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Journal Article
Science, ISSN 0036-8075, 5/2013, Volume 340, Issue 6136, pp. 1100 - 1106
Journal Article
Developmental Biology, ISSN 0012-1606, 10/2014, Volume 394, Issue 1, pp. 142 - 155
Specification of the trophectoderm (TE) and inner cell mass (ICM) lineages in the mouse blastocyst correlates with cell position, as TE derives from outer... 
Trophectoderm | Cell lineage | YAP | Cell polarity | CDX2 | Inner cell mass | LINEAGE DIFFERENTIATION | PREIMPLANTATION EMBRYO | STEM-CELLS | KINASE | EPITHELIAL POLARITY | FATE SPECIFICATION | DEVELOPMENTAL BIOLOGY | BINDING PROTEIN RHO | YAP PATHWAY | rho GTP-Binding Proteins - antagonists & inhibitors | Tumor Suppressor Proteins - antagonists & inhibitors | rho-Associated Kinases - antagonists & inhibitors | Ectoderm - metabolism | RNA Interference | rho-Associated Kinases - metabolism | Gene Expression Regulation, Developmental | Tumor Suppressor Proteins - genetics | Mice, Inbred DBA | Cell Differentiation | Protein-Serine-Threonine Kinases - metabolism | Amides - pharmacology | Homeodomain Proteins - biosynthesis | Nanog Homeobox Protein | Phosphoproteins - biosynthesis | Signal Transduction | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - biosynthesis | Protein Kinase C - antagonists & inhibitors | Cell Lineage | Animals | Blastocyst Inner Cell Mass - metabolism | Homeodomain Proteins - antagonists & inhibitors | rho GTP-Binding Proteins - metabolism | Cell Polarity - physiology | Adaptor Proteins, Signal Transducing - biosynthesis | Mice | Pyridines - pharmacology | RNA, Small Interfering | CDX2 Transcription Factor | G proteins | Index Medicus | trophectoderm | cell polarity | cell lineage
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2012, Volume 109, Issue 45, pp. 18613 - 18618
Journal Article
Genes and Development, ISSN 0890-9369, 02/2013, Volume 27, Issue 11, pp. 1223 - 1232
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 04/2016, Volume 18, Issue 4, pp. 355 - 365
Aim: To determine the impact of a functional human islet clock on insulin secretion and gene transcription. Methods: Efficient circadian clock disruption was... 
human pancreatic islet | circadian bioluminescence | insulin secretion | RNA | circadian clock | sequencing | Circadian clock | RNA sequencing | Circadian bioluminescence | Human pancreatic islet | Insulin secretion | PERIPHERAL CLOCKS | SYSTEM | TRANSCRIPTOME | BEHAVIOR | BETA-CELLS | METABOLISM | CHANNEL | GENES | ENDOCRINOLOGY & METABOLISM | OSCILLATIONS | EXPRESSION | Islets of Langerhans - drug effects | Sodium-Potassium-Exchanging ATPase - genetics | Cation Transport Proteins - antagonists & inhibitors | Sodium-Potassium-Exchanging ATPase - chemistry | Zinc Transporter 8 | Humans | CLOCK Proteins - genetics | Gene Expression Profiling | Potassium Channels, Inwardly Rectifying - chemistry | Qa-SNARE Proteins - chemistry | CLOCK Proteins - metabolism | Insulin-Secreting Cells - metabolism | Vesicle-Associated Membrane Protein 3 - chemistry | GTP-Binding Protein alpha Subunits, Gq-G11 - chemistry | RNA Interference | Cation Transport Proteins - metabolism | Islets of Langerhans - metabolism | Islets of Langerhans - cytology | Qa-SNARE Proteins - genetics | Cation Transport Proteins - genetics | Potassium Channels, Inwardly Rectifying - antagonists & inhibitors | Insulin-Secreting Cells - cytology | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Insulin Secretion | Vesicle-Associated Membrane Protein 3 - antagonists & inhibitors | Vesicle-Associated Membrane Protein 3 - genetics | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors | Circadian Clocks - drug effects | Colforsin - pharmacology | Vesicle-Associated Membrane Protein 3 - metabolism | CLOCK Proteins - antagonists & inhibitors | Cells, Cultured | GTP-Binding Protein alpha Subunits, Gq-G11 - antagonists & inhibitors | Potassium Channels, Inwardly Rectifying - genetics | Gene Expression Regulation - drug effects | Hyperglycemia - metabolism | Sodium-Potassium-Exchanging ATPase - metabolism | Insulin - metabolism | Insulin-Secreting Cells - drug effects | Qa-SNARE Proteins - metabolism | Genes, Reporter - drug effects | Qa-SNARE Proteins - antagonists & inhibitors | RNA, Small Interfering | Cation Transport Proteins - chemistry | Potassium Channels, Inwardly Rectifying - metabolism | Pancreatic beta cells | Analysis | Glucose | Insulin | Dextrose | Circadian rhythm | Pancreas | Rodents | Circadian rhythms | Transcription | Secretion | Islet cells | siRNA | Islets of Langerhans | Gene expression | Index Medicus
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 9/2003, Volume 162, Issue 6, pp. 1079 - 1088
Cell migration occurs through the protrusion of the actin-enriched lamella. Here, we investigated the effects of RNAi depletion of ∼90 proteins implicated in... 
Cell motility | Scars | Delta cells | Microfilaments | Neurons | Drosophila | Cell lines | Actins | Actin depolymerizing factors | Cells | Polymerization | Lamella | Cytokinesis | Actin | SCAR | RNA INTERFERENCE | MIGRATION | polymerization | lamella | cytokinesis | ARP2/3 COMPLEX | HOMOLOG | MOTILITY DRIVEN | CELL BIOLOGY | YEAST | actin | FILAMENTS | CYCLASE-ASSOCIATED PROTEIN | DYNAMICS | NUCLEATION | Pseudopodia - ultrastructure | Cytoskeletal Proteins - antagonists & inhibitors | Cytoskeletal Proteins - genetics | Actins - metabolism | rac GTP-Binding Proteins - metabolism | Eukaryotic Cells - metabolism | Drosophila Proteins - metabolism | Cell Movement - physiology | Actins - genetics | Cell Cycle Proteins - antagonists & inhibitors | Actins - deficiency | RNA Interference | Profilins | Cell Cycle Proteins - genetics | Cytoskeletal Proteins - metabolism | Destrin | Drosophila Proteins - antagonists & inhibitors | Microfilament Proteins - genetics | Cell Line | Actin Cytoskeleton - metabolism | Microfilament Proteins - deficiency | Carrier Proteins - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Actin Depolymerizing Factors | Carrier Proteins - genetics | Adaptor Proteins, Signal Transducing | Actins - antagonists & inhibitors | Animals | Carrier Proteins - metabolism | Microfilament Proteins - antagonists & inhibitors | Caenorhabditis elegans Proteins - antagonists & inhibitors | Pseudopodia - metabolism | Drosophila Proteins - deficiency | Actin-Related Protein 2 | Eukaryotic Cells - cytology | Drosophila Proteins - genetics | Actin Cytoskeleton - ultrastructure | Caenorhabditis elegans Proteins - genetics | Drosophila melanogaster | Contractile Proteins | RNA | Listeria | Bacterial proteins | Cytology | Physiological aspects | Genetic aspects | Research | Cell migration | Proteins | Cytoskeleton | Cellular biology | Insects | Cell adhesion & migration | Index Medicus | actin; lamella; polymerization; SCAR; cytokinesis
Journal Article
Science, ISSN 0036-8075, 1/2009, Volume 323, Issue 5911, pp. 269 - 272
The Vibrio parahaemolyticus type III effector VopS is implicated in cell rounding and the collapse of the actin cytoskeleton by inhibiting Rho guanosine... 
Proteins | Phosphates | Enzymes | HeLa cells | Amino acids | Ions | Mass spectroscopy | Reports | Infections | Biochemistry | Post translational modification | ACTIVATION | PROTEIN | PARAHAEMOLYTICUS | MULTIDISCIPLINARY SCIENCES | III SECRETION SYSTEM | Phosphorylation | Threonine - chemistry | rho GTP-Binding Proteins - antagonists & inhibitors | Humans | Bacterial Proteins - chemistry | Molecular Sequence Data | rac GTP-Binding Proteins - metabolism | Vibrio parahaemolyticus - metabolism | cdc42 GTP-Binding Protein - metabolism | Threonine - metabolism | Recombinant Fusion Proteins - metabolism | rac GTP-Binding Proteins - antagonists & inhibitors | Cell Shape | cdc42 GTP-Binding Protein - antagonists & inhibitors | rho GTP-Binding Proteins - chemistry | Binding Sites | Protein Structure, Tertiary | Amino Acid Sequence | Signal Transduction | Adenosine Monophosphate - metabolism | Bacterial Proteins - genetics | Mutant Proteins - metabolism | Vibrio parahaemolyticus - pathogenicity | Amino Acid Motifs | Mutant Proteins - chemistry | rho GTP-Binding Proteins - metabolism | rac GTP-Binding Proteins - chemistry | Bacterial Proteins - metabolism | cdc42 GTP-Binding Protein - chemistry | Protein Processing, Post-Translational | HeLa Cells | Genetic aspects | Chemical properties | Guanosine triphosphatase | Vibrio | Signal transduction | Eukaryotes | Cellular biology | Molecular biology | Binding sites | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2016, Volume 291, Issue 9, pp. 4323 - 4333
Invadosomes are actin-rich membrane protrusions that degrade the extracellular matrix to drive tumor cell invasion. Key players in invadosome formation are... 
Receptors, Lysophosphatidic Acid - metabolism | Lysophospholipids - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Extracellular Matrix - metabolism | Melanoma - enzymology | Podosomes - enzymology | Neoplasm Proteins - antagonists & inhibitors | Receptors, Lysophosphatidic Acid - agonists | Receptors, Lysophosphatidic Acid - genetics | cdc42 GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - genetics | Endothelins - metabolism | Neoplasm Proteins - metabolism | Time-Lapse Imaging | Podosomes - metabolism | RNA Interference | cdc42 GTP-Binding Protein - antagonists & inhibitors | Fluorescence Resonance Energy Transfer | Receptors, Lysophosphatidic Acid - antagonists & inhibitors | Neoplasm Proteins - genetics | Biomarkers - metabolism | Melanoma - metabolism | Recombinant Proteins - metabolism | rac1 GTP-Binding Protein - agonists | rhoA GTP-Binding Protein - antagonists & inhibitors | Recombinant Proteins - genetics | Melanoma - pathology | cdc42 GTP-Binding Protein - agonists | Hydrolysis | Podosomes - pathology | Microscopy, Confocal | Neoplasm Proteins - agonists | cdc42 GTP-Binding Protein - genetics | Receptors, G-Protein-Coupled - antagonists & inhibitors | rac1 GTP-Binding Protein - antagonists & inhibitors | Cell Line, Tumor | Luminescent Proteins - genetics | Receptors, G-Protein-Coupled - genetics | Extracellular Matrix - pathology | Microscopy, Fluorescence | rac1 GTP-Binding Protein - metabolism | Luminescent Proteins - metabolism | rac1 GTP-Binding Protein - genetics | Index Medicus | CDC42 | invadopodia | biosensor | fluorescence resonance energy transfer (FRET) | calcium intracellular release | G protein-coupled receptor (GPCR) | Rho (Rho GTPase) | phosphatidylinositide 3-kinase (PI 3-kinase) | imaging | Rac (Rac GTPase) | Cell Biology
Journal Article
Nature Cell Biology, ISSN 1465-7392, 01/2010, Volume 12, Issue 1, pp. 19 - 30
Journal Article