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PLoS Pathogens, ISSN 1553-7366, 04/2015, Volume 11, Issue 4, p. e1004794
Monoamines, such as 5-HT and tyramine (TA), paralyze both free-living and parasitic nematodes when applied exogenously and serotonergic agonists have been used... 
BIOACTIVITY | INFECTIONS | INDUCED PARALYSIS | FUNCTIONAL RECONSTITUTION | MICROBIOLOGY | GATED CHLORIDE CHANNEL | HAEMONCHUS-CONTORTUS | VIROLOGY | PROTEIN-COUPLED RECEPTOR | IN-VIVO | RESISTANCE | SEROTONIN | PARASITOLOGY | GTP-Binding Protein alpha Subunits - chemistry | Humans | Receptors, Biogenic Amine - genetics | Caenorhabditis elegans Proteins - metabolism | Motor Activity - drug effects | Serotonin 5-HT1 Receptor Agonists - pharmacology | Drug Discovery - methods | Drosophila Proteins - agonists | Drosophila Proteins - metabolism | Caenorhabditis elegans Proteins - agonists | Behavior, Animal - drug effects | Helminth Proteins - metabolism | Recombinant Proteins - metabolism | Caenorhabditis elegans - metabolism | GTP-Binding Protein alpha Subunits - metabolism | Caenorhabditis elegans - genetics | Chloride Channel Agonists - pharmacology | Nerve Tissue Proteins - agonists | Interneurons - drug effects | Recombinant Proteins - chemistry | GTP-Binding Protein alpha Subunits - genetics | Helminth Proteins - genetics | Recombinant Proteins - genetics | Hypotonic Solutions - toxicity | Animals, Genetically Modified - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Caenorhabditis elegans - drug effects | Interneurons - metabolism | Animals, Genetically Modified - genetics | Anthelmintics - pharmacology | Receptors, Biogenic Amine - metabolism | Haemonchus | Helminth Proteins - agonists | Drosophila Proteins - genetics | Caenorhabditis elegans Proteins - genetics | Drosophila melanogaster | Receptors, Biogenic Amine - agonists | Proteins | Nematodes | Parasites | Mutation | Permeability | Worms
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, p. e76541
Peroxisome proliferator activator receptors (PPAR) ligands such as 15-Delta 12,13-prostaglandin L(2) [PJ] and all trans retinoic acid (ATRA) have been shown to... 
IN-VITRO | GROWTH-INHIBITION | LIGANDS | NUCLEAR RECEPTORS | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | RETINOIC ACID RECEPTOR | HEPATIC-FIBROSIS | PANCREATIC-CANCER CELLS | MOLECULAR-MECHANISMS | ALL-TRANS | Cyclin D1 - metabolism | Rats, Wistar | TOR Serine-Threonine Kinases - metabolism | Actins - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - agonists | Hepatic Stellate Cells - metabolism | Male | G1 Phase - drug effects | PPAR gamma - metabolism | Receptors, Retinoic Acid - genetics | Actins - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Cyclin D1 - antagonists & inhibitors | Collagen Type I - genetics | TOR Serine-Threonine Kinases - genetics | Prostaglandin D2 - analogs & derivatives | G1 Phase - genetics | Retinoid X Receptors - antagonists & inhibitors | Retinoid X Receptors - genetics | Retinoid X Receptors - metabolism | Hepatic Stellate Cells - pathology | Hepatic Stellate Cells - drug effects | PPAR gamma - genetics | Tretinoin - pharmacology | Collagen Type I - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | rho GTP-Binding Proteins - genetics | Collagen Type I - antagonists & inhibitors | Rats | Receptors, Retinoic Acid - antagonists & inhibitors | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Receptors, Retinoic Acid - metabolism | rho GTP-Binding Proteins - agonists | Drug Synergism | Gene Expression Regulation - drug effects | Actins - antagonists & inhibitors | Animals | PPAR gamma - antagonists & inhibitors | Cyclin D1 - genetics | Signal Transduction - drug effects | rho GTP-Binding Proteins - metabolism | Cell Proliferation - drug effects | Prostaglandin D2 - pharmacology | Primary Cell Culture | Cyclin-Dependent Kinase Inhibitor p27 - genetics | TOR protein | Cell proliferation | Pediatrics | Flow cytometry | GTP-binding protein | Phosphorylation | Liver | Retinoic acid receptors | Activation | Kinases | Cyclin D1 | Proteins | Vitamin A | Receptors | Cell activation | Cell growth | Rodents | Gastroenterology | Cell cycle | Down-regulation | Extracellular matrix | Inhibition | Growth factors | G1 phase | Stellate cells | Liver diseases | Gene expression | Retinoid X receptors | Medicine | Hospitals | Acids | Collagen | Fibrosis | Ligands | Combined treatment | Peroxisome proliferator-activated receptors | Laboratory animals | Retinoic acid
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2016, Volume 291, Issue 9, pp. 4323 - 4333
Invadosomes are actin-rich membrane protrusions that degrade the extracellular matrix to drive tumor cell invasion. Key players in invadosome formation are... 
Receptors, Lysophosphatidic Acid - metabolism | Lysophospholipids - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Extracellular Matrix - metabolism | Melanoma - enzymology | Podosomes - enzymology | Neoplasm Proteins - antagonists & inhibitors | Receptors, Lysophosphatidic Acid - agonists | Receptors, Lysophosphatidic Acid - genetics | cdc42 GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - genetics | Endothelins - metabolism | Neoplasm Proteins - metabolism | Time-Lapse Imaging | Podosomes - metabolism | RNA Interference | cdc42 GTP-Binding Protein - antagonists & inhibitors | Fluorescence Resonance Energy Transfer | Receptors, Lysophosphatidic Acid - antagonists & inhibitors | Neoplasm Proteins - genetics | Biomarkers - metabolism | Melanoma - metabolism | Recombinant Proteins - metabolism | rac1 GTP-Binding Protein - agonists | rhoA GTP-Binding Protein - antagonists & inhibitors | Recombinant Proteins - genetics | Melanoma - pathology | cdc42 GTP-Binding Protein - agonists | Hydrolysis | Podosomes - pathology | Microscopy, Confocal | Neoplasm Proteins - agonists | cdc42 GTP-Binding Protein - genetics | Receptors, G-Protein-Coupled - antagonists & inhibitors | rac1 GTP-Binding Protein - antagonists & inhibitors | Cell Line, Tumor | Luminescent Proteins - genetics | Receptors, G-Protein-Coupled - genetics | Extracellular Matrix - pathology | Microscopy, Fluorescence | rac1 GTP-Binding Protein - metabolism | Luminescent Proteins - metabolism | rac1 GTP-Binding Protein - genetics | CDC42 | invadopodia | biosensor | fluorescence resonance energy transfer (FRET) | calcium intracellular release | G protein-coupled receptor (GPCR) | Rho (Rho GTPase) | phosphatidylinositide 3-kinase (PI 3-kinase) | imaging | Rac (Rac GTPase) | Cell Biology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 50, pp. 20599 - 20612
The short neuropeptide F (sNPF) neuropeptides, closely related to vertebrate neuropeptide Y (NPY), have been suggested to exert pleiotropic effects on many... 
signaling | DROSOPHILA-MELANOGASTER | neuropeptide | BIOCHEMISTRY & MOLECULAR BIOLOGY | INSECT CELLS | Bombyx mori | ANOPHELES-GAMBIAE | FUNCTIONAL-CHARACTERIZATION | TSETSE-FLY | silkworm | N-LINKED GLYCOSYLATION | FEEDING-BEHAVIOR | G protein-coupled receptor (GPCR) | GENE-EXPRESSION | GLOSSINA-MORSITANS-MORSITANS | NEUROHORMONE GPCRS | short neuropeptide F | GTP-Binding Protein alpha Subunits, Gi-Go - agonists | Phosphorylation | Receptors, G-Protein-Coupled - metabolism | Humans | Receptors, Neuropeptide - metabolism | Receptors, G-Protein-Coupled - agonists | Recombinant Fusion Proteins - metabolism | MAP Kinase Signaling System | Spodoptera | Bombyx - metabolism | Sf9 Cells | Protein Isoforms - metabolism | Protein Isoforms - agonists | HEK293 Cells | Insect Proteins - agonists | Receptors, Neuropeptide - agonists | Neuropeptides - genetics | Insect Proteins - metabolism | Peptide Fragments - genetics | Calcium Signaling | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Down-Regulation | Gene Expression Regulation | Insect Proteins - genetics | Receptors, Neuropeptide - genetics | Recombinant Proteins - chemistry | Neuropeptides - metabolism | Recombinant Fusion Proteins - chemistry | Protein Transport | Peptide Fragments - chemistry | Animals | GTP-Binding Protein alpha Subunits, Gi-Go - antagonists & inhibitors | Insect Proteins - chemistry | Protein Processing, Post-Translational | Receptors, G-Protein-Coupled - genetics | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Neuropeptides - chemistry | Protein Isoforms - genetics | Signal Transduction
Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7610, pp. 182 - 186
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 04/2013, Volume 123, Issue 4, pp. 1750 - 1762
Type 2 diabetes (T2D) has emerged as a major threat to human health in most parts of the world. Therapeutic strategies aimed at improving pancreatic beta cell... 
TRANSCRIPTION FACTORS | MEDICINE, RESEARCH & EXPERIMENTAL | REGULATOR | SIGNALING PATHWAYS | SUBSTRATE-2 | INSULIN-RESISTANCE | PROTEIN-COUPLED RECEPTORS | MECHANISMS | DIFFERENTIATION | SECRETION | EXPRESSION | Cell Proliferation | Gene Expression - drug effects | Receptors, G-Protein-Coupled - metabolism | Muscarinic Agonists - pharmacology | Male | Receptor, Muscarinic M3 - physiology | Insulin Receptor Substrate Proteins - metabolism | Receptors, G-Protein-Coupled - agonists | Molecular Targeted Therapy | MAP Kinase Signaling System | Clozapine - pharmacology | Insulin-Secreting Cells - metabolism | Diabetes Mellitus, Experimental - prevention & control | Protein Engineering | Female | Drug Evaluation, Preclinical | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Insulin Receptor Substrate Proteins - genetics | Insulin-Secreting Cells - physiology | Recombinant Proteins - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Insulin Receptor Substrate Proteins - physiology | Mice, Inbred C57BL | Mice, Transgenic | Recombinant Proteins - agonists | Recombinant Proteins - genetics | Clozapine - analogs & derivatives | Hypoglycemic Agents - pharmacology | Animals | Insulin-Secreting Cells - drug effects | Cell Line, Tumor | Diabetes Mellitus, Experimental - pathology | Mice | Receptors, G-Protein-Coupled - genetics | Receptor, Muscarinic M3 - agonists
Journal Article