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Neuron, ISSN 0896-6273, 08/2012, Volume 75, Issue 4, pp. 618 - 632
Mitochondrial abnormalities have been documented in Alzheimer’s disease and related neurodegenerative disorders, but the causal relationship between... 
ALZHEIMERS-DISEASE BRAIN | DOMINANT OPTIC ATROPHY | MITOCHONDRIAL-FUNCTION | MOUSE MODEL | LIGHT-CHAIN | FRONTOTEMPORAL DEMENTIA | AXONAL-TRANSPORT | NEUROSCIENCES | DYNAMIN-RELATED PROTEIN | PHOSPHORYLATION SITES | TRANSGENIC MICE | Neurons - pathology | Microtubule-Associated Proteins - genetics | Tauopathies - genetics | Cytoskeletal Proteins - genetics | Gelsolin - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Actins - metabolism | Tauopathies - pathology | Cytoplasm - metabolism | MicroRNAs - metabolism | Green Fluorescent Proteins - genetics | Mitochondrial Proteins - genetics | Drosophila Proteins - metabolism | GTP-Binding Proteins - genetics | Nerve Degeneration - metabolism | Neurons - ultrastructure | tau Proteins - genetics | Cell Death - genetics | Mitochondria - genetics | Mitochondrial Proteins - metabolism | ATP Synthetase Complexes - metabolism | Cell Cycle Proteins - genetics | Tauopathies - complications | Cytoskeletal Proteins - metabolism | Myosins - metabolism | Cytoplasm - genetics | RNA Interference - physiology | Disease Models, Animal | In Situ Nick-End Labeling | Green Fluorescent Proteins - metabolism | Animals, Genetically Modified | Gene Expression Regulation - genetics | Drosophila | Cell Cycle Proteins - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Mutation - genetics | Animals | GTP Phosphohydrolases - metabolism | Analysis of Variance | GTP Phosphohydrolases - genetics | Gelsolin - genetics | Mice | Drosophila Proteins - genetics | Nerve Degeneration - etiology | Voltage-Dependent Anion Channels - metabolism | GTP-Binding Proteins - metabolism | Nervous system diseases | Actin | Neurons | Utrophin | Myosin | Mitochondrial DNA | Alzheimer's disease | Proteins | Phosphorylation | Mitochondria | Neurotoxicity | Insects | Microscopy | Neurodegeneration | Pathogenesis | Morphology | Mutation | Defects | Index Medicus | Neurodegenerative diseases | Tau protein | Cell death | Elongation
Journal Article
Nature Genetics, ISSN 1061-4036, 12/2012, Volume 44, Issue 12, pp. 1321 - 1325
Journal Article
Neuron, ISSN 0896-6273, 02/2013, Volume 77, Issue 3, pp. 425 - 439
Recent genome-wide association studies have linked common variants in the human genome to Parkinson@s disease (PD) risk. Here we show that the consequences of... 
LOCALIZATION | RETROMER | TRANSPORT | ELEGANS | GENE-EXPRESSION | TRAFFICKING | ALPHA | NEURODEGENERATION | MICE | NEUROSCIENCES | DROSOPHILA | rab5 GTP-Binding Proteins - genetics | Immunoprecipitation | Humans | Middle Aged | Cerebral Cortex - pathology | Male | Tubulin - genetics | rab GTP-Binding Proteins - genetics | Green Fluorescent Proteins - genetics | Statistics as Topic | Vesicle-Associated Membrane Protein 2 - genetics | Cerebral Cortex - cytology | Tyrosine 3-Monooxygenase | rab5 GTP-Binding Proteins - metabolism | Tubulin - metabolism | Transfection | Aged, 80 and over | Female | Neurons - metabolism | Parkinson Disease - metabolism | Protein-Serine-Threonine Kinases - metabolism | Animals, Newborn | Synaptosomal-Associated Protein 25 - genetics | rab GTP-Binding Proteins - metabolism | Genetic Predisposition to Disease | Genome-Wide Association Study | Parkinson Disease - pathology | Animals, Genetically Modified | Drosophila | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Rats | Parkinson Disease - genetics | Mutation - genetics | Rats, Sprague-Dawley | Protein Transport - genetics | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Animals | Polymorphism, Single Nucleotide - genetics | Aged | Mice | Synaptosomal-Associated Protein 25 - metabolism | Vesicle-Associated Membrane Protein 2 - metabolism | Parkinson's disease | Neurons | Genomics | Risk factors | Brain | Laboratories | Parkinsons disease | Kinases | Gene expression | Experiments | Defects | Proteins | Pathology | Insects | Neurodegeneration | Gene loci | Mutation | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 2014, Volume 16, Issue 4, pp. 357 - 366
The YAP and TAZ mediators of the Hippo pathway ( hereafter called YAP/TAZ) promote tissue proliferation and organ growth. However, how their biological... 
ORGAN GROWTH | CHOLESTEROL | YAP/TAZ | TRANSCRIPTION | HIPPO PATHWAY | STATINS | CELL BIOLOGY | Phosphorylation - physiology | Cell Proliferation | Active Transport, Cell Nucleus - physiology | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Phosphoproteins - metabolism | Sterol Regulatory Element Binding Proteins - genetics | Breast Neoplasms - metabolism | Drosophila melanogaster - metabolism | RNA Interference | Tumor Suppressor Proteins - genetics | HEK293 Cells | Trans-Activators - genetics | Female | Transcription, Genetic | Hydroxymethylglutaryl-CoA Reductases, NAD-Dependent - metabolism | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | HCT116 Cells | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Sterol Regulatory Element Binding Proteins - metabolism | Transcription Factors - genetics | Mevalonic Acid - metabolism | Polyisoprenyl Phosphates - metabolism | Transcription Factors - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | rho GTP-Binding Proteins - metabolism | Trans-Activators - metabolism | Mice | Polyisoprenyl Phosphates - biosynthesis | Pyridines - pharmacology | RNA, Small Interfering | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Cell metabolism | Genetic research | Genetic aspects | Research | Cellular control mechanisms | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2010, Volume 5, Issue 2, pp. e8918 - e8918
Background: Glioblastoma multiforme (GBM) is the most common and aggressive type of brain tumor in humans and the first cancer with comprehensive genomic... 
GLIOMAS | PROTEIN-INTERACTION NETWORKS | HUMAN-DISEASE | BIOLOGICAL NETWORKS | METABOLIC NETWORKS | MULTIDISCIPLINARY SCIENCES | FUNCTIONAL MODULES | GENES | CANCER GENOME | PIKE-A | INTEGRATED ANALYSIS | Genetic Predisposition to Disease | Humans | Brain Neoplasms - genetics | Signal Transduction - genetics | Gene Regulatory Networks | GTP-Binding Proteins - genetics | Tumor Suppressor Protein p53 - genetics | Phosphatidylinositol 3-Kinases - genetics | Algorithms | Glioblastoma - genetics | Retinoblastoma Protein - genetics | Models, Genetic | Software | GTPase-Activating Proteins - genetics | Mutation | Genes | Brain tumors | Genomics | Natural language interfaces | Genomes | Protein-protein interactions | Technology application | Mobile communication systems | Wireless communication systems | Language processing | Analysis | Genetic aspects | Computational linguistics | Tumor proteins | Health aspects | Protein kinases | Cancer | Brain | Copy number | Modules | p53 Protein | Brain cancer | Glioblastoma | Biology | Metastasis | Software development tools | Kinases | Proteins | Signal transduction | Alterations | Pathways | Cellular communication | Network analysis | Phylogenetics | Bioinformatics | Deoxyribonucleic acid--DNA | Cartography | Nucleotide sequence | Retinoblastoma protein | Metabolism | Gene expression | Glioblastoma multiforme | 1-Phosphatidylinositol 3-kinase | Endothelium | Signaling | Hypotheses | Passengers | Protein interaction | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2012, Volume 14, Issue 3, pp. 311 - 317
Mitotic spindle positioning by cortical pulling forces(1) defines the cell division axis and location(2), which is critical for proper cell division and... 
ACTIVATION | PROTEIN | MECHANISM | KINETOCHORE | IMPORTIN-BETA | MITOTIC SPINDLE | SEGREGATION | ASYMMETRIC CELL-DIVISION | GRADIENT | RAN | CELL BIOLOGY | NIH 3T3 Cells | ran GTP-Binding Protein - genetics | Microtubule-Associated Proteins - genetics | Antigens, Nuclear - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Molecular Sequence Data | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Centrioles - physiology | Spindle Apparatus - metabolism | RNA Interference | Cell Cycle Proteins - genetics | Chromosome Segregation - physiology | Spindle Apparatus - physiology | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Cytoplasmic Dyneins - metabolism | Dyneins - metabolism | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Green Fluorescent Proteins - metabolism | Cell Cycle Proteins - metabolism | Cytoplasmic Dyneins - genetics | Protein-Serine-Threonine Kinases - genetics | Dynactin Complex | Nuclear Matrix-Associated Proteins - metabolism | Proto-Oncogene Proteins - genetics | ran GTP-Binding Protein - metabolism | Blotting, Western | Animals | Antigens, Nuclear - genetics | Mitosis - physiology | Nuclear Matrix-Associated Proteins - genetics | Models, Biological | Protein Binding | Signal Transduction - physiology | Mice | Centrioles - metabolism | Dyneins - genetics | HeLa Cells | Microscopy, Fluorescence | Spindle (Cell division) | Physiological aspects | Cell division | Research | Chromosomes | Dynein | Index Medicus
Journal Article
PLoS Genetics, ISSN 1553-7390, 01/2012, Volume 8, Issue 1, pp. e1002456 - e1002456
Pink1 is a mitochondrial kinase involved in Parkinson's disease, and loss of Pink1 function affects mitochondrial morphology via a pathway involving Parkin and... 
LIFE-SPAN | OXIDATIVE STRESS | DROSOPHILA-PARKIN MUTANTS | ALTERNATIVE OXIDASE | QUINONE OXIDOREDUCTASE | NDI1 GENE | HUMAN-CELLS | INCREASED SENSITIVITY | GENETICS & HEREDITY | MITOCHONDRIAL-DYSFUNCTION | RESERVE POOL | Electron Transport Complex III - genetics | Electron Transport Complex III - metabolism | Cytoskeletal Proteins - genetics | Saccharomyces cerevisiae - genetics | Humans | Male | Drosophila Proteins - metabolism | Ciona intestinalis - genetics | Drosophila melanogaster - genetics | Electron Transport Complex I - metabolism | GTP-Binding Proteins - genetics | Electron Transport Complex IV - metabolism | Drosophila melanogaster - metabolism | Mitochondria - genetics | Electron Transport Complex I - genetics | Mitochondrial Proteins - metabolism | Cytoskeletal Proteins - metabolism | Membrane Proteins - metabolism | Plant Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Oxidoreductases - metabolism | Membrane Proteins - genetics | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Mitochondria - metabolism | Electron Transport Complex IV - genetics | Parkinson Disease - genetics | Saccharomyces cerevisiae Proteins - genetics | Animals, Genetically Modified - metabolism | Animals | Animals, Genetically Modified - genetics | Saccharomyces cerevisiae Proteins - metabolism | Drosophila Proteins - genetics | Mutation | Ubiquitin-Protein Ligases - genetics | GTP-Binding Proteins - metabolism | Parkinson's disease | Physiological aspects | NADH dehydrogenase | Genetic aspects | Mitochondrial DNA | Research | Electron transport | Risk factors | Enzymes | Mitochondria | Yeast | Insects | Parkinsons disease | Genetic engineering | Grants | Experiments | Evacuations & rescues | Deoxyribonucleic acid--DNA | Defects | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Molecular Cell, ISSN 1097-2765, 2009, Volume 35, Issue 5, pp. 563 - 573
The target of rapamycin complex 1 (TORC1) is a central regulator of eukaryotic cell growth that is activated by a variety of hormones (e.g., insulin) and... 
CELLBIO | PROTEINS | SIGNALING | YEAST SACCHAROMYCES-CEREVISIAE | CELL-GROWTH CONTROL | SIGNALING PATHWAYS | FUNCTIONAL HOMOLOG | RAG GTPASES | VACUOLE FUSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMINO-ACID PERMEASE | COMPONENT | GTP-BINDING PROTEINS | GAP1 PERMEASE | CELL BIOLOGY | Vacuoles - enzymology | Intracellular Membranes - enzymology | Saccharomyces cerevisiae - genetics | Multiprotein Complexes | Adaptor Proteins, Vesicular Transport - genetics | Saccharomyces cerevisiae - drug effects | Guanosine Triphosphate - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Vacuoles - drug effects | DNA-Binding Proteins - metabolism | Amino Acids - metabolism | Time Factors | Guanine Nucleotide Exchange Factors - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Guanosine Diphosphate - metabolism | Protein Synthesis Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Guanine Nucleotide Exchange Factors - genetics | Signal Transduction | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Monomeric GTP-Binding Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Amino Acid Transport Systems - metabolism | Sirolimus - pharmacology | Cycloheximide - pharmacology | Protein Transport | Transcription Factors - metabolism | Monomeric GTP-Binding Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Saccharomyces cerevisiae - enzymology | Endosomes - enzymology | Intracellular Membranes - drug effects | Mutation | Saccharomyces cerevisiae - growth & development | Proteins | Purines | Amino acids | Gross domestic product | Guanosine | Index Medicus
Journal Article
Science, ISSN 0036-8075, 2/2008, Volume 319, Issue 5865, pp. 921 - 926
HIV-1 exploits multiple host proteins during infection. We performed a large-scale small interfering RNA screen to identify host factors required by HIV-1 and... 
T lymphocytes | HIV infections | HIV | Cell lines | Small interfering RNA | HeLa cells | Viruses | Infections | Genetic screening | Cells | Research Article | NUCLEAR IMPORT | COMPLEX | TRANSPORT | SNARE TLG1P | N-LINKED GLYCOSYLATION | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | GLYCOPROTEINS | CXCR4 | ENDOPLASMIC-RETICULUM | LATE GOLGI | HIV-1 - pathogenicity | Cytoskeletal Proteins - genetics | Human Immunodeficiency Virus Proteins - physiology | Genomics | Humans | rab GTP-Binding Proteins - genetics | Virus Internalization | Vesicular Transport Proteins - physiology | HIV-1 - physiology | RNA Interference | Transcription, Genetic | Cytoskeletal Proteins - physiology | Mediator Complex | Intracellular Signaling Peptides and Proteins - genetics | Proteins - physiology | HIV Infections - genetics | HIV Infections - virology | Vesicular Transport Proteins - genetics | Computational Biology | HIV-1 - genetics | Virus Integration | Karyopherins - physiology | Host-Pathogen Interactions | rab GTP-Binding Proteins - physiology | Virus Replication | Cell Line, Tumor | Karyopherins - genetics | RNA, Small Interfering | Intracellular Signaling Peptides and Proteins - physiology | HIV Infections - metabolism | Proteins | Gene targeting | RNA | Physiological aspects | Drug targeting | Genetic aspects | Research | Host-virus relationships | Properties | HIV infection | Health aspects | Biomedical research | Ribonucleic acid--RNA | Human immunodeficiency virus--HIV | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 06/2014, Volume 25, Issue 6, pp. 831 - 845
Journal Article