protein regulating... 
Unstable repeats | Molecular pathology | Muscle atrophy | Myotonic dystrophy | CNBP | REPEAT | unstable repeats | BIOCHEMISTRY & MOLECULAR BIOLOGY | DM2 PATIENTS | PATHOLOGY | TRANSLATION | ZNF9 | CELL BIOLOGY | myotonic dystrophy | EXPANSION | GSK3-BETA | muscle atrophy | VPS27P | molecular pathology | EXPRESSION
Journal Article
Genes and Development, ISSN 0890-9369, 01/2008, Volume 22, Issue 1, pp. 106 - 120
Journal Article