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The American Journal of Human Genetics, ISSN 0002-9297, 11/2016, Volume 99, Issue 5, pp. 1190 - 1198
Uveal melanoma (UM) is a rare intraocular tumor that, similar to cutaneous melanoma, originates from melanocytes. To gain insights into its genetics, we... 
OCULAR MELANOMA | CELLS | COLORECTAL-CANCER | PROTEINS DLK1 | METASTASES | GENETICS & HEREDITY | RISK | EXPRESSION | RADIATION | SF3B1 | SOMATIC MUTATIONS | Melanoma - diagnosis | Exons | Humans | Middle Aged | Male | Phosphoproteins - metabolism | Case-Control Studies | RNA Splicing Factors - metabolism | DNA Copy Number Variations | Melanoma - genetics | Melanocytes - pathology | Tumor Suppressor Proteins - genetics | Aged, 80 and over | Ubiquitin Thiolesterase - metabolism | Adult | Female | Membrane Proteins - metabolism | Eukaryotic Initiation Factor-1 - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Tumor Suppressor p53-Binding Protein 1 - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Uveal Neoplasms - genetics | Genome-Wide Association Study | Tumor Suppressor Proteins - metabolism | GTP-Binding Protein alpha Subunits - metabolism | Tumor Suppressor p53-Binding Protein 1 - genetics | Membrane Proteins - genetics | Eukaryotic Initiation Factor-1 - genetics | Ubiquitin-Protein Ligases - metabolism | GTP-Binding Protein alpha Subunits - genetics | Phosphoproteins - genetics | RNA Splicing Factors - genetics | Ubiquitin Thiolesterase - genetics | Skin Neoplasms | Uveal Neoplasms - diagnosis | Aged | Mutation | Ubiquitin-Protein Ligases - genetics | Genetic aspects | Nucleotide sequencing | Methods | Melanoma | DNA sequencing | Metastasis | Pathogenesis | Genomics | Deoxyribonucleic acid--DNA | Index Medicus | Report
Journal Article
Cancer Cell, ISSN 1535-6108, 06/2014, Volume 25, Issue 6, pp. 831 - 845
Journal Article
Journal Article
Nature, ISSN 0028-0836, 01/2009, Volume 457, Issue 7229, pp. 599 - 602
BRAF and NRAS are common targets for somatic mutations in benign and malignant neoplasms that arise from melanocytes situated in epithelial structures, and... 
CELLS | ALPHA-SUBUNIT | PATHWAY | MULTIDISCIPLINARY SCIENCES | KINASE-C | BRAF | CANCER | TUMORS | MELANOCYTOSIS | Cell Proliferation | GTP-Binding Protein alpha Subunits - chemistry | Humans | Melanoma - enzymology | Nevus, Blue - pathology | Uveal Neoplasms - enzymology | MAP Kinase Signaling System | Skin Neoplasms - enzymology | Nevus, Blue - genetics | DNA Mutational Analysis | Melanoma - genetics | ras Proteins - chemistry | Melanocytes - pathology | Codon - genetics | Protein Structure, Tertiary | Skin Neoplasms - pathology | Oncogenes - genetics | Uveal Neoplasms - genetics | Melanocytes - enzymology | GTP-Binding Protein alpha Subunits - metabolism | Uveal Neoplasms - pathology | Cells, Cultured | Nevus, Blue - enzymology | GTP-Binding Protein alpha Subunits - genetics | Melanoma - pathology | Mutation - genetics | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Biopsy | Cell Transformation, Neoplastic | Skin Neoplasms - genetics | GTP-Binding Protein alpha Subunits - deficiency | Enzyme Activation | Genes, Dominant - genetics | Apoptosis | Mitogen-Activated Protein Kinases - metabolism | Antibody diversity | Evaluation | Gene mutations | Uvea | Melanoma | Genetic aspects | Research | Health aspects | Cancer | Proteins | Studies | Enzymes | Cell cycle | Mutation | Kinases | Risk factors | Skin cancer | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2011, Volume 108, Issue 23, pp. 9420 - 9424
In G-protein signaling, an activated receptor catalyzes GDP/GTP exchange on the G α subunit of a heterotrimeric G protein. In an initial step, receptor... 
Proteins | Exchange rates | Receptors | Biochemical mechanisms | Software packages | Drug interactions | Biochemistry | Nucleotides | Color semiotics | Crystal structure | Signal transduction | Structural polymorphism | BETA-GAMMA | HETEROTRIMERIC G-PROTEIN | MECHANISM | signal transduction | structural polymorphism | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | HELIX | DISTANCE MEASUREMENTS | G(I-ALPHA-1) | PEPTIDE ANALOGS | GAMMA-SUBUNIT | BINDING | Receptors, G-Protein-Coupled - metabolism | GTP-Binding Protein alpha Subunits - chemistry | Molecular Sequence Data | Guanosine Triphosphate - metabolism | Spin Labels | Rhodopsin - metabolism | GTP-Binding Proteins - genetics | Cell Membrane - metabolism | Guanosine Triphosphate - chemistry | Guanosine Diphosphate - chemistry | Guanosine Diphosphate - metabolism | Rhodopsin - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Cross-Linking Reagents - chemistry | GTP-Binding Protein alpha Subunits - metabolism | GTP-Binding Proteins - chemistry | Protein Structure, Secondary | Models, Molecular | Rats | Electron Spin Resonance Spectroscopy - methods | Animals | Protein Binding | Mutation | Receptors, G-Protein-Coupled - chemistry | GTP-Binding Proteins - metabolism | Studies | Catalysis | Spectrum analysis | Binding sites | Index Medicus | Biological Sciences
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1996 - 15
Journal Article