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1. Full Text Quantification and assessment of the chemical form of residual gadolinium in the brain after repeated administration of gadolinium-based contrast agents comparative study in rats
by Frenzel, Thomas and Apte, Chirag and Jost, Gregor and Schöckel, Laura and Lohrke, Jessica and Pietsch, Hubertus
Investigative Radiology, ISSN 0020-9996, 2017, Volume 52, Issue 7, pp. 396 - 404
Objective: Multiple clinical and preclinical studies have reported a signal intensity increase and the presence of gadolinium (Gd) in the brain after repeated... 
Brain tissue extraction | Gadodiamide | Gadolinium brain retention | Gadopentetate | Gadobutrol | Globus pallidus | Gadoterate | Gadolinium-based contrast agents | Dentate nucleus | Chromatography | Gadobenate | gadopentetate | gadolinium-based contrast agents | GADODIAMIDE INJECTION | SAFETY | gadolinium brain retention | MACROCYCLIC-AGENTS | gadoterate | gadobenate | dentate nucleus | gadodiamide | INTRAVENOUS-INJECTION | brain tissue extraction | PHARMACOKINETICS | gadobutrol | chromatography | PLASMA-MASS SPECTROSCOPY | GADOBENATE DIMEGLUMINE | HEALTHY-VOLUNTEERS | globus pallidus | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | NEPHROGENIC SYSTEMIC FIBROSIS | Chromatography, Gel - methods | Rats, Wistar | Contrast Media - pharmacokinetics | Organometallic Compounds - pharmacokinetics | Rats | Sodium Chloride - administration & dosage | Meglumine - analogs & derivatives | Brain - metabolism | Animals | Contrast Media - administration & dosage | Meglumine - administration & dosage | Gadolinium DTPA - pharmacokinetics | Models, Animal | Gadolinium DTPA - administration & dosage | Chemical Fractionation - methods | Meglumine - pharmacokinetics | Organometallic Compounds - administration & dosage | Index Medicus | Original
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2. Full Text T1-Weighted Hypersignal in the Deep Cerebellar Nuclei After Repeated Administrations of Gadolinium-Based Contrast Agents in Healthy Rats: Difference Between Linear and Macrocyclic Agents
by Robert, Philippe and Lehericy, Stéphane and Grand, Sylvie and Violas, Xavier and Fretellier, Nathalie and Idée, Jean-Marc and Ballet, Sébastien and Corot, Claire
Investigative Radiology, ISSN 0020-9996, 08/2015, Volume 50, Issue 8, pp. 473 - 480
OBJECTIVESTo prospectively compare in healthy rats the effect of multiple injections of macrocyclic (gadoterate meglumine) and linear (gadodiamide)... 
signal intensity | magnetic resonance | gadoterate meglumine | deep cerebellar nuclei | cumulative doses | contrast agent | dentate nucleus | gadodiamide | gadolinium | DENTATE NUCLEUS | TRANSMETALATION | DEPOSITION | GLOBUS-PALLIDUS | CONSEQUENCES | BIODISTRIBUTION | MR-IMAGES | GADODIAMIDE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | NEPHROGENIC SYSTEMIC FIBROSIS | SIGNAL INTENSITY | Injections, Intravenous | Follow-Up Studies | Contrast Media - pharmacokinetics | Organometallic Compounds - pharmacokinetics | Rats | Cerebellar Nuclei - metabolism | Rats, Sprague-Dawley | Cerebellar Nuclei - drug effects | Magnetic Resonance Imaging | Animals | Contrast Media - administration & dosage | Meglumine - administration & dosage | Female | Gadolinium DTPA - pharmacokinetics | Gadolinium DTPA - administration & dosage | Meglumine - pharmacokinetics | Organometallic Compounds - administration & dosage | Index Medicus | Original
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3. Full Text A pH-Responsive Yolk-Like Nanoplatform for Tumor Targeted Dual-Mode Magnetic Resonance Imaging and Chemotherapy
by Sun, Xiao and Du, Ruohong and Zhang, Li and Zhang, Guilong and Zheng, Xiaojia and Qian, Junchao and Tian, Xiaohe and Zhou, Jiewen and He, Jiacai and Wang, Yuanyin and Wu, Yiqun and Zhong, Kai and Cai, Dongqing and Zou, Duohong and Wu, Zhengyan
ACS Nano, ISSN 1936-0851, 07/2017, Volume 11, Issue 7, pp. 7049 - 7059
Incorporation of T-1 and T-2 contrast material in one nanosystem performing their respective MR contrast role and simultaneously serving as an efficient drug... 
dual-mode MR imaging | cancer chemotherapy | targeted | drug delivery system | yolk-like Fe | cisplatin | @Gd | pH responsive | IRON-OXIDE NANOPARTICLES | GADOLINIUM | yolk-like Fe3O4@Gd2O3 | MATERIALS SCIENCE, MULTIDISCIPLINARY | DRUG-DELIVERY SYSTEM | CHEMISTRY, PHYSICAL | RELAXATION | NANOSCIENCE & NANOTECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | ANGIOGRAPHY | FACILE SYNTHESIS | dual-mode MR imaging drug delivery system | BIOIMAGING AGENT | SURFACE | T-1 | MRI CONTRAST AGENTS | Gadolinium - administration & dosage | Humans | Magnetic Resonance Imaging - methods | Delayed-Action Preparations - chemistry | Polyethylene Glycols - chemistry | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Folic Acid - administration & dosage | Cisplatin - administration & dosage | Delayed-Action Preparations - administration & dosage | Drug Delivery Systems | Theranostic Nanomedicine - methods | Contrast Media - administration & dosage | Ferrosoferric Oxide - administration & dosage | Nanostructures - ultrastructure | Folic Acid - chemistry | Ferrosoferric Oxide - chemistry | Neoplasms - diagnostic imaging | Gadolinium - chemistry | Polyethylene Glycols - administration & dosage | Neoplasms - drug therapy | Animals | Cisplatin - therapeutic use | Nanostructures - administration & dosage | Nanostructures - chemistry | Contrast Media - chemistry | Mice | HeLa Cells | Hydrogen-Ion Concentration | Index Medicus
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4. Full Text Probiotic helminth administration in relapsing–remitting multiple sclerosis: a phase 1 study
by Fleming, JO and Isaak, A and Lee, JE and Luzzio, CC and Carrithers, MD and Cook, TD and Field, AS and Boland, J and Fabry, Z
Multiple Sclerosis Journal, ISSN 1352-4585, 6/2011, Volume 17, Issue 6, pp. 743 - 754
Background: Probiotic treatment strategy based on the hygiene hypothesis, such as administration of ova from the non-pathogenic helminth, Trichuris suis, (TSO)... 
immunomodulation | probiotic | hygiene hypothesis | multiple sclerosis | whipworm | cytokines | Trichuris | CONTROLLED-TRIAL | PARASITES | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | TRICHURIS-SUIS INFECTION | NEUROSCIENCES | CLINICAL NEUROLOGY | INFLAMMATORY-BOWEL-DISEASE | REGULATORY T-CELLS | ENHANCED MRI | ALLERGIC DISEASES | ANTIGEN | Up-Regulation | Multiple Sclerosis, Relapsing-Remitting - immunology | Antibodies, Helminth - blood | Administration, Oral | Multiple Sclerosis, Relapsing-Remitting - therapy | Humans | Interleukin-10 - blood | Male | Treatment Outcome | Multiple Sclerosis, Relapsing-Remitting - diagnosis | Biomarkers - blood | Young Adult | Magnetic Resonance Imaging | Trichuris - immunology | Interleukin-4 - blood | Pilot Projects | Animals | C-Reactive Protein - metabolism | Time Factors | Brain - pathology | Adult | Female | Wisconsin | Probiotics - adverse effects | Multiple sclerosis | Inflammatory bowel diseases | Nuclear magnetic resonance--NMR | Immunomodulation | Gadolinium | Sclerosis | Probiotics | Side effects | Interleukin 4 | Immunology | Magnetic resonance imaging | Intestine | Interleukin 10 | Interferon | Ova | Index Medicus | Serum levels | Autoimmune diseases | Hygiene | probiotics
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5. Full Text High signal intensity in dentate nucleus on unenhanced T1-weighted MR images: Association with linear versus macrocyclic gadolinium chelate administration
by Kanda, Tomonori and Osawa, Marie and Oba, Hiroshi and Toyoda, Keiko and Kotoku, Jun'ichi and Haruyama, Takahiro and Takeshita, Koji and Furui, Shigeru
Radiology, ISSN 0033-8419, 06/2015, Volume 275, Issue 3, pp. 803 - 809
Purpose: To assess whether an association exists between hyper-intensity in the dentate nucleus (DN) on unenhanced T1-weighted magnetic resonance (MR) images... 
SPECTROSCOPY | OMNISCAN | MODELS | CONTRAST AGENTS | SMOOTHING PARAMETER-ESTIMATION | RETENTION | STABILITY | HUMAN BONE TISSUE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | LESIONS | NEPHROGENIC SYSTEMIC FIBROSIS | Brain Diseases - diagnosis | Humans | Middle Aged | Heterocyclic Compounds | Magnetic Resonance Imaging - methods | Gadolinium | Male | Cerebellar Nuclei - pathology | Organometallic Compounds | Young Adult | Contrast Media | Adolescent | Aged, 80 and over | Adult | Female | Aged | Retrospective Studies | Gadolinium DTPA | Index Medicus | Abridged Index Medicus
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6. Full Text Increased Signal Intensity in the Dentate Nucleus on Unenhanced T1-Weighted Images After Gadobenate Dimeglumine Administration
by Weberling, Lukas D and Kieslich, Pascal J and Kickingereder, Philipp and Wick, Wolfgang and Bendszus, Martin and Schlemmer, Heinz-Peter and Radbruch, Alexander
Investigative Radiology, ISSN 0020-9996, 11/2015, Volume 50, Issue 11, pp. 743 - 748
OBJECTIVESThe aim of this study was to compare changes in signal intensity (SI) ratios of the dentate nucleus (DN) to pons and cerebrospinal fluid (CSF) on... 
Linear gadolinium-based contrast agents | Gadolinium retention | Gadobenate dimeglumine | Dentate nucleus | Gadolinium deposition | HEALTHY RATS DIFFERENCE | HYPERSIGNAL | CONTRAST AGENTS | SAFETY | RETENTION | GLOBUS-PALLIDUS | MACROCYCLIC-AGENTS | dentate nucleus | DEEP CEREBELLAR NUCLEI | gadolinium retention | gadolinium deposition | SPECTROSCOPY | linear gadolinium-based contrast agents | GADODIAMIDE | gadobenate dimeglumine | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Reproducibility of Results | Drug Administration Schedule | Humans | Middle Aged | Magnetic Resonance Imaging - methods | Male | Cerebellar Nuclei - drug effects | Meglumine - analogs & derivatives | Dose-Response Relationship, Drug | Cerebellar Nuclei - anatomy & histology | Contrast Media - administration & dosage | Meglumine - administration & dosage | Sensitivity and Specificity | Female | Organometallic Compounds - administration & dosage | Index Medicus
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7. Full Text Diagnostic Value of the Magnetic Resonance Imaging With Intratympanic Gadolinium Administration (IT-Gd MRI) Versus Audio-Vestibular Tests in Menièreʼs Disease: IT-Gd MRI Makes the Difference
by Wesseler, Antje and Óvári, Attila and Javorkova, Andrea and Kwiatkowski, André and Meyer, Jens E and Kivelitz, Dietmar E
Otology & Neurotology, ISSN 1531-7129, 03/2019, Volume 40, Issue 3, pp. e225 - e232
OBJECTIVE:Our aim was to evaluate the validity and reliability of clinically relevant tests in the diagnosis of Menièreʼs disease (MD) according to the... 
VISUALIZATION | HEAD | ENDOLYMPHATIC HYDROPS | INNER-EAR | Intratympanic gadolinium magnetic resonance imaging | CLASSIFICATION | Video head impulse test | Caloric test | CLINICAL NEUROLOGY | Cervical-vestibular-evoked -myogenic-potentials | Reliability and validity | OTORHINOLARYNGOLOGY | Meniere's disease diagnostics | OTOLOGY
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8. Full Text Gadolinium Presence in the Brain After Administration of the Liver-Specific Gadolinium-Based Contrast Agent Gadoxetate: A Systematic Comparison to Multipurpose Agents in Rats
by Jost, Gregor and Frenzel, Thomas and Boyken, Janina and Schoeckel, Laura and Pietsch, Hubertus
Investigative Radiology, ISSN 0020-9996, 08/2019, Volume 54, Issue 8, pp. 468 - 474
OBJECTIVEClinical studies have reported different results regarding the signal intensity (SI) increase in the dentate nucleus on unenhanced T1-weighted... 
magnetic resonance imaging | gadoxetate disodium | contrast agents | UNENHANCED T1-WEIGHTED IMAGES | RETENTION | GLOBUS-PALLIDUS | brain | CEREBROSPINAL-FLUID | HEALTHY RATS | DENTATE NUCLEUS | SIGNAL INTENSITY INCREASE | Gd-EOB-DTPA | CENTRAL-NERVOUS-SYSTEM | RESIDUAL-GADOLINIUM | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | gadolinium | Usage | Rats as laboratory animals | Magnetic resonance imaging | Gadolinium | Research | Cerebrospinal fluid | Health aspects
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9. Full Text Gadolinium brain deposition after macrocyclic gadolinium administration: A pediatric case-control study
by Tibussek, Daniel and Rademacher, Christin and Caspers, Julian and Turowski, Bernd and Schaper, Jörg and Antoch, Gerald and Klee, Dirk
Radiology, ISSN 0033-8419, 10/2017, Volume 285, Issue 1, pp. 223 - 230
Purpose: To determine whether signal intensity (SI) in T1 sequences as a potential indicator of gadolinium deposition increases after repeated administration... 
T1-WEIGHTED MR-IMAGES | DENTATE NUCLEUS | 1.5 T | PROGRESSIVE INCREASE | RETENTION | GLOBUS-PALLIDUS | AGENTS | GADODIAMIDE | NORMAL RENAL-FUNCTION | HIGH SIGNAL INTENSITY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Gadolinium - administration & dosage | Meglumine - metabolism | Brain - diagnostic imaging | Gadolinium - pharmacology | Meglumine - therapeutic use | Humans | Child, Preschool | Male | Case-Control Studies | Brain - metabolism | Contrast Media - pharmacology | Contrast Media - administration & dosage | Organometallic Compounds - therapeutic use | Contrast Media - therapeutic use | Female | Retrospective Studies | Child | Gadolinium - therapeutic use | Brain - drug effects | Magnetic Resonance Imaging | Administration, Intravenous | Meglumine - pharmacology | Organometallic Compounds - metabolism | Meglumine - administration & dosage | Adolescent | Brain - pathology | Contrast Media - metabolism | Gadolinium - metabolism | Organometallic Compounds - pharmacology | Organometallic Compounds - administration & dosage | Index Medicus | Abridged Index Medicus
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10. Full Text Comparison of gadolinium concentrations within multiple rat organs after intravenous administration of linear versus macrocyclic gadolinium chelates
by McDonald, Robert J and McDonald, Jennifer S and Dai, Daying and Schroeder, Dana and Jentoft, Mark E and Murray, David L and Kadirvel, Ramanathan and Eckel, Laurence J and Kallmes, David F
Radiology, ISSN 0033-8419, 11/2017, Volume 285, Issue 2, pp. 536 - 545
Purpose: To compare gadolinium tissue concentrations of multiple linear and macrocyclic chelates in a rat model to better understand the scope and extent of... 
HIGH-SIGNAL INTENSITY | DENTATE NUCLEUS | CONTRAST AGENTS | RETENTION | GLOBUS-PALLIDUS | GADOTERIDOL | MICE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | BRAIN | Gadolinium - administration & dosage | Rats, Wistar | Heterocyclic Compounds - administration & dosage | Gadolinium - pharmacokinetics | Contrast Media - pharmacokinetics | Organometallic Compounds - pharmacokinetics | Rats | Male | Contrast Media - analysis | Liver - chemistry | Spleen - chemistry | Tissue Distribution | Magnetic Resonance Imaging | Administration, Intravenous | Animals | Contrast Media - administration & dosage | Gadolinium - analysis | Heterocyclic Compounds - pharmacokinetics | Cerebellum - chemistry | Retrospective Studies | Organometallic Compounds - administration & dosage | Index Medicus | Abridged Index Medicus
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11. Full Text Quantification of amide proton transfer effect pre‐ and post‐gadolinium contrast agent administration
by Tee, Yee Kai and Donahue, Manus J and Harston, George W.J and Payne, Stephen J and Chappell, Michael A
Journal of Magnetic Resonance Imaging, ISSN 1053-1807, 10/2014, Volume 40, Issue 4, pp. 832 - 838
Purpose: To compare quantification of the amide proton transfer (APT) effect pre- and post-gadolinium contrast agent (Gd) administration in order to establish... 
chemical exchange saturation transfer (CEST) imaging | gadolinium contrast agents | amide proton transfer (APT) imaging | magnetization transfer (MT) imaging | Chemical exchange saturation transfer (CEST) imaging | Gadolinium contrast agents | Amide proton transfer (APT) imaging | Magnetization transfer (MT) imaging | ROBUST | GD-DTPA-BMA | MAGNETIZATION-TRANSFER | MODEL | EXCHANGE SATURATION-TRANSFER | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | BRAIN | Gadolinium - administration & dosage | Protons | Reproducibility of Results | Algorithms | Contrast Media - administration & dosage | Humans | Image Interpretation, Computer-Assisted - methods | Sensitivity and Specificity | Amides | Magnetic Resonance Angiography - methods | Image Enhancement - methods | Carotid Stenosis - pathology | Gadolinium | Magnetization | Contrast media | Index Medicus
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12. Full Text Repeated intravenous administration of gadobutrol does not lead to increased signal intensity on unenhanced T1-weighted images—a voxel-based whole brain analysis
by Langner, Soenke and Kromrey, Marie-Luise and Kuehn, Jens-Peter and Grothe, Matthias and Domin, Martin
European Radiology, ISSN 0938-7994, 9/2017, Volume 27, Issue 9, pp. 3687 - 3693
To identify a possible association between repeated intravenous administration of gadobutrol and increased signal intensity in the grey and white matter using... 
Brain | Multiple sclerosis | Medicine & Public Health | Diagnostic Radiology | MRI | Gadolinium | Internal Medicine | Interventional Radiology | Imaging / Radiology | Ultrasound | Neuroradiology | Contrast media | CONTRAST AGENTS | RETENTION | GLOBUS-PALLIDUS | GADOLINIUM DEPOSITION | MACROCYCLIC-AGENTS | NORMAL RENAL-FUNCTION | DENTATE NUCLEUS | BONE TISSUE | PLASMA-MASS SPECTROSCOPY | GADODIAMIDE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Humans | Middle Aged | Magnetic Resonance Imaging - methods | Male | Brain Diseases - diagnostic imaging | Cerebellar Nuclei - pathology | Gray Matter - diagnostic imaging | Administration, Intravenous | White Matter - diagnostic imaging | Contrast Media - administration & dosage | Adult | Female | Aged | Retrospective Studies | Organometallic Compounds - administration & dosage | Algebra | Body weight | Neuroimaging | Nuclear magnetic resonance--NMR | Intravenous administration | Molecular structure | Granulocyte-macrophage colony-stimulating factor | Ions | Cerebrospinal fluid | Dosage | Substantia alba | Substantia grisea | Contrast agents | Magnetic resonance imaging | Mathematical analysis | Lie groups | Image contrast | Index Medicus
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13. Full Text Hyperintense dentate nuclei on t1-weighted mri: Relation to repeat gadolinium administration
by Adin, M.E and Kleinberg, L and Vaidya, D and Zan, E and Mirbagheri, X.S and Yousem, X.D.M
American Journal of Neuroradiology, ISSN 0195-6108, 10/2015, Volume 36, Issue 10, pp. 1859 - 1865
BACKGROUND AND PURPOSE: A hyperintense appearance of the dentate nucleus on T1-weighted MR images has been related to various clinical conditions, but the... 
Radiation dose | NDN-normal dentate nucleus | HDN-hyperintense appearance of the dentate nucleus | CEMRI-contrast-enhanced MRI | P 25-25th percentile | DN-dentate nucleus | MFS-magnetic field strength of the scanner | P75-75th percentile | RT-radiation therapy | IMAGES | DISEASE | SECONDARY | BASAL GANGLIA LESIONS | CONTRAST | CALCIFICATION | HIGH SIGNAL INTENSITY | NEUROIMAGING | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | BRAIN | CLINICAL NEUROLOGY | NEPHROGENIC SYSTEMIC FIBROSIS | Gadolinium - administration & dosage | Image Enhancement | Humans | Middle Aged | Child, Preschool | Male | Cerebellar Nuclei - pathology | Radiation Dosage | Cranial Irradiation | Young Adult | Magnetic Resonance Imaging | Contrast Media - administration & dosage | Adolescent | Adult | Female | Aged | Child | Index Medicus
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14. Full Text Lack of increased signal intensity in the dentate nucleus after repeated administration of a macrocyclic contrast agent in multiple sclerosis: An observational study
by Eisele, Philipp and Eisele, Philipp and Alonso, Angelika and Alonso, Angelika and Szabo, Kristina and Szabo, Kristina and Ebert, Anne and Ebert, Anne and Ong, Melissa and Ong, Melissa and Schoenberg, Stefan O and Schoenberg, Stefan O and Gass, Achim and Gass, Achim
Medicine (United States), ISSN 0025-7974, 2016, Volume 95, Issue 39, pp. e4624 - e4624
Recently, several studies reported increased signal intensity (SI) in the dentate nucleus (DN) after repeated application of gadolinium-based contrast agents... 
Gadolinium | Multiple sclerosis | MRI | Dentate nucleus | T1-WEIGHTED MR-IMAGES | MEDICINE, GENERAL & INTERNAL | DIMEGLUMINE | multiple sclerosis | GLOBUS-PALLIDUS | GADOBUTROL | dentate nucleus | LESIONS | gadolinium | Humans | Middle Aged | Contrast Media - pharmacokinetics | Organometallic Compounds - pharmacokinetics | Male | Cerebellar Nuclei - metabolism | Blood-Brain Barrier - metabolism | Young Adult | Magnetic Resonance Imaging | Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging | Adolescent | Adult | Female | Retrospective Studies | Multiple Sclerosis, Relapsing-Remitting - metabolism | Meglumine - pharmacokinetics | Usage | Care and treatment | Magnetic resonance imaging | Contrast media | Index Medicus | Abridged Index Medicus
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